BR112015025354A2 - compostos di-hidropirido-pirimidínicos como inibidores de autotaxina - Google Patents

compostos di-hidropirido-pirimidínicos como inibidores de autotaxina

Info

Publication number
BR112015025354A2
BR112015025354A2 BR112015025354A BR112015025354A BR112015025354A2 BR 112015025354 A2 BR112015025354 A2 BR 112015025354A2 BR 112015025354 A BR112015025354 A BR 112015025354A BR 112015025354 A BR112015025354 A BR 112015025354A BR 112015025354 A2 BR112015025354 A2 BR 112015025354A2
Authority
BR
Brazil
Prior art keywords
dihydropyrido
autotaxin inhibitors
pyrimidine compounds
compounds
autotaxin
Prior art date
Application number
BR112015025354A
Other languages
English (en)
Inventor
Hurst Norman Bryan
Allen Pfeifer Lance
Anthony Doti Robert
John Bleisch Thomas
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112015025354A2 publication Critical patent/BR112015025354A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

resumo patente de invenção: "compostos di-hidropirido-pirimidínicos como inibidores da autotaxina". a presente invenção refere-se a compostos da fórmula (i): i ou seu sal farmaceuticamente aceitável. os compostos da invenção são inibidores da autotaxina úteis no tratamento da dor associada com a osteoartrite.
BR112015025354A 2013-04-12 2014-04-04 compostos di-hidropirido-pirimidínicos como inibidores de autotaxina BR112015025354A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361811290P 2013-04-12 2013-04-12
US201361811280P 2013-04-12 2013-04-12
PCT/US2014/032946 WO2014168824A1 (en) 2013-04-12 2014-04-04 Dihydropyrido pyrimidine compounds as autotaxin inhibitors

Publications (1)

Publication Number Publication Date
BR112015025354A2 true BR112015025354A2 (pt) 2017-07-18

Family

ID=50680197

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015025354A BR112015025354A2 (pt) 2013-04-12 2014-04-04 compostos di-hidropirido-pirimidínicos como inibidores de autotaxina

Country Status (13)

Country Link
US (1) US9550774B2 (pt)
EP (1) EP2984091B1 (pt)
JP (1) JP6133491B2 (pt)
KR (1) KR20150126673A (pt)
CN (1) CN105102458B (pt)
AU (1) AU2014251250B2 (pt)
BR (1) BR112015025354A2 (pt)
CA (1) CA2908408C (pt)
EA (1) EA201591634A1 (pt)
ES (1) ES2623900T3 (pt)
MX (1) MX2015014298A (pt)
TW (1) TW201500356A (pt)
WO (1) WO2014168824A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499591B (zh) * 2013-01-11 2015-09-11 Lilly Co Eli 雙環嘧啶化合物
MX2016013049A (es) 2014-04-04 2017-04-27 X-Rx Inc Inhibidores de autotaxina espirociclicos sustituidos.
DK3164394T3 (da) * 2014-07-03 2020-05-04 Univ Texas Gls1-inhibitorer til behandling af sygdomme
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
WO2016197009A1 (en) 2015-06-05 2016-12-08 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
ES2794868T3 (es) 2015-06-30 2020-11-19 Univ Texas Inhibidores de GLS1 para el tratamiento de enfermedades
CN108602782B (zh) 2015-12-22 2022-06-17 德克萨斯大学***董事会 N-甲基-1h-1,2,3-***-4-甲酰胺化合物的盐形式和多晶型物
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
KR101798840B1 (ko) * 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
RU2020112558A (ru) 2017-10-18 2021-11-18 Боард Оф Регентс, Зе Юниверсити Оф Тексас Систем Терапия на основе ингибитора глутаминазы
CN108223589B (zh) * 2018-02-07 2023-10-31 广州市拓道新材料科技有限公司 一种轴承密封装置
WO2020119896A1 (en) * 2018-12-11 2020-06-18 F. Hoffmann-La Roche Ag Heterocyclic inhibitors of atx
WO2020123426A1 (en) * 2018-12-11 2020-06-18 F. Hoffmann-La Roche Ag Aminoazine amides
EP3782997A1 (en) * 2019-08-19 2021-02-24 Galapagos N.V. Fused pyrimidine compounds and pharmaceutical compositions thereof for the treatment of fibrotic diseases
US20230069174A1 (en) * 2019-12-11 2023-03-02 Sichuan Haisco Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic autotaxin inhibitor, and composition containing same and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405848A (en) * 1993-12-22 1995-04-11 Ortho Pharmaceutical Corporation Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors
SV2002000205A (es) * 1999-11-01 2002-06-07 Lilly Co Eli Compuestos farmaceuticos ref. x-01095
JPWO2003104230A1 (ja) 2002-06-07 2005-10-06 協和醗酵工業株式会社 二環性ピリミジン誘導体
ITRE20090102A1 (it) 2009-10-22 2011-04-23 Cgm Spa Stampo, attrezzatura e metodo per la formatura dietro compressione di oggetti di materiale termoplastico
WO2011103715A1 (en) * 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Task channel antagonists
EP2606031B1 (en) * 2010-08-20 2017-09-27 Amira Pharmaceuticals, Inc. Autotaxin inhibitors and uses thereof
AR084515A1 (es) * 2010-12-22 2013-05-22 Merz Pharma Gmbh & Co Kgaa Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras
TWI499591B (zh) * 2013-01-11 2015-09-11 Lilly Co Eli 雙環嘧啶化合物
TW201520219A (zh) * 2013-03-12 2015-06-01 Lilly Co Eli 咪唑並吡啶化合物

Also Published As

Publication number Publication date
EP2984091B1 (en) 2017-03-01
CN105102458B (zh) 2017-05-17
MX2015014298A (es) 2015-12-08
AU2014251250B2 (en) 2016-03-17
ES2623900T3 (es) 2017-07-12
US9550774B2 (en) 2017-01-24
CN105102458A (zh) 2015-11-25
CA2908408A1 (en) 2014-10-16
JP2016516771A (ja) 2016-06-09
KR20150126673A (ko) 2015-11-12
EA201591634A1 (ru) 2016-02-29
AU2014251250A1 (en) 2015-10-01
CA2908408C (en) 2017-11-28
WO2014168824A1 (en) 2014-10-16
TW201500356A (zh) 2015-01-01
US20150368240A1 (en) 2015-12-24
JP6133491B2 (ja) 2017-05-24
EP2984091A1 (en) 2016-02-17

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)