BR112015019627A2 - amidas heterocíclicas como inibidores de quinases - Google Patents

amidas heterocíclicas como inibidores de quinases

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Publication number
BR112015019627A2
BR112015019627A2 BR112015019627A BR112015019627A BR112015019627A2 BR 112015019627 A2 BR112015019627 A2 BR 112015019627A2 BR 112015019627 A BR112015019627 A BR 112015019627A BR 112015019627 A BR112015019627 A BR 112015019627A BR 112015019627 A2 BR112015019627 A2 BR 112015019627A2
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BR
Brazil
Prior art keywords
kinase inhibitors
heterocyclic amides
amides
heterocyclic
compounds
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BR112015019627A
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English (en)
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BR112015019627B1 (pt
Inventor
Lakdawala Shah Ami
Rahman Attiq
Wayne King Bryan
A Sehon Clark
Zhang Daohua
Bandyopadhyay Deepak
U Jeong Jae
Kang Jianxing
M Ramanjulu Joshi
Kathryn Leister Lara
M Eidam Patrick
J Gough Peter
Anthony Harris Philip
Singhaus Robert Jr
W Marquis Robert Jr
Original Assignee
Glaxosmithkline Ip Dev Ltd
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Application filed by Glaxosmithkline Ip Dev Ltd filed Critical Glaxosmithkline Ip Dev Ltd
Priority to BR122017002946A priority Critical patent/BR122017002946A2/pt
Priority to BR122017002949A priority patent/BR122017002949A2/pt
Priority to BR122017002951A priority patent/BR122017002951A2/pt
Publication of BR112015019627A2 publication Critical patent/BR112015019627A2/pt
Publication of BR112015019627B1 publication Critical patent/BR112015019627B1/pt

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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Abstract

resumo "amidas heterocíclicas como inibidores de quinases" a presente invenção refere-se a certos compostos tendo a fórmula: em que x, y, z1, z2, z3, z4, r5, ra, m, a. l e b são conforme aqui definidos, e a métodos para produzir e usar os compostos.figura 1ª.
BR112015019627-6A 2013-02-15 2014-02-14 Compostos de amidas heterocíclicas, composições farmacêuticas compreendendo ditos compostos e usos dos mesmos para tratar colite ulcerativa, doença de crohn, artrite reumatoide, psoríase, espondiloartrite, artrite idiopática juvenil de aparecimento sistêmico (sojia), osteoartrite e esclerose múltipla BR112015019627B1 (pt)

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