BR112014030795A2 - composto, composição farmacêutica, uso de um composto e processo para preparação de um composto - Google Patents

composto, composição farmacêutica, uso de um composto e processo para preparação de um composto

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Publication number
BR112014030795A2
BR112014030795A2 BR112014030795A BR112014030795A BR112014030795A2 BR 112014030795 A2 BR112014030795 A2 BR 112014030795A2 BR 112014030795 A BR112014030795 A BR 112014030795A BR 112014030795 A BR112014030795 A BR 112014030795A BR 112014030795 A2 BR112014030795 A2 BR 112014030795A2
Authority
BR
Brazil
Prior art keywords
compound
preparing
pharmaceutical composition
mpges
inhibitors
Prior art date
Application number
BR112014030795A
Other languages
English (en)
Inventor
Atmaram Gharat Laxmikant
Muthukaman Nagarajan
Khairatkar-Joshi Neelima
Ganapati Kattige Vidya
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of BR112014030795A2 publication Critical patent/BR112014030795A2/pt

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

resumo “composto, composição farmacêutica, uso de um composto e processo para preparação de um composto” a presente divulgação é direcionada a compostos da fórmula (i), e sais farmaceuticamente aceitáveis dos mesmos, como inibidores de mpges-1. esses compostos são inibidores da enzima prostaglandina e sintase-1 microssomal (mpges-1) e são, portanto, úteis no tratamento da dor e/ou inflamação decorrentes de uma variedade de doenças ou condições, tais como asma, osteoartrite, artrite reumatoide, dor aguda ou crônica e doenças neurodegenerativas. (i)
BR112014030795A 2012-06-15 2013-06-10 composto, composição farmacêutica, uso de um composto e processo para preparação de um composto BR112014030795A2 (pt)

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IN1733MU2012 2012-06-15
US201261668146P 2012-07-05 2012-07-05
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US201261735679P 2012-12-11 2012-12-11
IN387MU2013 2013-02-08
US201361792225P 2013-03-15 2013-03-15
PCT/IB2013/054752 WO2013186692A1 (en) 2012-06-15 2013-06-10 TRIAZOLONE COMPOUNDS AS mPGES-1 INHIBITORS

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