AU7174794A
(en)
*
|
1993-06-18 |
1995-01-17 |
Smithkline Beecham Corporation |
Compounds
|
GB9312853D0
(en)
|
1993-06-22 |
1993-08-04 |
Euro Celtique Sa |
Chemical compounds
|
AU7375194A
(en)
*
|
1993-07-30 |
1995-02-28 |
Smithkline Beecham Corporation |
3-cyano-3-(3,4-disubstituted)phenylcyclohexyl-1-carboxylates
|
US6013827A
(en)
*
|
1994-03-11 |
2000-01-11 |
Smithkline Beecham Corporation |
Compounds
|
GB9404706D0
(en)
*
|
1994-03-11 |
1994-04-27 |
Smithkline Beecham Corp |
Compounds
|
US5998428A
(en)
*
|
1995-05-31 |
1999-12-07 |
Smithkline Beecham Corporation |
Compounds and methods for treating PDE IV-related diseases
|
US20060019963A1
(en)
*
|
1994-06-17 |
2006-01-26 |
Smithkline Beecham Corporation |
Compounds
|
US5922751A
(en)
|
1994-06-24 |
1999-07-13 |
Euro-Celtique, S.A. |
Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
|
US5591776A
(en)
|
1994-06-24 |
1997-01-07 |
Euro-Celtique, S.A. |
Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
|
WO1996019994A1
(en)
*
|
1994-12-23 |
1996-07-04 |
Smithkline Beecham Corporation |
3,3-(disubstituted)cyclohexan-1-carboxylate monomers and related compounds
|
EP0796096A4
(en)
*
|
1994-12-23 |
1998-04-29 |
Smithkline Beecham Corp |
4,4- (DISUBSTITUTED) CYCLOHEXAN-1-CARBOXYLATE MONOMERS AND RELATED COMPOUNDS
|
EP0799187A4
(en)
*
|
1994-12-23 |
1998-03-25 |
Smithkline Beecham Corp |
4,4- (DISUBSTITUTED) CYCLOHEXAN-1-CARBONIC ACID DIMERS AND DERIVATIVES
|
EP0799181A4
(en)
*
|
1994-12-23 |
1998-03-25 |
Smithkline Beecham Corp |
DIMERES 3.3- (DISUBSTITUTED) CYCLOHEXANE-1-CARBOXYLATE AND RELATED COMPOUNDS
|
EP0799182A4
(en)
*
|
1994-12-23 |
1998-03-25 |
Smithkline Beecham Corp |
DIMERES 3.3- (DISUBSTITUTED) CYCLOHEXAN-1-OL AND RELATED COMPOUNDS
|
ATE231501T1
(de)
*
|
1995-05-18 |
2003-02-15 |
Altana Pharma Ag |
Phenyldihydrobenzofurane
|
AU705723B2
(en)
*
|
1995-05-18 |
1999-05-27 |
Altana Pharma Ag |
Cyclohexyl dihydrobenzofuranes
|
US6166041A
(en)
|
1995-10-11 |
2000-12-26 |
Euro-Celtique, S.A. |
2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
|
US5891883A
(en)
*
|
1995-12-21 |
1999-04-06 |
Smithkline Beecham Corporation |
4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds
|
US6075016A
(en)
|
1996-04-10 |
2000-06-13 |
Euro-Celtique S.A. |
6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
|
AP1147A
(en)
*
|
1996-05-03 |
2003-02-25 |
Pfizer |
Substituted indazole derivatives and related compounds.
|
WO1997048697A1
(en)
|
1996-06-19 |
1997-12-24 |
Rhone-Poulenc Rorer Limited |
Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
|
SI0912558T1
(en)
*
|
1996-06-25 |
2003-10-31 |
Pfizer Inc. |
Substituted indazole derivatives and their use as phosphodiesterase (pde) type iv and tumor necrosis factor (tnf) inhibitors
|
EP0941221B1
(en)
*
|
1996-11-20 |
2003-02-26 |
ALTANA Pharma AG |
Substituted dihydrobenzofurans as pde inhibitors
|
DK1295869T3
(da)
*
|
1997-02-12 |
2005-11-21 |
Smithkline Beecham Corp |
Forbindelser og fremgangsmåde til fremstilling af substituerede 4-phenyl-4-cyanocyclohexansyrer
|
UY24882A1
(es)
*
|
1997-02-12 |
2001-08-27 |
Smithkline Beecham Corp |
Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos
|
EP1524268B1
(en)
*
|
1997-02-12 |
2007-01-17 |
Smithkline Beecham Corporation |
Compounds and method for preparing sustituted 4-phenyl-4-cyanocyclohexanoic acids
|
UA67753C2
(uk)
*
|
1997-10-10 |
2004-07-15 |
Смітклайн Бічам Корпорейшн |
Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот
|
UY25338A1
(es)
*
|
1998-01-07 |
2001-08-27 |
Smithkline Beecham Corp |
Método para tratar copd
|
CA2317548A1
(en)
*
|
1998-01-07 |
1999-07-15 |
Theodore Torphy |
Method for treating multiple sclerosis
|
US6172118B1
(en)
*
|
1998-04-14 |
2001-01-09 |
Smithkline Beecham Corporation |
Compounds
|
US6395273B1
(en)
*
|
1998-06-10 |
2002-05-28 |
Promega Corporation |
Prevention and treatment of inflammatory bowel disease
|
US7115557B2
(en)
*
|
1998-09-25 |
2006-10-03 |
Sciaticon Ab |
Use of certain drugs for treating nerve root injury
|
US7811990B2
(en)
*
|
1998-09-25 |
2010-10-12 |
Sciaticon Ab |
Soluble cytokine receptors TNF-α blocking antibodies for treating spinal disorders mediated by nucleus pulposus
|
SE9803710L
(sv)
*
|
1998-09-25 |
2000-03-26 |
A & Science Invest Ab |
Användning av vissa substanser för behandling av nervrotsskador
|
US7906481B2
(en)
*
|
1998-09-25 |
2011-03-15 |
Sciaticon Ab |
Specific TNF-A inhibitors for treating spinal disorders mediated by nucleous pulposus
|
ATE287875T1
(de)
|
1998-10-06 |
2005-02-15 |
Dainippon Pharmaceutical Co |
2,3-disubstituierte pyridinderivate, verfahren zur derren herstellung, sie enthaltende wirkstoffzubereitungen und zwischenprodukte für die herstellung
|
MY121142A
(en)
*
|
1999-02-23 |
2005-12-30 |
Smithkline Beecham Corp |
Controlled release formulation for treating copd
|
US6419934B1
(en)
*
|
1999-02-24 |
2002-07-16 |
Edward L. Tobinick |
TNF modulators for treating neurological disorders associated with viral infection
|
AR035987A1
(es)
*
|
1999-03-01 |
2004-08-04 |
Smithkline Beecham Corp |
Uso de un compuesto inhibidor de la pde 4 para la manufactura de un medicamento y el medicamento para tratar asma inducida por ejercicio
|
DZ3019A1
(fr)
*
|
1999-03-01 |
2005-05-20 |
Smithkline Beecham Corp |
Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd.
|
CA2373607A1
(en)
*
|
1999-05-14 |
2000-11-23 |
Bristol-Myers Squibb Pharma Research Labs, Inc. |
Cyclic amine derivatives and their uses
|
AR024076A1
(es)
*
|
1999-05-25 |
2002-09-04 |
Smithkline Beecham Corp |
Sales de cis-[4-ciano-4-(3-ciclopentiloxi-4-metoxifenil) ciclohexan-1-carboxilato]
|
US6740765B1
(en)
*
|
1999-08-06 |
2004-05-25 |
Smithkline Beecham Corporation |
Method for preparing cyclohexane carboxylic acids
|
ECSP003599A
(es)
*
|
1999-08-06 |
2002-03-25 |
Smithkline Beecham Corp |
Procedimiento para preparar acidos a traves de alfa-coroepoxi-esteres
|
ECSP003600A
(es)
*
|
1999-08-06 |
2002-03-25 |
Smithkline Beecham Corp |
Metodo para preparar acidos ciclohexano- carboxilicos
|
US20040220424A1
(en)
*
|
1999-08-06 |
2004-11-04 |
Smithkline Beecham Corporation |
Process for preparing acids via alpha-chloroepoxy esters
|
DE60026855T2
(de)
*
|
1999-08-21 |
2006-12-07 |
Altana Pharma Ag |
Synergistische kombination von roflumilast und salmeterol
|
UY26333A1
(es)
*
|
1999-09-15 |
2001-07-31 |
Smithkline Beecham Corp |
Procedimiento e intermedios para preparar ácidos (4-ciano sustituido)- ciclohexanoicos
|
AR029788A1
(es)
*
|
2000-01-12 |
2003-07-16 |
Smithkline Beecham Corp |
Procedimiento para reducir acidos ciclohexeno carboxilicos alfa,beta-insaturados, procedimiento para preparar acidos 4-nitrilo-4-aril-ciclohexanoicos, procedimiento para preparar acidos ciclohexeno carboxilicos alfa,beta-insaturados, y procedimientos para preparar intermediarios
|
US20030050497A1
(en)
*
|
2002-07-11 |
2003-03-13 |
Webb Kevin Scott |
Process and intermediates for preparing a cyclohexylnitrile
|
PT1250313E
(pt)
*
|
2000-01-26 |
2007-01-31 |
Smithkline Beecham Corp |
Mono-hidrato de cis-ciano-4-3-( ciclopentiloxi )-4-metoxifenil ciclo-hexanocarboxilato de lítio
|
WO2001058441A1
(en)
*
|
2000-02-08 |
2001-08-16 |
Smithkline Beecham Corporation |
Method and compositions for treating an inflammatory disease
|
EP1261331A4
(en)
*
|
2000-02-16 |
2005-01-05 |
Univ Nebraska Medical Ct |
METHOD AND COMPOSITIONS FOR TREATING FIBROSANT DISEASES
|
US6555572B2
(en)
|
2000-03-16 |
2003-04-29 |
Inflazyme Pharmaceuticals Ltd. |
Benzylated PDE4 inhibitors
|
GB0011802D0
(en)
*
|
2000-05-16 |
2000-07-05 |
Smithkline Beecham |
Method for enhancing cognitive function
|
US20040005995A1
(en)
*
|
2001-07-26 |
2004-01-08 |
Edelson Jeffrey D |
Method for reducing exacerbations associated with copd
|
CO5310534A1
(es)
|
2000-08-05 |
2003-08-29 |
Glaxo Group Ltd |
Nuevos derivados de androstano anti-inflamatorios
|
WO2007137181A2
(en)
|
2006-05-19 |
2007-11-29 |
Helicon Therapeutics, Inc. |
Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
|
US20040224316A1
(en)
|
2000-08-10 |
2004-11-11 |
Tully Timothy P. |
Augmented cognitive training
|
EA200300652A1
(ru)
|
2001-01-31 |
2003-12-25 |
Пфайзер Продактс Инк. |
Эфирные производные, полезные в качестве ингибиторов изозимов pde4
|
US7250518B2
(en)
*
|
2001-01-31 |
2007-07-31 |
Pfizer Inc. |
Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
|
EA200300621A1
(ru)
|
2001-01-31 |
2003-12-25 |
Пфайзер Продактс Инк. |
Биарильные производные никотинамида, полезные в качестве ингибиторов изоферментов pde4
|
PL365443A1
(en)
|
2001-01-31 |
2005-01-10 |
Pfizer Products Inc. |
Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of pde4 isozymes
|
GB0103630D0
(en)
*
|
2001-02-14 |
2001-03-28 |
Glaxo Group Ltd |
Chemical compounds
|
DE60224172T2
(de)
*
|
2001-03-22 |
2008-12-04 |
Glaxo Group Ltd., Greenford |
Formanilid-derivative als beta2-adrenorezeptor-agonisten
|
ES2314052T3
(es)
|
2001-04-30 |
2009-03-16 |
Glaxo Group Limited |
Derivados de ester de 17beta-carbotioato de androstano con un grupo ester ciclico en la posicion 17alfa.
|
EP1389467B1
(en)
*
|
2001-05-23 |
2013-07-03 |
Mitsubishi Tanabe Pharma Corporation |
Therapeutic composition for the regenerative treatment of cartilage diseases
|
WO2002094321A1
(fr)
*
|
2001-05-23 |
2002-11-28 |
Tanabe Seiyaku Co., Ltd. |
Compositions favorisant la guérison d'une fracture osseuse
|
CA2458534C
(en)
*
|
2001-09-14 |
2011-11-01 |
Glaxo Group Limited |
Phenethanolamine derivatives for treatment of respiratory diseases
|
GB0201677D0
(en)
|
2002-01-25 |
2002-03-13 |
Glaxo Group Ltd |
Medicament dispenser
|
GB0217199D0
(en)
*
|
2002-07-25 |
2002-09-04 |
Glaxo Group Ltd |
Medicament dispenser
|
AU2003217676B2
(en)
|
2002-02-22 |
2009-06-11 |
Takeda Pharmaceutical Company Limited |
Active agent delivery systems and methods for protecting and administering active agents
|
GB0204719D0
(en)
*
|
2002-02-28 |
2002-04-17 |
Glaxo Group Ltd |
Medicinal compounds
|
JP2005523920A
(ja)
*
|
2002-04-25 |
2005-08-11 |
グラクソ グループ リミテッド |
フェネタノールアミン誘導体
|
US20030013905A1
(en)
*
|
2002-06-10 |
2003-01-16 |
Huang Guishu Kris |
Salts of cis-4-cyano-4[3(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid
|
GB0217196D0
(en)
*
|
2002-07-25 |
2002-09-04 |
Glaxo Group Ltd |
Medicament dispenser
|
GB0217225D0
(en)
|
2002-07-25 |
2002-09-04 |
Glaxo Group Ltd |
Medicinal compounds
|
GB0217198D0
(en)
*
|
2002-07-25 |
2002-09-04 |
Glaxo Group Ltd |
Medicament dispenser
|
JP2006506373A
(ja)
*
|
2002-10-22 |
2006-02-23 |
グラクソ グループ リミテッド |
医薬アリールエタノールアミン化合物
|
EP1556342B1
(en)
|
2002-10-28 |
2008-03-26 |
Glaxo Group Limited |
Phenethanolamine derivative for the treatment of respiratory diseases
|
AU2003286024A1
(en)
*
|
2002-11-22 |
2004-06-18 |
Daniel Dube |
Use of phosphodiesterase-4 inhibitors as enhancers of cognition
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
GB0303396D0
(en)
*
|
2003-02-14 |
2003-03-19 |
Glaxo Group Ltd |
Medicinal compounds
|
BRPI0409229A
(pt)
|
2003-04-01 |
2006-03-28 |
Applied Research Systems |
inibidores das fosfodiesterases na infertilidade
|
WO2005002626A2
(en)
*
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
WO2004098606A1
(en)
*
|
2003-05-12 |
2004-11-18 |
Altana Pharma Ag |
Composition comprising a pde4 inhibitor and shuil-1r ii
|
WO2004098578A2
(en)
*
|
2003-05-12 |
2004-11-18 |
Altana Pharma Ag |
Composition comprising a pde4 inhibitor and a tnf-alfa antagonist selected from infliximab, adalimumab, cdp870 and cdp517
|
KR20060021870A
(ko)
|
2003-05-30 |
2006-03-08 |
랜박시 래보러터리스 리미티드 |
치환된 피롤 유도체와 hmg―co 억제제로서의 이의용도
|
GB0316290D0
(en)
*
|
2003-07-11 |
2003-08-13 |
Glaxo Group Ltd |
Novel compounds
|
DE10331798B4
(de)
*
|
2003-07-14 |
2012-06-21 |
Giesecke & Devrient Gmbh |
Sicherheitselement, Wertgegenstand, Transfermaterial und Herstellungsverfahren
|
GB0317374D0
(en)
|
2003-07-24 |
2003-08-27 |
Glaxo Group Ltd |
Medicament dispenser
|
US20090274676A1
(en)
*
|
2003-07-31 |
2009-11-05 |
Robinson Cynthia B |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a pde-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
|
US20050085430A1
(en)
*
|
2003-07-31 |
2005-04-21 |
Robinson Cynthia B. |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
|
US20050026883A1
(en)
*
|
2003-07-31 |
2005-02-03 |
Robinson Cynthia B. |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a PDE-4 inhibitor for treatment of asthma or chronic obstructive pulmonary disease
|
GB0324654D0
(en)
*
|
2003-10-22 |
2003-11-26 |
Glaxo Group Ltd |
Medicinal compounds
|
GB0324886D0
(en)
*
|
2003-10-24 |
2003-11-26 |
Glaxo Group Ltd |
Medicinal compounds
|
GB0401334D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
US7846973B2
(en)
*
|
2004-04-02 |
2010-12-07 |
Theravance, Inc. |
Chemical process and new crystalline form
|
GB0411056D0
(en)
|
2004-05-18 |
2004-06-23 |
Novartis Ag |
Organic compounds
|
AR049384A1
(es)
|
2004-05-24 |
2006-07-26 |
Glaxo Group Ltd |
Derivados de purina
|
TWI307630B
(en)
|
2004-07-01 |
2009-03-21 |
Glaxo Group Ltd |
Immunoglobulins
|
GB0418045D0
(en)
|
2004-08-12 |
2004-09-15 |
Glaxo Group Ltd |
Compounds
|
KR101061850B1
(ko)
|
2004-09-08 |
2011-09-02 |
삼성전자주식회사 |
박막 트랜지스터 표시판 및 그 제조방법
|
GT200500281A
(es)
|
2004-10-22 |
2006-04-24 |
Novartis Ag |
Compuestos organicos.
|
GB0424284D0
(en)
|
2004-11-02 |
2004-12-01 |
Novartis Ag |
Organic compounds
|
GB0426164D0
(en)
|
2004-11-29 |
2004-12-29 |
Novartis Ag |
Organic compounds
|
ATE517908T1
(de)
*
|
2005-01-10 |
2011-08-15 |
Glaxo Group Ltd |
Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände
|
US20090124588A1
(en)
*
|
2005-01-10 |
2009-05-14 |
Glaxo Group Limited |
Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions
|
JP2008526805A
(ja)
*
|
2005-01-11 |
2008-07-24 |
グラクソ グループ リミテッド |
ベータ−2アドレナリン作動薬のケイヒ酸塩
|
PE20100737A1
(es)
|
2005-03-25 |
2010-11-27 |
Glaxo Group Ltd |
Nuevos compuestos
|
GB0507577D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
GB0514809D0
(en)
|
2005-07-19 |
2005-08-24 |
Glaxo Group Ltd |
Compounds
|
EP1957530A2
(en)
|
2005-10-21 |
2008-08-20 |
Novartis AG |
Human antibodies against il13 and therapeutic uses
|
WO2007054896A1
(en)
|
2005-11-08 |
2007-05-18 |
Ranbaxy Laboratories Limited |
Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
|
PE20071068A1
(es)
|
2005-12-20 |
2007-12-13 |
Glaxo Group Ltd |
Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3
|
GB0526244D0
(en)
|
2005-12-22 |
2006-02-01 |
Novartis Ag |
Organic compounds
|
WO2007081857A2
(en)
|
2006-01-06 |
2007-07-19 |
Sepracor Inc. |
Cycloalkylamines as monoamine reuptake inhibitors
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
US7943651B2
(en)
|
2006-04-20 |
2011-05-17 |
Glaxo Group Limited |
Compounds
|
PL2013211T3
(pl)
|
2006-04-21 |
2012-08-31 |
Novartis Ag |
Pochodne puryny do zastosowania jako agoniści receptora adenozyny A2A
|
GB0611587D0
(en)
|
2006-06-12 |
2006-07-19 |
Glaxo Group Ltd |
Novel compounds
|
AR061571A1
(es)
|
2006-06-23 |
2008-09-03 |
Smithkline Beecham Corp |
Compuesto sal del acido toluenosulfonico de 4-{[6-cloro-3-({[(2- cloro-3-fluorofenil) amino]carbonil} amino)- 2- hidroxifenil]sulfonil] -1- piperazinacarbxilato de 1.1-dimetiletilo, composicion farmaceutica que lo comprende su uso para la fabricacion de un medicamento combinacion farmaceutica con un
|
PT2363130E
(pt)
|
2006-07-05 |
2014-06-25 |
Takeda Gmbh |
Combinação de atorvastatina ou sinvastatina, inibidores de hmg-coa redutase, com um inibidor da fosfodiesterase 4, tal como roflumilaste, para o tratamento de doenças pulmonares inflamatórias
|
US20080019970A1
(en)
*
|
2006-07-07 |
2008-01-24 |
Gorman James R |
Methods for preventing, postponing or improving the outcome of spinal device and fusion procedures
|
ATE502943T1
(de)
|
2006-09-29 |
2011-04-15 |
Novartis Ag |
Pyrazolopyrimidine als pi3k-lipidkinasehemmer
|
BRPI0718266A2
(pt)
|
2006-10-30 |
2014-01-07 |
Novartis Ag |
Compostos heterocíclicos como agentes anti-inflamatórios.
|
AU2007334541A1
(en)
*
|
2006-12-13 |
2008-06-26 |
Gilead Sciences, Inc. |
Monophosphates as mutual prodrugs of anti-inflammatory signal transduction modulators (AISTM's) and beta-agonists for the treatment of pulmonary inflammation and bronchoconstriction
|
NZ577939A
(en)
|
2007-01-10 |
2011-03-31 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
AR065804A1
(es)
|
2007-03-23 |
2009-07-01 |
Smithkline Beecham Corp |
Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
|
MX2009010946A
(es)
*
|
2007-04-11 |
2009-10-29 |
Alcon Res Ltd |
Uso de un inhibidor del factor de necrosis tumoral alfa mas una antihistamina para tratar rinitis alergica y conjuntivitis alergica.
|
US20090182035A1
(en)
*
|
2007-04-11 |
2009-07-16 |
Alcon Research, Ltd. |
Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
|
PT2155721E
(pt)
|
2007-05-07 |
2011-05-09 |
Novartis Ag |
Compostos org?nicos
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
AU2008261102B2
(en)
|
2007-06-04 |
2013-11-28 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
AU2008258871B2
(en)
|
2007-06-05 |
2013-08-15 |
Sanofi-Aventis |
Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them
|
US7943658B2
(en)
*
|
2007-07-23 |
2011-05-17 |
Bristol-Myers Squibb Company |
Indole indane amide compounds useful as CB2 agonists and method
|
TW200920369A
(en)
*
|
2007-10-26 |
2009-05-16 |
Amira Pharmaceuticals Inc |
5-lipoxygenase activating protein (flap) inhibitor
|
TWI439462B
(zh)
|
2007-12-10 |
2014-06-01 |
Novartis Ag |
作為enac阻抑劑之螺環胍化合物
|
US8431578B2
(en)
|
2008-01-11 |
2013-04-30 |
Novartis Ag |
Organic compounds
|
BRPI0912267A2
(pt)
|
2008-05-23 |
2015-10-13 |
Amira Pharmaceuticals Inc |
sal farmaceuticamente aceitável, composição farmacêutica, artigo de fabricação, métodos para tratar asma, rinite alérgica, doença, lesões gástricas e dor, métodos para prevenir broncoconstrição e rinite alérgica, uso de um sal farmaceuticamente aceitável, e, processo para a preparação de um sal farmaceuticamente aceitável.
|
EP2328910B1
(en)
|
2008-06-04 |
2014-08-06 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
|
ATE552255T1
(de)
|
2008-06-05 |
2012-04-15 |
Glaxo Group Ltd |
4-aminoindazole
|
JP5502858B2
(ja)
|
2008-06-05 |
2014-05-28 |
グラクソ グループ リミテッド |
Pi3キナーゼの阻害剤として有用な4−カルボキサミドインダゾール誘導体
|
BRPI0915018A2
(pt)
|
2008-06-10 |
2015-10-27 |
Novartis Ag |
compostos orgânicos
|
EP3241839B1
(en)
|
2008-07-16 |
2019-09-04 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
PT2391366E
(pt)
|
2009-01-29 |
2013-02-05 |
Novartis Ag |
Benzimidazoles substituídos para o tratamento de astrocitomas
|
WO2010094643A1
(en)
|
2009-02-17 |
2010-08-26 |
Glaxo Group Limited |
Quinoline derivatives and their uses for rhinitis and urticaria
|
EP2406255B1
(en)
|
2009-03-09 |
2015-04-29 |
Glaxo Group Limited |
4-oxadiazol-2-yl-indazoles as inhibitors of pi3 kinases
|
WO2010102968A1
(en)
|
2009-03-10 |
2010-09-16 |
Glaxo Group Limited |
Indole derivatives as ikk2 inhibitors
|
US20120058984A1
(en)
|
2009-03-17 |
2012-03-08 |
Catherine Mary Alder |
Pyrimidine derivatives used as itk inhibitors
|
EA201171144A1
(ru)
|
2009-03-19 |
2012-04-30 |
Мерк Шарп Энд Домэ Корп. |
ОПОСРЕДОВАННОЕ РНК-ИНТЕРФЕРЕНЦИЕЙ ИНГИБИРОВАНИЕ ЭКСПРЕССИИ ГЕНА ГОМОЛОГА 1 BTB И CNC, ОСНОВНОГО ФАКТОРА ТРАНСКРИПЦИИ С ЛЕЙЦИНОВОЙ МОЛНИЕЙ 1 (Bach1) С ИСПОЛЬЗОВАНИЕМ МАЛОЙ ИНТЕРФЕРИРУЮЩЕЙ НУКЛЕИНОВОЙ КИСЛОТЫ (миНК)
|
US20120035247A1
(en)
|
2009-03-19 |
2012-02-09 |
Merck Sharp & Dohme Corp. |
RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 6 (STAT6) Gene Expression Using Short Interfering Nucleic Acid (siNA)
|
JP2012520685A
(ja)
|
2009-03-19 |
2012-09-10 |
メルク・シャープ・エンド・ドーム・コーポレイション |
低分子干渉核酸(siNA)を用いたGATA結合タンパク質3(GATA3)遺伝子発現のRNA干渉媒介性阻害
|
US20120016011A1
(en)
|
2009-03-19 |
2012-01-19 |
Merck Sharp & Dohme Corp. |
RNA Interference Mediated Inhibition of Connective Tissue Growth Factor (CTGF) Gene Expression Using Short Interfering Nucleic Acid (siNA)
|
US20120022143A1
(en)
|
2009-03-27 |
2012-01-26 |
Merck Sharp & Dohme Corp |
RNA Interference Mediated Inhibition of the Thymic Stromal Lymphopoietin (TSLP) Gene Expression Using Short Interfering Nucliec Acid (siNA)
|
WO2010111497A2
(en)
|
2009-03-27 |
2010-09-30 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF THE INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1)GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
JP2012521762A
(ja)
|
2009-03-27 |
2012-09-20 |
メルク・シャープ・エンド・ドーム・コーポレイション |
低分子干渉核酸(siNA)を用いた神経成長因子β鎖(NGFβ)遺伝子発現のRNA干渉媒介性阻害
|
WO2010111471A2
(en)
|
2009-03-27 |
2010-09-30 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
EP2411516A1
(en)
|
2009-03-27 |
2012-02-01 |
Merck Sharp&Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US8399436B2
(en)
|
2009-04-24 |
2013-03-19 |
Glaxo Group Limited |
N-pyrazolyl carboxamides as CRAC channel inhibitors
|
JP2012524754A
(ja)
|
2009-04-24 |
2012-10-18 |
グラクソ グループ リミテッド |
Cracチャネル阻害剤としてのピラゾールおよびトリアゾ−ルカルボキサミド
|
KR101679642B1
(ko)
|
2009-04-30 |
2016-11-25 |
글락소 그룹 리미티드 |
Pi3키나아제 억제제로서 옥사졸 치환된 인다졸
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
BR112012003262A8
(pt)
|
2009-08-12 |
2016-05-17 |
Novartis Ag |
compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
|
PE20121148A1
(es)
|
2009-08-17 |
2012-09-07 |
Intellikine Llc |
Compuestos heterociclicos y usos de los mismos
|
KR20120089463A
(ko)
|
2009-08-20 |
2012-08-10 |
노파르티스 아게 |
헤테로시클릭 옥심 화합물
|
CN102548536A
(zh)
*
|
2009-10-01 |
2012-07-04 |
爱尔康研究有限公司 |
奥洛他定组合物及其用途
|
CN102665715A
(zh)
|
2009-10-22 |
2012-09-12 |
沃泰克斯药物股份有限公司 |
治疗囊性纤维化和其他慢性疾病的组合物
|
EP2507226A1
(en)
|
2009-12-03 |
2012-10-10 |
Glaxo Group Limited |
Novel compounds
|
US20120238571A1
(en)
|
2009-12-03 |
2012-09-20 |
Glaxo Group Limited |
Indazole derivatives as pi 3-kinase
|
US20120245171A1
(en)
|
2009-12-03 |
2012-09-27 |
Glaxo Group Limited |
Benzpyrazole derivatives as inhibitors of pi3 kinases
|
WO2011084316A2
(en)
|
2009-12-16 |
2011-07-14 |
3M Innovative Properties Company |
Formulations and methods for controlling mdi particle size delivery
|
WO2011110575A1
(en)
|
2010-03-11 |
2011-09-15 |
Glaxo Group Limited |
Derivatives of 2-[2-(benzo- or pyrido-) thiazolylamino]-6-aminopyridine, useful in the treatment of respiratoric, allergic or inflammatory diseases
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
GB201007203D0
(en)
|
2010-04-29 |
2010-06-16 |
Glaxo Group Ltd |
Novel compounds
|
PT2614058E
(pt)
|
2010-09-08 |
2015-10-27 |
Glaxosmithkline Ip Dev Ltd |
Polimorfos e sais de n-[5-[4-(5-{[(2r,6s)-2,6-dimetil-4- morfolinil]metil}-1,3-oxazol-2-il)-1h-indazol-6-il]-2- (metiloxi)-3-piridinil]metanossulfonamida
|
EP2613781B1
(en)
|
2010-09-08 |
2016-08-24 |
GlaxoSmithKline Intellectual Property Development Limited |
Indazole derivatives for use in the treatment of influenza virus infection
|
US8637516B2
(en)
|
2010-09-09 |
2014-01-28 |
Irm Llc |
Compounds and compositions as TRK inhibitors
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
WO2012035055A1
(en)
|
2010-09-17 |
2012-03-22 |
Glaxo Group Limited |
Novel compounds
|
US8372845B2
(en)
|
2010-09-17 |
2013-02-12 |
Novartis Ag |
Pyrazine derivatives as enac blockers
|
JP5795643B2
(ja)
|
2010-10-21 |
2015-10-14 |
グラクソ グループ リミテッドGlaxo Group Limited |
アレルギー性状態、免疫性状態及び炎症性状態に作用するピラゾール化合物
|
JP2013544794A
(ja)
|
2010-10-21 |
2013-12-19 |
グラクソ グループ リミテッド |
アレルギー性障害、炎症性障害及び免疫障害に作用するピラゾール化合物
|
GB201018124D0
(en)
|
2010-10-27 |
2010-12-08 |
Glaxo Group Ltd |
Polymorphs and salts
|
EP2673277A1
(en)
|
2011-02-10 |
2013-12-18 |
Novartis AG |
[1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
MA34969B1
(fr)
|
2011-02-25 |
2014-03-01 |
Irm Llc |
Composes et compositions en tant qu inibiteurs de trk
|
MX357121B
(es)
|
2011-03-01 |
2018-06-27 |
Synergy Pharmaceuticals Inc Star |
Proceso de preparacion de agonistas c de guanilato ciclasa.
|
JP2014507458A
(ja)
|
2011-03-11 |
2014-03-27 |
グラクソ グループ リミテッド |
Sykインヒビターとしてのピリド[3,4−B]ピラジン誘導体
|
GB201104153D0
(en)
|
2011-03-11 |
2011-04-27 |
Glaxo Group Ltd |
Novel compounds
|
US8883819B2
(en)
|
2011-09-01 |
2014-11-11 |
Irm Llc |
Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
|
AU2012310168B2
(en)
|
2011-09-15 |
2015-07-16 |
Novartis Ag |
6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
|
WO2013038373A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
WO2013038381A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine/pyrazine amide derivatives
|
ES2882807T3
(es)
|
2011-09-16 |
2021-12-02 |
Novartis Ag |
Heterociclil carboxamidas N-sustituidas
|
JP5886433B2
(ja)
|
2011-09-16 |
2016-03-16 |
ノバルティス アーゲー |
嚢胞性線維症処置のためのヘテロ環式化合物
|
WO2013038378A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
CA2856803A1
(en)
|
2011-11-23 |
2013-05-30 |
Intellikine, Llc |
Enhanced treatment regimens using mtor inhibitors
|
WO2013084182A1
(en)
|
2011-12-08 |
2013-06-13 |
Glenmark Pharmaceuticals S.A. |
Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent
|
US8809340B2
(en)
|
2012-03-19 |
2014-08-19 |
Novartis Ag |
Crystalline form
|
JP2015512425A
(ja)
|
2012-04-03 |
2015-04-27 |
ノバルティス アーゲー |
チロシンキナーゼ阻害剤との組合せ製品及びそれらの使用
|
EP2958577A2
(en)
|
2013-02-25 |
2015-12-30 |
Synergy Pharmaceuticals Inc. |
Guanylate cyclase receptor agonists for use in colonic cleansing
|
US9073921B2
(en)
|
2013-03-01 |
2015-07-07 |
Novartis Ag |
Salt forms of bicyclic heterocyclic derivatives
|
AU2014235209B2
(en)
|
2013-03-15 |
2018-06-14 |
Bausch Health Ireland Limited |
Guanylate cyclase receptor agonists combined with other drugs
|
WO2014151206A1
(en)
|
2013-03-15 |
2014-09-25 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
CA2906542A1
(en)
|
2013-03-15 |
2014-09-25 |
Intellikine, Llc |
Combination of kinase inhibitors and uses thereof
|
BR112015030326A2
(pt)
|
2013-06-05 |
2017-08-29 |
Synergy Pharmaceuticals Inc |
Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
|
US20160184387A1
(en)
|
2013-08-09 |
2016-06-30 |
Dominique Charmot |
Compounds and methods for inhibiting phosphate transport
|
AU2014321419B2
(en)
|
2013-09-22 |
2017-06-15 |
Sunshine Lake Pharma Co., Ltd. |
Substituted aminopyrimidine compounds and methods of use
|
US20160256466A1
(en)
|
2013-10-17 |
2016-09-08 |
Glaxosmithkline Intellectual Property Development Limited |
Pi3k inhibitor for treatment of respiratory disease
|
AU2014336251A1
(en)
|
2013-10-17 |
2016-04-14 |
Glaxosmithkline Intellectual Property Development Limited |
PI3K inhibitor for treatment of respiratory disease
|
WO2015084804A1
(en)
|
2013-12-03 |
2015-06-11 |
Novartis Ag |
Combination of mdm2 inhibitor and braf inhibitor and their use
|
WO2015148867A1
(en)
|
2014-03-28 |
2015-10-01 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
MX2016013983A
(es)
|
2014-04-24 |
2017-04-06 |
Novartis Ag |
Derivados de pirazina como inhibidores de fosfatidil-inositol-3-ci nasa.
|
EA201692140A1
(ru)
|
2014-04-24 |
2017-04-28 |
Новартис Аг |
Производные аминопиридина в качестве ингибиторов фосфатидилинозитол 3-киназы
|
CN106458979B
(zh)
|
2014-04-24 |
2020-03-27 |
诺华股份有限公司 |
作为磷脂酰肌醇3-激酶抑制剂的氨基吡嗪衍生物
|
CA2948441A1
(en)
|
2014-05-12 |
2015-11-19 |
Glaxosmithkline Intellectual Property (No. 2) Limited |
Pharmaceutical compositions for treating infectious diseases
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
JP6526789B2
(ja)
|
2014-07-31 |
2019-06-05 |
ノバルティス アーゲー |
組み合わせ療法
|
JP2018527362A
(ja)
|
2015-09-11 |
2018-09-20 |
サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. |
置換されたヘテロアリール化合物および使用方法
|
EP3165224A1
(en)
|
2015-11-09 |
2017-05-10 |
Albert-Ludwigs-Universität Freiburg |
Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders
|
WO2017089347A1
(en)
|
2015-11-25 |
2017-06-01 |
Inserm (Institut National De La Sante Et De La Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
|
GB201602527D0
(en)
|
2016-02-12 |
2016-03-30 |
Glaxosmithkline Ip Dev Ltd |
Chemical compounds
|
EP3497100A1
(en)
|
2016-08-08 |
2019-06-19 |
GlaxoSmithKline Intellectual Property Development Limited |
Chemical compounds
|
US20190307975A1
(en)
|
2016-11-21 |
2019-10-10 |
Lupin Inc. |
Medicament dispenser
|
GB201706102D0
(en)
|
2017-04-18 |
2017-05-31 |
Glaxosmithkline Ip Dev Ltd |
Chemical compounds
|
GB201712081D0
(en)
|
2017-07-27 |
2017-09-13 |
Glaxosmithkline Ip Dev Ltd |
Chemical compounds
|
US10683297B2
(en)
|
2017-11-19 |
2020-06-16 |
Calitor Sciences, Llc |
Substituted heteroaryl compounds and methods of use
|
AU2019209960B2
(en)
|
2018-01-20 |
2023-11-23 |
Sunshine Lake Pharma Co., Ltd. |
Substituted aminopyrimidine compounds and methods of use
|
WO2019195711A1
(en)
|
2018-04-06 |
2019-10-10 |
Lupin Inc. |
Medicament dispenser
|
JP7410458B2
(ja)
*
|
2018-04-11 |
2024-01-10 |
三菱瓦斯化学株式会社 |
1,4-シクロヘキサンジカルボン酸誘導体、1,4-ジシアノシクロヘキサン、及び1,4-ビス(アミノメチル)シクロヘキサンの製造方法
|
WO2020058823A1
(en)
|
2018-09-17 |
2020-03-26 |
Lupin, Inc. |
Dose indicator assembly for a medicament dispenser
|
WO2020237096A1
(en)
|
2019-05-21 |
2020-11-26 |
Ardelyx, Inc. |
Combination for lowering serum phosphate in a patient
|
MX2021015133A
(es)
|
2019-06-10 |
2022-01-24 |
Novartis Ag |
Derivado de piridina y pirazina para el tratamiento de la fibrosis quistica, enfermedad pulmonar obstructiva cronica y bronquiectasia.
|
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(en)
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2019-08-28 |
2022-09-29 |
Novartis Ag |
Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease
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2020-03-25 |
2023-02-08 |
Lupin Inc. |
Multi-carrier medicament dispensers
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(en)
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2020-03-26 |
2023-02-08 |
GlaxoSmithKline Intellectual Property Development Limited |
Cathepsin inhibitors for preventing or treating viral infections
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(es)
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2020-07-23 |
2023-04-26 |
Lupin Inc |
Conjuntos contadores de dosis para dispensadores de medicamentos.
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