BR0015295A - Formulação e método antidiabético - Google Patents
Formulação e método antidiabéticoInfo
- Publication number
- BR0015295A BR0015295A BR0015295-1A BR0015295A BR0015295A BR 0015295 A BR0015295 A BR 0015295A BR 0015295 A BR0015295 A BR 0015295A BR 0015295 A BR0015295 A BR 0015295A
- Authority
- BR
- Brazil
- Prior art keywords
- diabetes
- drug
- formulation
- metformin
- related patients
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
"FORMULAçãO E MéTODO ANTIDIABéTICO". A presente invenção refere-se a uma formulação farmacêutica de dose baixa especialmente adaptada para tratar de diabete do Tipo II em pacientes cândidos a drogas, a qual inclui uma combinação de metformina (empregada em uma quantidade reduzida (menos que 800 mg de metformina por dia, em comparação com aquela empregada na prática médica geralmente aceita) e pelo menos um outro agente antidiabete tal como sulfonil uréia, por exemplo, gliburida, cuja combinação proporciona pelo menos cerca de eficácia substancialmente equivalente no tratamento de diabete em pacientes cândidos a drogas, como proporcionam formulações contendo metformina em dosagens prescritas na prática médica geralmente aceita para terapia de primeira linha no tratamento de diabete, mas com efeitos colaterais substancialmente reduzidos, tais como hipoglicemia e/ou dor gastrointestinal. A invenção refere-se também a um método para o tratamento de diabete, em pacientes cândidos a drogas, empregando a formulação acima para reduzir resistência à insulina e/ou excursão de glicose pós-prandial e/ou hemoglobina 1Ac, e/ou aumento de insulina pós-prandial, tratando assim a diabete.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/432,465 US6586438B2 (en) | 1999-11-03 | 1999-11-03 | Antidiabetic formulation and method |
PCT/US2000/028467 WO2001032158A2 (en) | 1999-11-03 | 2000-10-13 | Pharmaceutical composition comprising a combination of metformin and another antidiabetic agent |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0015295A true BR0015295A (pt) | 2003-06-24 |
Family
ID=23716278
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0015295-1A BR0015295A (pt) | 1999-11-03 | 2000-10-13 | Formulação e método antidiabético |
Country Status (34)
Country | Link |
---|---|
US (2) | US6586438B2 (pt) |
EP (1) | EP1253944A2 (pt) |
JP (2) | JP2003529551A (pt) |
KR (2) | KR20020050253A (pt) |
CN (3) | CN101273981B (pt) |
AR (1) | AR026355A1 (pt) |
AU (1) | AU781781B2 (pt) |
BG (2) | BG106732A (pt) |
BR (1) | BR0015295A (pt) |
CA (1) | CA2389931A1 (pt) |
CZ (2) | CZ20021547A3 (pt) |
DE (1) | DE60038455T2 (pt) |
EE (1) | EE05210B1 (pt) |
ES (1) | ES2302702T3 (pt) |
GE (2) | GEP20053539B (pt) |
HK (1) | HK1045655A1 (pt) |
HU (1) | HUP0300642A3 (pt) |
IL (3) | IL149138A0 (pt) |
LT (1) | LT5025B (pt) |
LV (1) | LV12907B (pt) |
MX (1) | MXPA02004290A (pt) |
MY (2) | MY136636A (pt) |
NO (1) | NO20022086L (pt) |
NZ (1) | NZ552074A (pt) |
PL (1) | PL366112A1 (pt) |
RO (1) | RO123109B1 (pt) |
RU (1) | RU2276604C2 (pt) |
SK (1) | SK4992002A3 (pt) |
TN (2) | TNSN00206A1 (pt) |
TW (1) | TWI241185B (pt) |
UA (2) | UA76706C2 (pt) |
UY (1) | UY26425A1 (pt) |
WO (1) | WO2001032158A2 (pt) |
ZA (2) | ZA200203367B (pt) |
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DK36392D0 (da) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
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TWI238064B (en) | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
IT1276130B1 (it) | 1995-11-14 | 1997-10-27 | Gentili Ist Spa | Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo |
US6011049A (en) * | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
US6153632A (en) | 1997-02-24 | 2000-11-28 | Rieveley; Robert B. | Method and composition for the treatment of diabetes |
AU729529B2 (en) * | 1997-06-06 | 2001-02-01 | Depomed, Inc. | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
ATE201139T1 (de) | 1997-06-13 | 2001-06-15 | Novo Nordisk As | Neue dosierung für diabetes type 2 |
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ATE250418T1 (de) | 1998-07-15 | 2003-10-15 | Merck Sante Sas | Tabletten enthaltend eine kombination von glibenclamid und metformin |
JP2002524517A (ja) | 1998-09-17 | 2002-08-06 | ブリストル−マイヤーズ スクイブ カンパニー | aP2阻害剤およびその組成物を用いる糖尿病の治療方法 |
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1999
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2000
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- 2000-10-13 CN CN2008100817553A patent/CN101273981B/zh not_active Expired - Lifetime
- 2000-10-13 SK SK499-2002A patent/SK4992002A3/sk not_active Application Discontinuation
- 2000-10-13 EE EEP200200241A patent/EE05210B1/xx not_active IP Right Cessation
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- 2000-10-13 MX MXPA02004290A patent/MXPA02004290A/es not_active Application Discontinuation
- 2000-10-13 KR KR1020027005673A patent/KR100769786B1/ko active IP Right Grant
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- 2002-05-24 LT LT2002062A patent/LT5025B/lt not_active IP Right Cessation
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