BR0112252A - Derivados de pirazole - Google Patents
Derivados de pirazoleInfo
- Publication number
- BR0112252A BR0112252A BR0112252-5A BR0112252A BR0112252A BR 0112252 A BR0112252 A BR 0112252A BR 0112252 A BR0112252 A BR 0112252A BR 0112252 A BR0112252 A BR 0112252A
- Authority
- BR
- Brazil
- Prior art keywords
- derivatives
- pyrazole derivatives
- pyrazole
- pirazole
- solvates
- Prior art date
Links
- 150000003217 pyrazoles Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
- C07D231/20—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE PIRAZOLE". Esta invenção relaciona-se com a utilização de derivados de pirazole de fórmula e dos seus sais e solvatos farmaceuticamente aceitáveis, para o fabrico de um inibidor ou modulador da transcriptase reversa, com certos derivados novos de pirazole e com os processos de preparação e com composições contendo estes novos derivados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0016787.4A GB0016787D0 (en) | 2000-07-07 | 2000-07-07 | Compounds useful in therapy |
PCT/IB2001/001174 WO2002004424A1 (en) | 2000-07-07 | 2001-06-21 | Pyrazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0112252A true BR0112252A (pt) | 2003-09-02 |
Family
ID=9895273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0112252-5A BR0112252A (pt) | 2000-07-07 | 2001-06-21 | Derivados de pirazole |
Country Status (20)
Country | Link |
---|---|
US (2) | US6750230B2 (pt) |
EP (1) | EP1299361B1 (pt) |
JP (1) | JP2004502760A (pt) |
AP (1) | AP2001002204A0 (pt) |
AT (1) | ATE333445T1 (pt) |
AU (1) | AU2001267766A1 (pt) |
BR (1) | BR0112252A (pt) |
CA (1) | CA2415492A1 (pt) |
DE (1) | DE60121590T2 (pt) |
ES (1) | ES2266212T3 (pt) |
GB (1) | GB0016787D0 (pt) |
GT (1) | GT200100132A (pt) |
HN (1) | HN2001000146A (pt) |
MX (1) | MXPA03000059A (pt) |
PA (1) | PA8521701A1 (pt) |
PE (1) | PE20020131A1 (pt) |
SV (1) | SV2002000520A (pt) |
TN (1) | TNSN01102A1 (pt) |
UY (1) | UY26819A1 (pt) |
WO (1) | WO2002004424A1 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6455559B1 (en) | 2001-07-19 | 2002-09-24 | Pharmacia Italia S.P.A. | Phenylacetamido-pyrazole derivatives, process for their preparation and their use as antitumor agents |
AU2002242926B2 (en) | 2001-04-10 | 2007-10-11 | Pfizer Inc. | Pyrazole derivatives for treating HIV |
GB0113524D0 (en) | 2001-06-04 | 2001-07-25 | Hoffmann La Roche | Pyrazole derivatives |
WO2003057673A1 (en) * | 2001-12-28 | 2003-07-17 | Bayer Pharmaceuticals Corporation | 1h-pyrazolyl derivative compounds, for use in diseases associated with the 5-ht2c receptor |
AU2003217712A1 (en) | 2002-03-07 | 2003-09-22 | Smithkline Beecham Corporation | Pyrazolopyrimidine and pyrazolotriazine derivatives and pharmaceutical compositions containing them |
UA79804C2 (en) * | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
GB0221477D0 (en) * | 2002-09-16 | 2002-10-23 | Pfizer Ltd | Chemical compounds |
US20040132793A1 (en) * | 2002-09-16 | 2004-07-08 | Pfizer Inc. | Pyrazole derivatives |
US7230025B2 (en) | 2002-09-26 | 2007-06-12 | Pfizer, Inc. | Pyrazole derivatives |
MXPA05002004A (es) | 2002-09-26 | 2005-04-28 | Pfizer | Derivados de pirazol. |
GB0223234D0 (en) * | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
GB0223232D0 (en) * | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
US6933312B2 (en) | 2002-10-07 | 2005-08-23 | Agouron Pharmaceuticals, Inc. | Pyrazole derivatives |
CA2515119A1 (en) | 2003-02-07 | 2004-08-19 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivative |
TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
JP2006526015A (ja) * | 2003-05-02 | 2006-11-16 | エラン ファーマシューティカルズ,インコーポレイテッド | 炎症疾患治療のためのブラジキニンb1受容体アンタゴニストとしての4−ブロモ−5−(2−クロロ−ベンゾイルアミノ)−1h−ピラゾール−3−カルボン酸アミド誘導体および関連化合物 |
US7220772B2 (en) | 2003-09-05 | 2007-05-22 | Pfizer, Inc. | Pyrazole derivatives |
BRPI0509853A (pt) * | 2004-04-14 | 2007-10-09 | Pfizer | compostos de imidazol ligados a enxofre para o tratamento de hiv |
WO2005118543A1 (ja) * | 2004-06-03 | 2005-12-15 | Ono Pharmaceutical Co., Ltd. | キナーゼ阻害薬およびその用途 |
US7531560B2 (en) * | 2004-11-10 | 2009-05-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Anti-cytokine heterocyclic compounds |
WO2006072833A1 (en) * | 2005-01-06 | 2006-07-13 | Pfizer Limited | Imidazole derivatives as enzyme reverse transcriptase modulators |
US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
WO2007022947A2 (de) | 2005-08-21 | 2007-03-01 | Abbott Gmbh & Co. Kg | 5-ring-heteroaromaten-verbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
CL2007001941A1 (es) * | 2006-07-05 | 2008-06-20 | Aventis Agriculture | Compuestos derivados de 1-aril-5-alquilo pirazol; composicion para tratar animales contra ectoparasitos; uso de dicha composicion; composicion insecticida; uso de dichos compuestos derivados; metodo para preparar composiciones pesticidas; metodo para |
WO2008019968A1 (en) | 2006-08-16 | 2008-02-21 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
WO2009000663A1 (en) | 2007-06-22 | 2008-12-31 | F. Hoffmann-La Roche Ag | Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors |
RU2495878C2 (ru) | 2007-12-21 | 2013-10-20 | Ф.Хоффманн-Ля Рош Аг | Гетероциклические антивирусные соединения |
BRPI0922043B1 (pt) | 2008-11-19 | 2019-04-24 | Merial, Inc. | Composições compreendendo um aril pirazol e/ou formamidina, métodos e usos das mesmas |
US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
US8748435B2 (en) | 2011-04-01 | 2014-06-10 | Novartis Ag | Pyrazolo pyrimidine derivatives |
CN103588707B (zh) * | 2013-06-09 | 2016-06-01 | 中国科学院上海有机化学研究所 | 多氮化合物及其合成方法 |
JOP20180092A1 (ar) * | 2017-10-13 | 2019-04-13 | Gilead Sciences Inc | مثبطات hiv بروتياز |
MX2020013769A (es) * | 2018-06-18 | 2021-03-02 | Bayer Ag | Carboxilatos de 3-pirazol disustituidos y un proceso para su preparacion mediante la acilacion de enolatos. |
IL310395A (en) | 2021-08-02 | 2024-03-01 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
WO2023110871A1 (en) | 2021-12-17 | 2023-06-22 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
WO2024068947A1 (en) | 2022-09-30 | 2024-04-04 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
Family Cites Families (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3154543A (en) | 1961-09-18 | 1964-10-27 | Norwich Pharma Co | Preparation of 5-aminofurans |
DE1261124B (de) | 1961-09-22 | 1968-02-15 | Hoechst Ag | Verfahren zur Herstellung von Pyrazolen |
US3303200A (en) * | 1963-11-05 | 1967-02-07 | American Home Prod | Pyrazole-1-ethanol derivatives |
JPS5030871A (pt) | 1973-07-16 | 1975-03-27 | ||
US3960836A (en) | 1974-07-22 | 1976-06-01 | Eli Lilly And Company | Acylated derivatives of pyrazofurin and process for their preparation |
US4041046A (en) | 1975-06-06 | 1977-08-09 | American Cyanamid Company | 1,2-Dialkyl-3,4,5-trisubstituted pyrazole compounds |
SU657745A3 (ru) | 1976-06-09 | 1979-04-15 | Санкио Компани Лимитед, (Фирма) | Способ получени производных пиразола или их солей или эфиров органических кислот |
DE2829289A1 (de) | 1978-07-04 | 1980-01-24 | Basf Ag | Pyrazolaetherderivate |
JPS5533413A (en) | 1978-08-29 | 1980-03-08 | Ishihara Sangyo Kaisha Ltd | Pyrazole derivative and herbicide containing the same |
JPS5535038A (en) | 1978-09-04 | 1980-03-11 | Sankyo Co Ltd | Weed controlling composition |
JPS5535036A (en) | 1978-09-04 | 1980-03-11 | Sankyo Co Ltd | Herbicidal composition |
JPS5535035A (en) | 1978-09-04 | 1980-03-11 | Sankyo Co Ltd | Herbicidal composition |
JPS5535039A (en) | 1978-09-04 | 1980-03-11 | Sankyo Co Ltd | Weed controlling composition |
JPS5535037A (en) | 1978-09-04 | 1980-03-11 | Sankyo Co Ltd | Herbicidal composition |
JPS5547602A (en) | 1978-10-25 | 1980-04-04 | Sankyo Co Ltd | Herbicide |
JPS577403A (en) | 1980-06-17 | 1982-01-14 | Ishihara Sangyo Kaisha Ltd | Herbicide for paddy field |
JPS58185568A (ja) | 1982-04-24 | 1983-10-29 | Nissan Chem Ind Ltd | ピラゾ−ル誘導体,その製造方法および該誘導体を含有する選択性除草剤 |
JPS58188858A (ja) | 1982-04-27 | 1983-11-04 | Mitsubishi Petrochem Co Ltd | 新規ピラゾ−ル誘導体 |
JPS5988470A (ja) | 1982-11-15 | 1984-05-22 | Nippon Nohyaku Co Ltd | ピラゾ−ル誘導体及び除草,殺ダニ剤 |
JPS59104362A (ja) | 1982-12-07 | 1984-06-16 | Nissan Chem Ind Ltd | ピラゾ−ル誘導体、その製造方法および該誘導体を含有する選択性除草剤 |
JPS59122472A (ja) | 1982-12-29 | 1984-07-14 | Nissan Chem Ind Ltd | ピラゾ−ル誘導体、その製造方法および該誘導体を含有する選択性除草剤 |
JPS59196869A (ja) * | 1983-04-22 | 1984-11-08 | Sankyo Co Ltd | ピラゾ−ル誘導体及び除草剤 |
NZ208555A (en) | 1983-06-23 | 1987-06-30 | American Cyanamid Co | (3-amino-1h-pyrazol-4-yl)-arylmethanone derivatives |
JPS608207A (ja) | 1983-06-29 | 1985-01-17 | Nissan Chem Ind Ltd | 除草剤組成物 |
JPS608208A (ja) | 1983-06-29 | 1985-01-17 | Nissan Chem Ind Ltd | 除草用組成物 |
JPS608204A (ja) | 1983-06-29 | 1985-01-17 | Nissan Chem Ind Ltd | 除草組成物 |
JPS6016974A (ja) | 1983-07-09 | 1985-01-28 | Nissan Chem Ind Ltd | ピラゾ−ル誘導体,その製造方法および選択性除草剤 |
JPS6034902A (ja) | 1983-08-05 | 1985-02-22 | Nissan Chem Ind Ltd | 除草性組成物 |
JPH0680047B2 (ja) | 1983-08-24 | 1994-10-12 | 日産化学工業株式会社 | ピラゾールスルホニルウレア誘導体、その製法および該誘導体を含有する選択性除草剤 |
JPS6064903A (ja) | 1983-09-21 | 1985-04-13 | Nissan Chem Ind Ltd | 除草剤組成物 |
JPS60197605A (ja) | 1984-03-19 | 1985-10-07 | Nissan Chem Ind Ltd | 除草剤組成物 |
JPS60202803A (ja) | 1984-03-28 | 1985-10-14 | Tokuyama Soda Co Ltd | 除草剤組成物 |
DE3575130D1 (de) | 1984-05-12 | 1990-02-08 | Fisons Plc | Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung. |
JPS6115802A (ja) | 1984-06-29 | 1986-01-23 | Nissan Chem Ind Ltd | 除草剤組成物 |
JPS61148105A (ja) | 1984-12-21 | 1986-07-05 | Tokuyama Soda Co Ltd | 除草剤組成物 |
US4656260A (en) | 1984-12-27 | 1987-04-07 | Kanto Ishi Pharmaceutical Co., Ltd. | Cyclic pyrazolo C-nucleoside compound and process for preparing the same |
US4744815A (en) | 1985-05-11 | 1988-05-17 | Nissan Chemical Industries, Ltd. | 4-benzoyl-1-alkyl (alkenyl) - pyrazoles, composition containing them, herbicidal method of using them, and intermediate in their preparation |
DE3602728A1 (de) | 1985-05-17 | 1986-11-20 | Bayer Ag, 51373 Leverkusen | Schaedlingsbekaempfungsmittel auf basis von pyrazolderivaten |
DE3520330A1 (de) | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | 5-amino-1-pyridyl-pyrazole |
DE3529829A1 (de) | 1985-08-21 | 1987-02-26 | Bayer Ag | 1-arylpyrazole |
JPH0655645B2 (ja) | 1985-12-09 | 1994-07-27 | ダイセル化学工業株式会社 | 除草剤組成物 |
JPS62145003A (ja) | 1985-12-19 | 1987-06-29 | Sumitomo Chem Co Ltd | 除草組成物 |
DE3545036A1 (de) | 1985-12-19 | 1987-09-10 | Bayer Ag | 5-heterocyclyl-1-aryl-pyrazole |
DE3600287A1 (de) | 1986-01-08 | 1987-07-16 | Bayer Ag | 1-arylpyrazole |
DE3603291A1 (de) | 1986-02-04 | 1987-08-06 | Bayer Ag | 5-amino-1-phenyl-pyrazole |
DE3606476A1 (de) | 1986-02-28 | 1987-09-03 | Bayer Ag | 1-arylpyrazole |
DE3617554A1 (de) | 1986-05-24 | 1987-11-26 | Bayer Ag | 5-oxy(thio)-pyrazol-derivate |
JPS6351304A (ja) | 1986-08-19 | 1988-03-04 | Nissan Chem Ind Ltd | 除草剤組成物 |
EP0264773A1 (en) | 1986-10-16 | 1988-04-27 | American Cyanamid Company | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines |
EP0272704A3 (en) | 1986-12-26 | 1990-11-22 | Sanwa Kagaku Kenkyusho Co., Ltd. | Use of pyrazole derivatives in the treatment of immunity diseases and nephropathy |
DE3711928A1 (de) | 1987-04-09 | 1988-10-20 | Bayer Ag | Substituierte 1-arylpyrazole |
JPS6413072A (en) | 1987-07-07 | 1989-01-17 | Fuji Photo Film Co Ltd | Production of 3-alkoxy-5-amino-1h-pyrazoles |
US4769907A (en) | 1987-07-27 | 1988-09-13 | Northern Telecom Limited | Method of making a circuit board pin |
DE3724920A1 (de) | 1987-07-28 | 1989-02-09 | Bayer Ag | Substituierte 1-aryl-5-(het)arylmethylamino-pyrazole |
JPH01113304A (ja) | 1987-10-28 | 1989-05-02 | Daikin Ind Ltd | 除草剤組成物 |
JPH01211582A (ja) | 1988-02-16 | 1989-08-24 | Tanabe Seiyaku Co Ltd | ベンゾジオキソール誘導体 |
JPH01210003A (ja) | 1988-02-18 | 1989-08-23 | Daicel Chem Ind Ltd | 芳香族ポリスルホン中空糸膜ならびにその製造法 |
JP2622707B2 (ja) | 1988-02-19 | 1997-06-18 | 日本カーバイド工業株式会社 | アルミ建材の再塗装方法 |
JPH0296472A (ja) | 1988-09-30 | 1990-04-09 | Matsushita Graphic Commun Syst Inc | 画像データ縮小方法 |
GB2224208A (en) | 1988-10-20 | 1990-05-02 | Shell Int Research | Fungicidal pyrazolyl aryl ketones |
JP2694369B2 (ja) | 1989-11-27 | 1997-12-24 | 京セラ株式会社 | 窒化珪素質焼結体 |
US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
DE4023215A1 (de) | 1990-07-21 | 1992-01-23 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, sie enthaltende mittel und deren verwendung |
DE4023488A1 (de) | 1990-07-24 | 1992-01-30 | Bayer Ag | 1-(pyri(mi)dyl-(2)) -5-hydroxy-pyrazol-mikrobizide |
JP2753659B2 (ja) | 1990-09-03 | 1998-05-20 | 株式会社大塚製薬工場 | ピラゾール誘導体 |
JPH0532662A (ja) | 1990-11-09 | 1993-02-09 | Nissan Chem Ind Ltd | 置換ピラゾール誘導体および農園芸用殺菌剤 |
DK0565593T3 (da) | 1990-12-31 | 1999-09-27 | Monsanto Co | Reducering af pesticidinteraktion i afgrøder |
PH30258A (en) | 1991-12-30 | 1997-02-05 | Janssen Pharmaceutica Nv | Heterocycle-substituted benzenemethanamine derivatives |
JPH05262741A (ja) | 1992-01-09 | 1993-10-12 | Nissan Chem Ind Ltd | フェニルピラゾール誘導体および有害生物防除剤 |
WO1993015060A1 (en) | 1992-01-22 | 1993-08-05 | Nissan Chemical Industries, Ltd. | Substituted pyrazole derivative and agrohorticultural bactericide |
FR2687675B1 (fr) | 1992-01-31 | 1997-04-18 | Roussel Uclaf | Nouveaux derives bicycliques de la pyridine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
CA2106387A1 (en) | 1992-02-26 | 1993-08-27 | Ming-Chu Hsu | Benzodiazepinones |
US5274111A (en) | 1992-04-07 | 1993-12-28 | American Home Products Corporation | Trifluoromethyl substituted 1H-pyrazoles and derivatives thereof |
GB9207591D0 (en) | 1992-04-07 | 1992-05-20 | Glaxo Group Ltd | Chemical processes |
US5264451A (en) | 1992-04-07 | 1993-11-23 | American Home Products Corporation | Process for treating hyperglycemia using trifluoromethyl substituted 3H-pyrazol-3-ones |
JPH0665237A (ja) | 1992-05-07 | 1994-03-08 | Nissan Chem Ind Ltd | 置換ピラゾール誘導体および農園芸用殺菌剤 |
EP0577023A3 (en) | 1992-07-01 | 1996-12-18 | Hoechst Ag | Angiotensin-ii receptor-antagonists for the treatment of arrhythmices |
EP0577025A3 (de) | 1992-07-01 | 1998-02-04 | Hoechst Aktiengesellschaft | Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen |
JPH0625177A (ja) | 1992-07-09 | 1994-02-01 | Nissan Chem Ind Ltd | ピラゾール誘導体及び除草剤 |
DK0674631T3 (da) * | 1992-12-17 | 2000-04-10 | Pfizer | Substituerede pyrazoler som CRF-antogonister |
RU2142946C1 (ru) | 1992-12-17 | 1999-12-20 | Пфайзер Инк. | Производные пиразола и фармацевтическая композиция, содержащая их |
TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
US6005109A (en) | 1997-10-30 | 1999-12-21 | Pflizer Inc. | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
US6103900A (en) | 1992-12-17 | 2000-08-15 | Pfizer Inc | Pyrazoles and pyrazolopyrimidines having CRF antagonistic activity |
JP3170374B2 (ja) | 1993-01-14 | 2001-05-28 | 山本化成株式会社 | フルオラン化合物及びこの化合物を含有する記録材料 |
JPH06239864A (ja) | 1993-02-15 | 1994-08-30 | Fujisawa Pharmaceut Co Ltd | 新規複素環誘導体 |
WO1994022830A1 (en) | 1993-03-31 | 1994-10-13 | Smithkline Beecham Corporation | Chemical compounds |
DE4333659C2 (de) | 1993-10-02 | 2003-11-06 | Guenter Ege | 4-Arylmethyl-1H-pyrazol-3-amine, deren Salze und Verfahren zu ihrer Herstellung |
JPH07165724A (ja) | 1993-12-13 | 1995-06-27 | Nkk Corp | ピラゾール誘導体及び血液凝固阻害剤 |
DE69408950T2 (de) | 1993-12-14 | 1998-10-15 | Mitsubishi Chem Corp | N-Pyrazolylcarbamatderivate und Fungizide für Landwirtschaft und Gartenbau, die diese als aktive Bestandteile erhalten, Produktion und Zwischenprodukte |
JPH07224041A (ja) | 1994-02-10 | 1995-08-22 | Mitsubishi Chem Corp | ピラゾリル酢酸誘導体およびこれを有効成分とする農園芸用殺菌剤 |
JP3791015B2 (ja) | 1994-03-31 | 2006-06-28 | 日産化学工業株式会社 | スルホンアミド誘導体の製造方法 |
DE4411235A1 (de) | 1994-03-31 | 1995-10-05 | Bayer Ag | Thiazolylpyrazolinone |
CA2188809A1 (en) | 1994-05-13 | 1995-11-23 | Gee-Hong Kuo | Therapeutic phenoxyalkylazoles and phenoxyalkylazines |
US5646152A (en) * | 1994-06-15 | 1997-07-08 | Pfizer Inc. | Methods of administering CRF antagonists |
JP3155009B2 (ja) * | 1994-09-26 | 2001-04-09 | 塩野義製薬株式会社 | イミダゾール誘導体 |
AU664686B3 (en) | 1994-11-15 | 1995-11-23 | Efisio Theo Pettena | A road barrier for a vehicle |
US5663199A (en) | 1994-11-30 | 1997-09-02 | Uniroyal Chemical Ltd./Ltee | Anti-viral aromatic O-alkylated oximes, ethers and thioethers |
US5550280A (en) | 1994-11-30 | 1996-08-27 | Uniroyal Chemical Ltd./ Uniroyal Chemical Ltee | Hindered aromatic ester compounds useful as anti-viral agents |
JP3734180B2 (ja) | 1994-12-28 | 2006-01-11 | エーザイ株式会社 | 新規ピラゾール誘導体 |
JPH08208620A (ja) | 1995-02-03 | 1996-08-13 | Takeda Chem Ind Ltd | アミノピラゾール誘導体、その製造法および用途 |
US5939559A (en) | 1995-02-07 | 1999-08-17 | Nissan Chemical Industries, Ltd. | Pyrazole derivative and herbicidal composition |
DE19518054A1 (de) | 1995-03-08 | 1996-09-12 | Hoechst Schering Agrevo Gmbh | N-Arylpyrazolketone und deren Derivate, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel |
ATE301457T1 (de) | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
DE19521822A1 (de) | 1995-06-16 | 1996-12-19 | Dresden Arzneimittel | Neue, antikonvulsiv wirkende 3-Aminopyrazole, Verfahren zu deren Herstellung und ihre Verwendung |
JPH0995482A (ja) | 1995-09-29 | 1997-04-08 | Shionogi & Co Ltd | α−置換酢酸を有する複素環誘導体、その製造用中間体ならびにそれを含有する農薬 |
GB2310207A (en) | 1996-02-15 | 1997-08-20 | Pharmacia Spa | Antiviral ureido derivatives of substituted heterocyclic compounds |
FR2745467A1 (fr) | 1996-03-04 | 1997-09-05 | Rhone Poulenc Agrochimie | Pyrazoles contre les virus des plantes |
US6011052A (en) | 1996-04-30 | 2000-01-04 | Warner-Lambert Company | Pyrazolone derivatives as MCP-1 antagonists |
DE19622189A1 (de) | 1996-06-03 | 1997-12-04 | Bayer Ag | 3-Cyanaryl-pyrazole |
DE19629826A1 (de) | 1996-07-24 | 1998-01-29 | Bayer Ag | 1,3-Dimethyl-5-fluor-pyrazol-4-carboxamide |
GB9625045D0 (en) * | 1996-11-30 | 1997-01-22 | Pfizer Ltd | Parasiticidal compounds |
US6020357A (en) | 1996-12-23 | 2000-02-01 | Dupont Pharmaceuticals Company | Nitrogen containing heteroaromatics as factor Xa inhibitors |
JP4123542B2 (ja) | 1997-07-07 | 2008-07-23 | 住友化学株式会社 | ピラゾリノン誘導体の製造法 |
DE19827855A1 (de) | 1998-06-23 | 1999-12-30 | Hoechst Schering Agrevo Gmbh | Kombinationen aus Herbiziden und Safenern |
DE19829616A1 (de) | 1998-07-02 | 2000-01-05 | Bayer Ag | Verfahren zur Herstellung von 1-Alkyl-pyrazol-5-carbonsäureestern |
JP2000053649A (ja) | 1998-08-11 | 2000-02-22 | Sumitomo Pharmaceut Co Ltd | スルホニルウレイドピラゾール誘導体 |
DE19837067A1 (de) | 1998-08-17 | 2000-02-24 | Bayer Ag | Verfahren zur Herstellung von 1-Alkyl-pyrazol-5-carbonsäureestern |
JPH11228312A (ja) | 1998-10-16 | 1999-08-24 | Mitsubishi Chemical Corp | 水性懸濁状除草剤原液組成物 |
FR2795726A1 (fr) | 1999-06-30 | 2001-01-05 | Aventis Cropscience Sa | Nouveaux pyrazoles fongicides |
CA2315614C (en) * | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
-
2000
- 2000-07-07 GB GBGB0016787.4A patent/GB0016787D0/en not_active Ceased
-
2001
- 2001-06-21 DE DE60121590T patent/DE60121590T2/de not_active Expired - Fee Related
- 2001-06-21 EP EP01945553A patent/EP1299361B1/en not_active Expired - Lifetime
- 2001-06-21 BR BR0112252-5A patent/BR0112252A/pt not_active IP Right Cessation
- 2001-06-21 JP JP2002509291A patent/JP2004502760A/ja active Pending
- 2001-06-21 ES ES01945553T patent/ES2266212T3/es not_active Expired - Lifetime
- 2001-06-21 AP APAP/P/2001/002204A patent/AP2001002204A0/en unknown
- 2001-06-21 AT AT01945553T patent/ATE333445T1/de not_active IP Right Cessation
- 2001-06-21 CA CA002415492A patent/CA2415492A1/en not_active Abandoned
- 2001-06-21 MX MXPA03000059A patent/MXPA03000059A/es active IP Right Grant
- 2001-06-21 WO PCT/IB2001/001174 patent/WO2002004424A1/en active IP Right Grant
- 2001-06-21 AU AU2001267766A patent/AU2001267766A1/en not_active Abandoned
- 2001-07-02 PE PE2001000653A patent/PE20020131A1/es not_active Application Discontinuation
- 2001-07-04 PA PA20018521701A patent/PA8521701A1/es unknown
- 2001-07-04 GT GT200100132A patent/GT200100132A/es unknown
- 2001-07-04 HN HN2001000146A patent/HN2001000146A/es unknown
- 2001-07-05 US US09/899,322 patent/US6750230B2/en not_active Expired - Fee Related
- 2001-07-06 TN TNTNSN01102A patent/TNSN01102A1/fr unknown
- 2001-07-06 SV SV2001000520A patent/SV2002000520A/es not_active Application Discontinuation
- 2001-07-06 UY UY26819A patent/UY26819A1/es not_active Application Discontinuation
-
2004
- 2004-04-26 US US10/832,920 patent/US7141585B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2004502760A (ja) | 2004-01-29 |
EP1299361B1 (en) | 2006-07-19 |
PE20020131A1 (es) | 2002-02-21 |
AP2001002204A0 (en) | 2001-09-30 |
MXPA03000059A (es) | 2003-10-15 |
HN2001000146A (es) | 2002-01-11 |
DE60121590T2 (de) | 2006-11-30 |
US7141585B2 (en) | 2006-11-28 |
US6750230B2 (en) | 2004-06-15 |
SV2002000520A (es) | 2002-12-02 |
ATE333445T1 (de) | 2006-08-15 |
US20020032184A1 (en) | 2002-03-14 |
EP1299361A1 (en) | 2003-04-09 |
US20040209862A1 (en) | 2004-10-21 |
CA2415492A1 (en) | 2002-01-17 |
AU2001267766A1 (en) | 2002-01-21 |
GT200100132A (es) | 2002-03-22 |
UY26819A1 (es) | 2002-01-31 |
TNSN01102A1 (fr) | 2005-11-10 |
WO2002004424A9 (en) | 2002-12-12 |
ES2266212T3 (es) | 2007-03-01 |
GB0016787D0 (en) | 2000-08-30 |
WO2002004424A1 (en) | 2002-01-17 |
DE60121590D1 (en) | 2006-08-31 |
PA8521701A1 (es) | 2002-08-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0112252A (pt) | Derivados de pirazole | |
BR0111263A (pt) | Derivados de 2-aminocarbonil-9h-purina | |
BRPI0212894B8 (pt) | composto ou sal do mesmo farmaceuticamente aceitável e composição farmacêutica | |
BR0307607A (pt) | Derivados de carbonilamino como inibidores de histona desacetilase | |
BR0215240A (pt) | Derivados de calcona e seu uso no tratamento de doenças | |
EA199900937A1 (ru) | Фармацевтические композиции, содержащие вориконазол | |
TR200201505T2 (tr) | Terapötik maddeler olarak pirazolopirimidinler | |
BR0309427A (pt) | Novo uso de um composto (2z)-2-ciano-3-hidroxi-n-[4-(trifluorometil)fenil]-2-hep tano-6-inamida ou 5-(3-butinil)-n-[4-(trifluorometil)fenil]-4-isoxazoleca rbo-amida | |
BR0208811A (pt) | Derivados de pirazol para tratamento de hiv | |
BR0108893A (pt) | Composição farmacêutica, composto e processo de preparação de compostos | |
DK1263730T3 (da) | Aminderivater til behandling af apoptose | |
BRPI0212726B8 (pt) | compostos contendo lactamas, e derivados dos mesmos, composição farmacêutica que os compreende e seus usos | |
HRP20050213A2 (en) | 2,4-substituted indoles and their use as 5-ht6 modulators | |
MA29550B1 (fr) | Derives de n- (pyridine-2-yl) - sulfonamide | |
BR0115411A (pt) | Combinações sinergìsticas compreendendo um inibidor de renina para doenças cardiovasculares | |
BR9915132A (pt) | Método para inibir a atividade de quinase de proteìna, compostos da fórmula i e sais farmaceuticamente aceitáveis dos mesmos, uso do mesmo, e, composição farmacêutica. | |
BR0210538A (pt) | Derivados de 5-halotriptamina usados como ligantes dos receptores de serotonina 5-ht6 e/ou 5-ht7 | |
BR0210874A (pt) | Derivados de tiazol-benzamida e composições farmacêuticas para a inibição da proliferação celular e métodos para o seu uso | |
BR0212386A (pt) | Composto, formulação farmacêutica, e, uso de um composto | |
BR0113590A (pt) | 7-oxo-piridopirimidinas | |
CO5550439A2 (es) | Compuestos derivados de arilsulfonil-piperazina que tienen afinidad al receptor 5-ht6 y composiciones farmaceuticas que los contienen | |
BR0113389A (pt) | Compostos que inibem a atividade do fator xa | |
AR035889A1 (es) | Citrato de 5,7,14-triazatetraciclo[10.3.1.02,11.04,9]hexadeca-2(11),3,5,7,9- pentaeno y composiciones farmaceuticas que la contienen y su uso para la elaboracion de medicamentos | |
ATE384714T1 (de) | Pyrazolderivate | |
HUP0203226A2 (hu) | Hatóanyagként benzamidszármazékot tartalmazó gyógyszerkészítmény |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009. |