PH12020552148A1 - Purinone compounds and their use in treating cancer - Google Patents
Purinone compounds and their use in treating cancerInfo
- Publication number
- PH12020552148A1 PH12020552148A1 PH12020552148A PH12020552148A PH12020552148A1 PH 12020552148 A1 PH12020552148 A1 PH 12020552148A1 PH 12020552148 A PH12020552148 A PH 12020552148A PH 12020552148 A PH12020552148 A PH 12020552148A PH 12020552148 A1 PH12020552148 A1 PH 12020552148A1
- Authority
- PH
- Philippines
- Prior art keywords
- compounds
- salts
- treating cancer
- manufacture
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
The specification generally relates to compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, where R1, A1, A2 and A3 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862685325P | 2018-06-15 | 2018-06-15 | |
| PCT/EP2019/065686 WO2019238929A1 (en) | 2018-06-15 | 2019-06-14 | Purinone compounds and their use in treating cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12020552148A1 true PH12020552148A1 (en) | 2021-07-05 |
Family
ID=67107385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12020552148A PH12020552148A1 (en) | 2018-06-15 | 2020-12-12 | Purinone compounds and their use in treating cancer |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US11884671B2 (en) |
| EP (1) | EP3807278B1 (en) |
| JP (1) | JP7472044B2 (en) |
| KR (1) | KR20210020944A (en) |
| CN (1) | CN112236431B (en) |
| AR (1) | AR114971A1 (en) |
| AU (1) | AU2019287295B2 (en) |
| BR (1) | BR112020025127A2 (en) |
| CA (1) | CA3102195A1 (en) |
| CL (1) | CL2020003131A1 (en) |
| CO (1) | CO2020015758A2 (en) |
| CR (1) | CR20200620A (en) |
| DO (1) | DOP2020000241A (en) |
| EA (1) | EA202190006A1 (en) |
| EC (1) | ECSP20080276A (en) |
| ES (1) | ES2931448T3 (en) |
| IL (1) | IL279370A (en) |
| JO (1) | JOP20200315A1 (en) |
| MA (1) | MA52886A (en) |
| MX (1) | MX2020013570A (en) |
| NI (1) | NI202000099A (en) |
| PE (1) | PE20210003A1 (en) |
| PH (1) | PH12020552148A1 (en) |
| SG (1) | SG11202012035WA (en) |
| TW (1) | TWI820146B (en) |
| UA (1) | UA126837C2 (en) |
| UY (1) | UY38263A (en) |
| WO (1) | WO2019238929A1 (en) |
| ZA (1) | ZA202100195B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202110849A (en) * | 2019-05-27 | 2021-03-16 | 大陸商迪哲（江蘇）醫藥股份有限公司 | Dna-dependent protein kinase inhibitor |
| JP7383818B2 (en) * | 2019-11-25 | 2023-11-20 | ザイ ラボ （シャンハイ） カンパニー、リミテッド． | Pyrimidoimidazole compounds as DNA-PK inhibitors |
| WO2021136462A1 (en) * | 2019-12-31 | 2021-07-08 | 成都百裕制药股份有限公司 | Furan derivatives and application thereof in medicine |
| US20220402920A1 (en) | 2019-12-31 | 2022-12-22 | Chengdu Baiyu Pharmaceutical Co., Ltd. | Purine derivative and medical use thereof |
| WO2021136461A1 (en) * | 2019-12-31 | 2021-07-08 | 成都百裕制药股份有限公司 | Purine derivative and medical use thereof |
| WO2021204111A1 (en) * | 2020-04-10 | 2021-10-14 | 南京明德新药研发有限公司 | Aminopyrimidine compound as dna-pk inhibitor and derivatives thereof |
| WO2021260583A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and dna-pk inhibitor |
| WO2022017368A1 (en) * | 2020-07-20 | 2022-01-27 | 首药控股(北京)股份有限公司 | Dna-pk selective inhibitor, preparation method therefor and use thereof |
| WO2022135360A1 (en) * | 2020-12-21 | 2022-06-30 | 江苏恒瑞医药股份有限公司 | Purinone derivative, preparation method therefor, and application thereof in medicine |
| CN114656486B (en) * | 2020-12-22 | 2023-09-19 | 江苏恒瑞医药股份有限公司 | Purinone compound, preparation method and medical application thereof |
| CN114656487B (en) * | 2020-12-22 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | Fused pyrimidine compound, preparation method thereof and application thereof in medicine |
| TW202229281A (en) * | 2020-12-24 | 2022-08-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | Purinone compounds, their preparation methods and medical use |
| CN116917288A (en) * | 2021-03-22 | 2023-10-20 | 成都赜灵生物医药科技有限公司 | 7, 9-dihydro purine derivative and pharmaceutical application thereof |
| WO2023274310A1 (en) * | 2021-06-29 | 2023-01-05 | 成都百裕制药股份有限公司 | Crystal form of purine derivatives and pharmaceutical compositions thereof |
| WO2023036156A1 (en) * | 2021-09-07 | 2023-03-16 | 首药控股(北京)股份有限公司 | Dna-pk selective inhibitor, and preparation method therefor and use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ584138A (en) | 2007-08-23 | 2011-10-28 | Astrazeneca Ab | 2-anilinopurin-8-ones as inhibitors of ttk/mps1 for the treatment of proliferative disorders |
| WO2010118207A1 (en) * | 2009-04-09 | 2010-10-14 | Schering Corporation | Pyrazolo [1, 5-a] pyrimidine derivatives as mtor inhibitors |
| CA2778680C (en) | 2009-10-29 | 2016-12-13 | Carmen Almansa Rosales | N-containing heteroaryl derivatives as jak3 kinase inhibitors |
| DE102010035744A1 (en) | 2010-08-28 | 2012-03-01 | Merck Patent Gmbh | Imidazolonylchinoline |
| EP2683377A1 (en) * | 2011-03-11 | 2014-01-15 | Gilead Calistoga LLC | Combination therapies for hematologic malignancies |
| EP2527344A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
| PE20191474A1 (en) * | 2016-12-20 | 2019-10-16 | Astrazeneca Ab | AMINO-TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER |
-
2019
- 2019-06-06 TW TW108119642A patent/TWI820146B/en active
- 2019-06-14 CN CN201980038412.5A patent/CN112236431B/en active Active
- 2019-06-14 CA CA3102195A patent/CA3102195A1/en active Pending
- 2019-06-14 AU AU2019287295A patent/AU2019287295B2/en active Active
- 2019-06-14 UY UY0001038263A patent/UY38263A/en unknown
- 2019-06-14 EP EP19734289.2A patent/EP3807278B1/en active Active
- 2019-06-14 ES ES19734289T patent/ES2931448T3/en active Active
- 2019-06-14 CR CR20200620A patent/CR20200620A/en unknown
- 2019-06-14 US US16/973,862 patent/US11884671B2/en active Active
- 2019-06-14 JO JOP/2020/0315A patent/JOP20200315A1/en unknown
- 2019-06-14 KR KR1020207037917A patent/KR20210020944A/en not_active Application Discontinuation
- 2019-06-14 UA UAA202100011A patent/UA126837C2/en unknown
- 2019-06-14 MA MA052886A patent/MA52886A/en unknown
- 2019-06-14 PE PE2020002005A patent/PE20210003A1/en unknown
- 2019-06-14 AR ARP190101659A patent/AR114971A1/en unknown
- 2019-06-14 SG SG11202012035WA patent/SG11202012035WA/en unknown
- 2019-06-14 EA EA202190006A patent/EA202190006A1/en unknown
- 2019-06-14 MX MX2020013570A patent/MX2020013570A/en unknown
- 2019-06-14 WO PCT/EP2019/065686 patent/WO2019238929A1/en active Application Filing
- 2019-06-14 JP JP2020569143A patent/JP7472044B2/en active Active
- 2019-06-14 BR BR112020025127-5A patent/BR112020025127A2/en unknown
-
2020
- 2020-12-02 CL CL2020003131A patent/CL2020003131A1/en unknown
- 2020-12-09 DO DO2020000241A patent/DOP2020000241A/en unknown
- 2020-12-10 NI NI202000099A patent/NI202000099A/en unknown
- 2020-12-10 IL IL279370A patent/IL279370A/en unknown
- 2020-12-11 EC ECSENADI202080276A patent/ECSP20080276A/en unknown
- 2020-12-12 PH PH12020552148A patent/PH12020552148A1/en unknown
- 2020-12-15 CO CONC2020/0015758A patent/CO2020015758A2/en unknown
-
2021
- 2021-01-12 ZA ZA2021/00195A patent/ZA202100195B/en unknown
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2023
- 2023-12-14 US US18/540,129 patent/US20240150355A1/en active Pending
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