BR112013001632A2 - composto, composição farmacêutica, método de inibir uma atividade uma jak quinase in vitro, uso de um composto, ou da composição farmacêutica, e, método de fabricar um composto - Google Patents
composto, composição farmacêutica, método de inibir uma atividade uma jak quinase in vitro, uso de um composto, ou da composição farmacêutica, e, método de fabricar um compostoInfo
- Publication number
- BR112013001632A2 BR112013001632A2 BR112013001632A BR112013001632A BR112013001632A2 BR 112013001632 A2 BR112013001632 A2 BR 112013001632A2 BR 112013001632 A BR112013001632 A BR 112013001632A BR 112013001632 A BR112013001632 A BR 112013001632A BR 112013001632 A2 BR112013001632 A2 BR 112013001632A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- making
- jak
- vitro
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Abstract
composto, composição farmacêutica, método de inibir uma atividade uma jak quinase in vitro, uso de um composto, ou da composição farmacêutica, e, método de fabricar um composto. são divulgados compostos da fórmula i, composições que os contenham, e métodos de uso para os compostos e compostos no tratamento de condições em que a modulação do trajeto de jak ou a inibição das jak quinases, particularmente jak 2 e jak3, são terapeuticamente úteis. também são divulgados métodos de fabricar os compostos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36857010P | 2010-07-28 | 2010-07-28 | |
US61/368570 | 2010-07-28 | ||
PCT/US2011/045609 WO2012015972A1 (en) | 2010-07-28 | 2011-07-27 | Compositions and methods for inhibition of the jak pathway |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013001632A2 true BR112013001632A2 (pt) | 2016-05-24 |
BR112013001632B1 BR112013001632B1 (pt) | 2021-05-25 |
Family
ID=44504225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013001632-9A BR112013001632B1 (pt) | 2010-07-28 | 2011-07-27 | composto, composição farmacêutica, e, método de fabricar um composto |
Country Status (20)
Country | Link |
---|---|
US (8) | US8343954B2 (pt) |
EP (1) | EP2598500B1 (pt) |
JP (2) | JP6073221B2 (pt) |
KR (1) | KR101937495B1 (pt) |
CN (1) | CN103201280B (pt) |
AR (2) | AR082408A1 (pt) |
AU (1) | AU2011282742B2 (pt) |
BR (1) | BR112013001632B1 (pt) |
CA (1) | CA2804199C (pt) |
DK (1) | DK2598500T3 (pt) |
EA (1) | EA201390015A1 (pt) |
ES (1) | ES2880622T3 (pt) |
IL (1) | IL223855A (pt) |
MX (2) | MX347331B (pt) |
PL (1) | PL2598500T3 (pt) |
PT (1) | PT2598500T (pt) |
RU (1) | RU2672100C2 (pt) |
TW (1) | TWI582090B (pt) |
WO (1) | WO2012015972A1 (pt) |
ZA (1) | ZA201300388B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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US20070203161A1 (en) * | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
JP5802136B2 (ja) * | 2009-01-23 | 2015-10-28 | ライジェル ファーマシューティカルズ, インコーポレイテッド | Jak経路の阻害のための組成物および方法 |
AU2011282742B2 (en) | 2010-07-28 | 2015-08-27 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the JAK pathway |
US9321763B2 (en) | 2012-04-04 | 2016-04-26 | Rigel Pharmaceuticals, Inc. | Protein kinase C inhibitors and uses thereof |
US20130310340A1 (en) * | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
US20140213555A1 (en) | 2013-01-25 | 2014-07-31 | Rigel Pharmaceuticals, Inc. | Compounds and method for treating autoimmune diseases |
US9169249B2 (en) | 2013-03-14 | 2015-10-27 | Rigel Pharmaceuticals, Inc. | Protein kinase C inhibitors and uses thereof |
WO2016090079A1 (en) * | 2014-12-05 | 2016-06-09 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
WO2016100452A2 (en) * | 2014-12-17 | 2016-06-23 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
WO2017007658A1 (en) * | 2015-07-07 | 2017-01-12 | Rigel Pharmaceuticals, Inc. | A combination for immune mediated cancer treatment |
US20190060311A1 (en) * | 2017-08-24 | 2019-02-28 | Aclaris Therapeutics, Inc. | Compositions and methods for treatment of vitiligo |
ES2925450T3 (es) | 2017-11-06 | 2022-10-18 | Bristol Myers Squibb Co | Compuestos de isofuranona útiles como inhibidores de HPK1 |
KR20210012006A (ko) | 2018-05-24 | 2021-02-02 | 아스트라제네카 아베 | 5-((5-메틸-2-((3,4,5-트리메틸페닐)아미노)피리미딘-4-일)아미노)-벤조[d]옥사졸-2(3h)-온의 푸마레이트 염 |
WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
CN110078633B (zh) * | 2019-05-24 | 2021-05-11 | 爱斯特(成都)生物制药股份有限公司 | 一种4-氟-3-甲氧基-5-甲基苯胺盐酸盐制备方法 |
CA3180623A1 (en) * | 2020-05-29 | 2021-12-02 | Changyou MA | Pyrimidine compound as axl inhibitor |
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-
2011
- 2011-07-27 AU AU2011282742A patent/AU2011282742B2/en not_active Ceased
- 2011-07-27 KR KR1020137004970A patent/KR101937495B1/ko active IP Right Grant
- 2011-07-27 BR BR112013001632-9A patent/BR112013001632B1/pt active IP Right Grant
- 2011-07-27 DK DK11745858.8T patent/DK2598500T3/da active
- 2011-07-27 EA EA201390015A patent/EA201390015A1/ru unknown
- 2011-07-27 MX MX2013000757A patent/MX347331B/es active IP Right Grant
- 2011-07-27 CA CA2804199A patent/CA2804199C/en active Active
- 2011-07-27 US US13/192,344 patent/US8343954B2/en active Active
- 2011-07-27 ES ES11745858T patent/ES2880622T3/es active Active
- 2011-07-27 PL PL11745858T patent/PL2598500T3/pl unknown
- 2011-07-27 EP EP11745858.8A patent/EP2598500B1/en active Active
- 2011-07-27 RU RU2015122016A patent/RU2672100C2/ru active
- 2011-07-27 WO PCT/US2011/045609 patent/WO2012015972A1/en active Application Filing
- 2011-07-27 PT PT117458588T patent/PT2598500T/pt unknown
- 2011-07-27 CN CN201180036682.6A patent/CN103201280B/zh active Active
- 2011-07-27 JP JP2013521954A patent/JP6073221B2/ja not_active Expired - Fee Related
- 2011-07-28 AR ARP110102733A patent/AR082408A1/es active IP Right Grant
- 2011-07-28 TW TW100126853A patent/TWI582090B/zh not_active IP Right Cessation
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2012
- 2012-11-26 US US13/685,433 patent/US9067925B2/en not_active Ceased
- 2012-12-25 IL IL223855A patent/IL223855A/en active IP Right Grant
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2013
- 2013-01-15 ZA ZA2013/00388A patent/ZA201300388B/en unknown
- 2013-01-18 MX MX2020009397A patent/MX2020009397A/es unknown
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2015
- 2015-05-29 US US14/725,932 patent/US9611260B2/en active Active
- 2015-10-20 US US14/918,353 patent/USRE47396E1/en active Active
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2016
- 2016-11-14 JP JP2016221423A patent/JP2017061518A/ja not_active Withdrawn
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2017
- 2017-02-22 US US15/439,705 patent/US9920041B2/en active Active
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2018
- 2018-02-08 US US15/892,224 patent/US10479783B2/en active Active
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2019
- 2019-10-17 US US16/656,461 patent/US11174251B2/en active Active
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2020
- 2020-09-02 AR ARP200102456A patent/AR119882A2/es unknown
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2021
- 2021-10-05 US US17/494,370 patent/US20220024907A1/en active Pending
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