ATE485300T1 - Als aurora-kinase-inhibitoren nutzbare thienopyrimidine - Google Patents
Als aurora-kinase-inhibitoren nutzbare thienopyrimidineInfo
- Publication number
- ATE485300T1 ATE485300T1 AT05772519T AT05772519T ATE485300T1 AT E485300 T1 ATE485300 T1 AT E485300T1 AT 05772519 T AT05772519 T AT 05772519T AT 05772519 T AT05772519 T AT 05772519T AT E485300 T1 ATE485300 T1 AT E485300T1
- Authority
- AT
- Austria
- Prior art keywords
- thienopyrimidines
- usable
- kinase inhibitors
- aurora kinase
- aurora
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58871804P | 2004-07-16 | 2004-07-16 | |
US63256804P | 2004-12-01 | 2004-12-01 | |
PCT/US2005/025340 WO2006036266A1 (en) | 2004-07-16 | 2005-07-15 | Thienopyrimidines useful as aurora kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE485300T1 true ATE485300T1 (de) | 2010-11-15 |
Family
ID=35527256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05772519T ATE485300T1 (de) | 2004-07-16 | 2005-07-15 | Als aurora-kinase-inhibitoren nutzbare thienopyrimidine |
Country Status (14)
Country | Link |
---|---|
US (2) | US7601725B2 (de) |
EP (1) | EP1768984B1 (de) |
JP (1) | JP2008506714A (de) |
KR (1) | KR20070057792A (de) |
AT (1) | ATE485300T1 (de) |
AU (1) | AU2005290226A1 (de) |
BR (1) | BRPI0513405A (de) |
CA (1) | CA2573999A1 (de) |
DE (1) | DE602005024274D1 (de) |
IL (1) | IL180722A0 (de) |
MX (1) | MX2007000631A (de) |
NZ (1) | NZ552751A (de) |
SG (1) | SG156650A1 (de) |
WO (1) | WO2006036266A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101031570B (zh) | 2004-07-30 | 2012-09-05 | 梅特希尔基因公司 | Vegf受体和hgf受体信号的抑制剂 |
BRPI0610322B8 (pt) | 2005-05-20 | 2021-05-25 | Methylgene Inc | inibidores de sinalização de receptor de vegf e de receptor de hgf e composição farmacêutica |
EP1904504B1 (de) | 2005-05-20 | 2014-03-19 | MethylGene Inc. | Vegf- und hgf-rezeptorensignalisierungshemmer |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
EP1998777A1 (de) * | 2006-03-20 | 2008-12-10 | F. Hoffmann-La Roche AG | Verfahren zum inhibieren von btk- und syk-proteinkinasen |
JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
US7968536B2 (en) * | 2007-06-29 | 2011-06-28 | Millennium Pharmaceuticals, Inc. | Heterocyclic compounds useful as RAF kinase inhibitors |
EP2014663A1 (de) * | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma AG | Thienopyrimidylamine als Modulatoren des EP2-Rezeptors |
US8729268B2 (en) | 2008-03-05 | 2014-05-20 | Methylgene Inc. | Inhibitors of protein tyrosine kinase activity |
WO2009113637A1 (ja) * | 2008-03-12 | 2009-09-17 | 東ソー株式会社 | 新規なチアゾール誘導体、チアゾール誘導体固定化マトリックス、及びそれらの製造方法 |
JP5455380B2 (ja) * | 2008-03-12 | 2014-03-26 | 公益財団法人相模中央化学研究所 | 新規なチアゾール誘導体、及びその製造方法 |
JP5498025B2 (ja) * | 2008-03-13 | 2014-05-21 | 公益財団法人相模中央化学研究所 | 新規なチアゾール誘導体固定化マトリックス、及びその製造方法 |
WO2009114856A2 (en) * | 2008-03-14 | 2009-09-17 | Sunesis Pharmaceuticals, Inc. | Aurora kinase inhibitors |
EP2257637B1 (de) * | 2008-03-25 | 2015-09-23 | Sunesis Pharmaceuticals, Inc. | Verfahren für chemotypentwicklung |
CA2722220C (en) * | 2008-04-30 | 2016-06-07 | National Health Research Institutes | Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
US20100063047A1 (en) * | 2008-09-10 | 2010-03-11 | Kalypsys, Inc. | Aminopyrimidine inhibitors of histamine receptors for the treatment of disease |
WO2010036629A2 (en) * | 2008-09-26 | 2010-04-01 | National Health Research Institutes | Fused multicyclic compounds as protein kinase inhibitors |
BRPI0923579A2 (pt) | 2008-12-22 | 2020-01-14 | Millennium Pharm Inc | combinação de inibidores de aurora quinase e anticorpos anti-cd20 |
EP2922857B1 (de) * | 2012-11-20 | 2018-01-03 | ProQinase GmbH | Thioetherderivate als proteinkinase-inhibitoren |
CN103012428A (zh) | 2013-01-08 | 2013-04-03 | 中国药科大学 | 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途 |
WO2015085289A1 (en) | 2013-12-06 | 2015-06-11 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd30 antibodies |
FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP2018123058A (ja) * | 2015-06-08 | 2018-08-09 | 石原産業株式会社 | ジフルオロメチレン化合物 |
GB201705263D0 (en) * | 2017-03-31 | 2017-05-17 | Probiodrug Ag | Novel inhibitors |
US11874276B2 (en) | 2018-04-05 | 2024-01-16 | Dana-Farber Cancer Institute, Inc. | STING levels as a biomarker for cancer immunotherapy |
WO2020049208A1 (es) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida |
WO2021041532A1 (en) | 2019-08-26 | 2021-03-04 | Dana-Farber Cancer Institute, Inc. | Use of heparin to promote type 1 interferon signaling |
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GB1570494A (en) | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
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US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
US6407124B1 (en) | 1998-06-18 | 2002-06-18 | Bristol-Myers Squibb Company | Carbon substituted aminothiazole inhibitors of cyclin dependent kinases |
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US6503914B1 (en) | 2000-10-23 | 2003-01-07 | Board Of Regents, The University Of Texas System | Thienopyrimidine-based inhibitors of the Src family |
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JP4847868B2 (ja) | 2003-05-14 | 2011-12-28 | ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド | 化合物、及び、アミロイドベータの調節におけるその使用 |
-
2005
- 2005-07-15 AT AT05772519T patent/ATE485300T1/de not_active IP Right Cessation
- 2005-07-15 NZ NZ552751A patent/NZ552751A/en not_active IP Right Cessation
- 2005-07-15 SG SG200906907-1A patent/SG156650A1/en unknown
- 2005-07-15 US US11/182,215 patent/US7601725B2/en not_active Expired - Fee Related
- 2005-07-15 AU AU2005290226A patent/AU2005290226A1/en not_active Abandoned
- 2005-07-15 WO PCT/US2005/025340 patent/WO2006036266A1/en active Application Filing
- 2005-07-15 JP JP2007521708A patent/JP2008506714A/ja active Pending
- 2005-07-15 EP EP05772519A patent/EP1768984B1/de active Active
- 2005-07-15 MX MX2007000631A patent/MX2007000631A/es not_active Application Discontinuation
- 2005-07-15 BR BRPI0513405-6A patent/BRPI0513405A/pt not_active IP Right Cessation
- 2005-07-15 CA CA002573999A patent/CA2573999A1/en not_active Abandoned
- 2005-07-15 DE DE602005024274T patent/DE602005024274D1/de active Active
- 2005-07-15 KR KR1020077003002A patent/KR20070057792A/ko not_active Application Discontinuation
-
2007
- 2007-01-16 IL IL180722A patent/IL180722A0/en unknown
-
2009
- 2009-10-08 US US12/575,560 patent/US20100179123A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1768984B1 (de) | 2010-10-20 |
JP2008506714A (ja) | 2008-03-06 |
US7601725B2 (en) | 2009-10-13 |
US20060035908A1 (en) | 2006-02-16 |
IL180722A0 (en) | 2007-06-03 |
KR20070057792A (ko) | 2007-06-07 |
SG156650A1 (en) | 2009-11-26 |
AU2005290226A1 (en) | 2006-04-06 |
DE602005024274D1 (de) | 2010-12-02 |
CA2573999A1 (en) | 2006-04-06 |
US20100179123A1 (en) | 2010-07-15 |
NZ552751A (en) | 2010-11-26 |
BRPI0513405A (pt) | 2008-05-06 |
EP1768984A1 (de) | 2007-04-04 |
WO2006036266A1 (en) | 2006-04-06 |
MX2007000631A (es) | 2007-03-30 |
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