EA200800546A1 - Бензимидазолтиофеновые соединения в качестве ингибиторов polo-подобных киназ (plk) - Google Patents
Бензимидазолтиофеновые соединения в качестве ингибиторов polo-подобных киназ (plk)Info
- Publication number
- EA200800546A1 EA200800546A1 EA200800546A EA200800546A EA200800546A1 EA 200800546 A1 EA200800546 A1 EA 200800546A1 EA 200800546 A EA200800546 A EA 200800546A EA 200800546 A EA200800546 A EA 200800546A EA 200800546 A1 EA200800546 A1 EA 200800546A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- benzimidazolthiophene
- compounds
- plk
- polo
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
В настоящем изобретении предложены бензимидазолтиофеновые соединения, фармацевтические композиции, содержащие их, способы их получения и их применение в качестве фармацевтических агентов (формулы А-Н).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71433705P | 2005-09-06 | 2005-09-06 | |
US78624406P | 2006-03-27 | 2006-03-27 | |
PCT/US2006/033683 WO2007030361A2 (en) | 2005-09-06 | 2006-08-28 | Benzimidazole thiophene compounds as plk inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200800546A1 true EA200800546A1 (ru) | 2008-08-29 |
EA014111B1 EA014111B1 (ru) | 2010-10-29 |
Family
ID=37631488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200800546A EA014111B1 (ru) | 2005-09-06 | 2006-08-28 | Бензимидазолтиофеновые соединения в качестве ингибиторов polo-подобных киназ (plk) |
Country Status (29)
Country | Link |
---|---|
US (2) | US7786127B2 (ru) |
EP (1) | EP1937671B1 (ru) |
JP (1) | JP5002597B2 (ru) |
KR (1) | KR20080047585A (ru) |
AR (1) | AR055616A1 (ru) |
AT (1) | ATE452132T1 (ru) |
AU (1) | AU2006287766B2 (ru) |
BR (1) | BRPI0615668A2 (ru) |
CA (1) | CA2621879A1 (ru) |
CR (1) | CR9786A (ru) |
CY (1) | CY1109916T1 (ru) |
DE (1) | DE602006011192D1 (ru) |
DK (1) | DK1937671T3 (ru) |
EA (1) | EA014111B1 (ru) |
ES (1) | ES2337929T3 (ru) |
HK (1) | HK1117504A1 (ru) |
HR (1) | HRP20100122T1 (ru) |
IL (1) | IL189897A0 (ru) |
JO (1) | JO2578B1 (ru) |
MA (1) | MA29816B1 (ru) |
MX (1) | MX2008003173A (ru) |
NO (1) | NO20081160L (ru) |
NZ (1) | NZ566345A (ru) |
PE (1) | PE20070518A1 (ru) |
PL (1) | PL1937671T3 (ru) |
PT (1) | PT1937671E (ru) |
SI (1) | SI1937671T1 (ru) |
TW (1) | TW200800967A (ru) |
WO (1) | WO2007030361A2 (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009538305A (ja) * | 2006-05-23 | 2009-11-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なチオフェンカルボキサミド |
US7615643B2 (en) | 2006-06-02 | 2009-11-10 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds |
EP2032563B1 (en) * | 2006-06-02 | 2010-06-02 | GlaxoSmithKline LLC | Benzimidazol substituted thiophene derivatives with activity on plk |
JP2009539771A (ja) * | 2006-06-02 | 2009-11-19 | スミスクライン ビーチャム コーポレーション | 置換ベンゾイミダゾールチオフェンベンジルエーテル化合物 |
WO2008087736A1 (ja) * | 2007-01-19 | 2008-07-24 | Ube Industries, Ltd. | アラルキルオキシ又はヘテロアラルキルオキシ基を有する芳香族アミンの製法 |
JP2010531887A (ja) * | 2007-06-26 | 2010-09-30 | グラクソスミスクライン エルエルシー | ベンズイミダゾールチオフェンの調製方法 |
WO2009003911A1 (en) * | 2007-06-29 | 2009-01-08 | 4Sc Ag | Thiophene-imidazopyridines |
EP2100894A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Pyridopyrimidines used as Plk1 (polo-like kinase) inhibitors |
WO2009151914A1 (en) * | 2008-05-27 | 2009-12-17 | Smithkline Beecham Corporation | Methods for treating neoplasms with a combination of a plk inhibitor and retinoid |
WO2009154645A1 (en) * | 2008-06-20 | 2009-12-23 | Smithkline Beecham Corporation | Methods for the treatment of central nervous system tumors |
CA2745596A1 (en) | 2008-12-18 | 2010-10-28 | F. Hoffmann-La Roche Ag | Thiazolyl-benzimidazoles |
WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
MX352661B (es) | 2009-11-05 | 2017-12-04 | Rhizen Pharmaceuticals S A Star | Moduladores novedosos de benzopiran cinasa. |
CA2833935C (en) | 2011-05-04 | 2020-09-15 | Dhanapalan Nagarathnam | Novel compounds as modulators of protein kinases |
EP2870157B1 (en) | 2012-07-04 | 2017-08-30 | Rhizen Pharmaceuticals S.A. | Selective pi3k delta inhibitors |
KR102574152B1 (ko) * | 2020-03-27 | 2023-09-05 | (주) 업테라 | Plk1의 선택적 분해를 유도하는 벤즈이미다졸 티오펜 유도체 화합물 |
KR102337029B1 (ko) * | 2020-03-27 | 2021-12-09 | (주) 업테라 | Plk1 선택적 분해 유도 화합물 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
AU760020B2 (en) | 1998-08-31 | 2003-05-08 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
CA2493908A1 (en) | 2002-08-08 | 2004-02-19 | Smithkline Beecham Corporation | Thiophene compounds |
AU2003903440A0 (en) * | 2003-07-04 | 2003-07-17 | James Hardie International Finance B.V. | Rainscreen apparatus and method |
WO2005037827A1 (en) * | 2003-10-16 | 2005-04-28 | Smithkline Beecham Corporation | Process for preparing benzimidazole thiophenes |
WO2005037627A1 (ja) | 2003-10-20 | 2005-04-28 | Nsk Ltd. | ステアリング装置 |
GB0402809D0 (en) * | 2004-02-09 | 2004-03-10 | Glaxo Group Ltd | Chemical compounds |
CN101304986A (zh) * | 2005-09-06 | 2008-11-12 | 史密丝克莱恩比彻姆公司 | 制备苯并咪唑噻吩类的区域选择性方法 |
US20080214563A1 (en) * | 2005-09-06 | 2008-09-04 | Mui Cheung | Benzimidazole Thiophene Compounds As Plk Modulators |
EP2474546A1 (en) | 2006-01-23 | 2012-07-11 | Vertex Pharmaceuticals Inc. | Thiophene-carboxamides useful as inhibitors of protein kinases |
JP2009539771A (ja) * | 2006-06-02 | 2009-11-19 | スミスクライン ビーチャム コーポレーション | 置換ベンゾイミダゾールチオフェンベンジルエーテル化合物 |
EP2032563B1 (en) * | 2006-06-02 | 2010-06-02 | GlaxoSmithKline LLC | Benzimidazol substituted thiophene derivatives with activity on plk |
-
2006
- 2006-08-28 PL PL06813896T patent/PL1937671T3/pl unknown
- 2006-08-28 EP EP06813896A patent/EP1937671B1/en active Active
- 2006-08-28 ES ES06813896T patent/ES2337929T3/es active Active
- 2006-08-28 NZ NZ566345A patent/NZ566345A/en not_active IP Right Cessation
- 2006-08-28 US US12/065,668 patent/US7786127B2/en not_active Expired - Fee Related
- 2006-08-28 MX MX2008003173A patent/MX2008003173A/es active IP Right Grant
- 2006-08-28 PE PE2006001041A patent/PE20070518A1/es not_active Application Discontinuation
- 2006-08-28 SI SI200630582T patent/SI1937671T1/sl unknown
- 2006-08-28 JP JP2008529190A patent/JP5002597B2/ja not_active Expired - Fee Related
- 2006-08-28 TW TW095131590A patent/TW200800967A/zh unknown
- 2006-08-28 JO JO2006286A patent/JO2578B1/en active
- 2006-08-28 EA EA200800546A patent/EA014111B1/ru not_active IP Right Cessation
- 2006-08-28 AT AT06813896T patent/ATE452132T1/de active
- 2006-08-28 US US11/467,577 patent/US7595330B2/en not_active Expired - Fee Related
- 2006-08-28 DE DE602006011192T patent/DE602006011192D1/de active Active
- 2006-08-28 PT PT06813896T patent/PT1937671E/pt unknown
- 2006-08-28 BR BRPI0615668-1A patent/BRPI0615668A2/pt not_active IP Right Cessation
- 2006-08-28 AU AU2006287766A patent/AU2006287766B2/en not_active Ceased
- 2006-08-28 DK DK06813896.5T patent/DK1937671T3/da active
- 2006-08-28 AR ARP060103742A patent/AR055616A1/es not_active Application Discontinuation
- 2006-08-28 WO PCT/US2006/033683 patent/WO2007030361A2/en active Application Filing
- 2006-08-28 CA CA002621879A patent/CA2621879A1/en not_active Abandoned
- 2006-08-28 KR KR1020087007794A patent/KR20080047585A/ko not_active Application Discontinuation
-
2008
- 2008-02-29 CR CR9786A patent/CR9786A/es not_active Application Discontinuation
- 2008-03-03 IL IL189897A patent/IL189897A0/en unknown
- 2008-03-05 NO NO20081160A patent/NO20081160L/no not_active Application Discontinuation
- 2008-03-31 MA MA30794A patent/MA29816B1/fr unknown
- 2008-07-15 HK HK08107811.4A patent/HK1117504A1/xx not_active IP Right Cessation
-
2010
- 2010-03-04 HR HR20100122T patent/HRP20100122T1/hr unknown
- 2010-03-09 CY CY20101100224T patent/CY1109916T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |