EA201591915A1 - Соединения феноксиэтил дигидро-1h-изохинолина - Google Patents

Соединения феноксиэтил дигидро-1h-изохинолина

Info

Publication number
EA201591915A1
EA201591915A1 EA201591915A EA201591915A EA201591915A1 EA 201591915 A1 EA201591915 A1 EA 201591915A1 EA 201591915 A EA201591915 A EA 201591915A EA 201591915 A EA201591915 A EA 201591915A EA 201591915 A1 EA201591915 A1 EA 201591915A1
Authority
EA
Eurasian Patent Office
Prior art keywords
izohinolina
compounds
phenoxyethyl
dihydro
phenoxyethyl dihydro
Prior art date
Application number
EA201591915A
Other languages
English (en)
Other versions
EA027306B1 (ru
Inventor
Джереми Шуленбург Йорк
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201591915A1 publication Critical patent/EA201591915A1/ru
Publication of EA027306B1 publication Critical patent/EA027306B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

В настоящем изобретении предложено соединение формулы Iгде R представляет собой Н или F; или его фармацевтически приемлемая соль.
EA201591915A 2013-05-17 2014-05-09 Соединения феноксиэтил дигидро-1h-изохинолина в качестве селективных антагонистов ер4 EA027306B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361824436P 2013-05-17 2013-05-17
PCT/US2014/037416 WO2014186218A1 (en) 2013-05-17 2014-05-09 Phenoxyethyl dihydro-1h-isoquinoline compounds

Publications (2)

Publication Number Publication Date
EA201591915A1 true EA201591915A1 (ru) 2016-04-29
EA027306B1 EA027306B1 (ru) 2017-07-31

Family

ID=50877688

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591915A EA027306B1 (ru) 2013-05-17 2014-05-09 Соединения феноксиэтил дигидро-1h-изохинолина в качестве селективных антагонистов ер4

Country Status (17)

Country Link
US (1) US9371289B2 (ru)
EP (1) EP2997015B1 (ru)
JP (1) JP6148400B2 (ru)
KR (1) KR101798315B1 (ru)
CN (1) CN105209438B (ru)
BR (1) BR112015026967B1 (ru)
CA (1) CA2908400C (ru)
EA (1) EA027306B1 (ru)
ES (1) ES2626976T3 (ru)
HU (1) HUE033574T2 (ru)
MX (1) MX2015015841A (ru)
PL (1) PL2997015T3 (ru)
PT (1) PT2997015T (ru)
SA (1) SA515370035B1 (ru)
TW (1) TWI636046B (ru)
WO (1) WO2014186218A1 (ru)
ZA (1) ZA201507566B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105793242B (zh) * 2013-12-17 2018-02-16 伊莱利利公司 苯氧基乙基环状胺衍生物及其作为ep4受体调节剂的活性
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
TW201900179A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 作為pge2受體調節劑之苯并呋喃及苯并噻吩衍生物
TW201900178A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 作為pge2受體調節劑之嘧啶衍生物
UA124748C2 (uk) 2017-05-18 2021-11-10 Ідорсія Фармасьютікалз Лтд N-заміщені індольні похідні
CA3063788A1 (en) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
MA49126B1 (fr) 2017-05-18 2021-10-29 Idorsia Pharmaceuticals Ltd Dérivés de phényle utilisés en tant que modulateurs des récepteurs des pge2
KR20230107228A (ko) 2020-11-13 2023-07-14 오노 야꾸힝 고교 가부시키가이샤 Ep4 길항약과 면역 체크포인트 저해 물질의 병용에 의한 암 치료

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DE2500157C2 (de) 1975-01-03 1983-09-15 Hoechst Ag, 6230 Frankfurt N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung
IT1270615B (it) 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina
US6649606B1 (en) * 2001-11-09 2003-11-18 Bristol-Myers Squibb Co. Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
JP4663233B2 (ja) 2001-11-09 2011-04-06 エンゾン，インコーポレーテッド ベンジル脱離系を利用する高分子チオール結合プロドラッグ
EP1558253A4 (en) * 2002-10-30 2007-07-25 Merck & Co Inc PIPERIDINYL ALPHA AMINOAMIDE MODULATORS DERCHEMOKIN RECEPTOR ACTIVITY
CA2531796A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
BRPI0414130B8 (pt) 2003-09-03 2021-05-25 Askat Inc compostos de fenilamida ou piridilamida, seu uso e composições farmacêuticas que os compreendem.
CA2565813C (en) 2004-05-04 2010-10-26 Pfizer Inc. Substituted methyl aryl or heteroaryl amide compounds
JP4054369B2 (ja) 2004-05-04 2008-02-27 ファイザー株式会社 オルト置換アリールまたはヘテロアリールアミド化合物
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
WO2007121578A1 (en) 2006-04-24 2007-11-01 Merck Frosst Canada Ltd. Indole amide derivatives as ep4 receptor antagonists
AU2007260529B2 (en) 2006-06-12 2012-04-19 Merck Canada Inc. Indoline amide derivatives as EP4 receptor ligands
SI2565191T1 (sl) * 2008-05-14 2014-12-31 Astellas Pharma Inc. Derivati 4-(indol-7-ilkarbonilaminometil)cikloheksan karboksilne kisline kot EP4 receptorski antagonisti, uporabni za zdravljenje kronične ledvične odpovedi ali diabetične nefropatije
CA2733247C (en) 2008-08-14 2018-04-03 Beta Pharma Canada Inc. Heterocyclic amide derivatives as ep4 receptor antagonists
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ES2559513T3 (es) * 2011-07-04 2016-02-12 Rottapharm Biotech S.R.L. Derivados de amina cíclica como antagonistas del receptor EP4
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JO3296B1 (ar) 2012-06-29 2018-09-16 Lilly Co Eli مركبات فينوكسي إيثيل بيبريدين

Also Published As

Publication number Publication date
CA2908400C (en) 2017-04-11
TWI636046B (zh) 2018-09-21
ZA201507566B (en) 2017-06-28
TW201534588A (zh) 2015-09-16
EA027306B1 (ru) 2017-07-31
HUE033574T2 (hu) 2017-12-28
AU2014265762A1 (en) 2015-10-15
CA2908400A1 (en) 2014-11-20
WO2014186218A1 (en) 2014-11-20
US9371289B2 (en) 2016-06-21
SA515370035B1 (ar) 2018-01-04
EP2997015A1 (en) 2016-03-23
BR112015026967A2 (pt) 2017-07-25
CN105209438A (zh) 2015-12-30
MX2015015841A (es) 2016-03-04
PL2997015T3 (pl) 2017-09-29
PT2997015T (pt) 2017-04-24
BR112015026967B1 (pt) 2023-01-10
KR101798315B1 (ko) 2017-11-15
JP6148400B2 (ja) 2017-06-14
EP2997015B1 (en) 2017-04-05
KR20150140831A (ko) 2015-12-16
JP2016519140A (ja) 2016-06-30
BR112015026967A8 (pt) 2018-01-30
CN105209438B (zh) 2017-04-12
ES2626976T3 (es) 2017-07-26
US20160052889A1 (en) 2016-02-25

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM