BR112015031903A2 - composto, sal farmaceuticamente aceitável do composto, composição farmacêutica e utilização de um composto - Google Patents

composto, sal farmaceuticamente aceitável do composto, composição farmacêutica e utilização de um composto

Info

Publication number
BR112015031903A2
BR112015031903A2 BR112015031903A BR112015031903A BR112015031903A2 BR 112015031903 A2 BR112015031903 A2 BR 112015031903A2 BR 112015031903 A BR112015031903 A BR 112015031903A BR 112015031903 A BR112015031903 A BR 112015031903A BR 112015031903 A2 BR112015031903 A2 BR 112015031903A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
pharmaceutical composition
compounds
Prior art date
Application number
BR112015031903A
Other languages
English (en)
Other versions
BR112015031903A8 (pt
Inventor
Chow Maneval Edna
H Hager Jeffrey
Kahraman Mehmet
D Smith Nicholas
P Govek Steven
Original Assignee
Seragon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52105249&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015031903(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seragon Pharmaceuticals Inc filed Critical Seragon Pharmaceuticals Inc
Publication of BR112015031903A2 publication Critical patent/BR112015031903A2/pt
Publication of BR112015031903A8 publication Critical patent/BR112015031903A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Abstract

resumo “composto, sal farmaceuticamente aceitável do composto, composição farmacêutica e utilização de um composto” a presente invenção se refere aos compostos que são moduladores do receptor de estrogênio. a presente invenção também se refere às composições e medicamentos farmacêuticos que incluem os compostos descritos no presente, bem como aos métodos de utilização de tais moduladores do receptor de estrogênio, isoladamente e em combinação com outros compostos, para o tratamento de doenças ou condições que são mediadas ou dependentes dos receptores de estrogênio.
BR112015031903A 2013-06-19 2014-06-18 composto, sal farmaceuticamente aceitável, composição farmacêutica e uso de um composto BR112015031903A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361836901P 2013-06-19 2013-06-19
US201461952430P 2014-03-13 2014-03-13
PCT/US2014/043040 WO2014205138A1 (en) 2013-06-19 2014-06-18 Estrogen receptor modulator and uses thereof

Publications (2)

Publication Number Publication Date
BR112015031903A2 true BR112015031903A2 (pt) 2017-07-25
BR112015031903A8 BR112015031903A8 (pt) 2019-12-31

Family

ID=52105249

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015031903A BR112015031903A8 (pt) 2013-06-19 2014-06-18 composto, sal farmaceuticamente aceitável, composição farmacêutica e uso de um composto

Country Status (20)

Country Link
US (2) US9873684B2 (pt)
EP (1) EP3010501B1 (pt)
JP (2) JP6576916B2 (pt)
KR (1) KR20160021277A (pt)
CN (1) CN105324115B (pt)
AU (1) AU2014281511A1 (pt)
BR (1) BR112015031903A8 (pt)
CA (1) CA2912853A1 (pt)
CL (1) CL2015003456A1 (pt)
CR (1) CR20150664A (pt)
EA (1) EA031077B1 (pt)
HK (1) HK1214532A1 (pt)
IL (1) IL242611B (pt)
MX (1) MX2015017655A (pt)
PE (1) PE20160157A1 (pt)
PH (1) PH12015502621A1 (pt)
SG (1) SG11201509508YA (pt)
TW (1) TW201501710A (pt)
UA (1) UA117249C2 (pt)
WO (1) WO2014205138A1 (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009061345A2 (en) 2007-11-07 2009-05-14 Cornell Research Foundation, Inc. Targeting cdk4 and cdk6 in cancer therapy
KR20160021277A (ko) * 2013-06-19 2016-02-24 세라곤 파마슈티컬스, 인크. 에스트로겐 수용체 조절제 및 이의 용도
JP6389517B2 (ja) 2013-06-19 2018-09-12 セラゴン ファーマシューティカルズ， インク． アゼチジンエストロゲン受容体調節因子及びその使用
EP2862880A1 (en) 2013-10-16 2015-04-22 Solvay Acetow GmbH Acylation process
CN106572990A (zh) * 2014-03-13 2017-04-19 豪夫迈·罗氏有限公司 含有***受体调节剂的治疗性组合产品
HUE046567T2 (hu) 2014-03-13 2020-03-30 Univ Indiana Res & Tech Corp Hepatitis B mag protein allosztérikus modulátorok
CA2941161A1 (en) 2014-03-13 2015-09-17 F.Hoffmann-La Roche Ag Methods and compositions for modulating estrogen receptor mutants
WO2016097071A1 (en) 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag Estrogen receptor modulators and uses thereof
EP3233852B1 (en) 2014-12-18 2020-07-15 F. Hoffmann-La Roche AG Tetrahydro-pyrido[3,4-b]indoles as estrogen receptor modulators and uses thereof
EP3233818A1 (en) * 2014-12-18 2017-10-25 F. Hoffmann-La Roche AG Derivatives of 2,3-diphenylchromene useful for the treatment of cancer
CN113024466A (zh) 2015-05-29 2021-06-25 卫材 R&D 管理有限公司 四取代的烯烃化合物及其用途
WO2017024319A1 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Tunable endogenous protein degradation
TWI721016B (zh) 2015-09-15 2021-03-11 美商艾森伯利生物科學公司 B型肝炎核心蛋白質調節劑
HUE055321T2 (hu) 2015-10-01 2021-11-29 Olema Pharmaceuticals Inc Tetrahidro-1H-pirido[3,4-b]indol anti-ösztrogén hatóanyagok
HUE059386T2 (hu) 2015-10-27 2022-11-28 Sun Pharma Advanced Res Co Ltd Új heterociklusos antiösztrogének
PT3386500T (pt) 2015-12-09 2023-01-06 Univ Illinois Supressores seletivos do recetor de estrogénio à base de benzotiofeno
WO2017182493A1 (en) 2016-04-20 2017-10-26 Astrazeneca Ab Indazole derivatives for use in down-regulation of the estrogen receptor for the treatment of cancer
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
EP3454862A4 (en) 2016-05-10 2020-02-12 C4 Therapeutics, Inc. SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US20180002344A1 (en) 2016-06-16 2018-01-04 Genentech, Inc. Heteroaryl estrogen receptor modulators and uses thereof
EP3478294A4 (en) 2016-07-01 2020-06-10 G1 Therapeutics, Inc. PYRIMIDINE-BASED ANTIPROLIFERATIVE ACTIVE SUBSTANCES
TW201815789A (zh) 2016-07-25 2018-05-01 瑞典商阿斯特捷利康公司 化合物
CN109937201A (zh) 2016-09-15 2019-06-25 组装生物科学股份有限公司 乙型肝炎核心蛋白调节剂
JP2020011901A (ja) * 2016-10-20 2020-01-23 協和キリン株式会社 ピロリジン化合物の製造方法
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
HRP20220255T1 (hr) 2016-10-24 2022-04-29 Astrazeneca Ab Derivati 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]izokinolina koji su korisni u liječenju raka
JP2019532999A (ja) * 2016-11-04 2019-11-14 ジェネンテック， インコーポレイテッド Ｈｅｒ２陽性乳がんの治療
SG11201903795WA (en) 2016-11-28 2019-05-30 Eisai R&D Man Co Ltd Salts of indazole derivative and crystals thereof
WO2018108954A1 (en) 2016-12-12 2018-06-21 F. Hoffmann-La Roche Ag Process for the preparation of 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol
KR102576011B1 (ko) 2017-01-06 2023-09-06 쥐원 쎄라퓨틱스, 인크. 암의 치료를 위한 조합 요법
CN110214140B (zh) 2017-01-30 2022-08-30 阿斯利康(瑞典)有限公司 ***受体调节剂
CN111386263A (zh) 2017-02-08 2020-07-07 达纳-法伯癌症研究所有限公司 调节嵌合抗原受体
CA3052810A1 (en) 2017-02-10 2018-08-16 G1 Therapeutics, Inc. Benzothiophene estrogen receptor modulators
BR112019018230A2 (pt) 2017-03-02 2020-07-21 Assembly Biosciences, Inc. compostos de sulfamida cíclica e métodos de sua utilização
WO2018169907A1 (en) 2017-03-13 2018-09-20 Assembly Biosciences, Inc. Process for making hepatitis b core protein modulators
EA201992768A1 (ru) 2017-06-29 2020-05-19 Г1 Терапьютикс, Инк. Морфологические формы g1t38 и способы их получения
EP3697436A1 (en) 2017-10-18 2020-08-26 Novartis AG Compositions and methods for selective protein degradation
JP2021503448A (ja) 2017-11-16 2021-02-12 ノバルティス アーゲー Ｌｓｚ１０２及びリボシクリブを含む医薬組合せ
JP2021504384A (ja) * 2017-12-01 2021-02-15 ノバルティス アーゲー Ｌｓｚ１０２及びアルペリシブを含む医薬品の組合せ
CN110343101B (zh) * 2018-04-04 2022-07-12 青岛福沃药业有限公司 用于治疗乳腺癌的***受体降解剂
WO2019245974A1 (en) 2018-06-21 2019-12-26 Genentech, Inc. Solid forms of 3-((1r,3r)-1-(2,6-difluoro-4-((1-(3-fluoropropyl)azetidin-3-yl)amino)phenyl)-3-methyl-1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indol-2-yl)-2,2-difluoropropan-1-ol and processes for preparing fused tricyclic compounds comprising a substituted phenyl or pyridinyl moiety, including methods of their use
EP3897631A4 (en) 2018-12-20 2022-11-23 C4 Therapeutics, Inc. TARGETED PROTEIN DEGRADATION
WO2020219742A1 (en) 2019-04-24 2020-10-29 Novartis Ag Compositions and methods for selective protein degradation
PE20221588A1 (es) 2019-07-22 2022-10-10 Sun Pharma Advanced Res Co Ltd Degradador selectivo del receptor de estrogeno
WO2024030968A1 (en) 2022-08-03 2024-02-08 Brystol-Myers Squibb Company Compounds for modulating ret protein
CN115872996B (zh) * 2023-02-21 2023-05-05 山东绿叶制药有限公司 一种***受体降解剂化合物及其制备方法和应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229447A (en) 1979-06-04 1980-10-21 American Home Products Corporation Intraoral methods of using benzodiazepines
US4596795A (en) 1984-04-25 1986-06-24 The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
DE3684446D1 (de) 1985-12-28 1992-04-23 Sumitomo Pharma Arzneimittel mit verzoegerter stossweiser freisetzung.
US4755386A (en) 1986-01-22 1988-07-05 Schering Corporation Buccal formulation
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
US5739136A (en) 1989-10-17 1998-04-14 Ellinwood, Jr.; Everett H. Intraoral dosing method of administering medicaments
US5017381A (en) 1990-05-02 1991-05-21 Alza Corporation Multi-unit pulsatile delivery system
US5229135A (en) 1991-11-22 1993-07-20 Prographarm Laboratories Sustained release diltiazem formulation
US6060503A (en) * 1991-12-02 2000-05-09 Endorecherche, Inc. Benzopyran-containing compounds and method for their use
US5407947A (en) * 1993-11-05 1995-04-18 Eli Lilly And Company Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5840329A (en) 1997-05-15 1998-11-24 Bioadvances Llc Pulsatile drug delivery system
US6262270B1 (en) * 1998-08-14 2001-07-17 Schering Corporation Enantioselective synthesis
EP1237925B1 (en) 1999-12-07 2007-07-11 Sumitomo Chemical Company, Limited Mutant er-alpha and test systems for transactivation
DE10013782A1 (de) 2000-03-15 2001-10-18 Schering Ag 4-Fluoralkyl-2H-benzopyrane mit antiestrogener Wirksamkeit, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln
CA2435775A1 (en) 2001-01-24 2002-08-01 Chiesi Farmaceutici S.P.A. 2h-1-benzopyran derivatives, processes for their preparation and pharmaceutical compositions thereof
US7105679B2 (en) 2001-12-19 2006-09-12 Kanojia Ramesh M Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
WO2004091488A2 (en) 2003-04-14 2004-10-28 Merck & Co., Inc. Estrogen receptor modulators
HUE033581T2 (hu) * 2010-06-10 2017-12-28 Seragon Pharmaceuticals Inc Ösztrogén receptor modulátorok és alkalmazásaik
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
SG10202110077QA (en) * 2011-10-14 2021-10-28 Genentech Inc Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab
WO2013056178A2 (en) 2011-10-14 2013-04-18 Foundation Medicine, Inc. Novel estrogen receptor mutations and uses thereof
WO2013090829A1 (en) * 2011-12-14 2013-06-20 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
NZ630124A (en) 2012-03-20 2016-01-29 Seragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
CA2873882C (en) * 2012-04-05 2020-12-15 Boehringer Ingelheim International Gmbh 1,8-naphthyridin-2(1h)-one derivatives as cytomegalovirus inhibitors
RU2015138964A (ru) 2013-03-14 2017-04-18 Серагон Фармасьютикалз, Инк. Полициклические модуляторы рецептора эстрогена и их применения
JP6389517B2 (ja) 2013-06-19 2018-09-12 セラゴン ファーマシューティカルズ， インク． アゼチジンエストロゲン受容体調節因子及びその使用
KR20160021277A (ko) * 2013-06-19 2016-02-24 세라곤 파마슈티컬스, 인크. 에스트로겐 수용체 조절제 및 이의 용도
CA2932106A1 (en) 2013-12-06 2015-06-11 F. Hoffmann-La Roche Ag Estrogen receptor modulator for the treatment of locally advanced or metastatic estrogen receptor positive breast cancer
CN106572990A (zh) 2014-03-13 2017-04-19 豪夫迈·罗氏有限公司 含有***受体调节剂的治疗性组合产品
CA2941161A1 (en) 2014-03-13 2015-09-17 F.Hoffmann-La Roche Ag Methods and compositions for modulating estrogen receptor mutants
MX2017000795A (es) 2014-07-18 2017-08-07 Williams Scotsman Inc Sistema de conexión de paneles de pared para unidades de construcción modulares.
EP3233818A1 (en) 2014-12-18 2017-10-25 F. Hoffmann-La Roche AG Derivatives of 2,3-diphenylchromene useful for the treatment of cancer
WO2016097071A1 (en) 2014-12-18 2016-06-23 F. Hoffmann-La Roche Ag Estrogen receptor modulators and uses thereof

Also Published As

Publication number Publication date
KR20160021277A (ko) 2016-02-24
TW201501710A (zh) 2015-01-16
CN105324115B (zh) 2019-01-04
WO2014205138A1 (en) 2014-12-24
EP3010501A4 (en) 2017-02-01
US20160090378A1 (en) 2016-03-31
EA201592214A1 (ru) 2016-06-30
EP3010501A1 (en) 2016-04-27
BR112015031903A8 (pt) 2019-12-31
JP2016523253A (ja) 2016-08-08
CA2912853A1 (en) 2014-12-24
CR20150664A (es) 2016-01-29
US10227334B2 (en) 2019-03-12
CN105324115A (zh) 2016-02-10
PE20160157A1 (es) 2016-03-18
AU2014281511A1 (en) 2015-12-03
HK1214532A1 (zh) 2016-07-29
CL2015003456A1 (es) 2016-07-29
EP3010501B1 (en) 2021-11-03
MX2015017655A (es) 2016-04-15
US9873684B2 (en) 2018-01-23
UA117249C2 (uk) 2018-07-10
US20170275273A1 (en) 2017-09-28
JP6576916B2 (ja) 2019-09-18
SG11201509508YA (en) 2015-12-30
PH12015502621A1 (en) 2016-03-07
IL242611B (en) 2018-10-31
JP2019142871A (ja) 2019-08-29
EA031077B1 (ru) 2018-11-30

Similar Documents

Publication Publication Date Title
BR112015031903A2 (pt) composto, sal farmaceuticamente aceitável do composto, composição farmacêutica e utilização de um composto
BR112015022566A2 (pt) composto e composição farmacêutica
BR112015030595A2 (pt) moduladores de receptor de estrogênio de azetidina e usos dos mesmos
BR112017007662A8 (pt) Composto, composição farmacêutica e uso de um composto
BR112014014124A2 (pt) Moduladores do receptor de estrogênio fluorados e usos dos mesmos
BR112017002053A2 (pt) composto de acordo com a fórmula (i), composição farmacêutica, e usos de um composto
BR112013006395A2 (pt) moduladores do receptor de estrogênio e seus usos.
PH12014502095A1 (en) Estrogen receptor modulators and uses thereof
EA201270815A1 (ru) Модуляторы рецепторов эстрогена и их применение
BR112012007102A2 (pt) compostos policíclicos como antagonistas de receptores do ácido lisofosfatpidico
BR112012020558A2 (pt) moduladores do receptor de androgênio e seus usos
BR112015003188A2 (pt) Composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente
CO6771417A2 (es) Antagonistas del receptor de ácido lisofosfatidico y su uso en el tratamiento de fibrosis
BR112017007123A2 (pt) derivados de tetrahidroisoquinolina
CR20140144A (es) Derivados de estra-1,3,5 (10), 16-tetraen-3-carboxamida, procedimientos para su preparación, preparados farmacéuticos que los contienen, así como su uso para la preparación de medicamentos
BR112015010791A2 (pt) moduladores de gpr40 de di-hidropirazol
DOP2015000005A (es) Derivados de estra 1,3,5(10), 16 tetraeno 3 sustituidos, métodos para su preparación, preparaciones farmacéuticas que los contienen, así como su uso para la preparación de medicamentos
UY35906A (es) Novedosos derivados de bencimidazol como ligandos de ep4
BR112015030387A2 (pt) compostos de pirazol como moduladores de fshr e usos dos mesmos
EA201591196A1 (ru) Композиции и способы для трансдермальной доставки гормонов и других лекарственных средств
BR112014012459A2 (pt) 2h-indazóis como antagonistas do receptor de ep2
BR112013030391A2 (pt) derivados de piperidina 3- espirocíclicos como agonistas dos receptores de grelina
EA201501163A1 (ru) Модуляторы рецептора cxcr7
BR112017013998A2 (pt) novos derivados de benzimidazol como agentes anti-histamínicos
BR112018073419A2 (pt) combinação, uso da combinação, método para o tratamento, composto, método para o tratamento de doença de alzheimer e composição farmacêutica

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]