AR075798A1 - Proteinas de union a il-17 (interleuquina 17) - Google Patents
Proteinas de union a il-17 (interleuquina 17)Info
- Publication number
- AR075798A1 AR075798A1 ARP100100680A ARP100100680A AR075798A1 AR 075798 A1 AR075798 A1 AR 075798A1 AR P100100680 A ARP100100680 A AR P100100680A AR P100100680 A ARP100100680 A AR P100100680A AR 075798 A1 AR075798 A1 AR 075798A1
- Authority
- AR
- Argentina
- Prior art keywords
- present
- cdr
- seq
- proteins
- interleuquina
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- G—PHYSICS
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Abstract
Proteínas de union a IL-17 y/o IL-17F, su uso en composiciones y métodos para el tratamiento, prevencion, y diagnostico de enfermedades relacionadas con IL-17 y para detectar IL-17 en células, tejidos, muestras y composiciones. Reivindicacion 1: Una proteína de union que comprende un dominio de union al antígeno capaz de unir IL-17 humana, caracterizada porque dicho dominio de union al antígeno comprende al menos una CDR que comprende una secuencia de aminoácidos seleccionada del grupo formado por: CDR-H 1. X1-X2-X3-X4-X5 (SEQ ID Ns:919), en donde; X1 es D o S; X2 es Y; X3 es E o G; X4.es l, M, V, o F; X5 es H; CDR-H2. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17 (SEQ ID Ns:920), en donde; X1 es V; X2 es T, 1, o N; X3 es D, H, o W; X4 es P o no está presente; X5 es E, G, o S; X6 es S, N, o D; X7 es G; X8 es G o T, X9 es T; X10 es L, A, T, o F; X11 es H o Y; X12 es N; X13 es P, Q, o S; X14 es K, A, o N; X15 es F o L; X16 es D, K, o R; y X17 es G, D, o S; CDR-H3. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12 (SEQ ID Ns:921), en donde; X1 es Y, F, o D; X2 es Y, L, S, o G; X3 es K, T, R, o Y; X4 es Y o W; X5 es E, D, o I; X6 es S, G, o Y; X7 es F, Y, o T; X8 es Y, F, o M; X9 es G, T, o no está presente; X10 es M o no está presente; X11 es D; y X12 es Y; CDR-L1. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16 (SEQ ID Ns:922), en donde; X1 es S, K, o R; X2 es A o S; X3 es S; X4 es S o Q; X5 es S o no está presente; X6 es L o no está presente; X7 es V o no está presente; X8 es H o no está presente; X9 es S o no está presente; X10 es S, N, o no está presente; X11 es S, V, o G; X12 es I, N, o S; X13 es S, N, T, o I; X14 es Y o D; X15 es M, V, L, o I; y X16 es C, A, H, Y, o G; CDR-L2. X1-X2-X3-X4-X5-X6-X7 (SEQ ID Ns:923), en donde; X1 es D, Y, K, A, o H; X2 es T, A, o V; X3 es S o F; X4 es K, N, o E; X5 es L o R; X6 es A, Y, o F; y X7 es S o T; y CDR-L3. X1-X2-X3-X4-X5-X6-X7-X8-X9 (SEQ ID Ns:924), en donde; X1 es Q, S, o H; X2 es Q; X3 es R, D, S, o G; X4 es S, Y, o T; X5 es S, G, o H; X6 es Y, S, V, o A; X7 es P o no está presente; X8 es W, Y, o L; y X9 es T.
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ARP100100680A AR075798A1 (es) | 2009-03-05 | 2010-03-05 | Proteinas de union a il-17 (interleuquina 17) |
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US (7) | US8835610B2 (es) |
EP (4) | EP3235509A1 (es) |
JP (3) | JP5836807B2 (es) |
KR (2) | KR101579771B1 (es) |
CN (2) | CN102781470B (es) |
AR (1) | AR075798A1 (es) |
BR (1) | BRPI1013688A8 (es) |
CA (1) | CA2752648A1 (es) |
CL (2) | CL2011002129A1 (es) |
CO (1) | CO6410314A2 (es) |
CR (1) | CR20110470A (es) |
DO (1) | DOP2011000274A (es) |
EC (1) | ECSP11011297A (es) |
HK (2) | HK1200320A1 (es) |
IL (1) | IL214851A0 (es) |
MX (1) | MX2011009362A (es) |
NZ (2) | NZ611324A (es) |
PE (3) | PE20160651A1 (es) |
PH (1) | PH12015500093A1 (es) |
RU (2) | RU2015132478A (es) |
SG (2) | SG173705A1 (es) |
TW (2) | TW201613969A (es) |
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