AR073113A1 - Produccion de metionina sin n- acil -metionina - Google Patents
Produccion de metionina sin n- acil -metioninaInfo
- Publication number
- AR073113A1 AR073113A1 ARP090103230A ARP090103230A AR073113A1 AR 073113 A1 AR073113 A1 AR 073113A1 AR P090103230 A ARP090103230 A AR P090103230A AR P090103230 A ARP090103230 A AR P090103230A AR 073113 A1 AR073113 A1 AR 073113A1
- Authority
- AR
- Argentina
- Prior art keywords
- methionine
- expression
- production
- microorganism
- source
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/66—Aspergillus
- C12R2001/69—Aspergillus oryzae
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Reivindicacion 1: Un procedimiento para la produccion de metionina, o sus precursores en un proceso fermentativo que comprende las siguientes etapas: i) cultivo de un microorganismo modificado en un medio de cultivo apropiado que comprende una fuente de carbono, una fuente de azufre y una fuente de nitrogeno y ii) recuperacion de metionina y/o sus derivados a partir del medio de cultivo, en el que en comparacion con un microorganismo o un procedimiento no modificado, la acumulacion del subproducto N-acil-metionina es reducida. Reivindicacion 3: Procedimiento de la reivindicacion 1 en el que dicha reduccion de la acumulacion de N-acil-metionina se logra mediante una de las siguientes modificaciones: i) Atenuacion de la expresion de al menos una enzima metionina transacilasa, y/o, ii) Expresion o potenciacion de la expresion de al menos una aminoacilasa específica de la metionina, y/o, iii) Cambio de las condiciones de cultivo. Reivindicacion 19: Un microorganismo que comprende las modificaciones reivindicadas en la reivindicacion 3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2008/061005 WO2010020290A1 (en) | 2008-08-22 | 2008-08-22 | Producing methionine without n-acetyl methionine |
US12/370,422 US8748136B2 (en) | 2008-08-22 | 2009-02-12 | Producing methionine without N-acyl-methionine |
Publications (1)
Publication Number | Publication Date |
---|---|
AR073113A1 true AR073113A1 (es) | 2010-10-13 |
Family
ID=40683227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090103230A AR073113A1 (es) | 2008-08-22 | 2009-08-21 | Produccion de metionina sin n- acil -metionina |
Country Status (13)
Country | Link |
---|---|
US (1) | US8748136B2 (es) |
EP (1) | EP2326724B1 (es) |
JP (1) | JP5805533B2 (es) |
KR (1) | KR101660060B1 (es) |
CN (2) | CN104293845A (es) |
AR (1) | AR073113A1 (es) |
BR (1) | BRPI0917192A2 (es) |
ES (1) | ES2739466T3 (es) |
MX (1) | MX2011001962A (es) |
MY (1) | MY174404A (es) |
PL (1) | PL2326724T3 (es) |
RU (1) | RU2011108705A (es) |
WO (2) | WO2010020290A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN2012DN06442A (es) | 2009-12-30 | 2015-10-09 | Metabolic Explorer Sa | |
AR083468A1 (es) * | 2010-10-25 | 2013-02-27 | Metabolic Explorer Sa | Aumento de la disponibilidad de nadph para la produccion de metionina |
EP2468383A1 (de) * | 2010-12-22 | 2012-06-27 | Evonik Degussa GmbH | Verfahren zur thermischen Nachverbrennung von Abgasen aus der Acrolein- und aus der Blausäureherstellung |
WO2012090021A1 (en) | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
KR101770150B1 (ko) | 2010-12-30 | 2017-08-23 | 에보니크 데구사 게엠베하 | 메티오닌 히드록시 유사체 (mha)의 발효 생산 |
EP2479279A1 (de) | 2011-01-20 | 2012-07-25 | Evonik Degussa GmbH | Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren |
US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
EP2695940B1 (en) | 2011-04-01 | 2016-11-30 | Ajinomoto Co., Inc. | Method for producing l-cysteine |
AR086790A1 (es) * | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
AU2012383221A1 (en) | 2012-06-18 | 2015-01-15 | Evonik Degussa Gmbh | Recombinant microorganism for the fermentative production of methionine |
ES2689754T3 (es) | 2012-08-20 | 2018-11-15 | Evonik Degussa Gmbh | Procedimiento para la preparación fermentativa de L-aminoácidos utilizando cepas mejoradas de la familia Enterobacteriaceae |
EP2762571A1 (de) | 2013-01-30 | 2014-08-06 | Evonik Industries AG | Mikroorganismus und Verfahren zur fermentativen Herstellung von Aminosäuren |
PL3039153T3 (pl) | 2013-08-30 | 2019-02-28 | Evonik Degussa Gmbh | Mikroorganizm do wytwarzania metioniny o ulepszonej aktywności syntazy metioniny i wypływie metioniny |
MX2017002662A (es) | 2014-09-01 | 2017-05-30 | Metabolic Explorer Sa | Metodo y microorganismo para produccion de metionina por fermentacion con eflujo de metionina mejorado. |
WO2017025766A1 (en) | 2015-08-07 | 2017-02-16 | Metabolic Explorer | Protein thiocarboxylate-dependent l-methionine production by fermentation |
FR3041658B1 (fr) | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
FR3041659B1 (fr) | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
RU2729012C2 (ru) | 2015-11-27 | 2020-08-03 | Эвоник Оперейшенс ГмбХ | Способ получения l-метионина |
EP3296404A1 (en) * | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
KR102472558B1 (ko) * | 2019-06-28 | 2022-12-01 | 씨제이제일제당 주식회사 | 황 함유 아미노산 또는 그 유도체 제조방법 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1295130A2 (en) | 2000-03-10 | 2003-03-26 | Trustees Of Tufts College | Nimr compositions and their methods of use |
JP4682454B2 (ja) * | 2000-06-28 | 2011-05-11 | 味の素株式会社 | 新規変異型n−アセチルグルタミン酸合成酵素及びl−アルギニンの製造法 |
DE10144493A1 (de) * | 2001-09-11 | 2003-07-03 | Degussa | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coyneformer Bakterien |
DE102004013503A1 (de) * | 2004-03-18 | 2005-10-06 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
DE102004055414A1 (de) * | 2004-11-17 | 2006-05-24 | Degussa Ag | Allele des metK-Gens aus coryneformen Bakterien |
DE602006018468D1 (de) * | 2005-07-18 | 2011-01-05 | Evonik Degussa Gmbh | Verwendung von dimethyldisulfid für die methioninproduktion in mikroorganismen |
CA2626900C (en) * | 2005-08-20 | 2013-07-23 | Scarab Genomics, Llc | Reduced genome e. coli |
CN101291590A (zh) * | 2005-10-31 | 2008-10-22 | 巴斯夫欧洲公司 | 用于制备l-甲硫氨酸的微生物和方法 |
BRPI0620880B1 (pt) * | 2006-01-04 | 2018-10-09 | Evonik Degussa Gmbh | método para a produção de metionina, pelo cultivo de um microorganismo, e, microorganismo |
WO2009043372A1 (en) * | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
WO2010020289A1 (en) * | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Production of n-acetylated sulphur-containing amino acids with microorganisms having enhanced n-acetyltransferase enzymatic activity |
-
2008
- 2008-08-22 WO PCT/EP2008/061005 patent/WO2010020290A1/en active Application Filing
-
2009
- 2009-02-12 US US12/370,422 patent/US8748136B2/en active Active
- 2009-08-21 MY MYPI2011000771A patent/MY174404A/en unknown
- 2009-08-21 CN CN201410478758.6A patent/CN104293845A/zh active Pending
- 2009-08-21 AR ARP090103230A patent/AR073113A1/es unknown
- 2009-08-21 WO PCT/EP2009/060811 patent/WO2010020681A1/en active Application Filing
- 2009-08-21 KR KR1020117006419A patent/KR101660060B1/ko active IP Right Grant
- 2009-08-21 BR BRPI0917192-4A2A patent/BRPI0917192A2/pt active IP Right Grant
- 2009-08-21 RU RU2011108705/10A patent/RU2011108705A/ru not_active Application Discontinuation
- 2009-08-21 EP EP09782063.3A patent/EP2326724B1/en not_active Not-in-force
- 2009-08-21 PL PL09782063T patent/PL2326724T3/pl unknown
- 2009-08-21 MX MX2011001962A patent/MX2011001962A/es active IP Right Grant
- 2009-08-21 JP JP2011523426A patent/JP5805533B2/ja not_active Expired - Fee Related
- 2009-08-21 ES ES09782063T patent/ES2739466T3/es active Active
- 2009-08-21 CN CN2009801419503A patent/CN102203270A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
CN102203270A (zh) | 2011-09-28 |
MX2011001962A (es) | 2011-03-21 |
WO2010020290A1 (en) | 2010-02-25 |
BRPI0917192A2 (pt) | 2015-02-18 |
JP2012500622A (ja) | 2012-01-12 |
KR20110046542A (ko) | 2011-05-04 |
RU2011108705A (ru) | 2012-09-27 |
CN104293845A (zh) | 2015-01-21 |
ES2739466T3 (es) | 2020-01-31 |
EP2326724B1 (en) | 2019-05-22 |
US8748136B2 (en) | 2014-06-10 |
PL2326724T3 (pl) | 2019-11-29 |
JP5805533B2 (ja) | 2015-11-04 |
KR101660060B1 (ko) | 2016-09-26 |
EP2326724A1 (en) | 2011-06-01 |
MY174404A (en) | 2020-04-16 |
WO2010020681A1 (en) | 2010-02-25 |
US20100047879A1 (en) | 2010-02-25 |
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Legal Events
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FB | Suspension of granting procedure |