BRPI0618713B8 - cardiolipina modificada e seus usos - Google Patents

cardiolipina modificada e seus usos

Info

Publication number
BRPI0618713B8
BRPI0618713B8 BRPI0618713A BRPI0618713A BRPI0618713B8 BR PI0618713 B8 BRPI0618713 B8 BR PI0618713B8 BR PI0618713 A BRPI0618713 A BR PI0618713A BR PI0618713 A BRPI0618713 A BR PI0618713A BR PI0618713 B8 BRPI0618713 B8 BR PI0618713B8
Authority
BR
Brazil
Prior art keywords
antibodies
cardiolipin
treponemic
allow
detection
Prior art date
Application number
BRPI0618713A
Other languages
English (en)
Inventor
r castro Arnold
Wang Huiying
Original Assignee
The Government Of The United State Of America Representado Por The Secretary Of The Dept Of Health A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Government Of The United State Of America Representado Por The Secretary Of The Dept Of Health A filed Critical The Government Of The United State Of America Representado Por The Secretary Of The Dept Of Health A
Publication of BRPI0618713A2 publication Critical patent/BRPI0618713A2/pt
Publication of BRPI0618713B1 publication Critical patent/BRPI0618713B1/pt
Publication of BRPI0618713B8 publication Critical patent/BRPI0618713B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/571—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses for venereal disease, e.g. syphilis, gonorrhoea
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/20—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

cardiolipina modificada e seus usos. são descritas composições, métodos e dispositivos para a detecção de anticorpos anti-lipídicos e para o diagnóstico de doenças como, por exemplo, a sífilis. em particular, são descritas cardiolipinas oxidadas, que podem ser conjugadas com uma variedade de moléculas de ligação, tais como asb, hff, biotina, proteína sintética maps, igy, estreptavidina ou avidina. tal cardiolipina oxidada, isolada ou complexada com uma ou mais moléculas de ligação, é útil para detectar anticorpos anti-lipídios em sujeitos, por exemplo, quando utilizada em dispositivos de fluxo lateral. são descritos dispositivos de fluxo lateral que permitem a detecção de anticorpos anti-lipídicos, e que permitem a co-detecção de anticorpos não-treponêmicos e treponêmicos em amostras biológicas.
BRPI0618713A 2005-11-18 2006-11-17 cardiolipina modificada e seus usos BRPI0618713B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73790105P 2005-11-18 2005-11-18
US60/737,901 2005-11-18
PCT/US2006/044572 WO2007061793A2 (en) 2005-11-18 2006-11-17 Modified cardiolipin and uses therefor

Publications (3)

Publication Number Publication Date
BRPI0618713A2 BRPI0618713A2 (pt) 2012-12-04
BRPI0618713B1 BRPI0618713B1 (pt) 2018-01-02
BRPI0618713B8 true BRPI0618713B8 (pt) 2021-07-27

Family

ID=38067762

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0618713A BRPI0618713B8 (pt) 2005-11-18 2006-11-17 cardiolipina modificada e seus usos

Country Status (6)

Country Link
US (2) US7888043B2 (pt)
EP (1) EP1949108B1 (pt)
JP (2) JP4837743B2 (pt)
CN (1) CN101360997B (pt)
BR (1) BRPI0618713B8 (pt)
WO (1) WO2007061793A2 (pt)

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Also Published As

Publication number Publication date
JP4837743B2 (ja) 2011-12-14
BRPI0618713A2 (pt) 2012-12-04
US20080311597A1 (en) 2008-12-18
US7888043B2 (en) 2011-02-15
WO2007061793A2 (en) 2007-05-31
EP1949108A2 (en) 2008-07-30
EP1949108B1 (en) 2013-09-25
WO2007061793A3 (en) 2007-08-09
CN101360997B (zh) 2013-05-01
JP5307198B2 (ja) 2013-10-02
US20110136143A1 (en) 2011-06-09
JP2011237443A (ja) 2011-11-24
JP2009516199A (ja) 2009-04-16
BRPI0618713B1 (pt) 2018-01-02
US8906603B2 (en) 2014-12-09
CN101360997A (zh) 2009-02-04

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