DK1943232T3 - Kvadratsyrederivater som inhibitorer af histondeacetylase - Google Patents

Kvadratsyrederivater som inhibitorer af histondeacetylase

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Publication number
DK1943232T3
DK1943232T3 DK06807466.5T DK06807466T DK1943232T3 DK 1943232 T3 DK1943232 T3 DK 1943232T3 DK 06807466 T DK06807466 T DK 06807466T DK 1943232 T3 DK1943232 T3 DK 1943232T3
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DK
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Prior art keywords
histone deacetylase
inhibitors
acid derivatives
quadric
quadric acid
Prior art date
Application number
DK06807466.5T
Other languages
English (en)
Inventor
Emelen Kristof Van
Original Assignee
Janssen Pharmaceutica Nv
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Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
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Publication of DK1943232T3 publication Critical patent/DK1943232T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
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DK06807466.5T 2005-10-27 2006-10-23 Kvadratsyrederivater som inhibitorer af histondeacetylase DK1943232T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05110080 2005-10-27
PCT/EP2006/067656 WO2007048767A1 (en) 2005-10-27 2006-10-23 Squaric acid derivatives as inhibitors of histone deacetylase

Publications (1)

Publication Number Publication Date
DK1943232T3 true DK1943232T3 (da) 2011-08-29

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ID=36192996

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06807466.5T DK1943232T3 (da) 2005-10-27 2006-10-23 Kvadratsyrederivater som inhibitorer af histondeacetylase

Country Status (9)

Country Link
US (1) US7884105B2 (da)
EP (1) EP1943232B1 (da)
JP (1) JP5070214B2 (da)
AT (1) ATE509920T1 (da)
AU (1) AU2006307918B2 (da)
CA (1) CA2623360C (da)
DK (1) DK1943232T3 (da)
ES (1) ES2366132T3 (da)
WO (1) WO2007048767A1 (da)

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PL213783B1 (pl) 2002-03-13 2013-05-31 Janssen Pharmaceutica Nv Podstawiona pochodna piperydyny lub piperazyny, jej zastosowanie i sposób wytwarzania oraz kompozycja farmaceutyczna
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ES2306858T3 (es) 2002-03-13 2008-11-16 Janssen Pharmaceutica Nv Derivados de carbonilamino como nuevos inhibidores de las histonadesacetilasas.
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ME01060B (me) 2006-01-19 2012-10-20 Janssen Pharmaceutica Nv Derivati aminofenila kao novi inhibitori histon deacetilaze
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WO2012120262A1 (en) 2011-03-09 2012-09-13 Larsson Pia Compounds and methods for improving impaired endogenous fibrinolysis using histone deacetylase inhibitors
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CA2623360A1 (en) 2007-05-03
ATE509920T1 (de) 2011-06-15
CA2623360C (en) 2014-04-22
ES2366132T3 (es) 2011-10-17
AU2006307918B2 (en) 2012-06-21
JP2009513599A (ja) 2009-04-02
EP1943232A1 (en) 2008-07-16
EP1943232B1 (en) 2011-05-18
US7884105B2 (en) 2011-02-08

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