MX2021015969A - Compuestos heterocíclicos para mediar la actividad de la tirosina cinasa 2. - Google Patents

Compuestos heterocíclicos para mediar la actividad de la tirosina cinasa 2.

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Publication number
MX2021015969A
MX2021015969A MX2021015969A MX2021015969A MX2021015969A MX 2021015969 A MX2021015969 A MX 2021015969A MX 2021015969 A MX2021015969 A MX 2021015969A MX 2021015969 A MX2021015969 A MX 2021015969A MX 2021015969 A MX2021015969 A MX 2021015969A
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MX
Mexico
Prior art keywords
activity
tyrosine kinase
heterocyclic compounds
mediating
mediating tyrosine
Prior art date
Application number
MX2021015969A
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English (en)
Inventor
Xiangyang Chen
Yucheng Pang
Original Assignee
Guangzhou Innocare Pharma Tech Co Ltd
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Filing date
Publication date
Application filed by Guangzhou Innocare Pharma Tech Co Ltd filed Critical Guangzhou Innocare Pharma Tech Co Ltd
Publication of MX2021015969A publication Critical patent/MX2021015969A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

Compuestos heterocíclicos mostrados en la Fórmula (I) adecuados para inhibir o regular la actividad de Janus quinasa (JAK), particularmente tirosina quinasa 2 (TYK2). Los compuestos son útiles para prevenir y/o tratar enfermedades relevantes mediadas por JAK, tales como enfermedades autoinmunes, enfermedades inflamatorias y cánceres.
MX2021015969A 2019-06-28 2020-06-24 Compuestos heterocíclicos para mediar la actividad de la tirosina cinasa 2. MX2021015969A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910572091.9A CN112142743A (zh) 2019-06-28 2019-06-28 杂环类化合物、其制备方法及其在医药学上的应用
PCT/CN2020/098105 WO2020259584A1 (en) 2019-06-28 2020-06-24 Heterocyclic compounds for mediating tyrosine kinase 2 activity

Publications (1)

Publication Number Publication Date
MX2021015969A true MX2021015969A (es) 2022-04-18

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ID=73869063

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MX2021015969A MX2021015969A (es) 2019-06-28 2020-06-24 Compuestos heterocíclicos para mediar la actividad de la tirosina cinasa 2.

Country Status (11)

Country Link
US (1) US20220112200A1 (es)
EP (1) EP3990449A4 (es)
JP (1) JP2022540353A (es)
KR (1) KR20220042344A (es)
CN (2) CN112142743A (es)
AU (1) AU2020301437A1 (es)
BR (1) BR112021026531A2 (es)
CA (1) CA3144799A1 (es)
MX (1) MX2021015969A (es)
TW (1) TW202115034A (es)
WO (1) WO2020259584A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
TWI782599B (zh) * 2020-07-02 2022-11-01 美商輝瑞股份有限公司 胺基嘧啶基衍生物
CN113234081A (zh) * 2021-05-27 2021-08-10 东南大学 一种吡咯并吡唑衍生物与dmpeda做脲的制备方法
WO2023076161A1 (en) 2021-10-25 2023-05-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2638018A1 (en) * 2010-11-09 2013-09-18 Cellzome Limited Pyridine compounds and aza analogues thereof as tyk2 inhibitors
US9586962B2 (en) * 2011-04-20 2017-03-07 Janssen Pharmaceutica Nv Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators
EP2832734A4 (en) * 2012-03-28 2015-08-26 Takeda Pharmaceutical HETEROCYCLIC CONNECTION
CN105622638B (zh) * 2014-10-29 2018-10-02 广州必贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
KR20180041119A (ko) * 2015-07-09 2018-04-23 메르크 파텐트 게엠베하 Btk 억제제로서 피리미딘 유도체 및 이의 용도
US11649251B2 (en) * 2017-09-20 2023-05-16 Kura Oncology, Inc. Substituted inhibitors of menin-MLL and methods of use
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用

Also Published As

Publication number Publication date
CN112142743A (zh) 2020-12-29
EP3990449A4 (en) 2023-07-26
JP2022540353A (ja) 2022-09-15
US20220112200A1 (en) 2022-04-14
KR20220042344A (ko) 2022-04-05
CN114096532A (zh) 2022-02-25
EP3990449A1 (en) 2022-05-04
BR112021026531A2 (pt) 2022-02-15
WO2020259584A1 (en) 2020-12-30
CN114096532B (zh) 2023-12-01
TW202115034A (zh) 2021-04-16
CA3144799A1 (en) 2020-12-30
AU2020301437A1 (en) 2022-02-17

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