ATE494289T1 - Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin - Google Patents

Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

Info

Publication number
ATE494289T1
ATE494289T1 AT07788196T AT07788196T ATE494289T1 AT E494289 T1 ATE494289 T1 AT E494289T1 AT 07788196 T AT07788196 T AT 07788196T AT 07788196 T AT07788196 T AT 07788196T AT E494289 T1 ATE494289 T1 AT E494289T1
Authority
AT
Austria
Prior art keywords
medicine
production
substituted pyrazolopyrimidines
pyrazolopyrimidines
substituted
Prior art date
Application number
AT07788196T
Other languages
English (en)
Inventor
Wojciech Danysz
Andrzej Dekundy
Mirko Hechenberger
Markus Henrich
Claudia Jatzke
Jens Nagel
Christopher Graham Raphael Parsons
Tanja Weil
Juris Fotins
Aleksandra Gutcaits
Ivars Kalvinsh
Ronalds Zemribo
Valerjans Kauss
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Application granted granted Critical
Publication of ATE494289T1 publication Critical patent/ATE494289T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
AT07788196T 2006-08-04 2007-08-03 Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin ATE494289T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83582006P 2006-08-04 2006-08-04
US87754406P 2006-12-28 2006-12-28
PCT/EP2007/058060 WO2008015269A1 (en) 2006-08-04 2007-08-03 Substituted pyrazolopyrimidines, a process for their preparation and their use as medicine

Publications (1)

Publication Number Publication Date
ATE494289T1 true ATE494289T1 (de) 2011-01-15

Family

ID=38710494

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07788197T ATE488520T1 (de) 2006-08-04 2007-08-03 Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin
AT07788196T ATE494289T1 (de) 2006-08-04 2007-08-03 Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07788197T ATE488520T1 (de) 2006-08-04 2007-08-03 Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

Country Status (21)

Country Link
US (4) US7947689B2 (de)
EP (3) EP2295439A1 (de)
JP (2) JP2009545569A (de)
KR (1) KR20090047450A (de)
AR (3) AR062210A1 (de)
AT (2) ATE488520T1 (de)
AU (2) AU2007280429A1 (de)
BR (2) BRPI0714622A2 (de)
CA (2) CA2659876A1 (de)
CY (1) CY1112003T1 (de)
DE (2) DE602007010640D1 (de)
DK (1) DK2054416T3 (de)
HR (1) HRP20110128T1 (de)
IL (2) IL196008A0 (de)
MX (2) MX2009000919A (de)
PL (1) PL2054416T3 (de)
PT (1) PT2054416E (de)
RU (2) RU2009107688A (de)
TW (3) TW200815432A (de)
WO (3) WO2008015270A1 (de)
ZA (1) ZA200810605B (de)

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CA2820262A1 (en) 2010-12-08 2012-06-14 Vanderbilt University Bicyclic pyrazole compounds as allosteric modulators of mglur5 receptors
US8865725B2 (en) 2011-03-15 2014-10-21 Vanderbilt University Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors
CA2830220A1 (en) * 2011-03-15 2012-09-20 Vanderbilt University Substituted imidazopyrimidin-5(6h)-ones as allosteric modulators of mglur5 receptors
WO2012139876A1 (en) 2011-04-14 2012-10-18 Merz Pharma Gmbh & Co. Kgaa Enteric formulations of metabotropic glutamate receptor modulators
US8791108B2 (en) 2011-08-18 2014-07-29 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2013087808A1 (en) 2011-12-15 2013-06-20 Merz Pharma Gmbh & Co. Kgaa Pharmaceutical composition comprising a pyrazolopyrimidme and cyclodextrin
WO2013087815A1 (en) 2011-12-15 2013-06-20 Merz Pharma Gmbh & Co. Kgaa Liquid pharmaceutical composition containing a pyrazolopyrimidine derivative and pharmaceutical uses thereof
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
EP2831074B1 (de) * 2012-03-29 2016-09-14 Boehringer Ingelheim International GmbH Neuartige pyrazolopyrimidine als metabotrope glutamat 5 rezeptor antagonisten zur behandlung psychischer erkrankungen
JO3407B1 (ar) * 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
WO2014035707A1 (en) * 2012-08-25 2014-03-06 The Johns Hopkins University Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
EP2958915B1 (de) 2013-02-19 2017-07-05 Pfizer Inc Azabenzimidazolverbindungen als inhibitoren von pde4-isoenzymen zur behandlung von zns und anderen erkrankungen
WO2014164467A1 (en) 2013-03-13 2014-10-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2014164428A1 (en) 2013-03-13 2014-10-09 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
CN105008369B (zh) 2013-03-14 2017-07-11 百时美施贵宝公司 人类免疫缺陷病毒复制抑制剂
EP3036219A4 (de) * 2013-06-04 2017-08-23 Temple University Of The Commonwealth System Of Higher Education Neuartige beta-lactame als modulatoren einer glutamataufnahme und verfahren zur verwendung davon
MX2016005994A (es) 2013-11-05 2017-01-11 Univ Temple Anifífilos policatónicos como agentes antimicrobianos.
US10398142B2 (en) 2013-11-05 2019-09-03 Temple University Of The Commonwealth System Of Higher Education Polycationic amphiphiles as antimicrobial agents
GB201320905D0 (en) 2013-11-27 2014-01-08 Takeda Pharmaceutical Therapeutic compounds
US9273067B2 (en) 2014-02-19 2016-03-01 Bristol-Myers Squibb Company Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
WO2016012896A1 (en) 2014-07-24 2016-01-28 Pfizer Inc. Pyrazolopyrimidine compounds
JP6506833B2 (ja) 2014-08-06 2019-04-24 ファイザー・インク イミダゾピリダジン化合物
CA3222584A1 (en) 2016-01-27 2017-08-03 Universitat Zurich Use of gabaa receptor modulators for treatment of itch

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