BR112017022845A2 - neoepítopos de câncer - Google Patents

neoepítopos de câncer

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Publication number
BR112017022845A2
BR112017022845A2 BR112017022845-9A BR112017022845A BR112017022845A2 BR 112017022845 A2 BR112017022845 A2 BR 112017022845A2 BR 112017022845 A BR112017022845 A BR 112017022845A BR 112017022845 A2 BR112017022845 A2 BR 112017022845A2
Authority
BR
Brazil
Prior art keywords
neoepitopes
therapeutic
cancer
cancer neoepitopes
cellular
Prior art date
Application number
BR112017022845-9A
Other languages
English (en)
Inventor
Nguyen Andrew
Niazi Kayvan
Soon-Shiong Patrick
Rabizadeh Shahrooz
Charles Benz Stephen
Original Assignee
Nantomics, Llc
Nant Holdings Ip, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nantomics, Llc, Nant Holdings Ip, Llc filed Critical Nantomics, Llc
Publication of BR112017022845A2 publication Critical patent/BR112017022845A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61P35/00—Antineoplastic agents
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • G—PHYSICS
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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Abstract

trata-se de composições e métodos que são dirigidos a neoepítopos de câncer e usos de tais neoepítopos, especialmente para gerar anticorpos sintéticos contra neoepítopos que podem ser, então, empregados na fabricação de um agente terapêutico. os agentes terapêuticos preferenciais irão compreender um anticorpo sintético contra um neoepítopo e, com a máxima preferência, em combinação com um componente celular ou não celular para o uso como um agente terapêutico ou de diagnóstico.
BR112017022845-9A 2015-04-23 2016-04-25 neoepítopos de câncer BR112017022845A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562178956P 2015-04-23 2015-04-23
US62/178,956 2015-04-23
US201562159145P 2015-05-08 2015-05-08
US62/159,145 2015-05-08
PCT/US2016/029244 WO2016172722A1 (en) 2015-04-23 2016-04-25 Cancer neoepitopes

Publications (1)

Publication Number Publication Date
BR112017022845A2 true BR112017022845A2 (pt) 2018-07-17

Family

ID=57144677

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017022845-9A BR112017022845A2 (pt) 2015-04-23 2016-04-25 neoepítopos de câncer

Country Status (11)

Country Link
US (2) US11421016B2 (pt)
EP (1) EP3286361A4 (pt)
JP (2) JP7236216B2 (pt)
CN (1) CN108513593A (pt)
AU (1) AU2016253145B2 (pt)
BR (1) BR112017022845A2 (pt)
CA (3) CA3172682A1 (pt)
IL (1) IL255217B (pt)
MX (1) MX2017013613A (pt)
RU (1) RU2719033C2 (pt)
WO (1) WO2016172722A1 (pt)

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