ATE113952T1 - Verfahren zur herstellung von 3- exomethylencephamderivaten. - Google Patents

Verfahren zur herstellung von 3- exomethylencephamderivaten.

Info

Publication number
ATE113952T1
ATE113952T1 AT88201495T AT88201495T ATE113952T1 AT E113952 T1 ATE113952 T1 AT E113952T1 AT 88201495 T AT88201495 T AT 88201495T AT 88201495 T AT88201495 T AT 88201495T AT E113952 T1 ATE113952 T1 AT E113952T1
Authority
AT
Austria
Prior art keywords
derivatives
preparation
cephem
exomethylencepham
cepham
Prior art date
Application number
AT88201495T
Other languages
English (en)
Inventor
Koning Jan Jacobus De
Hendrik Adrianus Witkamp
Jan Verweij
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Application granted granted Critical
Publication of ATE113952T1 publication Critical patent/ATE113952T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT88201495T 1987-07-13 1988-07-13 Verfahren zur herstellung von 3- exomethylencephamderivaten. ATE113952T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87201323 1987-07-13

Publications (1)

Publication Number Publication Date
ATE113952T1 true ATE113952T1 (de) 1994-11-15

Family

ID=8197638

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88201495T ATE113952T1 (de) 1987-07-13 1988-07-13 Verfahren zur herstellung von 3- exomethylencephamderivaten.

Country Status (19)

Country Link
US (3) US4985554A (de)
EP (1) EP0299587B1 (de)
JP (1) JPH0742291B2 (de)
KR (1) KR0137221B1 (de)
CN (1) CN1040441C (de)
AT (1) ATE113952T1 (de)
AU (1) AU619201B2 (de)
CA (1) CA1338607C (de)
DE (1) DE3852065T2 (de)
DK (1) DK116889D0 (de)
ES (1) ES2067465T3 (de)
FI (1) FI891191A (de)
HU (1) HU207865B (de)
IE (1) IE66466B1 (de)
IL (1) IL87110A (de)
NO (1) NO891044L (de)
NZ (1) NZ225388A (de)
PT (1) PT87985B (de)
WO (1) WO1989000572A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300546B1 (de) * 1987-07-10 1995-08-09 Gist-Brocades N.V. Cephalosporinderivate und Verfahren zur Herstellung von Cephem-Verbindungen
US5159071A (en) * 1990-09-06 1992-10-27 Ranbaxy Laboratories Limited Process for the manufacture of 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester
US6248881B1 (en) 1991-03-08 2001-06-19 Biochemie Gmbh Intermediates and process for the production of 3-vinyl cephalosporins
US5604222A (en) 1993-12-27 1997-02-18 Lupin Laboratories, Ltd. Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) 1994-07-11 1996-11-26 Lupin Laboratories Limited Process for preparation of 3-exomethylene cepham sulfoxide esters
DE907654T1 (de) * 1995-11-06 1999-09-16 Gist Brocades Bv Verfahren zur de-esterifikation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731443A (en) * 1979-11-19 1988-03-15 Fujisawa Pharmaceutical Co., Ltd. 7-acylamino-3-vinylcephalosporanic acid derivatives
US4354022A (en) * 1981-06-05 1982-10-12 Fujisawa Pharmaceutical Co., Ltd. Process for preparing 3-methylenecepham compounds or a salt thereof
US4558123A (en) * 1983-07-22 1985-12-10 Eli Lilly And Company 3-Exomethylene cephalosporins
US4705851A (en) * 1984-09-28 1987-11-10 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of 3-phosphoniummethyl-3-cephem compounds

Also Published As

Publication number Publication date
DE3852065D1 (de) 1994-12-15
CN1040441C (zh) 1998-10-28
EP0299587A1 (de) 1989-01-18
AU619201B2 (en) 1992-01-23
IE66466B1 (en) 1995-12-27
FI891191A0 (fi) 1989-03-13
FI891191A (fi) 1989-03-13
AU2078388A (en) 1989-02-13
DE3852065T2 (de) 1995-04-06
KR0137221B1 (ko) 1998-04-25
IL87110A (en) 1993-04-04
HUT52512A (de) 1990-07-28
DK116889A (da) 1989-03-10
CN1031534A (zh) 1989-03-08
ES2067465T3 (es) 1995-04-01
CA1338607C (en) 1996-09-24
IE882137L (en) 1989-01-13
US5109132A (en) 1992-04-28
DK116889D0 (da) 1989-03-10
NZ225388A (en) 1991-07-26
US4985554A (en) 1991-01-15
JPH02500843A (ja) 1990-03-22
IL87110A0 (en) 1988-12-30
NO891044D0 (no) 1989-03-10
PT87985A (pt) 1989-06-30
PT87985B (pt) 1995-03-01
US4994454A (en) 1991-02-19
JPH0742291B2 (ja) 1995-05-10
HU207865B (en) 1993-06-28
NO891044L (no) 1989-03-10
KR890701593A (ko) 1989-12-21
EP0299587B1 (de) 1994-11-09
WO1989000572A1 (en) 1989-01-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee