ATE426045T1 - Prozess zur synthetisierung von nukleinsaure - Google Patents

Prozess zur synthetisierung von nukleinsaure

Info

Publication number
ATE426045T1
ATE426045T1 AT07014809T AT07014809T ATE426045T1 AT E426045 T1 ATE426045 T1 AT E426045T1 AT 07014809 T AT07014809 T AT 07014809T AT 07014809 T AT07014809 T AT 07014809T AT E426045 T1 ATE426045 T1 AT E426045T1
Authority
AT
Austria
Prior art keywords
nucleic acid
primer
synthesizing
synthesizing nucleic
oligonucleotide
Prior art date
Application number
AT07014809T
Other languages
English (en)
Inventor
Tsugunori Notomi
Tetsu Hase
Original Assignee
Eiken Chemical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18088663&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE426045(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eiken Chemical filed Critical Eiken Chemical
Application granted granted Critical
Publication of ATE426045T1 publication Critical patent/ATE426045T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/101—Temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/125—Specific component of sample, medium or buffer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/119—Strand displacement amplification [SDA]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT07014809T 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsaure ATE426045T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31747698 1998-11-09

Publications (1)

Publication Number Publication Date
ATE426045T1 true ATE426045T1 (de) 2009-04-15

Family

ID=18088663

Family Applications (3)

Application Number Title Priority Date Filing Date
AT07014809T ATE426045T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsaure
AT99954435T ATE374833T1 (de) 1998-11-09 1999-11-08 Verfahren zur synthese von nukleinsäuren
AT09000525T ATE521718T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsäure

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT99954435T ATE374833T1 (de) 1998-11-09 1999-11-08 Verfahren zur synthese von nukleinsäuren
AT09000525T ATE521718T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsäure

Country Status (9)

Country Link
US (5) US6410278B1 (de)
EP (4) EP1873260B1 (de)
JP (2) JP3313358B2 (de)
AT (3) ATE426045T1 (de)
DE (3) DE1020534T1 (de)
ES (4) ES2320814T3 (de)
HK (3) HK1029378A1 (de)
MY (3) MY157626A (de)
WO (1) WO2000028082A1 (de)

Families Citing this family (376)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US7256020B2 (en) * 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US8445664B2 (en) 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
ATE426045T1 (de) * 1998-11-09 2009-04-15 Eiken Chemical Prozess zur synthetisierung von nukleinsaure
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
DK1218542T3 (da) 1999-09-13 2004-08-02 Nugen Technologies Inc Fremgangsmåder og sammensætninger til lineær isotermisk amplifikation af polynukleotidsekvenser
WO2001034838A1 (fr) * 1999-11-08 2001-05-17 Eiken Kagaku Kabushiki Kaisha Methode de detection d'une variation ou d'un polymorphisme
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および／または多型の検出方法
EP1275715B1 (de) * 2000-04-07 2015-07-15 Eiken Kagaku Kabushiki Kaisha Verfahren zur amplifikation und erkennung von nukleinsäuren unter verwendung von doppelsträngigen nukleinsäuren als schablone
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
ATE437225T1 (de) 2000-09-19 2009-08-15 Eiken Chemical Verfahren zur polynukleotidsynthese
AU2001296015A1 (en) * 2000-10-27 2002-05-06 Eiken Kagaku Kabushiki Kaisha Method of synthesizing single-stranded nucleic acid
JP2002171999A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
JP2002171997A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
JP2002171998A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
EP1427847B1 (de) 2000-12-13 2010-07-28 Nugen Technologies, Inc. Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben
JP2002186481A (ja) * 2000-12-18 2002-07-02 Eiken Chem Co Ltd 光学的特性の測定による核酸増幅産物の検出方法
KR20030071854A (ko) * 2001-02-06 2003-09-06 다카라 바이오 가부시키가이샤 증폭 핵산 및 그의 고정화물
IL153504A0 (en) * 2001-03-09 2003-07-06 Nugen Technologies Inc Methods and compositions for amplification of rna sequences
JP2002272475A (ja) * 2001-03-22 2002-09-24 Eiken Chem Co Ltd 蛍光偏光法による核酸増幅産物の検出方法
JPWO2002090538A1 (ja) * 2001-05-08 2004-08-26 栄研化学株式会社 核酸を合成する方法
US7838270B2 (en) 2001-05-22 2010-11-23 The University Of Chicago Target-dependent transcription using deletion mutants of N4 RNA polymerase
US8137911B2 (en) 2001-05-22 2012-03-20 Cellscript, Inc. Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
JP2002345499A (ja) * 2001-05-29 2002-12-03 Eiken Chem Co Ltd 核酸配列を検出する方法及びその方法に使用するキット
CA2450397A1 (en) * 2001-06-12 2002-12-19 Takara Bio Inc. Method of stabilizing reagent for amplifying or detecting nucleic acid and storage method
JP2005052002A (ja) * 2001-07-06 2005-03-03 Wakunaga Pharmaceut Co Ltd 非環状核酸断片の増幅方法
US7056671B2 (en) 2001-08-20 2006-06-06 Takara Bio Inc. Isothermal chimeric primer nucleic acid amplification methods using blocking oglionucleotide
DE60231543D1 (de) * 2001-11-19 2009-04-23 Parallele Bioscience Inc Multiplex-oligonukleotidaddition und zielamplifikation
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
EP1484394A4 (de) 2002-02-20 2005-11-09 Sysmex Corp PRIMER ZUR NUKLEINSÄUREAMPLIFIKATION BEIM NACHWEISEN VON HAUSHALTUNGSGEN-mRNA SOWIE TESTVERFAHREN MIT DIESEN PRIMERN
ATE516365T1 (de) 2002-05-21 2011-07-15 Sysmex Corp Nukleinsäureamplifikationsprimer zum nachweis von cytokeratinen und untersuchungsverfahren mit verwendung der primer
GB0218215D0 (en) * 2002-08-06 2002-09-11 Tepnel Medical Ltd Amplification of nucleic acids
WO2004016755A2 (en) * 2002-08-16 2004-02-26 Geneohm Sciences Amplification of target nucleotide sequence without polymerase chain reaction
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
JP4560285B2 (ja) * 2002-10-02 2010-10-13 栄研化学株式会社 核酸沈澱剤を利用した核酸増幅産物のハイブリダイゼーションアッセイ
WO2004040019A1 (ja) * 2002-10-29 2004-05-13 Riken 核酸の増幅法
JP2004154088A (ja) * 2002-11-08 2004-06-03 Sysmex Corp Ｃｅａ検出のための核酸増幅用プライマーおよび該プライマーを用いた検査方法
US7413857B2 (en) 2002-11-21 2008-08-19 Epicentre Technologies Methods for using riboprimers for strand displacement replication of target sequences
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
JP4280519B2 (ja) * 2003-03-07 2009-06-17 アークレイ株式会社 Ｄｎａ増幅法およびそのためのキット
AU2004230494A1 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
WO2005031005A2 (en) 2003-05-19 2005-04-07 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
CN1813064B (zh) 2003-06-27 2011-11-02 荣研化学株式会社 检测sars冠状病毒的方法
DE602004004955T2 (de) * 2003-08-20 2007-12-06 Sysmex Corp. Probenanalysegerät und eine Vorrichtung zur Detektion von Nukleinsäuren
US20050042145A1 (en) 2003-08-22 2005-02-24 Sysmex Corporation Container for analyzer, detection container, reaction container and packing container for storing detection container
KR100968901B1 (ko) 2003-12-10 2010-07-14 다카라 바이오 가부시키가이샤 핵산의 증폭방법
EP2415878A1 (de) 2003-12-25 2012-02-08 Riken Verfahren zur Amplifikation von Nukleinsäure und Verfahren zur Erkennung von mutierter Nukleinsäure damit
JP4542345B2 (ja) * 2004-01-15 2010-09-15 シスメックス株式会社 分析装置
JP4505230B2 (ja) * 2004-01-20 2010-07-21 シスメックス株式会社 分析装置
JP4632670B2 (ja) * 2004-01-21 2011-02-16 シスメックス株式会社 濁度検出用光学装置及びそれを用いた濁度検出装置
JP4320266B2 (ja) * 2004-01-22 2009-08-26 シスメックス株式会社 分注装置およびそれを備えた分析装置
US20050164375A1 (en) * 2004-01-23 2005-07-28 Sysmex Corporation Nucleic acid detection apparatus
ATE508756T1 (de) 2004-03-05 2011-05-15 Gen Probe Inc Verfahren zur deaktivierung von nukleinsäuren
WO2005093059A1 (ja) * 2004-03-25 2005-10-06 Sapporo Breweries Limited 酵母、乳酸菌及び偏性嫌気性菌検出・識別のためのプライマー及びプライマーセット並びにそれらを用いた検出・識別方法
WO2005113816A2 (en) 2004-05-07 2005-12-01 Henry M. Jackson Foundation For The Advancement Of Military Medicine Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer
ES2401879T3 (es) 2004-08-31 2013-04-25 Eiken Kagaku Kabushiki Kaisha Método de análisis de ácidos nucleicos
JP2008000002A (ja) * 2004-09-30 2008-01-10 Sysmex Corp リブロース２リン酸カルボキシラーゼスモールチェーン１Ａ（ＲＢＣＳ−１Ａ）遺伝子及び／又は該遺伝子のｍＲＮＡを検出するための核酸増幅用プライマ、及び内部標準として該遺伝子及び／又は該遺伝子のｍＲＮＡを用いた検査方法。
US7888014B2 (en) * 2004-10-19 2011-02-15 Nihon University Method of detecting Haemophilus influenzae type b, primer set and kit for the use in the method
ES2382446T3 (es) 2004-11-01 2012-06-08 Eiken Kagaku Kabushiki Kaisha Método de detección del virus de la gripe aviar H5
JP5160725B2 (ja) * 2004-11-02 2013-03-13 シスメックス株式会社 チップラックおよびチップ組立品
WO2006063355A2 (en) * 2004-12-11 2006-06-15 Cytogenix , Inc. Cell free biosynthesis of high-quality nucleic acid and uses thereof
US7964413B2 (en) 2005-03-10 2011-06-21 Gen-Probe Incorporated Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay
EP1930730B1 (de) 2005-03-10 2019-08-14 Gen-Probe Incorporated Systeme und Verfahren zur Durchführung von Tests zum Nachweis oder zur Quantifizierung von Analyten
FR2885140B1 (fr) 2005-04-29 2010-12-31 Millipore Corp Procede de detection et de caracterisation de microorgarnismes sur une membrane.
NZ620811A (en) 2005-05-09 2015-09-25 Theranos Inc Point-of-care fluidic systems and uses thereof
WO2006123423A1 (ja) * 2005-05-20 2006-11-23 Sapporo Breweries Limited フザリウム属菌検出用プライマー
JP4733456B2 (ja) * 2005-07-26 2011-07-27 シスメックス株式会社 前処理の外部精度管理方法、核酸検出処理の外部精度管理方法、検量線作成処理の外部精度管理方法、前処理の外部精度管理コンピュータ、核酸検出処理の外部精度管理コンピュータ、検量線作成処理の外部精度管理コンピュータ、前処理装置、及び核酸検出装置
CN101233243A (zh) 2005-08-10 2008-07-30 财团法人浜松科学技术研究振兴会 大肠癌标记的检测方法
JP2007043997A (ja) * 2005-08-11 2007-02-22 Tosoh Corp 新規な標的核酸の増幅キット
WO2007021004A1 (ja) 2005-08-18 2007-02-22 Eisai R & D Management Co., Ltd. ドーパミン産生ニューロン増殖前駆細胞マーカーＭｓｘ１／２
US20070054301A1 (en) * 2005-09-06 2007-03-08 Gen-Probe Incorporated Methods, compositions and kits for isothermal amplification of nucleic acids
EP1929046B1 (de) * 2005-09-07 2012-07-11 Nugen Technologies, Inc. Verbessertes nukleinsäureamplifikationsverfahren
US8831887B2 (en) * 2005-10-12 2014-09-09 The Research Foundation For The State University Of New York Absolute PCR quantification
US7910719B2 (en) * 2005-12-08 2011-03-22 Kabushiki Kaisha Toshiba Method of detecting human papilloma virus by using nucleic acid amplification method and nucleic acid chain-immobilized carrier
JP4580875B2 (ja) 2006-01-20 2010-11-17 株式会社東芝 核酸検出法のためのプライマーの設計方法
JP4989493B2 (ja) 2006-01-20 2012-08-01 オリンパス株式会社 分子内プローブによる核酸配列の検出方法
JP4516032B2 (ja) * 2006-01-20 2010-08-04 株式会社東芝 ハイブリダイゼーションによる核酸の検出方法およびアッセイキット
JP4881623B2 (ja) * 2006-01-27 2012-02-22 シスメックス株式会社 Ｃｅａ核酸増幅用プライマー、プライマーセット、及びがんの診断支援方法
US7488581B2 (en) 2006-03-20 2009-02-10 Kabushiki Kaisha Toshiba Method for detecting a target nucleic acid sequence
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8198081B2 (en) 2006-04-11 2012-06-12 Eisai R&D Management Co., Ltd. Dopaminergic neuron progenitor cell marker 187A5
JPWO2007123265A1 (ja) * 2006-04-19 2009-09-10 学校法人日本大学 各有莢膜型インフルエンザ菌の検出方法、検出用プライマーセット、及び検出用キット
ES2700606T3 (es) 2006-04-28 2019-02-18 Igor Kutyavin Uso de trifosfatos de desoxinucleósidos modificados en sus bases para mejorar la detección de ácidos nucleicos
US9121056B2 (en) * 2006-04-28 2015-09-01 Igor Kutyavin Use of products of PCR amplification carrying elements of secondary structure to improve PCR-based nucleic acid detection
RU2404255C2 (ru) 2006-05-16 2010-11-20 Кирин Бир Кабусики Кайся Набор праймеров для использования при детекции дрожжей рода dekkera и дрожжей рода brettanomyces
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
DK2017356T3 (da) 2006-06-06 2012-01-30 Gen Probe Inc Mærkede oligonukleotider og anvendelse deraf i fremgangsmåder til amplifikation af nukleinsyrer
JP4918409B2 (ja) * 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
ATE538216T1 (de) * 2006-07-31 2012-01-15 Wanli Bi Nukleinsäureverstärkung mithilfe eines reversibel modifizierten oligonukleotids
US9045522B2 (en) 2006-07-31 2015-06-02 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
EP2520935A3 (de) 2006-08-09 2013-02-13 Homestead Clinical Corporation Organspezifische Proteine und Verfahren zu deren Verwendung
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
EP2058396A4 (de) 2006-08-31 2010-06-30 Toyo Seikan Kaisha Ltd Nukleinsäureamplifikationsverfahren
CA2665188C (en) 2006-10-04 2014-08-19 Third Wave Technologies, Inc. Snap-back primers and detectable hairpin structures
DE112007002345T5 (de) 2006-10-05 2010-12-16 Kirin Beer Kabushiki Kaisha Primersatz zur Verwendung in der Detektion eines Hefepilzes der Gattung Saccharomyces
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
JP2008136389A (ja) * 2006-11-30 2008-06-19 Sapporo Breweries Ltd アップルモザイクウイルスの検出方法、検出用プライマーセット及び検出用キット
JP2008136386A (ja) * 2006-11-30 2008-06-19 Sapporo Breweries Ltd ホップ潜在ウイルスの検出方法、検出用プライマーセット及び検出用キット
JP2008194028A (ja) 2007-01-15 2008-08-28 Sysmex Corp 胃がんのリンパ節転移判定方法
CN101605911A (zh) 2007-01-17 2009-12-16 梅里第安生物科学公司 有效用于核酸的环-介导的等温扩增(lamp)的稳定试剂和试剂盒
JP4331216B2 (ja) 2007-02-09 2009-09-16 株式会社東芝 遺伝子変異の検出方法
JP2008212009A (ja) 2007-02-28 2008-09-18 Sysmex Corp Ｄｎａメチル化検出用試料の調製方法
WO2008111464A1 (ja) 2007-03-05 2008-09-18 Eisai R & D Management Co., Ltd. スプライシング異常を指標とする抗ガン剤の作用検定方法
JPWO2008111466A1 (ja) 2007-03-05 2010-06-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 遺伝子の発現量減少を指標とする抗ガン剤の作用検定方法
CA2622649C (en) 2007-03-09 2018-04-24 Riken Nucleic acid amplification method using primer exhibiting exciton effect
US8153064B2 (en) 2007-03-22 2012-04-10 Doebler Ii Robert W Systems and devices for isothermal biochemical reactions and/or analysis
JP4410268B2 (ja) * 2007-03-28 2010-02-03 株式会社東芝 メチレンテトラヒドロ葉酸還元酵素（ｍｔｈｆｒ）の遺伝子型を検出するための核酸プライマーセット及び核酸プローブ
JP4410269B2 (ja) 2007-03-28 2010-02-03 株式会社東芝 Ｎ−アセチルトランスフェラーゼ２（ｎａｔ２）の遺伝子型を検出するための核酸プライマーセット、キット、及び該プライマーセットを用いた検出方法
JP4490988B2 (ja) * 2007-04-26 2010-06-30 株式会社東芝 血清アミロイドａ１（ｓａａ１）の遺伝子型を検出するための核酸プライマーセット、キット、及び該プライマーセットを用いた検出方法
EP2527475B1 (de) 2007-05-28 2015-05-13 Ehime University Primer zur Detektion von Plasmodium
JP2009000044A (ja) * 2007-06-21 2009-01-08 Hitachi High-Technologies Corp 核酸増幅法
EP2175999B1 (de) 2007-06-21 2017-01-04 Gen-Probe Incorporated Behälter zur durchführung von prozessen
JP4551917B2 (ja) * 2007-07-18 2010-09-29 株式会社東芝 ヒトチトクロームｐ４５０（ｃｙｐ）２ｄ６遺伝子変異の検出方法
WO2009042291A2 (en) * 2007-08-03 2009-04-02 Igor Kutyavin Accelerated cascade amplification (aca) of nucleic acids comprising strand and sequence specific dna nicking
CA2701794C (en) 2007-10-02 2017-10-31 Theranos, Inc. Modular point-of-care devices and uses thereof
WO2009054510A1 (ja) 2007-10-25 2009-04-30 Riken 等温増幅方法およびそれに用いるｄｎａポリメラーゼ
US20090162856A1 (en) * 2007-11-06 2009-06-25 Hayato Miyoshi Rna detection method
WO2009089466A2 (en) 2008-01-09 2009-07-16 Keck Graduate Institute System, apparatus and method for material preparation and/or handling
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
JPWO2009119331A1 (ja) * 2008-03-28 2011-07-21 シスメックス株式会社 サイトケラチン７のｍＲＮＡの検出用プライマを含む試薬
EP2479287B1 (de) 2008-05-13 2014-07-23 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und Fangen von Zielnukleinsäuresequenzen
WO2009143603A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
EP2298884B1 (de) 2008-05-28 2014-06-18 Kao Corporation Verfahren zum nachweis eines thermotoleranten bakteriums
EP2298885A4 (de) * 2008-05-29 2012-12-19 Sysmex Corp Primer zum nachweis von tyrosinase-mrna
EP2325309B1 (de) 2008-05-29 2014-10-22 Kao Corporation Verfahren zum nachweis von paecilomyces variotii
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
JP5383105B2 (ja) * 2008-06-30 2014-01-08 キユーピー株式会社 オリゴヌクレオチド及びこれをプライマーとして用いたバチルス・コアグランスの検出法
US20110171649A1 (en) * 2008-09-10 2011-07-14 Igor Kutyavin Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
US9080211B2 (en) 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
EP3272879B1 (de) 2008-10-24 2019-08-07 Epicentre Technologies Corporation Transposonendenzusammensetzungen und verfahren zur modifizierung von nukleinsäuren
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
EP2371951A4 (de) 2008-11-27 2012-07-18 Riken NEUARTIGES MutS-PROTEIN UND SEINE VERWENDUNG ZUR BESTIMMUNG VON MUTATIONEN
KR101805927B1 (ko) 2008-12-25 2017-12-06 유니바사루 바이오 리사치 가부시키가이샤 검체의 전처리 방법, 및 생체 관련 물질의 측정 방법
CA2750820A1 (en) * 2009-01-27 2010-08-05 Qiagen Gaithersburg Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
WO2010088496A1 (en) 2009-01-30 2010-08-05 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
US8409805B2 (en) * 2009-02-13 2013-04-02 Asuragen, Inc. Method of amplification of GC-rich DNA templates
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
EP2411532B1 (de) * 2009-03-24 2017-04-05 Asuragen, Inc. Pcr-verfahren zur charakterisierung des 5 -nichttranslatierten bereichs der gene fmr1 und fmr2
EP3360978A3 (de) 2009-05-07 2018-09-26 Veracyte, Inc. Verfahren zur diagnose von schilddrüsenerkrankungen
US9260475B2 (en) 2009-06-26 2016-02-16 Claremont Biosolutions Llc Capture and elution of bio-analytes via beads that are used to disrupt specimens
EP2272980A1 (de) * 2009-07-09 2011-01-12 Bioesplora SRL Molekulare Sonden zum Nachweis und zur Quantifizierung von Target-Nukleinsäure
EP2272978B1 (de) 2009-07-10 2012-04-18 Biotrin International Limited Hochsensibles schnelles isothermisches Verfahren zur Detektion von Punktmutationen und SNPs
JPWO2011007889A1 (ja) 2009-07-17 2012-12-27 東洋製罐株式会社 核酸の増幅方法
EP2287335A1 (de) 2009-08-05 2011-02-23 DiaSorin S.p.A. Hoch empfindliches schnelles isothermisches Verfahren zur Erkennung von Methylierungsstrukturen
AU2010284329B2 (en) * 2009-08-18 2015-04-16 Takeda Pharmaceutical Company Limited Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
US8598327B2 (en) 2009-08-18 2013-12-03 Baxter International Inc. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
EP2473624B1 (de) 2009-08-31 2019-05-01 Gen-Probe Incorporated Test für dengue-virus
WO2011037802A2 (en) 2009-09-28 2011-03-31 Igor Kutyavin Methods and compositions for detection of nucleic acids based on stabilized oligonucleotide probe complexes
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
CA2896129C (en) 2010-01-22 2015-12-29 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
JP2012000031A (ja) 2010-06-15 2012-01-05 Sysmex Corp 肺がんのリンパ節転移の検査方法、肺がんのリンパ節転移判定装置およびコンピュータプログラム
CN102985566B (zh) 2010-06-30 2015-06-17 简.探针公司 使用分析物和过程控制信号的单次读取确定而鉴定含分析物的样品的方法和设备
WO2012029993A1 (en) 2010-09-02 2012-03-08 Riken Method of detecting type ii diabetes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012054638A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the detection of analytes
WO2012061283A1 (en) 2010-11-04 2012-05-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rapid molecular assays for specific detection and quantitation of loa loa microfilaremia
TWI435935B (zh) * 2010-12-06 2014-05-01 Univ Nat Cheng Kung 快速檢測標靶核酸片段之套組及方法
US9845495B2 (en) 2010-12-10 2017-12-19 Abbott Laboratories Method and kit for detecting target nucleic acid
CN106290159A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的***和方法
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
CN103097531B (zh) 2011-06-29 2016-11-23 达纳福股份有限公司 生物样本的预处理方法、rna的检测方法及预处理试剂盒
GB201112140D0 (en) 2011-07-14 2011-08-31 Dna Electronics Nucleic acid amplification
EP2746395B1 (de) * 2011-09-08 2017-11-29 Kabushiki Kaisha DNAFORM Primer-set, verfahren zur amplifizierung einer nukleinsäuresequenz damit und verfahren zur erkennung von mutierter nukleinsäure damit
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
WO2013044097A1 (en) 2011-09-21 2013-03-28 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
EP3865875A1 (de) 2011-09-25 2021-08-18 Labrador Diagnostics LLC Systeme und verfahren für mehrfachanalyse
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
ES2755934T3 (es) 2011-10-31 2020-04-24 Eiken Chemical Método para detectar ácido nucleico diana
WO2013067272A1 (en) * 2011-11-04 2013-05-10 Diagnostics For All, Inc. Low cost, disposable molecular diagnostic devices
WO2013090620A1 (en) 2011-12-13 2013-06-20 Genomedx Biosciences, Inc. Cancer diagnostics using non-coding transcripts
WO2013129542A1 (ja) 2012-02-29 2013-09-06 独立行政法人理化学研究所 Ｈｌａ－ａ＊３１：０１アレルの検出方法
EP3486332B1 (de) 2012-03-29 2023-04-26 Becton, Dickinson and Company Nukleinsäuren zur nukleinsäureamplifikation
CN107727874B (zh) 2012-04-13 2021-03-05 贝克顿·迪金森公司 使用先前检验的残余材料反射检验样本
WO2014007402A1 (ja) 2012-07-06 2014-01-09 京都府公立大学法人 眼細胞の分化マーカーおよび分化制御
US20140038182A1 (en) 2012-07-17 2014-02-06 Dna Logix, Inc. Cooperative primers, probes, and applications thereof
US9371560B2 (en) 2012-07-20 2016-06-21 Asuragen, Inc. Comprehensive FMR1 genotyping
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
CA2881627A1 (en) 2012-08-16 2014-02-20 Genomedx Biosciences Inc. Cancer diagnostics using biomarkers
WO2014042986A1 (en) 2012-09-11 2014-03-20 Theranos, Inc. Information management systems and methods using a biological signature
JP2015536672A (ja) 2012-11-28 2015-12-24 エービーウィズ バイオ，インク． 単一プライマー増幅における使用のための遺伝子特異的なテンプレートの調製
JP6200281B2 (ja) 2012-11-29 2017-09-20 シスメックス株式会社 甲状腺腫瘍の性状の判別を補助する方法およびその方法に用いるマーカーセット
CN105164508B (zh) 2013-02-18 2019-04-02 赛拉诺斯知识产权有限责任公司 用于采集和传输测定结果的***和方法
AU2014248813B2 (en) 2013-03-11 2016-05-19 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
AU2013202788B2 (en) 2013-03-14 2015-10-01 Gen-Probe Incorporated Indexing signal detection module
AU2013202778A1 (en) 2013-03-14 2014-10-02 Gen-Probe Incorporated Systems, methods, and apparatuses for performing automated reagent-based assays
EP3587592A1 (de) 2013-03-15 2020-01-01 Theranos IP Company, LLC Nukleinsäureamplifikation
WO2014151177A1 (en) 2013-03-15 2014-09-25 3M Innovative Properties Company Sample concentrator and method of use
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
EP2971123B1 (de) * 2013-03-15 2021-05-05 Labrador Diagnostics LLC Nukleinsäureamplifikation
AU2014233213A1 (en) 2013-03-15 2015-09-17 Theranos Ip Company, Llc Thermostable blunt-end ligase and methods of use
US9994916B2 (en) 2013-03-15 2018-06-12 Becton, Dickinson And Company Detection of neisseria gonorrhoeaes
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
KR20150130387A (ko) 2013-03-15 2015-11-23 테라노스, 인코포레이티드 시료 준비용 기기, 시스템 및 방법
WO2014145298A1 (en) 2013-03-15 2014-09-18 Theranos, Inc. Nucleic acid amplification
JP6286419B2 (ja) 2013-03-26 2018-02-28 株式会社ニッポンジーン 遺伝子多型の識別に用いるプライマーとプローブのセットおよびその利用
JP5951545B2 (ja) 2013-03-29 2016-07-13 シスメックス株式会社 検体分析装置、検体分析方法、及びコンピュータプログラム
EP3004433B1 (de) 2013-05-30 2018-09-05 The Regents of The University of California Im wesentlichen gleichmässige amplifizierung von genomen
CN103276083B (zh) * 2013-05-30 2014-11-19 首都医科大学附属北京友谊医院 肺炎支原体检测试剂盒
US10392670B2 (en) 2013-07-25 2019-08-27 Dch Molecular Diagnostics, Inc. Methods and compositions for detecting bacterial contamination
EP3029140A4 (de) 2013-07-30 2017-06-28 Kyoto Prefectural Public University Corporation Hornhautendothel-zellmarker
EP3030680B1 (de) 2013-08-09 2018-10-03 Luminex Corporation Schmelzunterscheidung und multiplexierung in nukleinsäuretests
CN105452480B (zh) * 2013-08-09 2020-01-31 基因生物***股份有限公司 经由剪刀状结构的dna扩增(dasl)
EP3042208A4 (de) 2013-09-06 2017-04-19 Theranos, Inc. Systeme und verfahren zur erkennung von infektionskrankheiten
JP6118223B2 (ja) 2013-09-27 2017-04-19 シスメックス株式会社 液体吸引装置、検体分析装置、およびチップ収容容器
JP6339787B2 (ja) * 2013-10-09 2018-06-06 株式会社日立ハイテクノロジーズ 核酸の分析方法
WO2015058008A2 (en) 2013-10-18 2015-04-23 California Institute Of Technology Enhanced nucleic acid identification and detection
EP3063272A2 (de) 2013-10-30 2016-09-07 Green Life Biotech, LLC Pathogenesequantifizierungssysteme und behandlungsverfahren für mehltau von zitrusgewächsen
JP2015087329A (ja) 2013-10-31 2015-05-07 シスメックス株式会社 吸引部の位置調整方法及び検体処理装置
US10385335B2 (en) 2013-12-05 2019-08-20 Centrillion Technology Holdings Corporation Modified surfaces
EP3077545B1 (de) 2013-12-05 2020-09-16 Centrillion Technology Holdings Corporation Verfahren zur sequenzierung von nukleinsäuren
EP3628747B1 (de) 2013-12-05 2022-10-05 Centrillion Technology Holdings Corporation Herstellung von gemusterten anordnungen
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CN104946737B (zh) 2013-12-11 2019-02-22 安可济控股有限公司 用于检测罕见序列变体的组合物和方法
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
ES2754251T3 (es) 2014-01-15 2020-04-16 Abbott Lab Secuencia cubierta de conversión de ADN y métodos de detección
CN103789436B (zh) * 2014-01-30 2015-09-30 思博奥科生物信息科技（北京）有限公司 一种基于人工修饰引物的定量突变检测***
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
EA037029B1 (ru) 2014-03-31 2021-01-28 КАБУСИКИ КАЙСЯ ДиЭнЭйФОРМ Флуоресцентно меченная одноцепочечная нуклеиновая кислота и ее применение
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
WO2015183837A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
WO2015183836A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
EP3151965B1 (de) 2014-06-04 2021-02-24 Edan Instruments, Inc. Vorrichtungen zur probennahme und -analyse
US10017759B2 (en) 2014-06-26 2018-07-10 Illumina, Inc. Library preparation of tagged nucleic acid
US10364458B2 (en) 2014-07-16 2019-07-30 Tangen Biosciences, Inc. Isothermal methods for amplifying nucleic acid samples
CA2956812C (en) 2014-08-11 2023-04-11 Luminex Corporation Probes for improved melt discrimination and multiplexing in nucleic acid assays
JP6773651B2 (ja) 2014-10-14 2020-10-21 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ ポリｄｎａスペーサー配列を有する配列変換およびシグナル増幅ｄｎａならびにそれらを用いた検出方法
JP6491458B2 (ja) 2014-10-31 2019-03-27 シスメックス株式会社 核酸増幅方法
CN107208012B (zh) 2014-11-03 2021-06-29 唐恩生物科学公司 用于细胞、孢子或病毒捕获和破碎的装置和方法
CN114606309A (zh) 2014-11-05 2022-06-10 威拉赛特公司 使用机器学习和高维转录数据的诊断***和方法
CA2967351A1 (en) 2014-11-11 2016-05-19 Illumina, Inc. Polynucleotide amplification using crispr-cas systems
CN108064312B (zh) 2014-12-24 2022-04-08 雅培实验室 基于具有靶扩增的信号放大dna级联反应的检测方法
US10724091B1 (en) 2015-02-10 2020-07-28 National Technology & Engineering Solutions Of Sandia, Llc Endpoint detection of amplified nucleic acids
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
JP6518110B2 (ja) * 2015-03-31 2019-05-22 株式会社カネカ クレブシエラ・ニューモニエ（Ｋｌｅｂｓｉｅｌｌａｐｎｅｕｍｏｎｉａｅ）を検出するためのプライマー及び方法
EP3283512A4 (de) 2015-04-17 2018-10-03 Distributed Bio Inc Verfahren zur massenhumanisierung von nichthumanen antikörpern
AU2016252998B2 (en) 2015-04-24 2021-11-04 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
AU2016252551B2 (en) 2015-04-24 2020-07-02 Becton, Dickinson And Company Multiplex detection of vulvovaginal candidiasis, trichomoniasis and bacterial vaginosis
US11015217B2 (en) 2015-05-29 2021-05-25 Roche Molecular Systems, Inc. Method of inactivating microbes by citraconic anhydride
US10260090B2 (en) 2015-07-16 2019-04-16 Arizona Board Of Regents On Behalf Of Arizona State University Accelerated isothermal amplification of DNA
EP3325153B1 (de) 2015-07-17 2020-03-18 Cue Health Inc. Kartusche zur probenanalyse
US11214829B2 (en) 2015-07-23 2022-01-04 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
KR20180055905A (ko) 2015-10-09 2018-05-25 아큐라젠 홀딩스 리미티드 증폭 산물의 농축을 위한 방법 및 조성물
CN108699505A (zh) 2015-12-03 2018-10-23 安可济控股有限公司 用于形成连接产物的方法和组合物
US20190032104A1 (en) 2016-01-21 2019-01-31 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
US20190083543A1 (en) 2016-02-15 2019-03-21 Kyoto Prefectural Public University Corporation Human functional corneal endothelial cell and application thereof
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
WO2017173342A1 (en) 2016-03-31 2017-10-05 William Beaumont Hospital Methods for detecting, diagnosing and treating ulcerative interstitial cystitis
EP3443124B1 (de) 2016-04-14 2022-08-17 T2 Biosystems, Inc. Verfahren zur amplifikation in komplexen proben
WO2017197027A1 (en) 2016-05-11 2017-11-16 Illumina, Inc. Polynucleotide enrichment and amplification using argonaute systems
US11427866B2 (en) 2016-05-16 2022-08-30 Accuragen Holdings Limited Method of improved sequencing by strand identification
WO2017212904A1 (ja) * 2016-06-06 2017-12-14 国立大学法人 宮崎大学 複数のプライマーセットを組み合わせたｌａｍｐ法を用いたアフリカ豚コレラウイルスの迅速検出法
SG11201901296TA (en) 2016-08-15 2019-03-28 Accuragen Holdings Ltd Compositions and methods for detecting rare sequence variants
WO2018039490A1 (en) 2016-08-24 2018-03-01 Genomedx Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
AU2017325833B2 (en) 2016-09-15 2022-06-16 Abbott Laboratories Devices and methods for sample analysis
US10724089B2 (en) 2016-10-06 2020-07-28 The Board Of Trustees Of The University Of Illinois Spatial molecular analysis of tissue
EP3565907B1 (de) 2017-01-06 2022-05-04 Editas Medicine, Inc. Verfahren zur beurteilung der nukleasespaltung
AU2018210695A1 (en) 2017-01-20 2019-08-08 The University Of British Columbia Molecular subtyping, prognosis, and treatment of bladder cancer
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
WO2018165600A1 (en) 2017-03-09 2018-09-13 Genomedx Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
JP6924600B2 (ja) 2017-04-10 2021-08-25 シスメックス株式会社 測定方法、測定装置、プログラム、演算式の取得方法および定性判定結果の表示方法
US11366116B1 (en) 2017-04-12 2022-06-21 National Technology & Engineering Solutions Of Sandia, Llc Real time autonomous surveillance of pathogens
CN110809495A (zh) 2017-04-26 2020-02-18 伯克利之光生命科技公司 使用具有优化电润湿表面的微流体装置的生物处理***和方法
EP3619533B1 (de) 2017-05-05 2022-09-28 bioMérieux Erkennungsverfahren einer zellulären immunantwort
US11078542B2 (en) 2017-05-12 2021-08-03 Decipher Biosciences, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
US10914729B2 (en) 2017-05-22 2021-02-09 The Trustees Of Princeton University Methods for detecting protein binding sequences and tagging nucleic acids
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
EP3643790A4 (de) 2017-06-23 2021-03-24 Eiken Kagaku Kabushiki Kaisha Verfahren zur nukleinsäuredetektion, primer zur nukleinsäuredetektion und kit zur nukleinsäuredetektion
WO2019073049A1 (en) 2017-10-12 2019-04-18 Danmarks Tekniske Universitet ISOTHERMIC AMPLIFICATION IN SOLID PHASE
CA3080117A1 (en) 2017-10-27 2019-05-02 Juno Diagnostics, Inc. Devices, systems and methods for ultra-low volume liquid biopsy
US10724083B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands
US10724017B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands
US10689629B1 (en) 2017-12-06 2020-06-23 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
CA3123182A1 (en) 2017-12-14 2019-06-20 Medicinal Genomics Corporation Methods and kits for classifying cannabinoid production in cannabis plants
EP3749786B1 (de) 2018-02-05 2024-01-17 Syngenta Participations Ag Verfahren zum nachweis von pilzen in rasengras mit einem lampentest mit neuen primersätzen
JP7176682B2 (ja) 2018-02-22 2022-11-22 佐藤製薬株式会社 白癬菌の遺伝子をｌａｍｐ法により検出するためのプライマーセット及びそれを含むキット並びにそれらを用いて白癬菌を検出する方法
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
FR3080185A1 (fr) 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
US11155873B2 (en) 2018-04-20 2021-10-26 Epigeneron, Inc. Method for detecting variation of reference sequence in target nucleic acid region
FR3085689A1 (fr) 2018-09-12 2020-03-13 Biomerieux Procede pour determiner in vitro ou ex vivo le statut immunitaire d'un individu
CN112714797A (zh) 2018-06-29 2021-04-27 生物梅里埃公司 用于体外或离体确定个体免疫状态的方法
AU2019319203A1 (en) 2018-08-08 2021-03-11 Gen-Probe Incorporated Compositions, methods and kits for detecting
JP2022511633A (ja) 2018-11-28 2022-02-01 キージーン ナムローゼ フェンノートシャップ エンドヌクレアーゼ保護による標的化濃縮
WO2020118255A1 (en) 2018-12-07 2020-06-11 Element Biosciences, Inc. Flow cell device and use thereof
CN113302314A (zh) 2019-01-15 2021-08-24 3M创新有限公司 用于产志贺毒素大肠杆菌(stec)检测的环介导的等温扩增引物
CN113474466A (zh) 2019-02-21 2021-10-01 主基因有限公司 多倍体基因分型
CN113924041A (zh) 2019-03-14 2022-01-11 因斯利克萨公司 基于时间门控的荧光检测的方法和***
EP3708678A1 (de) 2019-03-15 2020-09-16 Adisseo France S.A.S. Verfahren zur identifizierung eines stresszustands in einer person
CN113906146A (zh) 2019-03-27 2022-01-07 朱诺诊断学公司 优化的超低体积液体活检方法、***和设备
CN113646007A (zh) 2019-03-29 2021-11-12 希森美康株式会社 新人工核酸、其制造方法及用途
AR120629A1 (es) 2019-07-23 2022-03-02 Laboratorio Pablo Cassara S R L Kit de diagnóstico de fundamento molecular para la detección de secuencias nucleotídicas, y métodos para detectar agentes infecciosos usando dicho kit
US20220298548A1 (en) 2019-08-23 2022-09-22 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
FR3101358A1 (fr) 2019-09-27 2021-04-02 Bioaster Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3101423A1 (fr) 2019-10-01 2021-04-02 bioMérieux Procédé pour déterminer la capacité d’un individu à répondre à un stimulus
EP4038202A1 (de) 2019-10-01 2022-08-10 Biomérieux Verfahren zum bestimmen der ansprechbarkeit eines individuums auf einen stimulus
SG10201910254YA (en) * 2019-11-04 2021-06-29 Denka Company Ltd Nucleic Acid Detection Method Using Lamp And Probe Detection
WO2021095798A1 (ja) * 2019-11-15 2021-05-20 公立大学法人横浜市立大学 未分化マーカー遺伝子高感度検出法
EP4073245A1 (de) 2019-12-12 2022-10-19 Keygene N.V. Halbfestkörper-nukleinsäuremanipulation
EP4077661A1 (de) 2019-12-20 2022-10-26 Keygene N.V. Herstellung von ngs-bibliotheken unter verwendung von kovalent verschlossenen nukleinsäuremolekül-enden.
FR3107282A1 (fr) 2020-02-14 2021-08-20 Enalees Trousses et procédés pour l’extraction d’acides nucléiques à partir d’échantillons complexes
CN115103919A (zh) 2020-02-17 2022-09-23 3M创新有限公司 用于副溶血弧菌检测的环介导的等温扩增引物及其用途
WO2021172370A1 (ja) 2020-02-27 2021-09-02 栄研化学株式会社 一本鎖ｒｎａウイルスを検出する方法
JP7313537B2 (ja) * 2020-03-05 2023-07-24 栄研化学株式会社 コロナウイルス（ＳＡＲＳ－ＣｏＶ－２）の検出方法
EP3878971A1 (de) 2020-03-10 2021-09-15 Commissariat à l'énergie atomique et aux énergies alternatives Verfahren zum nachweis und gegebenenfalls zur quantifizierung eines analyten mit einem oligonukleotid mit doppelter haarnadelstruktur und dieses oligonukleotid
FR3108124A1 (fr) 2020-03-10 2021-09-17 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé pour détecter et éventuellement quantifier un analyte avec un oligonucléotide à double structure tige-boucle et ledit oligonucléotide
US10968493B1 (en) 2020-03-12 2021-04-06 New England Biolabs, Inc. Rapid diagnostic test using colorimetric LAMP
US11345970B2 (en) 2020-03-12 2022-05-31 New England Biolabs, Inc. Rapid diagnostic test for LAMP
EP4118233A1 (de) 2020-03-12 2023-01-18 New England Biolabs, Inc. Schneller diagnosetest für lampe
US11732315B2 (en) 2020-03-12 2023-08-22 New England Biolabs, Inc. Rapid diagnostic test for lamp
CN115867653A (zh) 2020-03-13 2023-03-28 艾优实验室公司 用于检测靶核酸的环状引物和loop-de-loop方法
US11149320B1 (en) 2020-03-31 2021-10-19 Diasorin S.P.A. Assays for the detection of SARS-CoV-2
WO2021220192A2 (en) 2020-04-30 2021-11-04 Stab Vida - Investigação E Serviços Em Ciências Biológicas, Lda Method and portable device for detection of nucleic sequences in suspected coronavirus samples
CA3177886A1 (en) 2020-05-05 2021-11-11 Miron TOKARSKI Diagnostic primers, kits and methods for viral detection
CA3186580A1 (en) 2020-06-12 2021-12-16 Sherlock Biosciences, Inc. Crispr-based sars-cov-2 detection
FR3112211A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112209A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de complication chez un patient
FR3112207A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112210A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112208A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
US11898197B2 (en) 2020-07-30 2024-02-13 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
US11904314B2 (en) 2020-07-30 2024-02-20 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
WO2022040443A2 (en) 2020-08-21 2022-02-24 New England Biolabs, Inc. A rapid diagnostic test for lamp
CN116322706A (zh) 2020-09-25 2023-06-23 株式会社理真思 新人工核酸、其制造方法和用途
EP4225914A1 (de) 2020-10-06 2023-08-16 Keygene N.V. Gezielte sequenzaddition
WO2022075403A1 (ja) 2020-10-08 2022-04-14 国立研究開発法人国立国際医療研究センター １種以上のｈｌａ遺伝子用プライマー
EP3992300A1 (de) 2020-10-30 2022-05-04 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO Probenvorbehandlung zur isothermen amplifikation
US20240011106A1 (en) 2020-11-05 2024-01-11 Becton, Dickinson And Company Multiplex detection and typing of vibrio cholerae
JP2023547535A (ja) 2020-11-05 2023-11-10 ベクトン・ディキンソン・アンド・カンパニー ビブリオ・パラヘモリティクスの迅速な同定及び分類
CA3194255A1 (en) 2020-11-05 2022-05-12 Becton, Dickinson And Company Multiplex detection of bacterial respiratory pathogens
CA3198242A1 (en) 2020-11-10 2022-05-19 Pavol Cekan Loop mediated isothermal nucleic acid amplification (lamp) using lna-modified primers and a metal-based colorimetric method for detecting an amplification product
WO2022106795A1 (fr) 2020-11-20 2022-05-27 bioMérieux Procédé de classification d'un individu
US20240002904A1 (en) 2020-11-24 2024-01-04 Keygene N.V. Targeted enrichment using nanopore selective sequencing
EP4251750A1 (de) 2020-11-25 2023-10-04 Koninklijke Nederlandse Akademie van Wetenschappen Ribosomale profilierung in einzelzellen
JP6972291B1 (ja) 2020-12-24 2021-11-24 栄研化学株式会社 核酸増幅方法、核酸増幅方法用プライマーセット、プローブ、及びキット
EP4281589A1 (de) 2021-01-25 2023-11-29 Life Technologies Corporation Zusammensetzungen, kits und verfahren zum nachweis viraler variantensequenzen
US11788129B2 (en) 2021-02-23 2023-10-17 Industrial Technology Research Institute Nucleic acid detection kit and nucleic acid detection method
JP2024510206A (ja) 2021-03-09 2024-03-06 イルミナ インコーポレイテッド ＣＡＳ－ｇＲＮＡリボ核タンパク質を使用するゲノムライブラリー調製及び標的化エピジェネティックアッセイ
JP2024509446A (ja) 2021-03-09 2024-03-01 イルミナ インコーポレイテッド 細胞におけるタンパク質コード変異体の発現の分析
EP4314350A1 (de) 2021-03-23 2024-02-07 Life Technologies Corporation Zusammensetzungen, kits und verfahren für den variantenresistenten nachweis von zielvirussequenzen
WO2022226870A1 (zh) * 2021-04-29 2022-11-03 中国科学院大学宁波生命与健康产业研究院 恒温条件下合成核酸的方法及试剂盒和应用
FR3125065A1 (fr) 2021-07-08 2023-01-13 bioMérieux Procédé et kit de détection d’un virus respiratoire réplicatif
WO2023014729A1 (en) 2021-08-02 2023-02-09 Life Technologies Corporation Compositions, kits, and methods for detection of nucleic acid sequence loads
EP4381094A1 (de) 2021-08-03 2024-06-12 Wageningen Universiteit Argonautenbasiertes nukleinsäurenachweissystem
WO2023018730A1 (en) 2021-08-11 2023-02-16 Illumina, Inc. Detection of analytes using targeted epigenetic assays, proximity-induced tagmentation, strand invasion, restriction, or ligation
FR3126983A1 (fr) 2021-09-15 2023-03-17 Commissariat A L'energie Atomique Et Aux Energies Alternatives Oligonucléotide à double structure tige-boucle et utilisation dans la détection d’analytes d’intérêt
WO2023069604A1 (en) 2021-10-20 2023-04-27 Life Technologies Corporation Compositions, kits, and methods for quantification of nucleic acid sequences using an internal quantitative standard
WO2023081221A1 (en) 2021-11-02 2023-05-11 Life Technologies Corporation Compositions and methods for reducing master mix contamination
KR20230078548A (ko) 2021-11-24 2023-06-02 주식회사 위즈바이오솔루션 루프-매개 등온 증폭 방법에서 다중 검출을 위한 형광 표지 물질 프라이머 셋트 및 이를 이용한 분자 진단 방법
WO2023118399A1 (en) 2021-12-24 2023-06-29 F. Hoffmann-La Roche Ag Improved detection of lamp amplification products
FR3131315A1 (fr) 2021-12-27 2023-06-30 Commissariat A L'energie Atomique Et Aux Energies Alternatives Oligonucléotide linéaire et utilisation dans la détection d’analytes d’intérêt
WO2024003114A1 (en) 2022-06-29 2024-01-04 Actome Gmbh Detection of biomolecules in single cells
FR3139579A1 (fr) 2022-09-09 2024-03-15 bioMérieux Procédé de détection in vitro ou ex vivo d’un statut immunodéprimé chez un sujet
WO2024054925A1 (en) 2022-09-09 2024-03-14 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
WO2024110392A1 (en) 2022-11-22 2024-05-30 bioMérieux New nucleic acid binding compounds and uses
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US6197563B1 (en) 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
US5104791A (en) 1988-02-09 1992-04-14 E. I. Du Pont De Nemours And Company Particle counting nucleic acid hybridization assays
JP2650159B2 (ja) 1988-02-24 1997-09-03 アクゾ・ノベル・エヌ・ベー 核酸増幅方法
DE4010465A1 (de) 1990-03-31 1991-10-02 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleinsaeuretemplates und zur bestimmung von nukleinsaeuren
US5595891A (en) 1990-07-19 1997-01-21 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5455166A (en) * 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5525462A (en) 1991-05-02 1996-06-11 Toyo Boseki Kabushiki Kaisha Nucleic acid sequence amplification method, detection method, and reagent kit therefor
US5714323A (en) * 1991-08-30 1998-02-03 The University Of Medecine And Dentistry Of New Jersey Over expression of single-stranded molecules
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5612199A (en) 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
ES2112302T3 (es) 1991-10-11 1998-04-01 Behringwerke Ag Metodo para producir un polinucleotido para uso en amplificacion con un unico cebador y oligonucleotidos que contienen fosforotioato como cebadores para la amplificacion de acidos nucleicos.
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
EP0639230A1 (de) 1992-04-27 1995-02-22 Research Corporation Technologies, Inc. Oligonukleotide und Nukleinsäuren zum Nachweis von Ureaplasma Urealyticum
AU689789B2 (en) 1993-07-23 1998-04-09 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
FR2708288B1 (fr) * 1993-07-26 1995-09-01 Bio Merieux Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
EP0669928A1 (de) 1993-08-18 1995-09-06 Chromagen, Inc. Anwendung von fluoreszierenden n-nukleosiden und fluoreszierenden strukturanalogen von n-nukleosiden
US5547861A (en) * 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5648211A (en) * 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5686271A (en) 1994-06-09 1997-11-11 Gamera Bioscience Corporation Apparatus for performing magnetic cycle reaction
FR2721945B1 (fr) * 1994-07-04 1996-10-18 David Fabrice Accroissement genique, un procede d'amplicication genique isotherme et ses applications
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
US5665545A (en) 1994-11-28 1997-09-09 Akzo Nobel N.V. Terminal repeat amplification method
US6270962B1 (en) 1995-01-30 2001-08-07 The Regents Of The University Of California Methods for the elimination of DNA sequencing artifacts
US5674683A (en) 1995-03-21 1997-10-07 Research Corporation Technologies, Inc. Stem-loop and circular oligonucleotides and method of using
GB9507238D0 (en) * 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
WO1997004131A1 (en) * 1995-07-21 1997-02-06 Forsyth Dental Infirmary For Children Single primer amplification of polynucleotide hairpins
US5888731A (en) * 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
US5866331A (en) 1995-10-20 1999-02-02 University Of Massachusetts Single molecule detection by in situ hybridization
JPH09168400A (ja) * 1995-12-20 1997-06-30 Sekisui Chem Co Ltd 核酸の定量方法
CA2268368A1 (en) * 1997-08-28 1999-03-11 The Perkin-Elmer Corporation Improved detection of mutations in nucleic acids by chemical cleavage
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6794133B1 (en) 1997-12-11 2004-09-21 The General Hospital Corporation Broad range PCR amplification techniques
JP3115270B2 (ja) * 1997-12-19 2000-12-04 コナミ株式会社 ゲームシステムおよびゲーム用プログラムが記録されたコンピュータ読み取り可能な記録媒体
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
ATE426045T1 (de) * 1998-11-09 2009-04-15 Eiken Chemical Prozess zur synthetisierung von nukleinsaure
EP1275715B1 (de) 2000-04-07 2015-07-15 Eiken Kagaku Kabushiki Kaisha Verfahren zur amplifikation und erkennung von nukleinsäuren unter verwendung von doppelsträngigen nukleinsäuren als schablone
WO2004040019A1 (ja) 2002-10-29 2004-05-13 Riken 核酸の増幅法

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