AR066794A1 - Proteina de union que comprende un dominio de union a antigeno que se une al globulomero beta amiloide (20-42), anticuerpos, molecula de acido nucleico que la codifica vector, celula huesped, metodo para su produccion, usos, composicion farmaceutia y metodo de diagnostico - Google Patents
Proteina de union que comprende un dominio de union a antigeno que se une al globulomero beta amiloide (20-42), anticuerpos, molecula de acido nucleico que la codifica vector, celula huesped, metodo para su produccion, usos, composicion farmaceutia y metodo de diagnosticoInfo
- Publication number
- AR066794A1 AR066794A1 ARP080102298A ARP080102298A AR066794A1 AR 066794 A1 AR066794 A1 AR 066794A1 AR P080102298 A ARP080102298 A AR P080102298A AR P080102298 A ARP080102298 A AR P080102298A AR 066794 A1 AR066794 A1 AR 066794A1
- Authority
- AR
- Argentina
- Prior art keywords
- cdr
- seq
- cell
- union
- protein
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 150000001450 anions Chemical class 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 6
- 108091008324 binding proteins Proteins 0.000 abstract 6
- 208000024827 Alzheimer disease Diseases 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Anticuerpos para uso en diagnostico, tratamiento y prevencion de la enfermedad de Alzheimer y enfermedades relacionadas. Se revela una proteína de union que comprende un dominio de union a antígeno que se une al globulomero beta amiloide (20-42), donde dicho dominio de union a antígeno comprende al menos una CDR que comprende una secuencia de aminoácidos seleccionada del grupo que consiste en: CDR-VH1. X1-X2-X3-X4-X5-X6-X7 (SEQ ID Ns 5), donde: X1 es T o S; X2 es F o Y; X3 es Y o A; X4 es I o M; y X5 es H o S; CDR-VH2. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15 X16-X17 (SEQ ID Ns 6), donde: X1 es M o S; X2 es I; X3 es G o H; X4 es P o N; X5 es G o R; X6 es S o G; X7 es G o T; X8 es N o l; X9 es T o F; X10 es Y; X11 es Y o L; X12 es N o D; X13 es E o S; X14 es M o V; x15 es F o K; X16 es K o G; y X17 es O o no está presente; CDR-VH3. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13 (SEQ ID Ns 7), donde: X1 es A o G; X2 es K o R; X3 es S; X4 es A o N; X5 es R o S; X6 es A o Y; X7 es A; X8 es W o M; X9 es F o D; X10 es A o Y; y X11 es Y o no está presente; CDR-VL1. X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15 X16 (SEQ ID Ns 8), donde: X1 es R; X2 es S; X3 es S o T; X4 es Q; X5 es S o T; X6 es V o L; X7 es V; X8 es Q o H; X9 es S o R; X10 es N; X11 es G; X12 es N o D; X13 es T; X14 es Y; X15 es N o L y X16 es E; CDR-VL2. X1-X2-X3-X4-X5-X6-X7-X8 (SEQ ID Ns 9), donde: X1 es K; X2 es V; X3 es S; X4 es N; X5 es R; X6 es F; y X7 es S; y CDR-VL3. X1-X2-X3-X4-X5-X6-X7-X8-X9 (SEQ ID Ns 10), donde: X1 es F; X2 es Q; X3 es G; X4 es S; X5 es H; X6 es V; X7 es P; X8 es P o Y; y X9 es T. También se describe un anticuerpo construido que comprende dicha proteína de union; un anticuerpo conjugado que comprende el anticuerpo construido; una molécula de ácido nucleico aislada que codifica una proteína de union; un vector que comprende dicha molécula de ácido nucleico aislada; célula huésped aislada que comprende dicho vector; método para producir una proteína capaz de unirse al globulomero Abeta(20-42) y proteína que se obtiene; composicion para la liberacion de una proteína de union; el uso de una composicion en la fabricacion de un medicamento; composicion farmacéutica; el uso de la proteína de union en la fabricacion de un medicamento reducir la actividad del globulomero Abeta(20-42); el uso de la proteína de union en la fabricacion de un medicamento para reducir la actividad del globulomero Abeta(20-42) humano; método para diagnosticar la enfermedad de Alzheimer; vacuna y método para detectar una secuencia de un péptido beta amiloide mutante en un paciente sospechado de padecer la enfermedad de Alzheimer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94093207P | 2007-05-30 | 2007-05-30 | |
| US99035907P | 2007-11-27 | 2007-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066794A1 true AR066794A1 (es) | 2009-09-09 |
Family
ID=39791050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080102298A AR066794A1 (es) | 2007-05-30 | 2008-05-30 | Proteina de union que comprende un dominio de union a antigeno que se une al globulomero beta amiloide (20-42), anticuerpos, molecula de acido nucleico que la codifica vector, celula huesped, metodo para su produccion, usos, composicion farmaceutia y metodo de diagnostico |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20090175847A1 (es) |
| EP (1) | EP2150563A1 (es) |
| JP (1) | JP2010530740A (es) |
| KR (1) | KR20100032398A (es) |
| CN (1) | CN101827862A (es) |
| AR (1) | AR066794A1 (es) |
| AU (1) | AU2008260062A1 (es) |
| BR (1) | BRPI0812005A2 (es) |
| CA (1) | CA2687414A1 (es) |
| CL (1) | CL2008001580A1 (es) |
| CO (1) | CO6251291A2 (es) |
| CR (1) | CR11179A (es) |
| DO (1) | DOP2009000269A (es) |
| EC (1) | ECSP099833A (es) |
| IL (1) | IL202243A0 (es) |
| MX (1) | MX2009012950A (es) |
| PA (1) | PA8782201A1 (es) |
| PE (1) | PE20090329A1 (es) |
| RU (1) | RU2009149370A (es) |
| TW (1) | TW200914465A (es) |
| UY (1) | UY31114A1 (es) |
| WO (1) | WO2008150949A1 (es) |
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| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| BRPI0506629A (pt) * | 2004-02-10 | 2007-05-02 | Univ Colorado | inibição do fator b, a via alternativa do sistema complemento e métodos relacionados |
| US20070045902A1 (en) | 2004-07-13 | 2007-03-01 | Brauker James H | Analyte sensor |
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| BRPI0618160A2 (pt) * | 2005-05-26 | 2011-08-16 | Univ Colorado | inibição da via alternativa complemento para tratamento de danos cerebrais traumáticos, danos na medula espinhal e condições relacionadas |
| PL2289909T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał |
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| CN101668773B (zh) | 2007-03-14 | 2016-08-31 | 亚力史制药公司 | 人工程化抗b因子抗体 |
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| CN102516360B (zh) * | 2011-12-08 | 2013-11-06 | 清华大学 | 一种抑制β分泌酶酶切作用的多肽及其应用 |
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-
2008
- 2008-05-29 US US12/129,469 patent/US20090175847A1/en not_active Abandoned
- 2008-05-29 PE PE2008000921A patent/PE20090329A1/es not_active Application Discontinuation
- 2008-05-30 BR BRPI0812005A patent/BRPI0812005A2/pt not_active IP Right Cessation
- 2008-05-30 EP EP08769847A patent/EP2150563A1/en not_active Withdrawn
- 2008-05-30 KR KR1020097027470A patent/KR20100032398A/ko not_active Application Discontinuation
- 2008-05-30 AR ARP080102298A patent/AR066794A1/es unknown
- 2008-05-30 MX MX2009012950A patent/MX2009012950A/es not_active Application Discontinuation
- 2008-05-30 PA PA20088782201A patent/PA8782201A1/es unknown
- 2008-05-30 CN CN200880101484A patent/CN101827862A/zh active Pending
- 2008-05-30 CL CL2008001580A patent/CL2008001580A1/es unknown
- 2008-05-30 TW TW097120376A patent/TW200914465A/zh unknown
- 2008-05-30 JP JP2010510504A patent/JP2010530740A/ja not_active Withdrawn
- 2008-05-30 AU AU2008260062A patent/AU2008260062A1/en not_active Abandoned
- 2008-05-30 WO PCT/US2008/065205 patent/WO2008150949A1/en active Application Filing
- 2008-05-30 RU RU2009149370/10A patent/RU2009149370A/ru unknown
- 2008-05-30 CA CA002687414A patent/CA2687414A1/en not_active Abandoned
- 2008-05-30 UY UY31114A patent/UY31114A1/es not_active Application Discontinuation
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2009
- 2009-11-19 IL IL202243A patent/IL202243A0/en unknown
- 2009-11-27 DO DO2009000269A patent/DOP2009000269A/es unknown
- 2009-12-18 CR CR11179A patent/CR11179A/es not_active Application Discontinuation
- 2009-12-21 CO CO09145798A patent/CO6251291A2/es not_active Application Discontinuation
- 2009-12-29 EC EC2009009833A patent/ECSP099833A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PA8782201A1 (es) | 2009-02-09 |
| US20090175847A1 (en) | 2009-07-09 |
| TW200914465A (en) | 2009-04-01 |
| JP2010530740A (ja) | 2010-09-16 |
| KR20100032398A (ko) | 2010-03-25 |
| RU2009149370A (ru) | 2011-07-10 |
| BRPI0812005A2 (pt) | 2019-09-24 |
| PE20090329A1 (es) | 2009-03-27 |
| DOP2009000269A (es) | 2009-12-15 |
| CL2008001580A1 (es) | 2008-12-05 |
| CN101827862A (zh) | 2010-09-08 |
| ECSP099833A (es) | 2010-01-29 |
| UY31114A1 (es) | 2009-01-05 |
| CA2687414A1 (en) | 2008-12-11 |
| CR11179A (es) | 2010-05-27 |
| CO6251291A2 (es) | 2011-02-21 |
| WO2008150949A1 (en) | 2008-12-11 |
| MX2009012950A (es) | 2010-03-26 |
| AU2008260062A1 (en) | 2008-12-11 |
| EP2150563A1 (en) | 2010-02-10 |
| IL202243A0 (en) | 2010-06-16 |
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