BR112015018504A2 - moduladores de flap - Google Patents

moduladores de flap

Info

Publication number
BR112015018504A2
BR112015018504A2 BR112015018504A BR112015018504A BR112015018504A2 BR 112015018504 A2 BR112015018504 A2 BR 112015018504A2 BR 112015018504 A BR112015018504 A BR 112015018504A BR 112015018504 A BR112015018504 A BR 112015018504A BR 112015018504 A2 BR112015018504 A2 BR 112015018504A2
Authority
BR
Brazil
Prior art keywords
compounds
formula
flap modulators
relates
modulators
Prior art date
Application number
BR112015018504A
Other languages
English (en)
Inventor
D Lebsack Alec
E Fitzgerald Anne
Liu Jing
M Keith John
J Mcclure Kelly
D Rosen Mark
D Hack Michael
A Hawryluk Natalie
S Mani Neelakandha
Krawczuk Paul
P Meduna Steven
Eccles Wendy
M Jones William
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112015018504A2 publication Critical patent/BR112015018504A2/pt

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Abstract

abstract the present invention relates to compounds of formula (i), (i) or a form thereof, wherein ring a, r1, l and r2 are as defined herein, useful as flap modulators. the invention also relates to pharmaceutical compositions comprising compounds of formula (i). methods of making and using the compounds of formula (i) are also within the scope of the invention. tradução do resumo resumo patente de invenção "moduladores de flap". a presente invenção refere-se a compostos da fórmula (i), (i) ou uma forma dos mesmos, em que o anel a, r1, l e r2 são conforme definidos no presente documento, úteis como moduladores de flap. a invenção também se refere a composições farmacêuticas que compreendem compostos da fórmula (i). os métodos de fabricação e o uso dos compostos da fórmula (i) também estão dentro do escopo da invenção.
BR112015018504A 2013-02-04 2014-01-31 moduladores de flap BR112015018504A2 (pt)

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US201361798951P 2013-03-15 2013-03-15
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HK1217489A1 (zh) 2017-01-13
US10047101B2 (en) 2018-08-14
EA030404B1 (ru) 2018-07-31
CN105073742A (zh) 2015-11-18
AU2014212193A1 (en) 2015-07-30
US9926333B2 (en) 2018-03-27
MX364069B (es) 2019-04-10
AU2014212193B2 (en) 2017-06-15
US20140221310A1 (en) 2014-08-07
US20150252008A1 (en) 2015-09-10
WO2014121040A1 (en) 2014-08-07
CN105073742B (zh) 2017-08-08
AU2017213500B2 (en) 2019-02-28
EP2951169A1 (en) 2015-12-09
TWI644899B (zh) 2018-12-21
AU2017213500A1 (en) 2017-08-31
UY35305A (es) 2014-08-29
WO2014121040A8 (en) 2015-02-12
TW201444799A (zh) 2014-12-01
US9073876B2 (en) 2015-07-07
US20170327514A1 (en) 2017-11-16
JP6328145B2 (ja) 2018-05-23
MX2015010106A (es) 2016-01-14
EA201591451A1 (ru) 2015-12-30
JP2016514089A (ja) 2016-05-19
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KR20160004258A (ko) 2016-01-12
US20150368270A1 (en) 2015-12-24

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