US4937188A
(en)
|
1986-04-15 |
1990-06-26 |
Northeastern University |
Enzyme activity amplification method for increasing assay sensitivity
|
US4801726A
(en)
|
1986-04-15 |
1989-01-31 |
Northeastern University |
Repetitive hit-and-run immunoassay and stable support-analyte conjugates; applied to T-2 toxin
|
US5190864A
(en)
|
1986-04-15 |
1993-03-02 |
Northeastern University |
Enzyme amplification by using free enzyme to release enzyme from an immobilized enzyme material
|
JPH07111423B2
(ja)
*
|
1986-10-01 |
1995-11-29 |
株式会社日立製作所 |
クロマトグラフのデ−タ処理方法
|
JPS6486060A
(en)
*
|
1987-09-29 |
1989-03-30 |
Shimadzu Corp |
Analysis data processor
|
US5412083A
(en)
|
1992-04-16 |
1995-05-02 |
Northeastern University |
Carbohydrate heterobifunctional cross-linking reagent
|
US5429746A
(en)
|
1994-02-22 |
1995-07-04 |
Smith Kline Beecham Corporation |
Antibody purification
|
AU4986596A
(en)
|
1995-02-16 |
1996-09-04 |
Massachusetts Health Research Institute, Inc. |
Purified tetanus toxoid and toxin
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
JP3180010B2
(ja)
*
|
1995-10-13 |
2001-06-25 |
株式会社日立製作所 |
クロマトグラフ分析装置
|
KR19990056559A
(ko)
*
|
1997-12-29 |
1999-07-15 |
윤종용 |
노이즈 감소방법 및 그 장치
|
EP0964057B1
(en)
|
1998-05-11 |
2004-12-22 |
Tosoh Corporation |
Method for separating nucleic acids by means of liquid chromatography
|
US7303746B2
(en)
|
1999-06-08 |
2007-12-04 |
Regeneron Pharmaceuticals, Inc. |
Methods of treating eye disorders with modified chimeric polypeptides
|
US7306799B2
(en)
|
1999-06-08 |
2007-12-11 |
Regeneron Pharmaceuticals, Inc. |
Use of VEGF inhibitors for treatment of eye disorders
|
US7087411B2
(en)
|
1999-06-08 |
2006-08-08 |
Regeneron Pharmaceuticals, Inc. |
Fusion protein capable of binding VEGF
|
US7070959B1
(en)
|
1999-06-08 |
2006-07-04 |
Regeneron Pharmaceuticals, Inc. |
Modified chimeric polypeptides with improved pharmacokinetic properties
|
IL155002A0
(en)
|
2000-10-12 |
2003-10-31 |
Genentech Inc |
Reduced-viscosity concentrated protein formulations
|
US20020064860A1
(en)
|
2000-11-29 |
2002-05-30 |
Schering Corporation |
Method for purifying adenoviruses
|
US7101982B2
(en)
|
2001-03-30 |
2006-09-05 |
Immunex Corporation |
Control of ph transitions during chromatography
|
WO2004020971A2
(en)
|
2002-08-28 |
2004-03-11 |
Introgen Therapeutics Inc. |
Chromatographic methods for adenovirus purification
|
CN1777435B
(zh)
|
2002-09-13 |
2011-01-12 |
拜奥根Idec公司 |
通过模拟移动床层析纯化多肽的方法
|
US20060257972A1
(en)
|
2003-03-31 |
2006-11-16 |
Takashi Ishihara |
Purification of human monoclonal antibody and human polyclonal antibody
|
CA2529945A1
(en)
|
2003-06-27 |
2005-01-06 |
Biogen Idec Ma Inc. |
Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
|
ES2342539T3
(es)
|
2003-10-24 |
2010-07-08 |
Amgen, Inc. |
Proceso para la purificacion de proteinas en una fraccion de flujo-directo de cromatografia de interaccion hidrofobica.
|
US8084032B2
(en)
|
2004-01-21 |
2011-12-27 |
Ajinomoto Co., Inc. |
Purification method which prevents denaturation of an antibody
|
US7750129B2
(en)
|
2004-02-27 |
2010-07-06 |
Ge Healthcare Bio-Sciences Ab |
Process for the purification of antibodies
|
SE0400501D0
(sv)
|
2004-02-27 |
2004-02-27 |
Amersham Biosciences Ab |
Antibody purification
|
SE0400886D0
(sv)
|
2004-04-02 |
2004-04-02 |
Amersham Biosciences Ab |
Process of purification
|
US7795405B2
(en)
|
2004-08-09 |
2010-09-14 |
Guild Associates, Inc. |
Procedure for the fractionation of proteins by using sequential ion exchange and hydrophobic interaction chromatography as prefractionation steps before analysis by two dimensional electrophoresis
|
WO2006020622A1
(en)
|
2004-08-09 |
2006-02-23 |
Guild Associates, Inc. |
Procedure for the fractionation of proteins by using sequential ion exchange and hydrophobic interaction chromatography as prefractionation steps before analysis by two dimensional electrophoresis
|
AU2005296351B2
(en)
|
2004-10-21 |
2010-12-02 |
Cytiva Bioprocess R&D Ab |
A method of antibody purification
|
WO2006088650A2
(en)
|
2005-02-02 |
2006-08-24 |
Regeneron Pharmaceuticals, Inc. |
Method of treating eye injury with local administration of a vegf inhibitor
|
WO2007064281A1
(en)
|
2005-12-02 |
2007-06-07 |
Ge Healthcare Bio-Sciences Ab |
Hydrophobic interaction chromatography
|
JP2009531371A
(ja)
|
2006-03-28 |
2009-09-03 |
エフ.ホフマン−ラ ロシュ アーゲー |
抗igf−1rヒト・モノクローナル抗体製剤
|
CN102887955A
(zh)
|
2006-04-05 |
2013-01-23 |
艾博特生物技术有限公司 |
抗体纯化
|
LT2944306T
(lt)
|
2006-06-16 |
2021-02-25 |
Regeneron Pharmaceuticals, Inc. |
Vfgf antagonisto kompozicijos, tinkamos įvedimui intravitrealiniu būdu
|
WO2008028974A1
(en)
|
2006-09-08 |
2008-03-13 |
Novo Nordisk A/S |
Methods of optimizing chromatographic separation of polypeptides
|
WO2008057683A2
(en)
|
2006-10-03 |
2008-05-15 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates
|
US20080299545A1
(en)
|
2007-03-06 |
2008-12-04 |
Shuyuan Zhang |
Chromatographic methods for assessing adenovirus purity
|
US8003364B2
(en)
|
2007-05-14 |
2011-08-23 |
Bavarian Nordic A/S |
Purification of vaccinia viruses using hydrophobic interaction chromatography
|
WO2009058769A1
(en)
|
2007-10-30 |
2009-05-07 |
Schering Corporation |
Purification of antibodies containing hydrophobic variants
|
CA2712732C
(en)
*
|
2008-01-25 |
2018-11-27 |
Biogen Idec Ma Inc. |
Automated system and method for monitoring chromatography column performance, and applications thereof
|
US7897405B2
(en)
|
2008-02-11 |
2011-03-01 |
Thermo Finnigan Llc |
Method for identifying the elution time of an analyte
|
US20090277254A1
(en)
*
|
2008-05-09 |
2009-11-12 |
Medlmmune, Llc |
Methods of improving packed-bed chromatography performance
|
JP5635509B2
(ja)
|
2008-08-15 |
2014-12-03 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
クロマトグラフィーカラムの性能を評価するための方法
|
US20100069617A1
(en)
|
2008-09-12 |
2010-03-18 |
Ge Healthcare Bio-Sciences Ab |
Enhanced protein aggregate removal by mixed mode chromatography on hydrophobic interaction media in the presence of protein-excluded zwitterions
|
JP5808249B2
(ja)
|
2008-10-20 |
2015-11-10 |
アッヴィ・インコーポレイテッド |
プロテインaアフィニティークロマトグラフィーを用いる抗体の単離および精製
|
TW201028433A
(en)
|
2008-10-20 |
2010-08-01 |
Abbott Lab |
Viral inactivation during purification of antibodies
|
JP2012526121A
(ja)
|
2009-05-04 |
2012-10-25 |
アボツト・バイオテクノロジー・リミテツド |
ヒト抗tnfアルファ抗体の安定した高蛋白質濃度製剤
|
SI3444335T1
(sl)
|
2009-06-16 |
2021-08-31 |
Genzyme Corporation |
Izboljšani postopki čiščenja vektorjev rekombinantnega AAV
|
US8821879B2
(en)
|
2009-09-04 |
2014-09-02 |
Xoma Technology Ltd. |
Anti-botulism antibody coformulations
|
SI3037104T1
(sl)
|
2009-10-20 |
2020-10-30 |
Abbvie Inc. |
Izolacija in prečiščevanje protiteles anti-IL-13 z uporabo afinitetne kromatografije beljakovine A
|
US8246833B2
(en)
|
2009-12-17 |
2012-08-21 |
Ge Healthcare Bio-Sciences Ab |
Chromatography column and maintenance method
|
AU2011214361C1
(en)
|
2010-02-12 |
2016-01-14 |
Dpx Holdings B.V. |
Single unit antibody purification
|
CN102906851B
(zh)
*
|
2010-06-10 |
2015-09-16 |
国际商业机器公司 |
分析质谱的方法及***
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
NZ609469A
(en)
|
2010-11-11 |
2015-02-27 |
Abbvie Biotechnology Ltd |
Improved high concentration anti-tnfα antibody liquid formulations
|
AU2011343813B2
(en)
|
2010-12-15 |
2015-05-21 |
Takeda Pharmaceutical Company Limited |
Eluate collection using conductivity gradient
|
US9943594B2
(en)
|
2011-10-11 |
2018-04-17 |
Sanofi Biotechnology |
Methods for the treatment of rheumatoid arthritis
|
TWI589299B
(zh)
|
2011-10-11 |
2017-07-01 |
再生元醫藥公司 |
用於治療類風濕性關節炎之組成物及其使用方法
|
US20140288278A1
(en)
|
2011-10-31 |
2014-09-25 |
Joseph Nti-Gyabaah |
Chromatography process for resolving heterogeneous antibody aggregates
|
KR102048189B1
(ko)
|
2011-11-14 |
2019-11-25 |
리제너론 파아마슈티컬스, 인크. |
Gdf8 및/또는 액티빈 a를 특이적으로 길항함으로써 근육량과 근육 강도를 증가시키는 조성물 및 방법
|
MX2014005885A
(es)
|
2011-11-21 |
2014-09-04 |
Genentech Inc |
Purificacion de anticuerpos anti-c-met.
|
JP6092892B2
(ja)
|
2011-12-15 |
2017-03-08 |
プレステージ バイオファーマ プライベート リミテッド |
抗体の精製方法
|
US20150051843A1
(en)
*
|
2012-01-16 |
2015-02-19 |
Leco Corporation |
Systems and Methods to Process Data in Chromatographic Systems
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
US9150645B2
(en)
|
2012-04-20 |
2015-10-06 |
Abbvie, Inc. |
Cell culture methods to reduce acidic species
|
WO2013177115A2
(en)
|
2012-05-21 |
2013-11-28 |
Abbvie Inc. |
Novel purification of human, humanized, or chimeric antibodies using protein a affinity chromatography
|
US20140154270A1
(en)
|
2012-05-21 |
2014-06-05 |
Chen Wang |
Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
|
WO2013176754A1
(en)
|
2012-05-24 |
2013-11-28 |
Abbvie Inc. |
Novel purification of antibodies using hydrophobic interaction chromatography
|
US8941405B2
(en)
|
2012-08-03 |
2015-01-27 |
International Business Machines Corporation |
FET pair based physically unclonable function (PUF) circuit with a constant common mode voltage
|
EP2879691B1
(en)
|
2012-08-06 |
2019-03-27 |
Biogen MA Inc. |
Methods for inactivating enveloped viruses
|
US9650411B2
(en)
|
2012-08-07 |
2017-05-16 |
Kyowa Hakko Kirin Co., Ltd. |
Method of purifying protein
|
CA2895198A1
(en)
|
2012-12-20 |
2014-06-26 |
Medimmune, Llc |
Liquid antibody formulation with improved aggregation properties
|
CA2902854C
(en)
|
2013-03-08 |
2024-01-23 |
Genzyme Corporation |
Integrated continuous manufacturing of therapeutic protein drug substances
|
EP2830651A4
(en)
|
2013-03-12 |
2015-09-02 |
Abbvie Inc |
HUMAN ANTIBODIES THAT BIND TNF-ALPHA AND PREPARATION METHODS
|
US10023608B1
(en)
|
2013-03-13 |
2018-07-17 |
Amgen Inc. |
Protein purification methods to remove impurities
|
AU2013384204B2
(en)
|
2013-03-14 |
2017-03-16 |
Abbvie Inc. |
Low acidic species compositions and methods for producing and using the same
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
PL2970378T3
(pl)
|
2013-03-15 |
2021-12-06 |
Biogen Ma Inc. |
Chromatografia oddziaływań hydrofobowych białek w warunkach bez soli
|
AR095615A1
(es)
|
2013-03-15 |
2015-10-28 |
Alder Biopharmaceuticals Inc |
Purificación de anticuerpos y monitoreo de pureza
|
LT2981822T
(lt)
|
2013-05-06 |
2020-12-28 |
Scholar Rock, Inc. |
Kompozicijos ir būdai, skirti augimo faktoriaus moduliacijai
|
US10111953B2
(en)
|
2013-05-30 |
2018-10-30 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
|
TWI682780B
(zh)
|
2013-05-30 |
2020-01-21 |
美商再生元醫藥公司 |
醫藥組成物用於製造治療與pcsk9功能獲得性突變有關之體染色體顯性高膽固醇血症的藥物之用途
|
TWI755763B
(zh)
|
2013-06-04 |
2022-02-21 |
美商再生元醫藥公司 |
藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
|
KR101569783B1
(ko)
|
2013-06-05 |
2015-11-19 |
한화케미칼 주식회사 |
항체의 정제 방법
|
US9150938B2
(en)
|
2013-06-12 |
2015-10-06 |
Orochem Technologies, Inc. |
Tagatose production from deproteinized whey and purification by continuous chromatography
|
TWI596107B
(zh)
|
2013-06-25 |
2017-08-21 |
卡地拉保健有限公司 |
單株抗體之新穎純化方法
|
US20150093800A1
(en)
|
2013-09-05 |
2015-04-02 |
Genentech, Inc. |
Method for chromatography reuse
|
EP3044323B1
(en)
|
2013-09-13 |
2022-04-06 |
F. Hoffmann-La Roche AG |
Methods for detecting and quantifying host cell protein in cell lines
|
CA2921999C
(en)
|
2013-09-13 |
2023-03-21 |
Genentech, Inc. |
Methods and compositions comprising an anti-il13 antibody and residual hamster phospholipase b-like 2
|
US8946395B1
(en)
|
2013-10-18 |
2015-02-03 |
Abbvie Inc. |
Purification of proteins using hydrophobic interaction chromatography
|
US20160251441A1
(en)
|
2013-10-25 |
2016-09-01 |
Medimmune, Llc |
Antibody purification
|
US10115576B2
(en)
|
2013-12-12 |
2018-10-30 |
Waters Technologies Corporation |
Method and an apparatus for analyzing a complex sample
|
JP6260351B2
(ja)
*
|
2014-03-04 |
2018-01-17 |
株式会社島津製作所 |
クロマトグラフ用データ処理装置及びデータ処理方法
|
JO3701B1
(ar)
|
2014-05-23 |
2021-01-31 |
Regeneron Pharma |
مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
|
FR3025515B1
(fr)
|
2014-09-05 |
2016-09-09 |
Lab Francais Du Fractionnement |
Procede de purification d'un anticorps monoclonal
|
TW201628649A
(zh)
|
2014-10-09 |
2016-08-16 |
再生元醫藥公司 |
減少醫藥調配物中微可見顆粒之方法
|
JP2017536391A
(ja)
|
2014-12-02 |
2017-12-07 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
Il−6rアンタゴニストを投与することによってドライアイ疾患を治療するための方法
|
US10696735B2
(en)
|
2015-01-21 |
2020-06-30 |
Outlook Therapeutics, Inc. |
Modulation of charge variants in a monoclonal antibody composition
|
TWI710573B
(zh)
|
2015-01-26 |
2020-11-21 |
美商再生元醫藥公司 |
抗伊波拉病毒醣蛋白之人類抗體
|
CN104748764B
(zh)
*
|
2015-04-01 |
2017-05-24 |
清华大学 |
一种声场可视化***中声像平面的空间角度标定方法
|
TWI756187B
(zh)
|
2015-10-09 |
2022-03-01 |
美商再生元醫藥公司 |
抗lag3抗體及其用途
|
BR112018012801B1
(pt)
|
2015-12-22 |
2024-03-12 |
Regeneron Pharmaceuticals, Inc |
Usos de uma combinação de anticorpos anti-pd-1 e anticorpos biespecíficos anti-cd20/anti-cd3 e de uma composição farmacêutica
|
EP3394102A1
(en)
|
2015-12-22 |
2018-10-31 |
Regeneron Pharmaceuticals, Inc. |
Bispecific anti-cd20/anti-cd3 antibodies to treat acute lymphoblastic leukemia
|
EP3184119A1
(en)
|
2015-12-23 |
2017-06-28 |
Themis Bioscience GmbH |
Chromatography based purification strategies for measles scaffold based viruses
|
GB201602938D0
(en)
|
2016-02-19 |
2016-04-06 |
Ucb Biopharma Sprl |
Protein purification
|
US10353868B2
(en)
*
|
2016-04-11 |
2019-07-16 |
RMC Pharmaceutical Solutions, Inc. |
Methods and systems for event based notifications
|
BR112018075667B1
(pt)
|
2016-06-14 |
2024-02-20 |
Biogen Ma, Inc |
Métodos para separar um oligonucleotídeo alvo de uma mistura contendo o oligonucleotídeo alvo e uma impureza relacionada com o produto
|
WO2018027195A1
(en)
|
2016-08-05 |
2018-02-08 |
Abbvie Biotherapeutics Inc. |
Compositions containing reduced amounts of daclizumab acidic isoforms and methods for preparing the same
|
KR20230119729A
(ko)
*
|
2016-10-25 |
2023-08-16 |
리제너론 파아마슈티컬스, 인크. |
크로마토그래피 데이터 분석을 위한 방법 및 시스템
|
US10626376B2
(en)
|
2016-11-14 |
2020-04-21 |
St. Jude Children's Research Hospital |
Method for isolating and purifying adeno-associated virus particles using salt
|
US11697670B2
(en)
|
2017-08-22 |
2023-07-11 |
Biogen Ma Inc. |
Methods for purifying antibodies having reduced high molecular weight aggregates
|
WO2019178489A1
(en)
|
2018-03-16 |
2019-09-19 |
Bristol-Myers Squibb Company |
Metabolic enzyme activity and disulfide bond reduction during protein production
|
WO2019178495A1
(en)
|
2018-03-16 |
2019-09-19 |
Biogen Ma Inc. |
Methods for purifying recombinant adeno-associated viruses
|
EP3774882A1
(en)
|
2018-03-29 |
2021-02-17 |
Bristol-Myers Squibb Company |
Methods of purifying monomeric monoclonal antibodies
|
EP3810650A1
(en)
|
2018-06-19 |
2021-04-28 |
Bristol-Myers Squibb Company |
Methods of purifying proteins using chromatography
|
TW202005694A
(zh)
|
2018-07-02 |
2020-02-01 |
美商里珍納龍藥品有限公司 |
自混合物製備多肽之系統及方法
|
US20220267369A1
(en)
|
2018-07-25 |
2022-08-25 |
Merck Sharp & Dohme Corp. |
Methods of separating host cell lipases from a production protein in chromatographic processes
|
KR20210045425A
(ko)
|
2018-08-15 |
2021-04-26 |
브리스톨-마이어스 스큅 컴퍼니 |
하류 크로마토그래피에서의 재산화에 의한 단백질 단편화 제어 전략
|
WO2020096958A1
(en)
|
2018-11-05 |
2020-05-14 |
Bristol-Myers Squibb Company |
Method for purifying pegylated protein
|
WO2020172658A1
(en)
|
2019-02-24 |
2020-08-27 |
Bristol-Myers Squibb Company |
Methods of isolating a protein
|
EP3948262A1
(en)
|
2019-03-29 |
2022-02-09 |
Bristol-Myers Squibb Company |
Methods of measuring hydrophobicity of chromatographic resins
|
JP2022539148A
(ja)
|
2019-06-28 |
2022-09-07 |
武田薬品工業株式会社 |
アデノ随伴ウイルスの精製方法
|