CN102887955A - 抗体纯化 - Google Patents
抗体纯化 Download PDFInfo
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- CN102887955A CN102887955A CN2012103014312A CN201210301431A CN102887955A CN 102887955 A CN102887955 A CN 102887955A CN 2012103014312 A CN2012103014312 A CN 2012103014312A CN 201210301431 A CN201210301431 A CN 201210301431A CN 102887955 A CN102887955 A CN 102887955A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
Description
Claims (73)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78972506P | 2006-04-05 | 2006-04-05 | |
US60/789,725 | 2006-04-05 | ||
US79041406P | 2006-04-06 | 2006-04-06 | |
US60/790,414 | 2006-04-06 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780019220.7A Division CN101454025B (zh) | 2006-04-05 | 2007-04-04 | 抗体纯化 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102887955A true CN102887955A (zh) | 2013-01-23 |
Family
ID=38581592
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110327798.7A Ceased CN102391358B (zh) | 2006-04-05 | 2007-04-04 | 抗体纯化 |
CN201310142761.6A Pending CN103509116A (zh) | 2006-04-05 | 2007-04-04 | 抗体纯化 |
CN200780019220.7A Active CN101454025B (zh) | 2006-04-05 | 2007-04-04 | 抗体纯化 |
CN2012103014312A Pending CN102887955A (zh) | 2006-04-05 | 2007-04-04 | 抗体纯化 |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110327798.7A Ceased CN102391358B (zh) | 2006-04-05 | 2007-04-04 | 抗体纯化 |
CN201310142761.6A Pending CN103509116A (zh) | 2006-04-05 | 2007-04-04 | 抗体纯化 |
CN200780019220.7A Active CN101454025B (zh) | 2006-04-05 | 2007-04-04 | 抗体纯化 |
Country Status (16)
Country | Link |
---|---|
US (17) | US7863426B2 (zh) |
EP (4) | EP2004689A4 (zh) |
JP (7) | JP2009532474A (zh) |
KR (4) | KR20150006085A (zh) |
CN (4) | CN102391358B (zh) |
AU (1) | AU2007235484B2 (zh) |
BR (1) | BRPI0709726A2 (zh) |
CA (2) | CA2647029A1 (zh) |
IL (1) | IL194236A (zh) |
MX (1) | MX2008012896A (zh) |
NZ (4) | NZ611859A (zh) |
RU (2) | RU2466740C2 (zh) |
SG (2) | SG10201406358SA (zh) |
TW (2) | TW201333030A (zh) |
WO (1) | WO2007117490A2 (zh) |
ZA (1) | ZA200808372B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015067147A1 (zh) * | 2013-11-06 | 2015-05-14 | 上海中信国健药业股份有限公司 | 重组蛋白质的纯化方法 |
CN106164086A (zh) * | 2014-02-27 | 2016-11-23 | 新加坡科技研究局 | 抗体纯化方法 |
Families Citing this family (156)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
RO123028B1 (ro) * | 1996-02-09 | 2010-07-30 | Abbott Laboratories (Bermuda) Ltd. | Anticorpi umani, care leagă tnf alpha uman |
CA2868614A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
US20040136990A1 (en) * | 2002-07-19 | 2004-07-15 | Abbott Biotechnology Ltd. | Treatment of pain using TNFalpha inhibitors |
US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
TWI556829B (zh) | 2004-04-09 | 2016-11-11 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
US20060083741A1 (en) * | 2004-10-08 | 2006-04-20 | Hoffman Rebecca S | Treatment of respiratory syncytial virus (RSV) infection |
US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
BRPI0610058A2 (pt) | 2005-05-16 | 2010-05-25 | Abbott Biotech Ltd | uso de inibidor de tnf para tratamento da poliartrite erosiva |
TW201337266A (zh) | 2005-11-01 | 2013-09-16 | Abbott Biotech Ltd | 利用生物標記診斷關節黏連脊椎炎之方法及組合物 |
CA2645739A1 (en) * | 2006-03-20 | 2007-09-27 | Medarex, Inc. | Protein purification |
BRPI0709726A2 (pt) | 2006-04-05 | 2011-07-26 | Abbott Biotechnology Ltd. | purificaÇço de anticorpo |
US9624295B2 (en) | 2006-04-10 | 2017-04-18 | Abbvie Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
US9399061B2 (en) | 2006-04-10 | 2016-07-26 | Abbvie Biotechnology Ltd | Methods for determining efficacy of TNF-α inhibitors for treatment of rheumatoid arthritis |
US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
WO2007120626A2 (en) | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
US20100021451A1 (en) | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
KR101440795B1 (ko) * | 2006-06-30 | 2014-09-22 | 애브비 바이오테크놀로지 리미티드 | 자동 주사 장치 |
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- 2016-08-24 JP JP2016163422A patent/JP6367277B2/ja active Active
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2017
- 2017-09-28 US US15/718,621 patent/US9913902B2/en active Active
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2018
- 2018-07-03 JP JP2018126553A patent/JP2018172416A/ja active Pending
- 2018-11-08 US US16/184,374 patent/US11083792B2/en active Active
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2021
- 2021-02-09 US US17/171,804 patent/US20210260186A1/en not_active Abandoned
- 2021-12-15 US US17/551,515 patent/US20220339284A1/en active Pending
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2015067147A1 (zh) * | 2013-11-06 | 2015-05-14 | 上海中信国健药业股份有限公司 | 重组蛋白质的纯化方法 |
CN104628846A (zh) * | 2013-11-06 | 2015-05-20 | 上海中信国健药业股份有限公司 | 重组蛋白质的纯化方法 |
CN104628846B (zh) * | 2013-11-06 | 2019-12-06 | 三生国健药业(上海)股份有限公司 | 重组蛋白质的纯化方法 |
CN106164086A (zh) * | 2014-02-27 | 2016-11-23 | 新加坡科技研究局 | 抗体纯化方法 |
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