CO5690574A2 - Nuevos compuestos derivados de indolina como inhibidores de la colesterol-actiltransferasa (acat) y uso medico del mismo - Google Patents
Nuevos compuestos derivados de indolina como inhibidores de la colesterol-actiltransferasa (acat) y uso medico del mismoInfo
- Publication number
- CO5690574A2 CO5690574A2 CO05013959A CO05013959A CO5690574A2 CO 5690574 A2 CO5690574 A2 CO 5690574A2 CO 05013959 A CO05013959 A CO 05013959A CO 05013959 A CO05013959 A CO 05013959A CO 5690574 A2 CO5690574 A2 CO 5690574A2
- Authority
- CO
- Colombia
- Prior art keywords
- acat
- actiltranspherase
- indolina
- cholesterol
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1.- Un nuevo compuesto de indolina representado por Ia fórmula (I) en dondeR1 y R3 son los mismos o diferentes y cada uno es un átomo de hidrógeno, grupo alquilo inferior o grupo alcoxi inferior,R2 es -NO2, -NHSO2R6 [R6 es grupo alquilo, grupo arilo o - NHR7 (R7 es átomo de hidrógeno, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior) o grupo alcoxicarbonilo inferior)], -NHCONH2 o grupo alquilo inferior sustituido por -NHSO2R6 [R6 es grupo alquilo, grupo arilo o - NHR7 (R7 es átomo de hidrógeno, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior) o grupo alcoxicarbonilo inferior)],R4 es átomo de hidrógeno, grupo alquilo, opcionalmente sustituido por grupo hidroxi, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior), grupo alquenilo inferior, grupo alcoxi inferior-alquilo inferior, grupo alquiltio inferior-alquilo inferior, grupo cicloalquilo, o grupo cicloalquilalquilo;R5 es grupo alquilo, grupo cicloalquilo, o grupo arilo;R12 es átomo de hidrógeno, grupo alquilo inferior, grupo alcoxi inferior-alquilo inferior o grupo alquiltio inferior-alquilo inferior; o una sal farmacéuticamente aceptable del mismo.2.- El nuevo compuesto de indolina según la reivindicación 1, en donde, en la fórmula (I), R1 y R3 son los mismos o diferentes y cada uno es átomo de hidrógeno, grupo alquilo inferior, o grupo alcoxi inferior, R2 es -NO2, -NHSO2R6 [R6 es grupo alquilo, grupo arilo o -NHR7 (R7 es átomo de hidrógeno, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior), o grupo alcoxicarbonilo inferior)], -NHCONH2 o grupo alquilo inferior sustituido por -NHSO2R6 [R6 es grupo alquilo, grupo arilo o -NHR7 (R7 es átomo de hidrógeno, -COR13 (R13 es átomo de hidrógeno o grupo alquilo inferior) o grupo alcoxicarbonilo inferior)], R4 es átomo de hidrógeno, grupo alquilo, grupo cicloalquilo o cicloalquilalquilo, R5 es grupo alquilo, grupo cicloalquilo o grupo arilo, y R12 es átomo de hidrógeno, o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002208878 | 2002-07-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5690574A2 true CO5690574A2 (es) | 2006-10-31 |
Family
ID=30112861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO05013959A CO5690574A2 (es) | 2002-07-17 | 2005-02-16 | Nuevos compuestos derivados de indolina como inhibidores de la colesterol-actiltransferasa (acat) y uso medico del mismo |
Country Status (22)
Country | Link |
---|---|
US (1) | US7429612B2 (es) |
EP (1) | EP1541553B1 (es) |
JP (1) | JP4485357B2 (es) |
CN (1) | CN100349868C (es) |
AT (1) | ATE469884T1 (es) |
AU (1) | AU2003252638B8 (es) |
BR (1) | BR0312734A (es) |
CA (1) | CA2492669A1 (es) |
CO (1) | CO5690574A2 (es) |
DE (1) | DE60332851D1 (es) |
DK (1) | DK1541553T3 (es) |
HK (1) | HK1083839A1 (es) |
IL (1) | IL166313A0 (es) |
MX (1) | MXPA05000749A (es) |
NO (1) | NO20050834L (es) |
NZ (1) | NZ538226A (es) |
PL (1) | PL374919A1 (es) |
RS (1) | RS20050127A (es) |
RU (1) | RU2318808C2 (es) |
TW (1) | TWI285196B (es) |
WO (1) | WO2004007450A1 (es) |
ZA (1) | ZA200501297B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102011076931A1 (de) | 2011-06-03 | 2012-12-06 | Basf Se | Wässrige Lösung, enthaltend Acrylsäure und deren konjugierte Base |
JP2018052818A (ja) * | 2015-01-28 | 2018-04-05 | 武田薬品工業株式会社 | スルホンアミド化合物 |
Family Cites Families (31)
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US4013404A (en) * | 1970-12-06 | 1977-03-22 | American Cyanamid Company | Method of dyeing hair with indolines, indoles and indazoles |
CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
US4803218A (en) | 1982-09-29 | 1989-02-07 | Mcneilab, Inc. | 3-aminoalkyl-1H-indole-5-urea and amide derivatives |
US4956372A (en) | 1987-10-02 | 1990-09-11 | Kyorin Pharmaceutical Co., Ltd. | Cyclic anthranilic acid derivatives and process for their preparation |
JPH02117651A (ja) | 1988-01-20 | 1990-05-02 | Yamanouchi Pharmaceut Co Ltd | ジウレア誘導体及びその製造法 |
US5166429A (en) | 1988-01-20 | 1992-11-24 | Yamanouchi Pharmaceutical Co., Ltd. | Diurea derivatives useful as medicaments and processes for the preparation thereof |
US5227492A (en) | 1988-01-20 | 1993-07-13 | Yamanouchi Pharmaceutical Co., Ltd. | Diurea derivatives useful as medicaments and processes for the preparation thereof |
CN1021819C (zh) | 1988-01-20 | 1993-08-18 | 山之内制药株式会社 | 作为药物有用的双脲衍生物的制备方法 |
IE892088L (en) | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
JPH0753714B2 (ja) | 1988-07-12 | 1995-06-07 | 武田薬品工業株式会社 | Acat阻害剤、キノリン誘導体及びその製造法 |
US5153226A (en) | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
DE69105786T2 (de) | 1990-03-12 | 1995-04-27 | Yamanouchi Pharma Co Ltd | Harnstoffderivate, deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen. |
US5258405A (en) | 1990-03-12 | 1993-11-02 | Yamanouchi Pharmaceutical Co., Ltd. | Urea derivatives and salts thereof in method for inhibiting the ACAT enzyme |
JPH0466568A (ja) | 1990-06-29 | 1992-03-02 | Takeda Chem Ind Ltd | 中枢性抗酸化剤化合物 |
US5256782A (en) | 1990-08-17 | 1993-10-26 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives which are intermediates |
JP3086295B2 (ja) | 1990-08-17 | 2000-09-11 | 武田薬品工業株式会社 | チエノピリジン誘導体、その製造法およびacat阻害剤 |
US5143919A (en) | 1990-08-17 | 1992-09-01 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives and their pharmaceutical use |
FR2673625B1 (fr) | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2674522B1 (fr) | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
IL101785A0 (en) | 1991-05-10 | 1992-12-30 | Fujisawa Pharmaceutical Co | Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
CA2121391A1 (en) | 1993-04-28 | 1994-10-29 | Atsuyuki Kojima | Indoloylguanidine derivatives |
US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
JP3720395B2 (ja) * | 1994-09-20 | 2005-11-24 | 京都薬品工業株式会社 | 新規ヘテロ環誘導体、その製造方法およびその医薬用途 |
JPH08208602A (ja) | 1994-10-18 | 1996-08-13 | Sumitomo Pharmaceut Co Ltd | インドロイルグアニジン誘導体 |
CA2160600A1 (en) | 1994-10-18 | 1996-04-19 | Masahumi Kitano | Indoloylguanidine derivatives |
US5767129A (en) | 1995-08-24 | 1998-06-16 | Warner-Lambert Company | Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof |
IL123939A (en) * | 1995-10-05 | 2001-11-25 | Kyoto Pharma Ind | The history of the heterocycles and the pharmaceutical preparations containing them |
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-
2003
- 2003-07-16 AU AU2003252638A patent/AU2003252638B8/en not_active Ceased
- 2003-07-16 ZA ZA200501297A patent/ZA200501297B/en unknown
- 2003-07-16 CA CA002492669A patent/CA2492669A1/en not_active Abandoned
- 2003-07-16 BR BR0312734-6A patent/BR0312734A/pt not_active IP Right Cessation
- 2003-07-16 DK DK03764206.3T patent/DK1541553T3/da active
- 2003-07-16 WO PCT/JP2003/009012 patent/WO2004007450A1/ja active Application Filing
- 2003-07-16 DE DE60332851T patent/DE60332851D1/de not_active Expired - Fee Related
- 2003-07-16 PL PL03374919A patent/PL374919A1/xx not_active Application Discontinuation
- 2003-07-16 EP EP03764206A patent/EP1541553B1/en not_active Expired - Lifetime
- 2003-07-16 US US10/521,175 patent/US7429612B2/en not_active Expired - Fee Related
- 2003-07-16 RS YUP-2005/0127A patent/RS20050127A/sr unknown
- 2003-07-16 CN CNB038220881A patent/CN100349868C/zh not_active Expired - Fee Related
- 2003-07-16 IL IL16631303A patent/IL166313A0/xx unknown
- 2003-07-16 RU RU2005104238/04A patent/RU2318808C2/ru not_active IP Right Cessation
- 2003-07-16 NZ NZ538226A patent/NZ538226A/en unknown
- 2003-07-16 AT AT03764206T patent/ATE469884T1/de not_active IP Right Cessation
- 2003-07-16 MX MXPA05000749A patent/MXPA05000749A/es active IP Right Grant
- 2003-07-16 JP JP2004521216A patent/JP4485357B2/ja not_active Expired - Fee Related
- 2003-07-17 TW TW092119477A patent/TWI285196B/zh not_active IP Right Cessation
-
2005
- 2005-02-16 CO CO05013959A patent/CO5690574A2/es not_active Application Discontinuation
- 2005-02-16 NO NO20050834A patent/NO20050834L/no not_active Application Discontinuation
-
2006
- 2006-03-30 HK HK06103972A patent/HK1083839A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20060128787A1 (en) | 2006-06-15 |
AU2003252638B2 (en) | 2009-02-05 |
TW200407304A (en) | 2004-05-16 |
US7429612B2 (en) | 2008-09-30 |
EP1541553B1 (en) | 2010-06-02 |
IL166313A0 (en) | 2006-01-15 |
JPWO2004007450A1 (ja) | 2005-11-10 |
EP1541553A4 (en) | 2007-04-11 |
WO2004007450A1 (ja) | 2004-01-22 |
JP4485357B2 (ja) | 2010-06-23 |
RU2005104238A (ru) | 2005-08-27 |
ZA200501297B (en) | 2006-10-25 |
AU2003252638B8 (en) | 2009-03-05 |
NO20050834L (no) | 2005-04-15 |
AU2003252638A1 (en) | 2004-02-02 |
CN100349868C (zh) | 2007-11-21 |
BR0312734A (pt) | 2005-04-26 |
DK1541553T3 (da) | 2010-09-20 |
PL374919A1 (en) | 2005-11-14 |
NZ538226A (en) | 2006-08-31 |
DE60332851D1 (de) | 2010-07-15 |
TWI285196B (en) | 2007-08-11 |
CA2492669A1 (en) | 2004-01-22 |
RU2318808C2 (ru) | 2008-03-10 |
MXPA05000749A (es) | 2005-04-28 |
EP1541553A1 (en) | 2005-06-15 |
CN1681781A (zh) | 2005-10-12 |
ATE469884T1 (de) | 2010-06-15 |
RS20050127A (en) | 2007-06-04 |
HK1083839A1 (en) | 2006-07-14 |
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Legal Events
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FG | Application granted | ||
FD | Application lapsed |