BR112021026531A2 - Composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2 - Google Patents

Composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2

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Publication number
BR112021026531A2
BR112021026531A2 BR112021026531A BR112021026531A BR112021026531A2 BR 112021026531 A2 BR112021026531 A2 BR 112021026531A2 BR 112021026531 A BR112021026531 A BR 112021026531A BR 112021026531 A BR112021026531 A BR 112021026531A BR 112021026531 A2 BR112021026531 A2 BR 112021026531A2
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BR
Brazil
Prior art keywords
preventing
treating
tyrosine kinase
compound
pharmaceutical composition
Prior art date
Application number
BR112021026531A
Other languages
English (en)
Inventor
Xiangyang Chen
Yucheng Pang
Original Assignee
Guangzhou Innocare Pharma Tech Co Ltd
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Publication date
Application filed by Guangzhou Innocare Pharma Tech Co Ltd filed Critical Guangzhou Innocare Pharma Tech Co Ltd
Publication of BR112021026531A2 publication Critical patent/BR112021026531A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2. compostos heterocíclicos mostrados na fórmula (i) adequados para inibir ou regular a atividade de janus cinase (jak), particularmente tirosina cinase 2 (tyk2). os compostos são úteis para prevenir e/ou tratar doenças mediadas por jak relevantes, tais como doenças autoimunes, doenças inflamatórias e cânceres.
BR112021026531A 2019-06-28 2020-06-24 Composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2 BR112021026531A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910572091.9A CN112142743A (zh) 2019-06-28 2019-06-28 杂环类化合物、其制备方法及其在医药学上的应用
PCT/CN2020/098105 WO2020259584A1 (en) 2019-06-28 2020-06-24 Heterocyclic compounds for mediating tyrosine kinase 2 activity

Publications (1)

Publication Number Publication Date
BR112021026531A2 true BR112021026531A2 (pt) 2022-02-15

Family

ID=73869063

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021026531A BR112021026531A2 (pt) 2019-06-28 2020-06-24 Composto, composição farmacêutica, e, método para prevenir ou tratar uma doença mediada pela tirosina cinase 2

Country Status (11)

Country Link
US (1) US20220112200A1 (pt)
EP (1) EP3990449A4 (pt)
JP (1) JP2022540353A (pt)
KR (1) KR20220042344A (pt)
CN (2) CN112142743A (pt)
AU (1) AU2020301437A1 (pt)
BR (1) BR112021026531A2 (pt)
CA (1) CA3144799A1 (pt)
MX (1) MX2021015969A (pt)
TW (1) TW202115034A (pt)
WO (1) WO2020259584A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
TWI782599B (zh) * 2020-07-02 2022-11-01 美商輝瑞股份有限公司 胺基嘧啶基衍生物
CN113234081A (zh) * 2021-05-27 2021-08-10 东南大学 一种吡咯并吡唑衍生物与dmpeda做脲的制备方法
WO2023076161A1 (en) 2021-10-25 2023-05-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011328237A1 (en) * 2010-11-09 2013-05-23 Cellzome Limited Pyridine compounds and aza analogues thereof as TYK2 inhibitors
WO2012145581A1 (en) * 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
EP2832734A4 (en) * 2012-03-28 2015-08-26 Takeda Pharmaceutical HETEROCYCLIC CONNECTION
CN105622638B (zh) * 2014-10-29 2018-10-02 广州必贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
KR20180041119A (ko) * 2015-07-09 2018-04-23 메르크 파텐트 게엠베하 Btk 억제제로서 피리미딘 유도체 및 이의 용도
TW201920170A (zh) * 2017-09-20 2019-06-01 美商庫拉腫瘤技術股份有限公司 經取代之menin-mll 抑制劑及使用方法
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用

Also Published As

Publication number Publication date
JP2022540353A (ja) 2022-09-15
CN114096532A (zh) 2022-02-25
CN114096532B (zh) 2023-12-01
CA3144799A1 (en) 2020-12-30
CN112142743A (zh) 2020-12-29
TW202115034A (zh) 2021-04-16
AU2020301437A1 (en) 2022-02-17
KR20220042344A (ko) 2022-04-05
WO2020259584A1 (en) 2020-12-30
MX2021015969A (es) 2022-04-18
US20220112200A1 (en) 2022-04-14
EP3990449A1 (en) 2022-05-04
EP3990449A4 (en) 2023-07-26

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