BR0316609A - Sinomenina e compostos de sinomenina, sìntese e uso - Google Patents
Sinomenina e compostos de sinomenina, sìntese e usoInfo
- Publication number
- BR0316609A BR0316609A BR0316609-0A BR0316609A BR0316609A BR 0316609 A BR0316609 A BR 0316609A BR 0316609 A BR0316609 A BR 0316609A BR 0316609 A BR0316609 A BR 0316609A
- Authority
- BR
- Brazil
- Prior art keywords
- synomenin
- compounds
- synthesis
- group
- synomenine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Abstract
"SINOMENINA E COMPOSTOS DE SINOMENINA, SìNTESE E USO". A invenção refere-se a sinomenina e a seus compostos e também a compostos da fórmula (I), em que R~ 1~ representa um grupo alquila; R~ 2~ representa um átomo de hidrogênio ou um grupo alquilcarbonila, um grupo haloalquilcarbonila ou um arilcarbonila; Y representa um grupo (IV); R~ 3~, R~ 4~, R<39>~ 4~, R<39>~ 5~ e R~ 6~ são como definidos na descrição; e X representa um átomo de halogênio. Medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021538190A CN1328280C (zh) | 2002-11-28 | 2002-11-28 | 汉防己碱和汉防己碱化合物,合成和应用 |
PCT/EP2003/014841 WO2004048340A1 (en) | 2002-11-28 | 2003-11-26 | Sinomenine and sinomenine compounds, synthesis and use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0316609A true BR0316609A (pt) | 2005-10-11 |
Family
ID=32331921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0316609-0A BR0316609A (pt) | 2002-11-28 | 2003-11-26 | Sinomenina e compostos de sinomenina, sìntese e uso |
Country Status (15)
Country | Link |
---|---|
US (1) | US20060009480A1 (pt) |
EP (1) | EP1565444A1 (pt) |
JP (1) | JP2006509755A (pt) |
KR (1) | KR100706462B1 (pt) |
CN (2) | CN1328280C (pt) |
AU (1) | AU2003290119A1 (pt) |
BR (1) | BR0316609A (pt) |
CA (1) | CA2507067A1 (pt) |
EA (1) | EA200500862A1 (pt) |
MA (1) | MA27573A1 (pt) |
MX (1) | MXPA05005687A (pt) |
NO (1) | NO20053139L (pt) |
PL (1) | PL377695A1 (pt) |
WO (1) | WO2004048340A1 (pt) |
ZA (1) | ZA200504055B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1298718C (zh) * | 2005-03-18 | 2007-02-07 | 中国科学院上海有机化学研究所 | C环连接有吡嗪环的青藤碱衍生物、合成方法及其用途 |
CN1298720C (zh) * | 2005-03-18 | 2007-02-07 | 中国科学院上海有机化学研究所 | C环连接有五元杂环的青藤碱衍生物和合成方法 |
CN100455571C (zh) * | 2005-12-09 | 2009-01-28 | 湖南正清制药集团股份有限公司 | 青藤碱盐化合物及其制备方法 |
CN101578101B (zh) * | 2005-12-15 | 2012-05-23 | 自然医学公司 | 青藤碱衍生物的制备和应用 |
US7932264B2 (en) | 2005-12-15 | 2011-04-26 | Naturemed Group Corporation | Sinomenine derivatives and preparation and uses thereof |
CN100408578C (zh) * | 2006-03-15 | 2008-08-06 | 南京大学 | 一类17-酰基青藤碱衍生物及其制备方法 |
CN1876634A (zh) * | 2006-06-19 | 2006-12-13 | 湖南正清制药集团股份有限公司 | 一种青藤碱结构改造化合物及其制备方法 |
CN101092397B (zh) * | 2006-06-19 | 2011-01-19 | 湖南正清制药集团股份有限公司 | 一种青藤碱结构改造化合物及其制备方法 |
US20070290378A1 (en) * | 2006-06-20 | 2007-12-20 | International Business Machines Corporation | Novel reworkable underfills for ceramic mcm c4 protection |
CN100396686C (zh) * | 2006-08-03 | 2008-06-25 | 西安皓天生物工程技术有限责任公司 | 一种汉防己甲素和汉防己乙素的制备方法 |
CN102093373A (zh) * | 2007-06-19 | 2011-06-15 | 湖南正清制药集团股份有限公司 | 一种青藤碱结构改造化合物及其制备方法 |
JP5579076B2 (ja) * | 2007-12-17 | 2014-08-27 | マリンクロッド エルエルシー | シノメニン誘導体およびそれらの合成のためのプロセス |
WO2010096790A1 (en) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-morphinananium n-oxides and processes for their production |
EP2340832A1 (en) * | 2009-12-23 | 2011-07-06 | Universität Innsbruck | Morphinan-6-one compounds for the treatment or prevention of neurodegenerative diseases |
CN101798285B (zh) * | 2010-02-10 | 2012-05-23 | 中国科学院上海有机化学研究所 | 一种青藤碱衍生物、合成方法及其用途 |
CN101899004A (zh) * | 2010-06-24 | 2010-12-01 | 江苏大学 | 青藤碱衍生物、制备方法及其医药用途 |
CN101948430A (zh) * | 2010-09-01 | 2011-01-19 | 南京大学 | 青藤碱衍生物及其制备方法和应用 |
CN102532024B (zh) * | 2011-12-28 | 2016-08-03 | 赵爱国 | 青藤碱衍生物 |
CN104274817B (zh) * | 2014-09-25 | 2016-06-15 | 中山大学 | Wrw三肽在制备治疗阿尔茨海默症药物中的用途 |
CN104306954B (zh) * | 2014-09-25 | 2016-08-24 | 中山大学 | Wry三肽在制备治疗阿尔茨海默症药物中的用途 |
CN104258372B (zh) * | 2014-09-25 | 2017-01-25 | 中山大学 | Rgd三肽在制备治疗阿尔茨海默症药物中的用途 |
CN104258371B (zh) * | 2014-09-25 | 2016-06-15 | 中山大学 | Www三肽在制备治疗阿尔茨海默症药物中的用途 |
AU2017217535A1 (en) | 2016-02-10 | 2018-09-27 | James Gray PILAAR | Enhanced inflatable sound attenuation system |
CN107648179A (zh) * | 2017-09-21 | 2018-02-02 | 浙江中医药大学 | 一种治疗类风湿性关节炎的新型皮肤给药制剂及其制备方法 |
CN108704640B (zh) * | 2018-06-13 | 2021-03-30 | 绍兴市梓昂新材料有限公司 | 一种多孔氧化铂催化剂的制备方法 |
CN110433132B (zh) * | 2019-08-19 | 2023-06-30 | 中国人民解放军军事科学院军事医学研究院 | 治疗创伤后应激障碍的粉防己碱鼻用制剂 |
CN113880764B (zh) * | 2020-07-01 | 2023-04-18 | 北京师范大学 | 青藤碱衍生物及其制备方法与应用 |
CN114831990A (zh) * | 2022-03-22 | 2022-08-02 | 台州恩泽医疗中心(集团) | 青藤碱在制备治疗帕金森病药物组合物中的应用 |
CN115260098A (zh) * | 2022-06-09 | 2022-11-01 | 澳门科技大学 | Abcb5抑制剂在制备多耐药性类风湿性关节炎治疗药物中的应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4912114A (en) * | 1988-03-18 | 1990-03-27 | Sandoz Ltd. | Morphinan derivatives |
WO1995003307A1 (fr) * | 1993-07-19 | 1995-02-02 | Toray Industries, Inc. | Agent de protection de cellules cerebrales |
US6372756B1 (en) * | 1998-02-20 | 2002-04-16 | Avmax, Inc. | Epimorphian compound and its use |
-
2002
- 2002-11-28 CN CNB021538190A patent/CN1328280C/zh not_active Expired - Fee Related
-
2003
- 2003-11-26 CN CNA200380104606XA patent/CN1720232A/zh active Pending
- 2003-11-26 BR BR0316609-0A patent/BR0316609A/pt not_active IP Right Cessation
- 2003-11-26 US US10/536,613 patent/US20060009480A1/en not_active Abandoned
- 2003-11-26 AU AU2003290119A patent/AU2003290119A1/en not_active Abandoned
- 2003-11-26 EA EA200500862A patent/EA200500862A1/ru unknown
- 2003-11-26 MX MXPA05005687A patent/MXPA05005687A/es not_active Application Discontinuation
- 2003-11-26 CA CA002507067A patent/CA2507067A1/en not_active Abandoned
- 2003-11-26 PL PL377695A patent/PL377695A1/pl unknown
- 2003-11-26 KR KR1020057009584A patent/KR100706462B1/ko not_active IP Right Cessation
- 2003-11-26 JP JP2004554526A patent/JP2006509755A/ja active Pending
- 2003-11-26 EP EP03782481A patent/EP1565444A1/en not_active Withdrawn
- 2003-11-26 WO PCT/EP2003/014841 patent/WO2004048340A1/en active Application Filing
-
2005
- 2005-05-19 ZA ZA200504055A patent/ZA200504055B/en unknown
- 2005-06-27 MA MA28362A patent/MA27573A1/fr unknown
- 2005-06-27 NO NO20053139A patent/NO20053139L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR100706462B1 (ko) | 2007-04-10 |
CN1504469A (zh) | 2004-06-16 |
AU2003290119A1 (en) | 2004-06-18 |
NO20053139L (no) | 2005-06-27 |
CN1720232A (zh) | 2006-01-11 |
JP2006509755A (ja) | 2006-03-23 |
KR20050071712A (ko) | 2005-07-07 |
PL377695A1 (pl) | 2006-02-06 |
MA27573A1 (fr) | 2005-10-03 |
ZA200504055B (en) | 2006-08-30 |
CA2507067A1 (en) | 2004-06-10 |
US20060009480A1 (en) | 2006-01-12 |
WO2004048340A8 (en) | 2005-07-07 |
MXPA05005687A (es) | 2005-08-16 |
WO2004048340A1 (en) | 2004-06-10 |
EP1565444A1 (en) | 2005-08-24 |
CN1328280C (zh) | 2007-07-25 |
EA200500862A1 (ru) | 2005-12-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 5A., 6A, E 7A. ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010. |