ATE367812T1 - Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) - Google Patents

Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1)

Info

Publication number
ATE367812T1
ATE367812T1 AT02744425T AT02744425T ATE367812T1 AT E367812 T1 ATE367812 T1 AT E367812T1 AT 02744425 T AT02744425 T AT 02744425T AT 02744425 T AT02744425 T AT 02744425T AT E367812 T1 ATE367812 T1 AT E367812T1
Authority
AT
Austria
Prior art keywords
sub
cycloalkyl
pyridinyl
pai
inhibitors
Prior art date
Application number
AT02744425T
Other languages
English (en)
Inventor
Hassan Elokdah
Geraldine Mcfarlane
David Li
Lee Jennings
David Crandall
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE367812T1 publication Critical patent/ATE367812T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02744425T 2001-06-20 2002-06-18 Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) ATE367812T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29965701P 2001-06-20 2001-06-20

Publications (1)

Publication Number Publication Date
ATE367812T1 true ATE367812T1 (de) 2007-08-15

Family

ID=23155702

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02744425T ATE367812T1 (de) 2001-06-20 2002-06-18 Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1)

Country Status (10)

Country Link
US (3) US7074817B2 (de)
EP (1) EP1397130B1 (de)
JP (1) JP4399253B2 (de)
AT (1) ATE367812T1 (de)
CY (1) CY1106901T1 (de)
DE (1) DE60221391T2 (de)
DK (1) DK1397130T3 (de)
ES (1) ES2290318T3 (de)
PT (1) PT1397130E (de)
WO (1) WO2003000253A1 (de)

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EP1397130A1 (de) 2004-03-17
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US20080214647A1 (en) 2008-09-04
US20030125371A1 (en) 2003-07-03
JP2004534817A (ja) 2004-11-18
DE60221391T2 (de) 2008-04-17
CY1106901T1 (el) 2012-09-26
DK1397130T3 (da) 2007-11-12
US7074817B2 (en) 2006-07-11
DE60221391D1 (de) 2007-09-06
US7368471B2 (en) 2008-05-06
EP1397130B1 (de) 2007-07-25
ES2290318T3 (es) 2008-02-16
US20060167059A1 (en) 2006-07-27
WO2003000253A1 (en) 2003-01-03

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