BR122021000068A8 - Composições e usos em métodos para estimular a eficácia de imunoterapia celular adotiva - Google Patents

Composições e usos em métodos para estimular a eficácia de imunoterapia celular adotiva

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Publication number
BR122021000068A8
BR122021000068A8 BR122021000068A BR122021000068A BR122021000068A8 BR 122021000068 A8 BR122021000068 A8 BR 122021000068A8 BR 122021000068 A BR122021000068 A BR 122021000068A BR 122021000068 A BR122021000068 A BR 122021000068A BR 122021000068 A8 BR122021000068 A8 BR 122021000068A8
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Brazil
Prior art keywords
cells
effectiveness
methods
compositions
stimulate
Prior art date
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BR122021000068A
Other languages
English (en)
Other versions
BR122021000068A2 (pt
Inventor
Carolina BERGER Susanna
R Riddell Stanley
Original Assignee
Hutchinson Fred Cancer Res
Fred Hutchinson Cancer Center
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Publication date
Application filed by Hutchinson Fred Cancer Res, Fred Hutchinson Cancer Center filed Critical Hutchinson Fred Cancer Res
Publication of BR122021000068A2 publication Critical patent/BR122021000068A2/pt
Publication of BR122021000068A8 publication Critical patent/BR122021000068A8/pt

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Abstract

COMPOSIÇÕES E USOS EM MÉTODOS PARA ESTIMULAR A EFICÁCIA DE IMUNOTERAPIA CELULAR ADOTIVA. A presente revelação fornece composições e métodos para estimular, aumentar ou aprimorar a eficácia da imunoterapia celular adotiva com o uso de células T modificadas que expressam uma proteína de ligação de antígeno em conjunto com células modificadas (tais como células progenitoras hematopoiéticas, células de sistema imunológico humanas modificadas ou uma combinação das mesmas) que expressam o antígeno especificamente ligado pela proteína de ligação de antígeno das células T modificadas.
BR122021000068A 2014-10-27 2015-10-27 Composições e usos em métodos para estimular a eficácia de imunoterapia celular adotiva BR122021000068A8 (pt)

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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016115559A1 (en) 2015-01-16 2016-07-21 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for ror1
JP7057748B2 (ja) 2015-07-16 2022-04-20 イェダ リサーチ アンド ディベロップメント カンパニー リミテッド 遺伝子改変された抗第三者中枢性メモリーｔ細胞および免疫療法におけるその使用
WO2017015320A1 (en) 2015-07-21 2017-01-26 Children's Medical Center Corporation Pd-l1 expressing hematopoietic stem cells and uses
AU2016306209B2 (en) 2015-08-07 2023-07-06 Seattle Children's Hospital (dba Seattle Children's Research Institute) Bispecific CAR T-cells for solid tumor targeting
CA3001941A1 (en) 2015-10-30 2017-05-04 Nbe-Therapeutics Ag Anti-ror1 antibodies
BR112018014615A2 (pt) 2016-01-20 2018-12-11 The Scripps Research Institute composições de anticorpo para ror1 e métodos relacionados
WO2017136607A1 (en) 2016-02-02 2017-08-10 Fred Hutchinson Cancer Research Center Anti-ror1 antibodies and uses thereof
JP7033549B2 (ja) 2016-05-04 2022-03-10 フレッド ハッチンソン キャンサー リサーチ センター 細胞に基づくネオ抗原ワクチンおよびその使用
MX2018013941A (es) * 2016-05-20 2019-03-21 Lilly Co Eli Terapia de combinacion con inhibidores de notch y pd-1 o pd-l1.
CN106199005B (zh) * 2016-07-26 2019-02-01 浙江大学 采用cd137表达量检测淋巴细胞抗大肠癌活性的方法
MA46963A (fr) 2016-12-03 2019-10-09 Juno Therapeutics Inc Méthodes pour déterminer le dosage de céllules car-t
CN110249046A (zh) 2016-12-05 2019-09-17 朱诺治疗学股份有限公司 用于过继细胞疗法的工程化细胞的产生
US11555178B2 (en) * 2017-01-18 2023-01-17 Yeda Research And Development Co. Ltd. Genetically modified veto cells and use of same in immunotherapy
CN107267555B (zh) * 2017-05-27 2020-03-20 上海优卡迪生物医药科技有限公司 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用
MX2020001212A (es) 2017-08-07 2020-03-20 Nbe Therapeutics Ag Conjugados anticuerpo-farmaco a base de antraciclina que tienen alta tolerabilidad in vivo.
US20210238250A9 (en) * 2017-08-11 2021-08-05 Fred Hutchinson Cancer Research Center Braf-specific tcrs and uses thereof
EP3684408A1 (en) * 2017-09-19 2020-07-29 Massachusetts Institute of Technology Compositions for chimeric antigen receptor t cell therapy and uses thereof
WO2019060708A1 (en) 2017-09-22 2019-03-28 The Children's Medical Center Corporation TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS
WO2019067504A1 (en) * 2017-09-26 2019-04-04 Longwood University SPECIFIC CHIMERIC ANTIGEN RECEPTOR AT PD-1 AS IMMUNOTHERAPY
TWI687227B (zh) * 2017-10-03 2020-03-11 生倍科技股份有限公司 用於t細胞免疫療法之組合及其用途
US20200209240A1 (en) * 2017-11-20 2020-07-02 Julius-Maximilians-Universität Würzburg Cd19cart cells eliminate myeloma cells that express very low levels of cd19
EP3716980A1 (en) 2017-12-01 2020-10-07 Juno Therapeutics, Inc. Methods for dosing and for modulation of genetically engineered cells
CN109810995B (zh) 2017-12-06 2020-10-02 阿思科力(苏州)生物科技有限公司 编码car的核苷酸序列、表达该car的robo1 car-nk细胞及其制备和应用
CN108148137B (zh) * 2017-12-29 2021-03-23 中国人民解放军第四军医大学 一种b7h4/1e10单克隆抗体及其应用
CN112930393A (zh) * 2018-08-28 2021-06-08 福瑞德哈金森癌症研究中心 结合诱导的Notch信号传导的过继T细胞疗法的方法和组合物
CN111544585A (zh) * 2019-02-11 2020-08-18 北京卡替医疗技术有限公司 一种可助推免疫细胞在体内扩增的佐剂
WO2021129927A1 (en) * 2019-12-23 2021-07-01 Biontech Cell & Gene Therapies Gmbh Treatment with immune effector cells engineered to express an antigen receptor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
GB9518220D0 (en) 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
US5853719A (en) 1996-04-30 1998-12-29 Duke University Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA
GB0224442D0 (en) 2002-10-21 2002-11-27 Molmed Spa A delivery system
US20050129671A1 (en) * 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
WO2006076678A2 (en) 2005-01-13 2006-07-20 The Johns Hopkins University Prostate stem cell antigen vaccines and uses thereof
US20090324630A1 (en) * 2008-04-21 2009-12-31 Jensen Michael C Fusion multiviral chimeric antigen
EP2258719A1 (en) 2009-05-19 2010-12-08 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Multiple target T cell receptor
ES2841983T3 (es) 2011-03-23 2021-07-12 Hutchinson Fred Cancer Res Método y composiciones para inmunoterapia celular
KR102028340B1 (ko) * 2011-04-13 2019-10-04 이뮤니쿰 에이비 항원-특이적 t 세포의 증식 방법
JP6117515B2 (ja) 2011-11-01 2017-04-19 国立大学法人名古屋大学 髄膜腫治療用医薬組成物
CN113684185A (zh) * 2013-02-26 2021-11-23 纪念斯隆-凯特琳癌症中心 用于免疫疗法的组合物和方法
TWI654206B (zh) * 2013-03-16 2019-03-21 諾華公司 使用人類化抗－ｃｄ１９嵌合抗原受體治療癌症
AU2014248119B2 (en) 2013-04-03 2019-06-20 Memorial Sloan-Kettering Cancer Center Effective generation of tumor-targeted T-cells derived from pluripotent stem cells

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