BR0011542A - Compostos de fenoxipropilamina - Google Patents
Compostos de fenoxipropilaminaInfo
- Publication number
- BR0011542A BR0011542A BR0011542-8A BR0011542A BR0011542A BR 0011542 A BR0011542 A BR 0011542A BR 0011542 A BR0011542 A BR 0011542A BR 0011542 A BR0011542 A BR 0011542A
- Authority
- BR
- Brazil
- Prior art keywords
- phenoxypropylamine
- compound
- antidepressants
- hydrates
- expressing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Abstract
Patente de Invenção: "COMPOSTOS DE FENOXIPROPILAMINA". A presente invenção refere-se a um composto de fenoxipropilamina da fórmula (I) em que cada símbolo é como definido no relatório, um seu composto oticamente ativo ou um seu sal farmaceuticamente aceitável e seus hidratos, que simultaneamente mostram afinidades seletiva de e atividade antagonística contra receptor de 5-HT~ 1A~, bem como atividade inibitória de recaptação de 5HT, e podem ser usados como antidepressores rápidos na expressão de um efeito antidepressivo.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14275099 | 1999-05-24 | ||
JP16616099 | 1999-06-14 | ||
JP27738499 | 1999-09-29 | ||
JP2000018080 | 2000-01-25 | ||
PCT/JP2000/003279 WO2000071517A1 (fr) | 1999-05-24 | 2000-05-22 | Compose de phenoxypropylamine |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011542A true BR0011542A (pt) | 2002-03-05 |
Family
ID=27472476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011542-8A BR0011542A (pt) | 1999-05-24 | 2000-05-22 | Compostos de fenoxipropilamina |
Country Status (17)
Country | Link |
---|---|
US (2) | US6720320B2 (pt) |
EP (1) | EP1188747B1 (pt) |
JP (1) | JP3893878B2 (pt) |
KR (2) | KR100799134B1 (pt) |
CN (1) | CN1164574C (pt) |
AT (1) | ATE303987T1 (pt) |
AU (1) | AU777594B2 (pt) |
BR (1) | BR0011542A (pt) |
CA (2) | CA2716369C (pt) |
DE (1) | DE60022504T2 (pt) |
DK (1) | DK1188747T3 (pt) |
EA (1) | EA004704B1 (pt) |
ES (1) | ES2244438T3 (pt) |
IL (2) | IL146564A0 (pt) |
MX (1) | MXPA01012046A (pt) |
NZ (1) | NZ516111A (pt) |
WO (1) | WO2000071517A1 (pt) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2049601A (en) * | 1999-12-20 | 2001-07-03 | Eli Lilly And Company | Benzofuran derivatives |
ES2259619T3 (es) * | 1999-12-20 | 2006-10-16 | Eli Lilly And Company | Derivados de indol para el tratamiento de depresion y ansiedad. |
JP4042566B2 (ja) * | 2000-11-27 | 2008-02-06 | 田辺三菱製薬株式会社 | ピペリジン化合物およびその医薬用途 |
CA2500115A1 (en) * | 2002-09-26 | 2004-04-08 | Warner-Lambert Company Llc | Heterocyclic substituted piperazines for the treatment of schizophrenia |
SE0303280D0 (sv) * | 2003-12-05 | 2003-12-05 | Astrazeneca Ab | Novel compounds |
BRPI0416739A (pt) * | 2003-12-08 | 2007-01-16 | Warner Lambert Co | derivados de indano substituìdo heterocìclico e compostos afins para o tratamento de esquizofrenia |
GB0407025D0 (en) * | 2004-03-29 | 2004-04-28 | Glaxo Group Ltd | Novel compounds |
US7674822B2 (en) | 2004-11-24 | 2010-03-09 | Wyeth | PTP1b inhibitors |
WO2006101454A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Benzothiophene derivatives: preparation and pharmaceutical applications |
TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
KR101386494B1 (ko) | 2005-05-10 | 2014-04-24 | 인사이트 코포레이션 | 인돌아민 2,3-디옥시게나제의 조절제 및 이의 사용방법 |
TWI329641B (en) | 2005-08-31 | 2010-09-01 | Otsuka Pharma Co Ltd | (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same |
WO2007065655A1 (en) * | 2005-12-07 | 2007-06-14 | Neurosearch Sweden Ab | Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission |
JP5294874B2 (ja) | 2005-12-20 | 2013-09-18 | インサイト・コーポレイション | インドールアミン2,3−ジオキシゲナーゼのモジュレーターとしてのn−ヒドロキシアミジノヘテロ環 |
US7910592B2 (en) | 2005-12-30 | 2011-03-22 | Merck Sharp & Dohme Corp. | CETP inhibitors |
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US7649098B2 (en) * | 2006-02-24 | 2010-01-19 | Lexicon Pharmaceuticals, Inc. | Imidazole-based compounds, compositions comprising them and methods of their use |
CL2007002650A1 (es) * | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
WO2008036642A2 (en) | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
JP2008195654A (ja) * | 2007-02-14 | 2008-08-28 | Mitsubishi Tanabe Pharma Corp | ベンゾ[b]フラン化合物の新規結晶形 |
US20090270496A1 (en) * | 2007-05-03 | 2009-10-29 | Courchesne William E | Antifungal compounds |
TW200920355A (en) * | 2007-09-06 | 2009-05-16 | Lexicon Pharmaceuticals Inc | Compositions and methods for treating immunological and inflammatory diseases and disorders |
IE20070928A1 (en) * | 2007-12-21 | 2009-09-30 | Giuliani Int Ltd | Multi target ligands |
KR101649548B1 (ko) | 2008-07-08 | 2016-08-19 | 인사이트 홀딩스 코포레이션 | 인돌아민 2,3-디옥시게나아제의 억제제로서의 1,2,5-옥사디아졸 |
US10316000B2 (en) | 2009-02-18 | 2019-06-11 | Cornell University | Coupled recognition/detection system for in vivo and in vitro use |
US8324250B2 (en) | 2009-03-19 | 2012-12-04 | Hoffmann-La Roche Inc. | Piperidine derivatives as NK3 receptor antagonists |
US8476309B2 (en) * | 2009-08-20 | 2013-07-02 | The University Of Tennessee Research Foundation | Benzofuran cannabinoid compounds and related methods of use |
WO2013016694A2 (en) | 2011-07-27 | 2013-01-31 | Cornell University | Methods for rna detection and quantification |
AU2014209200B2 (en) * | 2013-01-24 | 2018-11-01 | Minerva Neurosciences, Inc. | Use of phenoxypropylamine compounds to treat depression |
JP2016525071A (ja) | 2013-08-07 | 2016-08-22 | カディラ ヘルスケア リミテッド | ヤーヌスキナーゼのインヒビターとしてのn−シアノメチルアミド |
US9664676B2 (en) | 2013-09-06 | 2017-05-30 | Cornell University | RNA sequences that induce fluorescence of small molecule fluorophores |
US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
MX366874B (es) | 2013-11-08 | 2019-07-29 | Incyte Holdings Corp | Proceso para la síntesis de un inhibidor de indolamina 2,3-dioxigenasa. |
WO2016071293A2 (en) | 2014-11-03 | 2016-05-12 | Iomet Pharma Ltd | Pharmaceutical compound |
WO2016192657A1 (en) | 2015-06-03 | 2016-12-08 | Sunshine Lake Pharma Co., Ltd. | Substituted piperazine compounds and methods of use and use thereof |
WO2016203482A2 (en) | 2015-06-19 | 2016-12-22 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
SG11201810359PA (en) * | 2016-05-25 | 2018-12-28 | Mitsubishi Tanabe Pharma Corp | (2s)-1-[4-(3,4-dichlorophenyl)piperidin-l-yl]-3-[2-(5-methyl-l,3,4-oxadiazol-2-yl)benzo[b]furan-4-yloxy]propan-2-ol or its metabolite for treating anxiety disorders |
HUE064463T2 (hu) | 2016-07-11 | 2024-03-28 | Opko Biologics Ltd | Hosszantartó hatású VII. koagulációs faktor és az elõállítására vonatkozó eljárások |
KR20210061357A (ko) | 2018-09-04 | 2021-05-27 | 미네르바 뉴로사이언스즈, 인크. | 통증을 치료하기 위해 페녹시프로필아민 화합물을 사용하는 방법 |
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JPS5292610A (en) | 1976-01-26 | 1977-08-04 | Canon Kk | Electrostatic printing master |
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JPS60202872A (ja) | 1984-03-27 | 1985-10-14 | Kaken Pharmaceut Co Ltd | ベンゾフラン誘導体、その製法およびそれを有効成分とする降圧剤 |
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HU209759B (en) * | 1986-07-17 | 1994-10-28 | Hem Res Inc | Method for the preparation of synergistic pharmaceutical composition containing lymphokines and mismatched double-stranded rnas |
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JP4246822B2 (ja) | 1997-09-26 | 2009-04-02 | 興和株式会社 | テトラゾール誘導体 |
EP0905133B1 (en) * | 1997-09-26 | 2002-04-24 | Kowa Co. Ltd. | Tetrazole derivatives as LTD4 and H1 antagonists |
EP1076647A2 (en) * | 1998-04-29 | 2001-02-21 | American Home Products Corporation | Antipsychotic indolyl derivatives |
JP2000086603A (ja) * | 1998-07-15 | 2000-03-28 | Yoshitomi Pharmaceut Ind Ltd | 桂皮酸アミド誘導体および3―フェニルプロピオン酸アミド誘導体 |
CA2355694A1 (en) * | 1998-12-18 | 2000-06-29 | Yuhko Aoki | Novel bicyclic compounds |
JP4042566B2 (ja) * | 2000-11-27 | 2008-02-06 | 田辺三菱製薬株式会社 | ピペリジン化合物およびその医薬用途 |
-
2000
- 2000-05-22 AU AU46160/00A patent/AU777594B2/en not_active Ceased
- 2000-05-22 AT AT00927844T patent/ATE303987T1/de not_active IP Right Cessation
- 2000-05-22 EP EP00927844A patent/EP1188747B1/en not_active Expired - Lifetime
- 2000-05-22 DK DK00927844T patent/DK1188747T3/da active
- 2000-05-22 WO PCT/JP2000/003279 patent/WO2000071517A1/ja active IP Right Grant
- 2000-05-22 KR KR1020017015024A patent/KR100799134B1/ko active IP Right Grant
- 2000-05-22 EA EA200101232A patent/EA004704B1/ru not_active IP Right Cessation
- 2000-05-22 IL IL14656400A patent/IL146564A0/xx not_active IP Right Cessation
- 2000-05-22 JP JP2000619774A patent/JP3893878B2/ja not_active Expired - Lifetime
- 2000-05-22 NZ NZ516111A patent/NZ516111A/en unknown
- 2000-05-22 ES ES00927844T patent/ES2244438T3/es not_active Expired - Lifetime
- 2000-05-22 MX MXPA01012046A patent/MXPA01012046A/es active IP Right Grant
- 2000-05-22 CN CNB008086044A patent/CN1164574C/zh not_active Expired - Lifetime
- 2000-05-22 DE DE60022504T patent/DE60022504T2/de not_active Expired - Lifetime
- 2000-05-22 KR KR1020077026625A patent/KR100882544B1/ko active IP Right Grant
- 2000-05-22 BR BR0011542-8A patent/BR0011542A/pt not_active IP Right Cessation
- 2000-05-22 CA CA2716369A patent/CA2716369C/en not_active Expired - Lifetime
- 2000-05-22 CA CA2375008A patent/CA2375008C/en not_active Expired - Lifetime
-
2001
- 2001-11-19 IL IL146564A patent/IL146564A/en unknown
- 2001-11-23 US US09/990,389 patent/US6720320B2/en not_active Expired - Lifetime
-
2003
- 2003-12-22 US US10/740,418 patent/US7196199B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR20020012235A (ko) | 2002-02-15 |
AU777594B2 (en) | 2004-10-21 |
NZ516111A (en) | 2003-05-30 |
CN1164574C (zh) | 2004-09-01 |
EP1188747A4 (en) | 2002-10-09 |
CA2716369A1 (en) | 2000-11-30 |
AU4616000A (en) | 2000-12-12 |
ES2244438T3 (es) | 2005-12-16 |
MXPA01012046A (es) | 2003-09-04 |
CA2375008C (en) | 2011-01-04 |
US6720320B2 (en) | 2004-04-13 |
IL146564A0 (en) | 2002-07-25 |
EA200101232A1 (ru) | 2002-06-27 |
US20020111358A1 (en) | 2002-08-15 |
KR100799134B1 (ko) | 2008-01-29 |
DE60022504T2 (de) | 2006-06-29 |
ATE303987T1 (de) | 2005-09-15 |
EA004704B1 (ru) | 2004-06-24 |
EP1188747B1 (en) | 2005-09-07 |
KR20070118193A (ko) | 2007-12-13 |
WO2000071517A1 (fr) | 2000-11-30 |
DK1188747T3 (da) | 2006-01-23 |
EP1188747A1 (en) | 2002-03-20 |
CA2375008A1 (en) | 2000-11-30 |
US20040138227A1 (en) | 2004-07-15 |
JP3893878B2 (ja) | 2007-03-14 |
US7196199B2 (en) | 2007-03-27 |
CA2716369C (en) | 2013-05-14 |
KR100882544B1 (ko) | 2009-02-12 |
IL146564A (en) | 2006-12-31 |
DE60022504D1 (de) | 2005-10-13 |
CN1378533A (zh) | 2002-11-06 |
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