BR112013029201A2 - compostos de pirrolidinil ureia e pirrolidinil tioureia como inibidores de trka quinase - Google Patents

compostos de pirrolidinil ureia e pirrolidinil tioureia como inibidores de trka quinase

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Publication number
BR112013029201A2
BR112013029201A2 BR112013029201A BR112013029201A BR112013029201A2 BR 112013029201 A2 BR112013029201 A2 BR 112013029201A2 BR 112013029201 A BR112013029201 A BR 112013029201A BR 112013029201 A BR112013029201 A BR 112013029201A BR 112013029201 A2 BR112013029201 A2 BR 112013029201A2
Authority
BR
Brazil
Prior art keywords
pyrrolidinyl
trka kinase
kinase inhibitors
diseases
urea
Prior art date
Application number
BR112013029201A
Other languages
English (en)
Other versions
BR112013029201B1 (pt
Inventor
R Kolakowski Gabrielle
F Blake James
Seo Jeongbeob
Haas Julia
R Condroski Kevin
Huang Lily
Allen Shelley
W Andrews Steven
Kercher Timothy
Jiang Yutong
Original Assignee
Array Biopharma Inc
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Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of BR112013029201A2 publication Critical patent/BR112013029201A2/pt
Publication of BR112013029201B1 publication Critical patent/BR112013029201B1/pt

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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

abstract compounds of formula i: i or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where r1, r2, ra, rb, rc, rd, x, y, b, and ring c are as defined herein, and wherein the y-b moiety and the nh-c(=x)-nh moiety are in the trans configuration, are inhibitors of trka kinase and are useful in the treatment of diseases which can be treated with a trka kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases. tradução do resumo resumo patente de invenção: "compostos de pirrolidinil ureia e pirrolidinil tioureia como inibidores de trka quinase". compostos de fórmula i: i ou estereoisômeros, tautômeros ou sais farmaceuticamente aceitáveis, ou solvatos ou pró-drogas dos mesmos, onde r1, r2, ra, rb, rc, rd, x, y, b, e anel c são como definidos aqui e em que a fração y-b e a fração nh-c(=x)-nh estão na configuração trans, são inibidores de trka quinase e são úteis no tratamento de doenças as quais podem ser tratadas com um inibidor de trka quinase, tal como dor, câncer, inflamação, doenças neurodegenerativas e certas doenças infecciosas.
BR112013029201-6A 2011-05-13 2012-05-09 Compostos de pirrolidinil ureia e pirrolidinil tioureia, seu processo de preparação, seu uso e composições farmacêuticas BR112013029201B1 (pt)

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