BR112015022566A2 - composto e composição farmacêutica - Google Patents
composto e composição farmacêuticaInfo
- Publication number
- BR112015022566A2 BR112015022566A2 BR112015022566A BR112015022566A BR112015022566A2 BR 112015022566 A2 BR112015022566 A2 BR 112015022566A2 BR 112015022566 A BR112015022566 A BR 112015022566A BR 112015022566 A BR112015022566 A BR 112015022566A BR 112015022566 A2 BR112015022566 A2 BR 112015022566A2
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- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- compounds
- relates
- present
- Prior art date
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
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- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
resumo composto e composição farmacêutica a presente invenção se refere aos compostos que são moduladores do receptor de estrogênio. a presente invenção também se refere às composições e aos medicamentos farmacêuticos que incluem os compostos descritos no presente, bem como aos métodos de utilização de tais moduladores dos receptores de estrogênios, isoladamente e em combinação com outros compostos, para o tratamento de doenças ou condições que são mediadas ou dependentes dos receptores de estrogênio.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201361784578P | 2013-03-14 | 2013-03-14 | |
PCT/US2014/026632 WO2014151899A1 (en) | 2013-03-14 | 2014-03-13 | Polycyclic estrogen receptor modulators and uses thereof |
Publications (1)
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BR112015022566A2 true BR112015022566A2 (pt) | 2017-07-18 |
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BR112015022566A BR112015022566A2 (pt) | 2013-03-14 | 2014-03-13 | composto e composição farmacêutica |
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US (1) | US9586952B2 (pt) |
EP (1) | EP2970130A4 (pt) |
JP (1) | JP2016517420A (pt) |
KR (1) | KR20150129723A (pt) |
CN (1) | CN105121413B (pt) |
BR (1) | BR112015022566A2 (pt) |
CA (1) | CA2899969A1 (pt) |
HK (1) | HK1211923A1 (pt) |
MX (1) | MX2015011132A (pt) |
RU (1) | RU2015138964A (pt) |
WO (1) | WO2014151899A1 (pt) |
Families Citing this family (26)
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CA2912853A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulator and uses thereof |
BR112015030595A2 (pt) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
KR20160085915A (ko) | 2013-12-06 | 2016-07-18 | 에프. 호프만-라 로슈 아게 | 국소 진행성 또는 전이성 에스트로겐 수용체 양성 유방암을 치료하기 위한 에스트로겐 수용체 조절자 |
CA2941161A1 (en) | 2014-03-13 | 2015-09-17 | F.Hoffmann-La Roche Ag | Methods and compositions for modulating estrogen receptor mutants |
MA39741A (fr) | 2014-03-13 | 2017-01-18 | Hoffmann La Roche | Combinaisons thérapeutiques avec des modulateurs du récepteur des œstrogènes |
JP2017524009A (ja) | 2014-08-11 | 2017-08-24 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | エストロゲン受容体モジュレーターの結晶形態 |
JP6768711B2 (ja) | 2015-05-26 | 2020-10-14 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 複素環式エストロゲン受容体モジュレーター及びその使用 |
JP2018521988A (ja) | 2015-06-16 | 2018-08-09 | ジエンス ヘンルイ メデイシンカンパニー リミテッドJiangsu Hengrui Medicine Co.,Ltd. | ピペリジン誘導体およびその製造方法および医薬用途 |
JP2018533561A (ja) | 2015-10-07 | 2018-11-15 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | (e)−3−(4−((e)−2−(2−クロロ−4−フルオロフェニル)−1−(1h−インダゾール−5−イル)ブタ−1−エン−1−イル)フェニル)アクリル酸を調製するためのプロセス |
US10118910B2 (en) | 2015-12-09 | 2018-11-06 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective estrogen receptor downregulators |
CN107428721B (zh) | 2015-12-22 | 2020-07-28 | 江苏恒瑞医药股份有限公司 | 苯并哌啶类衍生物、其制备方法及其在医药上的应用 |
KR102479822B1 (ko) | 2016-02-05 | 2022-12-21 | 인벤티스바이오 엘엘씨 | 선택적 에스트로겐 수용체 분해제 및 이들의 용도 |
CA3017388C (en) | 2016-04-01 | 2024-03-12 | Zeno Royalties & Milestones, LLC | Estrogen receptor modulators |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
CN110177554B (zh) | 2017-01-06 | 2023-06-02 | G1治疗公司 | 用于治疗癌症的组合疗法 |
CN110461853A (zh) | 2017-02-10 | 2019-11-15 | G1治疗公司 | 苯并噻吩***受体调节剂 |
ES2912740T3 (es) | 2017-11-14 | 2022-05-27 | Kind Pharmaceutical | Compuesto heterocíclico y aplicación del mismo en medicina |
MX2021001857A (es) | 2018-08-17 | 2021-10-13 | Genentech Inc Star | Metodos de diagnostico y terapeuticos para el tratamiento del cancer de mama. |
CN114269342A (zh) | 2019-08-06 | 2022-04-01 | 里科瑞尔姆Ip控股有限责任公司 | 用于治疗突变的***受体调节剂 |
CA3164166A1 (en) | 2020-01-10 | 2021-07-15 | Jiangsu Hengrui Medicine Co., Ltd. | Tricyclic tetrahydroisoquinoline derivative, preparation method therefor and application thereof in medicine |
WO2022140744A1 (en) | 2020-12-23 | 2022-06-30 | Recurium Ip Holdings, Llc | Estrogen receptor modulators |
KR102503296B1 (ko) * | 2021-05-18 | 2023-02-24 | 재단법인 대구경북첨단의료산업진흥재단 | 신규 에텐 화합물 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
WO2022245124A1 (ko) * | 2021-05-18 | 2022-11-24 | 재단법인 대구경북첨단의료산업진흥재단 | 신규 에텐 화합물 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
KR20240035515A (ko) | 2021-07-09 | 2024-03-15 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 삼중 고리 테트라하이드로 이소퀴놀린계 유도체의 염의 형태 |
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JPS58157779A (ja) * | 1982-03-13 | 1983-09-19 | Kanzaki Paper Mfg Co Ltd | フタリド誘導体、その製造方法およびその誘導体を用いた感熱記録体 |
JPS62211185A (ja) * | 1986-03-11 | 1987-09-17 | Yamada Kagaku Kogyo Kk | 発色性記録材料 |
JPH05212957A (ja) * | 1991-07-26 | 1993-08-24 | Yamada Chem Co Ltd | 感圧記録材料 |
US6528681B2 (en) * | 2000-04-05 | 2003-03-04 | Bristol-Meyers Squibb Pharma Company | Halogenated triphenylethylene derivatives as selective estrogen receptor modulators |
WO2003016270A2 (en) * | 2001-08-11 | 2003-02-27 | Bristol-Myers Squibb Pharma Company | Selective estrogen receptor modulators |
ATE399775T1 (de) * | 2003-10-08 | 2008-07-15 | Smithkline Beecham Corp | Triphenylethyleneverbindungen als selektive modulatoren des östrogenrezeptors |
GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
US9499538B2 (en) | 2012-03-20 | 2016-11-22 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulators and uses thereof |
KR20160085915A (ko) | 2013-12-06 | 2016-07-18 | 에프. 호프만-라 로슈 아게 | 국소 진행성 또는 전이성 에스트로겐 수용체 양성 유방암을 치료하기 위한 에스트로겐 수용체 조절자 |
CA2941161A1 (en) | 2014-03-13 | 2015-09-17 | F.Hoffmann-La Roche Ag | Methods and compositions for modulating estrogen receptor mutants |
-
2014
- 2014-03-13 MX MX2015011132A patent/MX2015011132A/es unknown
- 2014-03-13 EP EP14769665.2A patent/EP2970130A4/en not_active Withdrawn
- 2014-03-13 KR KR1020157024740A patent/KR20150129723A/ko not_active Application Discontinuation
- 2014-03-13 US US14/851,215 patent/US9586952B2/en not_active Expired - Fee Related
- 2014-03-13 CA CA2899969A patent/CA2899969A1/en not_active Abandoned
- 2014-03-13 CN CN201480014573.8A patent/CN105121413B/zh not_active Expired - Fee Related
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- 2014-03-13 JP JP2016502200A patent/JP2016517420A/ja active Pending
- 2014-03-13 RU RU2015138964A patent/RU2015138964A/ru unknown
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2015
- 2015-12-24 HK HK15112674.1A patent/HK1211923A1/xx unknown
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WO2014151899A1 (en) | 2014-09-25 |
RU2015138964A (ru) | 2017-04-18 |
US20160355508A1 (en) | 2016-12-08 |
CN105121413B (zh) | 2018-09-14 |
MX2015011132A (es) | 2015-11-30 |
HK1211923A1 (en) | 2016-06-03 |
US9586952B2 (en) | 2017-03-07 |
JP2016517420A (ja) | 2016-06-16 |
EP2970130A4 (en) | 2016-08-03 |
KR20150129723A (ko) | 2015-11-20 |
EP2970130A1 (en) | 2016-01-20 |
CN105121413A (zh) | 2015-12-02 |
CA2899969A1 (en) | 2014-09-25 |
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