BG105327A - Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes - Google Patents

Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes

Info

Publication number
BG105327A
BG105327A BG105327A BG10532701A BG105327A BG 105327 A BG105327 A BG 105327A BG 105327 A BG105327 A BG 105327A BG 10532701 A BG10532701 A BG 10532701A BG 105327 A BG105327 A BG 105327A
Authority
BG
Bulgaria
Prior art keywords
inhibitory effect
cyclin
novel substituted
general formula
various kinases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
BG105327A
Other languages
Bulgarian (bg)
English (en)
Inventor
Rainer Walter
Wolfgang Grell
Armin Heckel
Frank Himmelsbach
Wolfgang Eberlein
Gerald Roth
Meel Jacobus Van
Norbert Redemann
Walter Spevak
- GRUNT Ulrike TONTSCH
Rueden Thomas Von
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19844003A external-priority patent/DE19844003A1/de
Priority claimed from DE19937496A external-priority patent/DE19937496A1/de
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of BG105327A publication Critical patent/BG105327A/xx
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG105327A 1998-09-25 2001-03-09 Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes Pending BG105327A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19844003A DE19844003A1 (de) 1998-09-25 1998-09-25 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19937496A DE19937496A1 (de) 1999-08-07 1999-08-07 Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/007040 WO2000018734A1 (de) 1998-09-25 1999-09-22 Neue substituierte indolinone mit inhibierender wirkung auf verschiedene kinasen und cyclin/cdk-komplexe

Publications (1)

Publication Number Publication Date
BG105327A true BG105327A (en) 2001-12-29

Family

ID=26049076

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105327A Pending BG105327A (en) 1998-09-25 2001-03-09 Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes

Country Status (28)

Country Link
US (1) US6855710B2 (xx)
EP (1) EP1115704B1 (xx)
JP (1) JP2002525356A (xx)
KR (1) KR20010085841A (xx)
CN (1) CN1319090A (xx)
AT (1) ATE243195T1 (xx)
AU (1) AU763361B2 (xx)
BG (1) BG105327A (xx)
BR (1) BR9914065A (xx)
CA (1) CA2342622A1 (xx)
DE (1) DE59906030D1 (xx)
DK (1) DK1115704T3 (xx)
EA (1) EA200100320A1 (xx)
EE (1) EE200100184A (xx)
ES (1) ES2196860T3 (xx)
HR (1) HRP20010216A2 (xx)
HU (1) HUP0104973A3 (xx)
ID (1) ID27757A (xx)
IL (1) IL141622A0 (xx)
NO (1) NO20011477D0 (xx)
NZ (1) NZ510845A (xx)
PL (1) PL346898A1 (xx)
PT (1) PT1115704E (xx)
SI (1) SI1115704T1 (xx)
SK (1) SK4032001A3 (xx)
TR (1) TR200100854T2 (xx)
WO (1) WO2000018734A1 (xx)
YU (1) YU21301A (xx)

Families Citing this family (35)

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Publication number Priority date Publication date Assignee Title
GB9904933D0 (en) * 1999-03-04 1999-04-28 Glaxo Group Ltd Compounds
WO2003027102A1 (en) * 2001-09-27 2003-04-03 Allergan, Inc. 3-(arylamino)methylene-1, 3-dihydro-2h-indol-2-ones as kinase inhibitors
US6797825B2 (en) 2001-12-13 2004-09-28 Abbott Laboratories Protein kinase inhibitors
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
CN1633296A (zh) 2002-03-26 2005-06-29 贝林格尔·英格海姆药物公司 糖皮质素模拟物、其制备方法、药物组合物及其用途
US7169936B2 (en) 2002-07-23 2007-01-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
PE20040701A1 (es) * 2002-07-23 2004-11-30 Boehringer Ingelheim Pharma Derivados de indolinona sustituidos en posicion 6 y su preparacion como medicamentos
DE10233366A1 (de) * 2002-07-23 2004-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg In 6-Stellung substituierte Indolinonderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
US7514468B2 (en) 2002-07-23 2009-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
DE10237423A1 (de) * 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
US20040204458A1 (en) 2002-08-16 2004-10-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of Lck inhibitors for treatment of immunologic diseases
MXPA05002297A (es) * 2002-08-29 2005-06-08 Boehringer Ingelheim Pharma Derivados-3(sulfoamidoetil)-indol para uso como compuestos mimeticos de glucocorticoides en el tratamiento de enfermedades inflamatorias, alergicas y proliferativas.
US7148249B2 (en) * 2002-09-12 2006-12-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
JP4879492B2 (ja) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド 疾患の治療のためのキナーゼ阻害剤
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7125996B2 (en) * 2003-10-03 2006-10-24 Boehringer Ingelheim Pharmaceuticals, Inc. Fluorescent probes for use in protein kinase inhibitor binding assay
KR101165863B1 (ko) 2004-03-11 2012-07-13 액테리온 파마슈티칼 리미티드 인돌-1-일-아세트산 유도체
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20061155A1 (es) * 2004-12-24 2006-12-16 Boehringer Ingelheim Int Derivados de indolinona como agentes para el tratamiento o la prevencion de enfermedades fibroticas
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2006071609A2 (en) 2004-12-27 2006-07-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
KR20080007645A (ko) 2005-04-28 2008-01-22 베링거 인겔하임 인터내셔날 게엠베하 염증성 질환 치료용 신규 화합물
AU2007329548A1 (en) 2006-12-06 2008-06-12 Boehringer Ingelheim International Gmbh Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20100086544A1 (en) * 2006-12-11 2010-04-08 Mass Robert D Compositions and methods for treating a neoplasm
CN101273991B (zh) * 2007-03-28 2010-05-26 广东同德药业有限公司 四氢吲哚酮/四氢吲唑酮/四氢咔唑衍生物及其盐在制备抗病毒药物中的应用
CL2008003598A1 (es) * 2007-12-03 2010-02-12 Boehringer Ingelheim Int Procedimiento de preparacion de 3-z-[1-(4-(n-((4-metil-piperazina-1-il)-metilcarbonil)-n-metil-amino)-anilino)-1-fenil-metilen]-6-metoxicarbonil-2-indolinona por descloroacetilacion en medio basico de uno de los compuestos intermediarios.
PE20091445A1 (es) * 2007-12-03 2009-10-19 Boehringer Ingelheim Int Derivados de indolinona y procedimiento para su fabricacion
PL2238108T3 (pl) * 2008-01-25 2013-01-31 Boehringer Ingelheim Int Postacie soli pochodnej 6-fluoro-1,2-dihydro-2-okso-3H-indol-3-ilidenu, sposób ich wytwarzania oraz kompozycje farmaceutyczne je zawierające
CN102112476A (zh) 2008-06-06 2011-06-29 贝林格尔.英格海姆国际有限公司 糖皮质激素模拟物、其制备方法、药物组合物及其用途
US8853420B2 (en) 2008-07-29 2014-10-07 Boehringer Ingelheim International Gmbh Compounds
JPWO2013137371A1 (ja) * 2012-03-15 2015-08-03 興和株式会社 新規ピリミジン化合物及びそれらを含有する医薬
CN103664737A (zh) * 2012-09-25 2014-03-26 杨子娇 一类治疗房角狭窄的化合物及其用途
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
CN114957084B (zh) * 2022-01-21 2023-05-09 九江学院 一种吲哚酮类化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501567D0 (en) * 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease

Also Published As

Publication number Publication date
EP1115704B1 (de) 2003-06-18
JP2002525356A (ja) 2002-08-13
EP1115704A1 (de) 2001-07-18
CA2342622A1 (en) 2000-04-06
NO20011477L (no) 2001-03-22
ATE243195T1 (de) 2003-07-15
SK4032001A3 (en) 2001-11-06
NO20011477D0 (no) 2001-03-22
EE200100184A (et) 2002-08-15
PL346898A1 (en) 2002-03-11
YU21301A (sh) 2003-04-30
ID27757A (id) 2001-04-26
HRP20010216A2 (en) 2002-04-30
TR200100854T2 (tr) 2001-12-21
PT1115704E (pt) 2003-11-28
ES2196860T3 (es) 2003-12-16
NZ510845A (en) 2003-10-31
US6855710B2 (en) 2005-02-15
IL141622A0 (en) 2002-03-10
HUP0104973A3 (en) 2002-06-28
WO2000018734A1 (de) 2000-04-06
HUP0104973A2 (hu) 2002-04-29
DE59906030D1 (de) 2003-07-24
BR9914065A (pt) 2001-06-19
US20040058978A1 (en) 2004-03-25
AU763361B2 (en) 2003-07-17
DK1115704T3 (da) 2003-09-29
AU6086399A (en) 2000-04-17
EA200100320A1 (ru) 2001-10-22
KR20010085841A (ko) 2001-09-07
SI1115704T1 (en) 2003-12-31
CN1319090A (zh) 2001-10-24

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