BG111004A - Антитела, които се свързват с човешки интерлевкин-18, и методи за получаване и използване - Google Patents
Антитела, които се свързват с човешки интерлевкин-18, и методи за получаване и използванеInfo
- Publication number
- BG111004A BG111004A BG10111004A BG11100411A BG111004A BG 111004 A BG111004 A BG 111004A BG 10111004 A BG10111004 A BG 10111004A BG 11100411 A BG11100411 A BG 11100411A BG 111004 A BG111004 A BG 111004A
- Authority
- BG
- Bulgaria
- Prior art keywords
- antibodies
- hil
- bind
- human
- production
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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Abstract
Осигурени са антитела, които се свързват с човешки интерлевкин-18 (hIL-18), по-специално антитела, конто се свързват с епитопа(ите) на човешки IL-18. Антителата могат да бъдат например изцяло човешки антитела, рекомбинантни антитела или моноклонални антитела. Предпочитаните антитела имат висок афинитет към hIL-18 и неутрализират активността на hIL-18 in vitro и in vivo. Антитяло от изобретениетоможе да бъде с пълната дължина на антитяло или антиген-свързваща негова част. Осигурени са също метод за получаване и метод за използване на антитела от изобретението. Антителата или части на антителата от изобретението се използват за детекция на hIL-18 и за инхибиране на активността на hIL-18, например в обект-човек, който страда от нарушение, при което активността на hIL-18 е вредна.
Applications Claiming Priority (2)
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US18160800P | 2000-02-10 | 2000-02-10 | |
PCT/US2001/004170 WO2001058956A2 (en) | 2000-02-10 | 2001-02-09 | Antibodies that bind human interleukin-18 and methods of making and using |
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BG111004A true BG111004A (bg) | 2011-11-30 |
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ID=22665007
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BG107045A BG107045A (bg) | 2000-02-10 | 2002-09-02 | Антитела, които се свързват с човешки интерлевкин-18, методи за получаването и използването им |
BG10111004A BG111004A (bg) | 2000-02-10 | 2011-07-29 | Антитела, които се свързват с човешки интерлевкин-18, и методи за получаване и използване |
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BG107045A BG107045A (bg) | 2000-02-10 | 2002-09-02 | Антитела, които се свързват с човешки интерлевкин-18, методи за получаването и използването им |
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US (3) | US7767207B2 (bg) |
EP (4) | EP2338515A3 (bg) |
JP (2) | JP2004500086A (bg) |
KR (4) | KR20120011898A (bg) |
CN (3) | CN1461310B (bg) |
AR (2) | AR027404A1 (bg) |
AU (3) | AU2001236807A1 (bg) |
BG (2) | BG107045A (bg) |
BR (1) | BR0108188A (bg) |
CA (2) | CA2399148A1 (bg) |
CL (1) | CL2012001063A1 (bg) |
HU (1) | HUP0300423A3 (bg) |
IL (2) | IL151044A0 (bg) |
MX (1) | MXPA02007756A (bg) |
MY (1) | MY146017A (bg) |
NO (1) | NO20023788L (bg) |
NZ (1) | NZ520392A (bg) |
PL (1) | PL356836A1 (bg) |
SK (1) | SK12942002A3 (bg) |
TW (3) | TWI335336B (bg) |
WO (1) | WO2001058956A2 (bg) |
ZA (1) | ZA200206266B (bg) |
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