ATE488520T1 - Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin - Google Patents

Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

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Publication number
ATE488520T1
ATE488520T1 AT07788197T AT07788197T ATE488520T1 AT E488520 T1 ATE488520 T1 AT E488520T1 AT 07788197 T AT07788197 T AT 07788197T AT 07788197 T AT07788197 T AT 07788197T AT E488520 T1 ATE488520 T1 AT E488520T1
Authority
AT
Austria
Prior art keywords
pyrazolopyrimidines
medicine
production
Prior art date
Application number
AT07788197T
Other languages
English (en)
Inventor
Wojciech Danysz
Andrzej Dekundy
Mirko Hechenberger
Markus Henrich
Claudia Jatzke
Jens Nagel
Christopher Graham Raphael Parsons
Tanja Weil
Juris Fotins
Aleksandra Gutcaits
Ivars Kalvinsh
Ronalds Zemribo
Valerjans Kauss
Original Assignee
Merz Pharma Gmbh & Co Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co Kgaa filed Critical Merz Pharma Gmbh & Co Kgaa
Application granted granted Critical
Publication of ATE488520T1 publication Critical patent/ATE488520T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
AT07788197T 2006-08-04 2007-08-03 Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin ATE488520T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83582006P 2006-08-04 2006-08-04
US87754406P 2006-12-28 2006-12-28
PCT/EP2007/058061 WO2008015270A1 (en) 2006-08-04 2007-08-03 Pyrazolopyrimidines, a process for their preparation and their use as medicine

Publications (1)

Publication Number Publication Date
ATE488520T1 true ATE488520T1 (de) 2010-12-15

Family

ID=38710494

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07788196T ATE494289T1 (de) 2006-08-04 2007-08-03 Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin
AT07788197T ATE488520T1 (de) 2006-08-04 2007-08-03 Pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07788196T ATE494289T1 (de) 2006-08-04 2007-08-03 Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin

Country Status (21)

Country Link
US (4) US20080032998A1 (de)
EP (3) EP2054416B8 (de)
JP (2) JP2010500288A (de)
KR (1) KR20090047450A (de)
AR (3) AR062210A1 (de)
AT (2) ATE494289T1 (de)
AU (2) AU2007280429A1 (de)
BR (2) BRPI0714622A2 (de)
CA (2) CA2659871A1 (de)
CY (1) CY1112003T1 (de)
DE (2) DE602007011773D1 (de)
DK (1) DK2054416T3 (de)
HR (1) HRP20110128T1 (de)
IL (2) IL196008A0 (de)
MX (2) MX2009001036A (de)
PL (1) PL2054416T3 (de)
PT (1) PT2054416E (de)
RU (2) RU2450004C2 (de)
TW (3) TW200823215A (de)
WO (3) WO2008015271A1 (de)
ZA (1) ZA200810605B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
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WO2008056176A1 (en) * 2006-11-10 2008-05-15 Scottish Biomedical Limited Pyrazolopyrimidines as phosphodiesterase inhibitors
HK1136565A1 (en) * 2007-03-31 2010-07-02 Intervet Int Bv Processes for making zilpaterol and salts thereof
EP2090576A1 (de) * 2008-02-01 2009-08-19 Merz Pharma GmbH & Co.KGaA 6-halo-Pyrazolo[1,5-a]pyridin-Verbindungen, Verfahren zu ihrer Herstellung und Verwendung als Modulatoren des Metabotropen Glutamatrezeptoren (mGluR)
EP2826478A1 (de) * 2008-06-30 2015-01-21 Novartis AG Kombinationsprodukte enthaltend MGLUR Modulatoren zur Behandlung DER PARKINSONKRANKHEIT
US20120283274A1 (en) 2009-11-25 2012-11-08 Patrick Plitt Crystalline forms of substituted pyrazolopyrimidines
US8703946B2 (en) 2010-12-08 2014-04-22 Vanderbilt University Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors
US8865725B2 (en) 2011-03-15 2014-10-21 Vanderbilt University Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors
EP2685825A4 (de) * 2011-03-15 2014-09-10 Univ Vanderbilt Substituierte imadazopyrimidin-5(6h)-one als allosterische modulatoren von mglur5-rezeptoren
WO2012139876A1 (en) 2011-04-14 2012-10-18 Merz Pharma Gmbh & Co. Kgaa Enteric formulations of metabotropic glutamate receptor modulators
US8791108B2 (en) 2011-08-18 2014-07-29 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
WO2013087808A1 (en) 2011-12-15 2013-06-20 Merz Pharma Gmbh & Co. Kgaa Pharmaceutical composition comprising a pyrazolopyrimidme and cyclodextrin
WO2013087815A1 (en) 2011-12-15 2013-06-20 Merz Pharma Gmbh & Co. Kgaa Liquid pharmaceutical composition containing a pyrazolopyrimidine derivative and pharmaceutical uses thereof
US9006235B2 (en) 2012-03-06 2015-04-14 Bristol-Myers Squibb Company Inhibitors of human immunodeficiency virus replication
US9029360B2 (en) * 2012-03-29 2015-05-12 Boehringer Ingelheim International Gmbh Pyrazolopyrimidines as metabotropic glutamate 5 receptor antagonists
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US20150218103A1 (en) 2012-08-25 2015-08-06 The Johns Hopkins University Gapdh cascade inhibitor compounds and methods of use and treatment of stress induced disorders including mental illness
CA2900302C (en) 2013-02-19 2018-07-03 Pfizer Inc. Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders
JP2016516692A (ja) 2013-03-13 2016-06-09 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ヒト免疫不全ウイルス複製の阻害剤
CN105189511B (zh) 2013-03-13 2017-05-24 百时美施贵宝公司 人免疫缺陷病毒复制的抑制剂
US9540393B2 (en) 2013-03-14 2017-01-10 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
WO2014197536A2 (en) 2013-06-04 2014-12-11 Temple University Of The Commonwealth Novel beta lactams as modulators of glutamate uptake and methods for use thereof
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