BR112016008632A8 - compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica - Google Patents

compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica Download PDF

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Publication number
BR112016008632A8
BR112016008632A8 BR112016008632A BR112016008632A BR112016008632A8 BR 112016008632 A8 BR112016008632 A8 BR 112016008632A8 BR 112016008632 A BR112016008632 A BR 112016008632A BR 112016008632 A BR112016008632 A BR 112016008632A BR 112016008632 A8 BR112016008632 A8 BR 112016008632A8
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Brazil
Prior art keywords
pharmaceutical composition
btk inhibitors
heteroaryl compounds
compounds
btk
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BR112016008632A
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English (en)
Inventor
Gardberg Anna
Neagu Constantin
Tate Devon
Qiu Hui
Mochalkin Igor
Liu-Bujalski Lesley
Jones Reinaldo
D Caldwell Richard
L Johnson Theresa
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Merck Patent Gmbh
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Publication of BR112016008632A8 publication Critical patent/BR112016008632A8/pt

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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

a presente invenção refere-se a compostos de piridina, pi-rimidina, pirazina, e piridazina, e composições farmaceuticamente aceitáveis dos mesmos, úteis como inibidores de btk.
BR112016008632A 2013-10-21 2014-10-21 compostos de heteroarila como inibidores de btk, seus usos, e composição farmacêutica BR112016008632A8 (pt)

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