BR0307624A - Inibidores de histona desacetilase - Google Patents

Inibidores de histona desacetilase

Info

Publication number
BR0307624A
BR0307624A BR0307624-5A BR0307624A BR0307624A BR 0307624 A BR0307624 A BR 0307624A BR 0307624 A BR0307624 A BR 0307624A BR 0307624 A BR0307624 A BR 0307624A
Authority
BR
Brazil
Prior art keywords
histone deacetylase
deacetylase inhibitors
histone
inhibitors
disacetilase
Prior art date
Application number
BR0307624-5A
Other languages
English (en)
Inventor
Kristof Van Emelen
Marc Gustaaf Celine Verdonck
Sven Franciscus Anna Va Brandt
Patrick Rene Angibaud
Lieven Meerpoel
Alexey Borisovich Dyatkin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR0307624A publication Critical patent/BR0307624A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

"INIBIDORES DE HISTONA DESACETILASE". Esta invenção compreende os novos compostos da fórmula (I) em que n, R^ 1^, R^ 2^, R^ 3^, R^ 4^, Q, X, Y, Z e tendo os significados definidos, possuem atividade enzimática inibidora de histona desacetilase; sua preparação, composições contendo-os e seu uso como uma medicina.
BR0307624-5A 2002-03-13 2003-03-11 Inibidores de histona desacetilase BR0307624A (pt)

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PCT/EP2003/002515 WO2003075929A1 (en) 2002-03-13 2003-03-11 Inhibitors of histone deacetylase

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