BR112015030387A8 - compostos de pirazol moduladores de fshr, seu processo de fabricação, composição farmacêutica que os compreende, bem como uso dos mesmos - Google Patents

compostos de pirazol moduladores de fshr, seu processo de fabricação, composição farmacêutica que os compreende, bem como uso dos mesmos Download PDF

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Publication number
BR112015030387A8
BR112015030387A8 BR112015030387A BR112015030387A BR112015030387A8 BR 112015030387 A8 BR112015030387 A8 BR 112015030387A8 BR 112015030387 A BR112015030387 A BR 112015030387A BR 112015030387 A BR112015030387 A BR 112015030387A BR 112015030387 A8 BR112015030387 A8 BR 112015030387A8
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BR
Brazil
Prior art keywords
fshr
pyrazole compounds
well
pharmaceutical composition
manufacturing process
Prior art date
Application number
BR112015030387A
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English (en)
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BR112015030387B1 (pt
BR112015030387A2 (pt
Inventor
Yu Henry
Donnelly Marianne
Nguyen Ngan
Jiang Xuliang
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR112015030387A2 publication Critical patent/BR112015030387A2/pt
Publication of BR112015030387A8 publication Critical patent/BR112015030387A8/pt
Publication of BR112015030387B1 publication Critical patent/BR112015030387B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

compostos de pirazol como moduladores de fshr e usos dos mesmos a presente invenção refere-se a compostos de pirazol, e composições farmaceuticamente aceitáveis dos mesmos, úteis como moduladores alostéricos positivos do receptor do hormônio estimulador de folículo (fshr).
BR112015030387-0A 2013-06-24 2014-06-24 compostos de pirazol moduladores de fshr, seus usos, e composição farmacêutica BR112015030387B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361838460P 2013-06-24 2013-06-24
US61/838,460 2013-06-24
US201361898608P 2013-11-01 2013-11-01
US61/898,608 2013-11-01
PCT/US2014/043838 WO2014209980A1 (en) 2013-06-24 2014-06-24 Pyrazole compounds as modulators of fshr and uses thereof

Publications (3)

Publication Number Publication Date
BR112015030387A2 BR112015030387A2 (pt) 2017-07-25
BR112015030387A8 true BR112015030387A8 (pt) 2019-12-24
BR112015030387B1 BR112015030387B1 (pt) 2021-02-09

Family

ID=51177212

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015030387-0A BR112015030387B1 (pt) 2013-06-24 2014-06-24 compostos de pirazol moduladores de fshr, seus usos, e composição farmacêutica

Country Status (16)

Country Link
US (2) US10081637B2 (pt)
EP (1) EP3013832B1 (pt)
JP (1) JP6625973B2 (pt)
KR (2) KR20210114561A (pt)
CN (1) CN105473596B (pt)
AU (1) AU2014302712B2 (pt)
BR (1) BR112015030387B1 (pt)
CA (1) CA2912921C (pt)
ES (1) ES2849434T3 (pt)
HK (1) HK1218757A1 (pt)
IL (1) IL243226B (pt)
MX (1) MX2015016825A (pt)
RU (1) RU2663898C2 (pt)
SG (1) SG11201509411VA (pt)
WO (1) WO2014209980A1 (pt)
ZA (1) ZA201508514B (pt)

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* Cited by examiner, † Cited by third party
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WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
CN107531721B (zh) * 2015-04-30 2020-07-17 诺华股份有限公司 用于调节法尼醇x受体的稠合的三环吡唑衍生物
CN106977523A (zh) * 2017-03-30 2017-07-25 河南师范大学 具有苯基并四氢吡咯结构的fshr拮抗剂及其制备方法
CN106967076A (zh) * 2017-03-30 2017-07-21 河南师范大学 一种具有6h‑二苯并吡喃结构化合物及其制备方法
CN106928243A (zh) * 2017-03-30 2017-07-07 毛阿龙 具有生物活性的苯并哌啶并苯胺基类化合物的制备方法
RU2716597C1 (ru) * 2019-11-29 2020-03-13 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) Производные 2-(хромено[4,3-d]пиримидин-5-ил)уксусной кислоты и способ их получения
CN113754678B (zh) * 2020-06-02 2023-03-10 江苏恒瑞医药股份有限公司 二氢硫代色烯并吡唑类衍生物、其制备方法及其在医药上的应用
WO2022007924A1 (zh) * 2020-07-09 2022-01-13 江苏恒瑞医药股份有限公司 氧杂氮杂双环类衍生物、其制备方法及其在医药上的应用
JP2023536442A (ja) 2020-07-29 2023-08-25 江蘇恒瑞医薬股▲ふん▼有限公司 オキサアザスピロ環系誘導体、その調製方法及びその医薬的応用
AU2022367432A1 (en) 2021-10-14 2024-05-02 Incyte Corporation Quinoline compounds as inhibitors of kras
WO2024044778A2 (en) * 2022-08-26 2024-02-29 Celmatix Inc. Novel modulators of fshr and uses thereof
WO2024077006A1 (en) * 2022-10-05 2024-04-11 Radionetics Oncology, Inc. Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof

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US5547975A (en) * 1994-09-20 1996-08-20 Talley; John J. Benzopyranopyrazolyl derivatives for the treatment of inflammation
JP4511042B2 (ja) 1998-08-07 2010-07-28 メルク セローノ ソシエテ アノニム 不妊症の治療のためのｆｓｈ模倣物
JP2004505051A (ja) 2000-07-27 2004-02-19 スミスクライン　ビーチャム　コーポレーション 卵胞刺激ホルモン活性のアゴニスト
SE0102404D0 (sv) * 2001-07-04 2001-07-04 Active Biotech Ab Novel immunomodulating compounds
CA2460939C (en) * 2001-09-19 2008-07-29 Pharmacia Corporation Substituted pyrazolyl compounds for the treatment of inflammation
CN100436445C (zh) * 2003-02-07 2008-11-26 第一制药株式会社 吡唑衍生物
PL377848A1 (pl) * 2003-02-07 2006-02-20 Daiichi Pharmaceutical Co., Ltd. Pochodne pirazoli
WO2008035356A2 (en) * 2006-09-20 2008-03-27 Glenmark Pharmaceuticals Limited Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
WO2009010824A1 (en) * 2007-07-13 2009-01-22 Glenmark Pharmaceuticals, S.A. Dihydrochromenopyrazole derivatives as vanilloid receptor ligands
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Also Published As

Publication number Publication date
RU2016101958A3 (pt) 2018-03-29
IL243226A0 (en) 2016-02-29
RU2663898C2 (ru) 2018-08-13
US11365199B2 (en) 2022-06-21
NZ714201A (en) 2021-02-26
ZA201508514B (en) 2019-07-31
CN105473596A (zh) 2016-04-06
US10081637B2 (en) 2018-09-25
EP3013832B1 (en) 2020-11-04
BR112015030387B1 (pt) 2021-02-09
US20160152626A1 (en) 2016-06-02
BR112015030387A2 (pt) 2017-07-25
JP2016523865A (ja) 2016-08-12
KR102318498B1 (ko) 2021-10-27
RU2016101958A (ru) 2017-07-28
CA2912921C (en) 2021-05-18
AU2014302712B2 (en) 2018-11-29
CN105473596B (zh) 2019-04-30
IL243226B (en) 2019-10-31
HK1218757A1 (zh) 2017-03-10
WO2014209980A1 (en) 2014-12-31
EP3013832A1 (en) 2016-05-04
AU2014302712A1 (en) 2015-12-03
KR20160021817A (ko) 2016-02-26
SG11201509411VA (en) 2015-12-30
JP6625973B2 (ja) 2019-12-25
CA2912921A1 (en) 2014-12-31
US20180354965A1 (en) 2018-12-13
ES2849434T3 (es) 2021-08-18
KR20210114561A (ko) 2021-09-23
MX2015016825A (es) 2016-04-18

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/06/2014, OBSERVADAS AS CONDICOES LEGAIS.