YU21301A - Novi supstituisani indolinoni sa inhibitorskim efektom za različite kinaze i komplekse ciklin/cdk - Google Patents
Novi supstituisani indolinoni sa inhibitorskim efektom za različite kinaze i komplekse ciklin/cdkInfo
- Publication number
- YU21301A YU21301A YU21301A YU21301A YU21301A YU 21301 A YU21301 A YU 21301A YU 21301 A YU21301 A YU 21301A YU 21301 A YU21301 A YU 21301A YU 21301 A YU21301 A YU 21301A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- inhibitory effect
- cyclin
- novel substituted
- general formula
- various kinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Pronalazak se odnosi na nove supstituisane indolinone, opšte formule (I), u kojoj su X i R1 do R5 definisani kao u zathevu 1, na njihove izomere i njihove soli, koji imaju dragocena svojstva. Gornja jedinjenja opšte formule (I), u kojoj R1 predstavlja atom vodonika, C1-3-alkil-grupu ili ostatak proleka, ispoljavaju dragocena farmakološka svojstva, naročito inzibitorsko dejstvo na različite kinaze, na virusni ciklin i na tirozin receptorske kinaze, a druga jedinjenja opšte formule (I), u kojoj R1 ne predstavlja atom vodonika, C1-3-alkil-grupu ili ostatak proleka, predstavljaju dragocene medjuproizvode za pripremanje prethodno pomenutih jedinjenja.[The invention relates to novel substituted indolinones of general formula (I), wherein X and R1 to R5 have the meanings given in claim no.1, and to isomers and salts thereof with useful properties. The above compounds of general formula (I), wherein R1 represents a hydrogen atom, a C1-3-alkyl group or a pro-drug radical, have useful pharmacological properties, especially an inhibitory effect on various kinases, on viral cyclin and on receptor tyrosine kinases. The other compounds of general formula (I), wherein R1 does not represent a hydrogen atom, a C1-3-alkyl group or pro-drug radical, represent useful intermediate products for producing the above-mentioned compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19844003A DE19844003A1 (de) | 1998-09-25 | 1998-09-25 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE19937496A DE19937496A1 (de) | 1999-08-07 | 1999-08-07 | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
YU21301A true YU21301A (sh) | 2003-04-30 |
Family
ID=26049076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU21301A YU21301A (sh) | 1998-09-25 | 1999-09-22 | Novi supstituisani indolinoni sa inhibitorskim efektom za različite kinaze i komplekse ciklin/cdk |
Country Status (28)
Country | Link |
---|---|
US (1) | US6855710B2 (sh) |
EP (1) | EP1115704B1 (sh) |
JP (1) | JP2002525356A (sh) |
KR (1) | KR20010085841A (sh) |
CN (1) | CN1319090A (sh) |
AT (1) | ATE243195T1 (sh) |
AU (1) | AU763361B2 (sh) |
BG (1) | BG105327A (sh) |
BR (1) | BR9914065A (sh) |
CA (1) | CA2342622A1 (sh) |
DE (1) | DE59906030D1 (sh) |
DK (1) | DK1115704T3 (sh) |
EA (1) | EA200100320A1 (sh) |
EE (1) | EE200100184A (sh) |
ES (1) | ES2196860T3 (sh) |
HR (1) | HRP20010216A2 (sh) |
HU (1) | HUP0104973A3 (sh) |
ID (1) | ID27757A (sh) |
IL (1) | IL141622A0 (sh) |
NO (1) | NO20011477D0 (sh) |
NZ (1) | NZ510845A (sh) |
PL (1) | PL346898A1 (sh) |
PT (1) | PT1115704E (sh) |
SI (1) | SI1115704T1 (sh) |
SK (1) | SK4032001A3 (sh) |
TR (1) | TR200100854T2 (sh) |
WO (1) | WO2000018734A1 (sh) |
YU (1) | YU21301A (sh) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9904933D0 (en) * | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
WO2003027102A1 (en) * | 2001-09-27 | 2003-04-03 | Allergan, Inc. | 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors |
US6797825B2 (en) | 2001-12-13 | 2004-09-28 | Abbott Laboratories | Protein kinase inhibitors |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
CN1633296A (zh) | 2002-03-26 | 2005-06-29 | 贝林格尔·英格海姆药物公司 | 糖皮质素模拟物、其制备方法、药物组合物及其用途 |
US7169936B2 (en) | 2002-07-23 | 2007-01-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments |
PE20040701A1 (es) * | 2002-07-23 | 2004-11-30 | Boehringer Ingelheim Pharma | Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos |
DE10233366A1 (de) * | 2002-07-23 | 2004-02-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
US7514468B2 (en) | 2002-07-23 | 2009-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions |
DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
MXPA05002297A (es) * | 2002-08-29 | 2005-06-08 | Boehringer Ingelheim Pharma | Derivados-3(sulfoamidoetil)-indol para uso como compuestos mimeticos de glucocorticoides en el tratamiento de enfermedades inflamatorias, alergicas y proliferativas. |
US7148249B2 (en) * | 2002-09-12 | 2006-12-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments |
JP4879492B2 (ja) * | 2002-11-27 | 2012-02-22 | アラーガン、インコーポレイテッド | 疾患の治療のためのキナーゼ阻害剤 |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
UY28526A1 (es) | 2003-09-24 | 2005-04-29 | Boehringer Ingelheim Pharma | Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos |
US7125996B2 (en) * | 2003-10-03 | 2006-10-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Fluorescent probes for use in protein kinase inhibitor binding assay |
KR101165863B1 (ko) | 2004-03-11 | 2012-07-13 | 액테리온 파마슈티칼 리미티드 | 인돌-1-일-아세트산 유도체 |
US7795272B2 (en) | 2004-03-13 | 2010-09-14 | Boehringer Ingelheim Pharmaceutical, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof |
PE20061155A1 (es) * | 2004-12-24 | 2006-12-16 | Boehringer Ingelheim Int | Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
WO2006071609A2 (en) | 2004-12-27 | 2006-07-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
KR20080007645A (ko) | 2005-04-28 | 2008-01-22 | 베링거 인겔하임 인터내셔날 게엠베하 | 염증성 질환 치료용 신규 화합물 |
AU2007329548A1 (en) | 2006-12-06 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
US20100086544A1 (en) * | 2006-12-11 | 2010-04-08 | Mass Robert D | Compositions and methods for treating a neoplasm |
CN101273991B (zh) * | 2007-03-28 | 2010-05-26 | 广东同德药业有限公司 | 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用 |
CL2008003598A1 (es) * | 2007-12-03 | 2010-02-12 | Boehringer Ingelheim Int | Procedimiento de preparacion de 3-z-[1-(4-(n-((4-metil-piperazina-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoxicarbonil-2-indolinona por descloroacetilacion en medio basico de uno de los compuestos intermediarios. |
PE20091445A1 (es) * | 2007-12-03 | 2009-10-19 | Boehringer Ingelheim Int | Derivados de indolinona y procedimiento para su fabricacion |
PL2238108T3 (pl) * | 2008-01-25 | 2013-01-31 | Boehringer Ingelheim Int | Postacie soli pochodnej 6-fluoro-1,2-dihydro-2-okso-3H-indol-3-ilidenu, sposób ich wytwarzania oraz kompozycje farmaceutyczne je zawierające |
CN102112476A (zh) | 2008-06-06 | 2011-06-29 | 贝林格尔.英格海姆国际有限公司 | 糖皮质激素模拟物、其制备方法、药物组合物及其用途 |
US8853420B2 (en) | 2008-07-29 | 2014-10-07 | Boehringer Ingelheim International Gmbh | Compounds |
JPWO2013137371A1 (ja) * | 2012-03-15 | 2015-08-03 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
CN103664737A (zh) * | 2012-09-25 | 2014-03-26 | 杨子娇 | 一类治疗房角狭窄的化合物及其用途 |
CN111683976B (zh) | 2018-02-05 | 2022-11-18 | 生物辐射实验室股份有限公司 | 具有阴离子交换-疏水混合模式配体的色谱树脂 |
CN114957084B (zh) * | 2022-01-21 | 2023-05-09 | 九江学院 | 一种吲哚酮类化合物及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9501567D0 (en) * | 1995-01-26 | 1995-03-15 | Pharmacia Spa | Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors |
US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
-
1999
- 1999-09-22 ES ES99947404T patent/ES2196860T3/es not_active Expired - Lifetime
- 1999-09-22 BR BR9914065-9A patent/BR9914065A/pt unknown
- 1999-09-22 PT PT99947404T patent/PT1115704E/pt unknown
- 1999-09-22 CA CA002342622A patent/CA2342622A1/en not_active Abandoned
- 1999-09-22 NZ NZ510845A patent/NZ510845A/en unknown
- 1999-09-22 EP EP99947404A patent/EP1115704B1/de not_active Expired - Lifetime
- 1999-09-22 HU HU0104973A patent/HUP0104973A3/hu unknown
- 1999-09-22 JP JP2000572194A patent/JP2002525356A/ja active Pending
- 1999-09-22 WO PCT/EP1999/007040 patent/WO2000018734A1/de not_active Application Discontinuation
- 1999-09-22 YU YU21301A patent/YU21301A/sh unknown
- 1999-09-22 DE DE59906030T patent/DE59906030D1/de not_active Expired - Fee Related
- 1999-09-22 AT AT99947404T patent/ATE243195T1/de not_active IP Right Cessation
- 1999-09-22 SI SI9930391T patent/SI1115704T1/xx unknown
- 1999-09-22 IL IL14162299A patent/IL141622A0/xx unknown
- 1999-09-22 EE EEP200100184A patent/EE200100184A/xx unknown
- 1999-09-22 TR TR2001/00854T patent/TR200100854T2/xx unknown
- 1999-09-22 ID IDW20010688A patent/ID27757A/id unknown
- 1999-09-22 AU AU60863/99A patent/AU763361B2/en not_active Ceased
- 1999-09-22 KR KR1020017003773A patent/KR20010085841A/ko not_active Application Discontinuation
- 1999-09-22 DK DK99947404T patent/DK1115704T3/da active
- 1999-09-22 PL PL99346898A patent/PL346898A1/xx not_active Application Discontinuation
- 1999-09-22 EA EA200100320A patent/EA200100320A1/ru unknown
- 1999-09-22 SK SK403-2001A patent/SK4032001A3/sk unknown
- 1999-09-22 CN CN99811297A patent/CN1319090A/zh active Pending
-
2001
- 2001-03-09 BG BG105327A patent/BG105327A/xx active Pending
- 2001-03-21 HR HR20010216A patent/HRP20010216A2/hr not_active Application Discontinuation
- 2001-03-22 NO NO20011477A patent/NO20011477D0/no not_active Application Discontinuation
-
2003
- 2003-09-19 US US10/666,643 patent/US6855710B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BG105327A (en) | 2001-12-29 |
EP1115704B1 (de) | 2003-06-18 |
JP2002525356A (ja) | 2002-08-13 |
EP1115704A1 (de) | 2001-07-18 |
CA2342622A1 (en) | 2000-04-06 |
NO20011477L (no) | 2001-03-22 |
ATE243195T1 (de) | 2003-07-15 |
SK4032001A3 (en) | 2001-11-06 |
NO20011477D0 (no) | 2001-03-22 |
EE200100184A (et) | 2002-08-15 |
PL346898A1 (en) | 2002-03-11 |
ID27757A (id) | 2001-04-26 |
HRP20010216A2 (en) | 2002-04-30 |
TR200100854T2 (tr) | 2001-12-21 |
PT1115704E (pt) | 2003-11-28 |
ES2196860T3 (es) | 2003-12-16 |
NZ510845A (en) | 2003-10-31 |
US6855710B2 (en) | 2005-02-15 |
IL141622A0 (en) | 2002-03-10 |
HUP0104973A3 (en) | 2002-06-28 |
WO2000018734A1 (de) | 2000-04-06 |
HUP0104973A2 (hu) | 2002-04-29 |
DE59906030D1 (de) | 2003-07-24 |
BR9914065A (pt) | 2001-06-19 |
US20040058978A1 (en) | 2004-03-25 |
AU763361B2 (en) | 2003-07-17 |
DK1115704T3 (da) | 2003-09-29 |
AU6086399A (en) | 2000-04-17 |
EA200100320A1 (ru) | 2001-10-22 |
KR20010085841A (ko) | 2001-09-07 |
SI1115704T1 (en) | 2003-12-31 |
CN1319090A (zh) | 2001-10-24 |
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