BR9914065A - Indolinonas substituìdas, sua preparação e seu uso como medicamentos - Google Patents
Indolinonas substituìdas, sua preparação e seu uso como medicamentosInfo
- Publication number
- BR9914065A BR9914065A BR9914065-9A BR9914065A BR9914065A BR 9914065 A BR9914065 A BR 9914065A BR 9914065 A BR9914065 A BR 9914065A BR 9914065 A BR9914065 A BR 9914065A
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- general formula
- medicines
- substituted indolinones
- compounds
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000651 prodrug Chemical group 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 102000016736 Cyclin Human genes 0.000 abstract 1
- 108050006400 Cyclin Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 abstract 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção: <B>"INDOLINONAS SUBSTITUìDAS, SUA PREPARAçãO E SEU USO COMO MEDICAMENTOS"<D>. A presente invenção refere-se a novas indolinonas substituídas da fórmula geral em que X e R~ 1~ a R~ 5~ são como definidos na reivindicação 1, os isómeros e os seus sais que têm propriedades de alto valor. Os compostos acima da fórmula geral I em que R~ 1~ significa um átomo de hidrogênio, um grupo C~ 1-3~ alquila ou um grupo de pró-droga têm propriedades farmacológicas de alto valor, particularmente um efeito de inibição sobre várias cinases, sobre ciclina viral e sobre cinases de tirosina de receptor, e os outros compostos da fórmula geral I acima em que R~ 1~ não representa um átomo de hidrogênio, um grupo C~ 1-3~ alquila ou um grupo de pró-droga são produtos intermediários de alto valor para a preparação dos compostos acima mencionados.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19844003A DE19844003A1 (de) | 1998-09-25 | 1998-09-25 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE19937496A DE19937496A1 (de) | 1999-08-07 | 1999-08-07 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
PCT/EP1999/007040 WO2000018734A1 (de) | 1998-09-25 | 1999-09-22 | Neue substituierte indolinone mit inhibierender wirkung auf verschiedene kinasen und cyclin/cdk-komplexe |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9914065A true BR9914065A (pt) | 2001-06-19 |
Family
ID=26049076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9914065-9A BR9914065A (pt) | 1998-09-25 | 1999-09-22 | Indolinonas substituìdas, sua preparação e seu uso como medicamentos |
Country Status (28)
Country | Link |
---|---|
US (1) | US6855710B2 (pt) |
EP (1) | EP1115704B1 (pt) |
JP (1) | JP2002525356A (pt) |
KR (1) | KR20010085841A (pt) |
CN (1) | CN1319090A (pt) |
AT (1) | ATE243195T1 (pt) |
AU (1) | AU763361B2 (pt) |
BG (1) | BG105327A (pt) |
BR (1) | BR9914065A (pt) |
CA (1) | CA2342622A1 (pt) |
DE (1) | DE59906030D1 (pt) |
DK (1) | DK1115704T3 (pt) |
EA (1) | EA200100320A1 (pt) |
EE (1) | EE200100184A (pt) |
ES (1) | ES2196860T3 (pt) |
HR (1) | HRP20010216A2 (pt) |
HU (1) | HUP0104973A3 (pt) |
ID (1) | ID27757A (pt) |
IL (1) | IL141622A0 (pt) |
NO (1) | NO20011477D0 (pt) |
NZ (1) | NZ510845A (pt) |
PL (1) | PL346898A1 (pt) |
PT (1) | PT1115704E (pt) |
SI (1) | SI1115704T1 (pt) |
SK (1) | SK4032001A3 (pt) |
TR (1) | TR200100854T2 (pt) |
WO (1) | WO2000018734A1 (pt) |
YU (1) | YU21301A (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
WO2003027102A1 (en) * | 2001-09-27 | 2003-04-03 | Allergan, Inc. | 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
CN1633296A (zh) | 2002-03-26 | 2005-06-29 | 贝林格尔·英格海姆药物公司 | 糖皮质素模拟物、其制备方法、药物组合物及其用途 |
US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
PE20040701A1 (es) * | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
MXPA05002297A (es) * | 2002-08-29 | 2005-06-08 | Boehringer Ingelheim Pharma | Derivados-3(sulfoamidoetil)-indol para uso como compuestos mimeticos de glucocorticoides en el tratamiento de enfermedades inflamatorias, alergicas y proliferativas. |
US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
US7125996B2 (en) * | 2003-10-03 | 2006-10-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Fluorescent probes for use in protein kinase inhibitor binding assay |
KR101165863B1 (ko) | 2004-03-11 | 2012-07-13 | 액테리온 파마슈티칼 리미티드 | 인돌-1-일-아세트산 유도체 |
US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
WO2006071609A2 (en) | 2004-12-27 | 2006-07-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
KR20080007645A (ko) | 2005-04-28 | 2008-01-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 염증성 질환 치료용 신규 화합물 |
AU2007329548A1 (en) | 2006-12-06 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
US20100086544A1 (en) * | 2006-12-11 | 2010-04-08 | Mass Robert D | Compositions and methods for treating a neoplasm |
CN101273991B (zh) * | 2007-03-28 | 2010-05-26 | 广东同德药业有限公司 | 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用 |
CL2008003598A1 (es) * | 2007-12-03 | 2010-02-12 | Boehringer Ingelheim Int | Procedimiento de preparacion de 3-z-[1-(4-(n-((4-metil-piperazina-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoxicarbonil-2-indolinona por descloroacetilacion en medio basico de uno de los compuestos intermediarios. |
PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
PL2238108T3 (pl) * | 2008-01-25 | 2013-01-31 | Boehringer Ingelheim Int | Postacie soli pochodnej 6-fluoro-1,2-dihydro-2-okso-3H-indol-3-ilidenu, sposób ich wytwarzania oraz kompozycje farmaceutyczne je zawierające |
CN102112476A (zh) | 2008-06-06 | 2011-06-29 | 贝林格尔.英格海姆国际有限公司 | 糖皮质激素模拟物、其制备方法、药物组合物及其用途 |
US8853420B2 (en) | 2008-07-29 | 2014-10-07 | Boehringer Ingelheim International Gmbh | Compounds |
JPWO2013137371A1 (ja) * | 2012-03-15 | 2015-08-03 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
CN111683976B (zh) | 2018-02-05 | 2022-11-18 | 生物辐射实验室股份有限公司 | 具有阴离子交换-疏水混合模式配体的色谱树脂 |
CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-09-22 ES ES99947404T patent/ES2196860T3/es not_active Expired - Lifetime
- 1999-09-22 BR BR9914065-9A patent/BR9914065A/pt unknown
- 1999-09-22 PT PT99947404T patent/PT1115704E/pt unknown
- 1999-09-22 CA CA002342622A patent/CA2342622A1/en not_active Abandoned
- 1999-09-22 NZ NZ510845A patent/NZ510845A/en unknown
- 1999-09-22 EP EP99947404A patent/EP1115704B1/de not_active Expired - Lifetime
- 1999-09-22 HU HU0104973A patent/HUP0104973A3/hu unknown
- 1999-09-22 JP JP2000572194A patent/JP2002525356A/ja active Pending
- 1999-09-22 WO PCT/EP1999/007040 patent/WO2000018734A1/de not_active Application Discontinuation
- 1999-09-22 YU YU21301A patent/YU21301A/sh unknown
- 1999-09-22 DE DE59906030T patent/DE59906030D1/de not_active Expired - Fee Related
- 1999-09-22 AT AT99947404T patent/ATE243195T1/de not_active IP Right Cessation
- 1999-09-22 SI SI9930391T patent/SI1115704T1/xx unknown
- 1999-09-22 IL IL14162299A patent/IL141622A0/xx unknown
- 1999-09-22 EE EEP200100184A patent/EE200100184A/xx unknown
- 1999-09-22 TR TR2001/00854T patent/TR200100854T2/xx unknown
- 1999-09-22 ID IDW20010688A patent/ID27757A/id unknown
- 1999-09-22 AU AU60863/99A patent/AU763361B2/en not_active Ceased
- 1999-09-22 KR KR1020017003773A patent/KR20010085841A/ko not_active Application Discontinuation
- 1999-09-22 DK DK99947404T patent/DK1115704T3/da active
- 1999-09-22 PL PL99346898A patent/PL346898A1/xx not_active Application Discontinuation
- 1999-09-22 EA EA200100320A patent/EA200100320A1/ru unknown
- 1999-09-22 SK SK403-2001A patent/SK4032001A3/sk unknown
- 1999-09-22 CN CN99811297A patent/CN1319090A/zh active Pending
-
2001
- 2001-03-09 BG BG105327A patent/BG105327A/xx active Pending
- 2001-03-21 HR HR20010216A patent/HRP20010216A2/hr not_active Application Discontinuation
- 2001-03-22 NO NO20011477A patent/NO20011477D0/no not_active Application Discontinuation
-
2003
- 2003-09-19 US US10/666,643 patent/US6855710B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BG105327A (en) | 2001-12-29 |
EP1115704B1 (de) | 2003-06-18 |
JP2002525356A (ja) | 2002-08-13 |
EP1115704A1 (de) | 2001-07-18 |
CA2342622A1 (en) | 2000-04-06 |
NO20011477L (no) | 2001-03-22 |
ATE243195T1 (de) | 2003-07-15 |
SK4032001A3 (en) | 2001-11-06 |
NO20011477D0 (no) | 2001-03-22 |
EE200100184A (et) | 2002-08-15 |
PL346898A1 (en) | 2002-03-11 |
YU21301A (sh) | 2003-04-30 |
ID27757A (id) | 2001-04-26 |
HRP20010216A2 (en) | 2002-04-30 |
TR200100854T2 (tr) | 2001-12-21 |
PT1115704E (pt) | 2003-11-28 |
ES2196860T3 (es) | 2003-12-16 |
NZ510845A (en) | 2003-10-31 |
US6855710B2 (en) | 2005-02-15 |
IL141622A0 (en) | 2002-03-10 |
HUP0104973A3 (en) | 2002-06-28 |
WO2000018734A1 (de) | 2000-04-06 |
HUP0104973A2 (hu) | 2002-04-29 |
DE59906030D1 (de) | 2003-07-24 |
US20040058978A1 (en) | 2004-03-25 |
AU763361B2 (en) | 2003-07-17 |
DK1115704T3 (da) | 2003-09-29 |
AU6086399A (en) | 2000-04-17 |
EA200100320A1 (ru) | 2001-10-22 |
KR20010085841A (ko) | 2001-09-07 |
SI1115704T1 (en) | 2003-12-31 |
CN1319090A (zh) | 2001-10-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25D | Requested change of name of applicant approved | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |