BR0106272A - Processo para preparação de citalopram puro - Google Patents

Processo para preparação de citalopram puro

Info

Publication number
BR0106272A
BR0106272A BR0106272-7A BR0106272A BR0106272A BR 0106272 A BR0106272 A BR 0106272A BR 0106272 A BR0106272 A BR 0106272A BR 0106272 A BR0106272 A BR 0106272A
Authority
BR
Brazil
Prior art keywords
citalopram
preparation
subjected
amide
product
Prior art date
Application number
BR0106272-7A
Other languages
English (en)
Inventor
Marco Villa
Federico Sbrogio
Robert Dancer
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR0106272A publication Critical patent/BR0106272A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE CITALOPRAM PURO". A presente invenção refere-se a um processo para a preparação e purificação de citalopram (I) no qual um composto de Fórmula (II) onde Z é iodo, bromo, cloro OU CF~ 3~-(CF~ 2~)~ n~-SO~ 2~-O-, n sendo 0, 1, 2, 3, 4, 5, 6, 7 ou 8, é submetido a uma reação de troca de cianeto com uma fonte de cianeto; o produto de citalopram bruto resultante é opcionalmente submetido a alguma purificação inicial e é subseq³entemente tratado com uma amida ou um agente formador de grupo similar a amida; a mistura da reação é então submetida a uma lavagem de ácido/base e/ou cristalização e recristalização de citalopram, a fim de remover as amidas formadas a partir da mistura de citalopram bruto; e o produto de citalopram resultante é opcionalmente mais purificado, elaborado e isolado como a base ou como um sal do mesmo aceitável na farmacologia.
BR0106272-7A 2000-12-22 2001-03-07 Processo para preparação de citalopram puro BR0106272A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001929 2000-12-22
PCT/DK2001/000147 WO2001045483A2 (en) 2000-12-22 2001-03-07 Method for the preparation of pure citalopram

Publications (1)

Publication Number Publication Date
BR0106272A true BR0106272A (pt) 2004-06-15

Family

ID=8159922

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0106272-7A BR0106272A (pt) 2000-12-22 2001-03-07 Processo para preparação de citalopram puro

Country Status (43)

Country Link
US (1) US6455710B1 (pt)
EP (2) EP1462447A3 (pt)
JP (1) JP3798982B2 (pt)
KR (1) KR100439329B1 (pt)
CN (1) CN1282648C (pt)
AR (1) AR030056A1 (pt)
AT (2) ATE277920T1 (pt)
AU (2) AU2001100405B4 (pt)
BE (2) BE1013212A6 (pt)
BG (1) BG65131B1 (pt)
BR (1) BR0106272A (pt)
CA (1) CA2360303C (pt)
CH (1) CH691535A5 (pt)
CZ (1) CZ292200B6 (pt)
DE (2) DE60105926T2 (pt)
DK (1) DK1181713T3 (pt)
EA (1) EA003581B1 (pt)
ES (2) ES2228824T3 (pt)
FI (2) FI108639B (pt)
FR (1) FR2812877B1 (pt)
GB (1) GB2357763B (pt)
GR (1) GR1003874B (pt)
HK (1) HK1048812B (pt)
HR (1) HRP20020004A2 (pt)
HU (2) HU0101029D0 (pt)
IE (1) IES20010254A2 (pt)
IL (1) IL147226A (pt)
IS (1) IS2060B (pt)
IT (1) ITMI20010602A1 (pt)
MX (1) MXPA01013151A (pt)
NL (2) NL1017525C1 (pt)
NO (1) NO20011271A (pt)
NZ (1) NZ516298A (pt)
PL (1) PL205724B1 (pt)
PT (1) PT1181713E (pt)
SE (1) SE517623C2 (pt)
SG (1) SG167655A1 (pt)
SI (1) SI1181713T1 (pt)
SK (2) SK284428B6 (pt)
TR (1) TR200201166T1 (pt)
UA (1) UA71634C2 (pt)
WO (1) WO2001045483A2 (pt)
ZA (1) ZA200110179B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) * 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
WO2001047909A1 (en) 1999-12-28 2001-07-05 H. Lundbeck A/S Method for the preparation of citalopram
PL198803B1 (pl) 1999-12-30 2008-07-31 Lundbeck & Co As H Sposób wytwarzania 5-cyjano-3H-izobenzofuran-1-onu
ES2206177T3 (es) 2000-01-14 2004-05-16 H. Lundbeck A/S Metodo para la preparacion de 5-cianoftalida.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
CA2402553A1 (en) 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
BR0109176A (pt) 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
IL151488A0 (en) 2000-03-14 2003-04-10 Lundbeck & Co As H Method for the preparation of citalopram
EP1274699A1 (en) * 2000-03-16 2003-01-15 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
RU2003130073A (ru) * 2001-03-09 2005-04-10 Ранбакси Лабораторис Лимитед (In) Способ получения циталопрама
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
MXPA04004368A (es) * 2001-11-08 2004-08-11 Sepracor Inc Metodos para tratar depresion y otros transtornos del sistema nervioso central utilizando desmetil-y didesmetil-metabolitos del citalopram enantiomericamente enriquecidos.
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
BR0316217B1 (pt) * 2002-11-15 2013-10-01 tratamento de purificaÇço/descoloraÇço para nitrilas graxas
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) * 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CA2546422A1 (en) * 2003-10-28 2005-05-12 Wockhardt Limited Improved process for the manufacture of citalopram hydrobromide
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE536169C (de) * 1926-08-21 1931-10-20 British Dyestuffs Corp Ltd Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
US1992111A (en) * 1931-06-20 1935-02-19 Du Pont Separation of secondary and tertiary amines
DE1032261B (de) * 1955-03-08 1958-06-19 Leda Chemicals Ltd Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
GB1143702A (pt) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4302399A (en) * 1978-09-28 1981-11-24 Dynapol Acetylation of crude reaction products containing polymeric colorants
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US4943591A (en) 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
DE3926765A1 (de) * 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EP0993524B1 (en) * 1997-06-30 2002-11-20 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
CZ292911B6 (cs) 1997-11-11 2004-01-14 H. Lundbeck A/S Způsob výroby citalopramu
PL199423B1 (pl) * 1998-10-20 2008-09-30 Lundbeck & Co As H Sposób wytwarzania citalopramu
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ATE237604T1 (de) 1999-04-14 2003-05-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
PT1181272E (pt) 2000-12-28 2003-01-31 Lundbeck & Co As H Processo para a preparacao de citalopram puro

Also Published As

Publication number Publication date
SK286283B6 (sk) 2008-06-06
ES2170732B2 (es) 2003-09-16
BG65131B1 (bg) 2007-03-30
SI1181713T1 (en) 2005-02-28
CA2360303A1 (en) 2001-06-28
CZ292200B6 (cs) 2003-08-13
SG167655A1 (en) 2011-01-28
FI20011577A0 (fi) 2001-07-26
AT4367U1 (de) 2001-06-25
BG106203A (en) 2002-08-30
BE1013213A6 (fr) 2001-10-02
SK284428B6 (sk) 2005-04-01
GR1003874B (el) 2002-04-24
HUP0102817A3 (en) 2003-07-28
PL205724B1 (pl) 2010-05-31
EP1462447A3 (en) 2004-11-17
KR100439329B1 (ko) 2004-07-07
BE1013212A6 (fr) 2001-10-02
HU0102817D0 (en) 2001-09-28
GB0105983D0 (en) 2001-05-02
NL1017525C1 (nl) 2001-04-26
ATE277920T1 (de) 2004-10-15
CN1366525A (zh) 2002-08-28
NZ516298A (en) 2002-12-20
AU3920101A (en) 2001-07-03
IL147226A0 (en) 2002-08-14
SE0103045L (sv) 2002-06-23
HK1048812B (zh) 2007-06-01
ES2228824T3 (es) 2005-04-16
WO2001045483A3 (en) 2001-12-27
AU2001100405B4 (en) 2002-03-21
IS2060B (is) 2005-11-15
SK18482001A3 (sk) 2002-05-09
HRP20020004A2 (en) 2003-04-30
US6455710B1 (en) 2002-09-24
HU0101029D0 (en) 2001-05-28
US20020120005A1 (en) 2002-08-29
GB2357763A (en) 2001-07-04
SE517623C2 (sv) 2002-06-25
EA003581B1 (ru) 2003-06-26
IES20010254A2 (en) 2002-03-06
NO312462B1 (no) 2002-05-13
FR2812877A1 (fr) 2002-02-15
SE0103045D0 (sv) 2001-09-14
EP1462447A2 (en) 2004-09-29
FR2812877B1 (fr) 2003-04-04
DE60105926T2 (de) 2005-11-24
TR200201166T1 (tr) 2002-10-21
DK1181713T3 (da) 2005-01-31
AR030056A1 (es) 2003-08-13
KR20020065345A (ko) 2002-08-13
HK1048812A1 (en) 2003-04-17
CA2360303C (en) 2003-08-12
MXPA01013151A (es) 2002-08-12
ITMI20010602A0 (it) 2001-03-22
DE10112829C1 (de) 2002-07-25
EA200200018A1 (ru) 2002-04-25
EP1181713A2 (en) 2002-02-27
NO20011271A (no) 2002-05-13
WO2001045483A2 (en) 2001-06-28
PL353398A1 (en) 2003-11-17
PT1181713E (pt) 2005-02-28
DE60105926D1 (de) 2004-11-04
IL147226A (en) 2006-04-10
FI108639B (fi) 2002-02-28
CH691535A5 (de) 2001-08-15
GB2357763B (en) 2002-01-16
JP2003517484A (ja) 2003-05-27
FI20010500A0 (fi) 2001-03-13
HUP0102817A2 (hu) 2001-12-28
ES2170732A1 (es) 2002-08-01
ZA200110179B (en) 2002-12-11
JP3798982B2 (ja) 2006-07-19
CZ2001890A3 (cs) 2002-08-14
AU2001100405A4 (en) 2001-11-01
IS5883A (is) 2001-06-20
UA71634C2 (uk) 2004-12-15
NO20011271D0 (no) 2001-03-13
NL1018360C1 (nl) 2001-10-04
EP1181713B1 (en) 2004-09-29
ITMI20010602A1 (it) 2002-09-22
CN1282648C (zh) 2006-11-01

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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