CY1119014T1 - Ενωσεις πυρρολιδινυλ ουριας και πυρρολιδινυλ θειοουριας ως αναστολεις κινασης trka - Google Patents

Ενωσεις πυρρολιδινυλ ουριας και πυρρολιδινυλ θειοουριας ως αναστολεις κινασης trka

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Publication number
CY1119014T1
CY1119014T1 CY20171100107T CY171100107T CY1119014T1 CY 1119014 T1 CY1119014 T1 CY 1119014T1 CY 20171100107 T CY20171100107 T CY 20171100107T CY 171100107 T CY171100107 T CY 171100107T CY 1119014 T1 CY1119014 T1 CY 1119014T1
Authority
CY
Cyprus
Prior art keywords
compounds
trka
thiouuria
purylidinyl
pyrrolidinyl
Prior art date
Application number
CY20171100107T
Other languages
English (en)
Inventor
Shelley Allen
Steven W Andrews
James F Blake
Kevin R Condroski
Julia Haas
Lily Huang
Yutong Jiang
Timothy Kercher
Gabrielle R Kolakowski
Jeongbeob Seo
Original Assignee
Array Biopharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma, Inc. filed Critical Array Biopharma, Inc.
Publication of CY1119014T1 publication Critical patent/CY1119014T1/el

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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Abstract

Ενώσεις του Τύπου I: ή στερεοϊσομερή, ταυτομερή ή φαρμακευτικά αποδεκτά άλατα, ή προϊόντα επιδιαλύτωσης ή προφάρμακα αυτών, όπου τα R1, R2, Ra, Rb, Rc, Rd, Χ, Υ, Β, και ο Δακτύλιος C είναι όπως ορίζεται εδώ και όπου το τμήμα Υ-Β και το τμήμα NH-C(=X)-NH ευρίσκονται σε διαμόρφωση trans, είναι αναστολείς της κινάσης TrkA και είναι χρήσιμες εις την αγωγή νοσημάτων τα οποία μπορούν να υποβληθούν σε αγωγή με έναν αναστολέα κινάσης TrkA, όπως πόνος, καρκίνος, φλεγμονή, νευροεκφυλιστικά νοσήματα και συγκεκριμένα μολυσματικά νοσήματα.
CY20171100107T 2011-05-13 2017-01-24 Ενωσεις πυρρολιδινυλ ουριας και πυρρολιδινυλ θειοουριας ως αναστολεις κινασης trka CY1119014T1 (el)

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