AR084433A1 - Inhibidores de la faah y composiciones farmaceuticas que los contienen - Google Patents
Inhibidores de la faah y composiciones farmaceuticas que los contienenInfo
- Publication number
- AR084433A1 AR084433A1 ARP110104811A ARP110104811A AR084433A1 AR 084433 A1 AR084433 A1 AR 084433A1 AR P110104811 A ARP110104811 A AR P110104811A AR P110104811 A ARP110104811 A AR P110104811A AR 084433 A1 AR084433 A1 AR 084433A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- faah inhibitors
- pharmaceutically acceptable
- faah
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
La presente se relaciona con compuestos útiles como inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH). La presente proporciona, además composiciones farmacéuticamente aceptables que comprenden los compuestos de la descripción y los métodos de usar las composiciones en el tratamiento de varios trastornos.Reivindicación 1: Un compuesto seleccionado de la Tabla (1), o una sal farmacéuticamente aceptable de éste.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201061426362P | 2010-12-22 | 2010-12-22 | |
US201161446808P | 2011-02-25 | 2011-02-25 |
Publications (1)
Publication Number | Publication Date |
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AR084433A1 true AR084433A1 (es) | 2013-05-15 |
Family
ID=45509695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110104811A AR084433A1 (es) | 2010-12-22 | 2011-12-20 | Inhibidores de la faah y composiciones farmaceuticas que los contienen |
Country Status (18)
Country | Link |
---|---|
US (1) | US9657012B2 (es) |
EP (1) | EP2655356B1 (es) |
JP (1) | JP5982397B2 (es) |
KR (1) | KR20140002709A (es) |
CN (1) | CN103502237B (es) |
AR (1) | AR084433A1 (es) |
AU (1) | AU2011348113A1 (es) |
BR (1) | BR112013016154A2 (es) |
CA (1) | CA2822842C (es) |
CL (1) | CL2013001772A1 (es) |
CO (1) | CO6781493A2 (es) |
ES (1) | ES2601499T3 (es) |
MX (1) | MX341110B (es) |
NZ (1) | NZ611798A (es) |
RU (1) | RU2013133884A (es) |
TW (1) | TW201307284A (es) |
UY (1) | UY33832A (es) |
WO (1) | WO2012088469A1 (es) |
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US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
EP2844227B1 (en) | 2012-05-03 | 2020-11-18 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
WO2014004676A1 (en) * | 2012-06-26 | 2014-01-03 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors as neuroprotective agents in the cns |
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WO2014127214A1 (en) | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
ES2831625T3 (es) | 2013-02-20 | 2021-06-09 | Kala Pharmaceuticals Inc | Compuestos terapéuticos y sus usos |
US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
JP6426194B2 (ja) | 2013-11-01 | 2018-11-21 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物の結晶形態及びその使用 |
MX2016016928A (es) | 2014-06-19 | 2017-04-25 | Merial Inc | Composiciones parasiticidas que comprenden derivados de indol, metodos y usos de los mismos. |
WO2016144860A1 (en) | 2015-03-06 | 2016-09-15 | Ironwood Pharmaceuticals, Inc. | Faah inhibitors for the treatment or prevention of nausea |
JP6851365B2 (ja) | 2015-03-26 | 2021-03-31 | ジャクリーン・エム・イヴァーセン | 宿酔に伴う症状を抑制するための方法及び組成物 |
EP3509421A4 (en) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
US10392399B2 (en) | 2016-09-08 | 2019-08-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
US20210355084A1 (en) * | 2018-06-26 | 2021-11-18 | Northeastern University | N-substituted indoles and use as allosteric modulators of cannabinoid receptors |
CN108912112A (zh) * | 2018-08-14 | 2018-11-30 | 李敬敬 | 一种化合物、制备方法以及其在治疗疼痛中的应用 |
US11390601B2 (en) * | 2020-07-31 | 2022-07-19 | University Of Sharjah | Conformationally-restricted analogues of sorafenib and regorafenib as selective kinase inhibitors for cancer treatment |
CN111743864B (zh) * | 2020-08-05 | 2022-04-01 | 牡丹江医学院 | 一种体育外伤喷雾剂及其制备方法 |
WO2022204140A1 (en) * | 2021-03-25 | 2022-09-29 | The Regents Of The University Of California | Algostatic agents for preventing transition from acute to chronic pain |
CN115616216A (zh) * | 2021-07-15 | 2023-01-17 | 华南理工大学 | 抑制或阻断faah与nlrp3之间相互作用的制剂的用途 |
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2011
- 2011-12-20 AR ARP110104811A patent/AR084433A1/es not_active Application Discontinuation
- 2011-12-22 TW TW100148110A patent/TW201307284A/zh unknown
- 2011-12-22 KR KR1020137019320A patent/KR20140002709A/ko not_active Application Discontinuation
- 2011-12-22 RU RU2013133884/04A patent/RU2013133884A/ru unknown
- 2011-12-22 NZ NZ611798A patent/NZ611798A/en not_active IP Right Cessation
- 2011-12-22 EP EP11811264.8A patent/EP2655356B1/en active Active
- 2011-12-22 WO PCT/US2011/066972 patent/WO2012088469A1/en active Application Filing
- 2011-12-22 UY UY0001033832A patent/UY33832A/es not_active Application Discontinuation
- 2011-12-22 JP JP2013546437A patent/JP5982397B2/ja not_active Expired - Fee Related
- 2011-12-22 BR BR112013016154A patent/BR112013016154A2/pt not_active IP Right Cessation
- 2011-12-22 AU AU2011348113A patent/AU2011348113A1/en not_active Abandoned
- 2011-12-22 CA CA2822842A patent/CA2822842C/en active Active
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- 2011-12-22 US US13/996,807 patent/US9657012B2/en active Active
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2013
- 2013-06-18 CL CL2013001772A patent/CL2013001772A1/es unknown
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Also Published As
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ES2601499T3 (es) | 2017-02-15 |
MX341110B (es) | 2016-08-09 |
JP2014500332A (ja) | 2014-01-09 |
BR112013016154A2 (pt) | 2018-07-10 |
US20150175599A1 (en) | 2015-06-25 |
EP2655356B1 (en) | 2016-08-03 |
RU2013133884A (ru) | 2015-01-27 |
WO2012088469A1 (en) | 2012-06-28 |
TW201307284A (zh) | 2013-02-16 |
UY33832A (es) | 2012-07-31 |
JP5982397B2 (ja) | 2016-08-31 |
NZ611798A (en) | 2015-07-31 |
CA2822842C (en) | 2019-06-04 |
US9657012B2 (en) | 2017-05-23 |
KR20140002709A (ko) | 2014-01-08 |
EP2655356A1 (en) | 2013-10-30 |
CL2013001772A1 (es) | 2013-12-27 |
CO6781493A2 (es) | 2013-10-31 |
CN103502237B (zh) | 2016-01-20 |
MX2013006598A (es) | 2013-12-06 |
CN103502237A (zh) | 2014-01-08 |
AU2011348113A1 (en) | 2013-06-27 |
CA2822842A1 (en) | 2012-06-28 |
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