AR086790A1 - Un microorganismo para la produccion de metionina con importacion de glucosa mejorada - Google Patents

Un microorganismo para la produccion de metionina con importacion de glucosa mejorada

Info

Publication number
AR086790A1
AR086790A1 ARP120102329A ARP120102329A AR086790A1 AR 086790 A1 AR086790 A1 AR 086790A1 AR P120102329 A ARP120102329 A AR P120102329A AR P120102329 A ARP120102329 A AR P120102329A AR 086790 A1 AR086790 A1 AR 086790A1
Authority
AR
Argentina
Prior art keywords
methionine
importation
glucose
microorganism
production
Prior art date
Application number
ARP120102329A
Other languages
English (en)
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of AR086790A1 publication Critical patent/AR086790A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Microorganismo recombinante para la producción de metionina mejorada que comprende modificaciones para producir metionina a partir de glucosa como fuente principal de carbono por fermentación, y modificaciones para mejorar la importación de glucosa, en donde la importación de glucosa se mejora mediante la modificación de la expresión de al menos un gen seleccionado de ptsG, sgrT sgrS y dgsA, y donde el microorganismo es la familia bacteriana Enterobacteriaceae o Corynebacteriaceae. También se divulga con un método para la producción fermentativa de metionina o derivados de metionina que comprende las etapas de: el cultivo del microorganismo recombinante tal como se ha descrito anteriormente en un medio de cultivo adecuado que comprende una fuente fermentable de carbono que contiene glucosa y una fuente de azufre, y la recuperación de metionina o derivados de metionina del medio de cultivo.
ARP120102329A 2011-06-29 2012-06-28 Un microorganismo para la produccion de metionina con importacion de glucosa mejorada AR086790A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161502528P 2011-06-29 2011-06-29
EP11305829 2011-06-29

Publications (1)

Publication Number Publication Date
AR086790A1 true AR086790A1 (es) 2014-01-22

Family

ID=47423448

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120102329A AR086790A1 (es) 2011-06-29 2012-06-28 Un microorganismo para la produccion de metionina con importacion de glucosa mejorada

Country Status (12)

Country Link
US (1) US9506092B2 (es)
EP (1) EP2726626B1 (es)
JP (1) JP2014522642A (es)
KR (1) KR102029819B1 (es)
CN (1) CN103781913B (es)
AR (1) AR086790A1 (es)
BR (1) BR112013033675B1 (es)
ES (1) ES2654589T3 (es)
MX (1) MX347843B (es)
MY (1) MY166543A (es)
PL (1) PL2726626T3 (es)
WO (1) WO2013001055A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2875139A1 (en) 2012-06-18 2013-12-27 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine
WO2015028675A1 (en) * 2013-08-30 2015-03-05 Metabolic Explorer A microorganism for methionine production with enhanced methionine efflux
WO2015028674A1 (en) 2013-08-30 2015-03-05 Metabolic Explorer Microorganism for methionine production with improved methionine synthase activity and methionine efflux
CA2959563A1 (en) * 2014-09-01 2016-03-10 Metabolic Explorer Method and microorganism for methionine production by fermentation with improved methionine efflux
EP3050970B1 (en) 2015-01-28 2019-09-18 Metabolic Explorer Modified microorganism for optimized production of 1,4-butanediol
MX2017011976A (es) * 2015-03-18 2018-02-09 Basf Se Microorganismo recombinante para la produccion mejorada de quimicos finos.
US10858675B2 (en) 2015-04-07 2020-12-08 Metabolic Explorer Modified microorganism for the optimized production of 2,4-dihydroxybutyrate with enhanced 2,4-dihydroxybutyrate efflux
WO2016162712A1 (en) 2015-04-07 2016-10-13 Metabolic Explorer Modified microorganism for the optimized production of 2,4-dihydroxyburyrate
US20180223319A1 (en) 2015-08-07 2018-08-09 Evonik Degussa Gmbh Protein thiocarboxylate-dependent l-methionine production by fermentation
US11034985B2 (en) 2015-11-27 2021-06-15 Evonik Operations Gmbh Method for producing L-methionine
KR20180093981A (ko) 2016-01-08 2018-08-22 에보니크 데구사 게엠베하 발효적 생산에 의해 l-메티오닌을 생산하는 방법
KR101853961B1 (ko) * 2016-04-19 2018-06-20 (주)휴맥스 포스 입력의 식별 서비스 제공 장치 및 방법
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
EP3354742A1 (en) 2017-01-26 2018-08-01 Metabolic Explorer Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid
WO2019011942A1 (en) 2017-07-11 2019-01-17 Adisseo France S.A.S. YEAST PRODUCING METHIONINE
EP3470512A1 (en) 2017-10-10 2019-04-17 Metabolic Explorer Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate
KR102221040B1 (ko) * 2019-05-09 2021-03-03 씨제이제일제당 주식회사 L-아미노산을 생산하는 미생물 및 이를 이용한 l-아미노산을 생산하는 방법
WO2023025656A1 (en) 2021-08-25 2023-03-02 Metabolic Explorer Dehydrogenase mutants and applications thereof in amino acid synthesis
WO2023089028A1 (en) 2021-11-17 2023-05-25 Metabolic Explorer Microorganism and method for the improved production of valine
WO2023166027A1 (en) 2022-03-01 2023-09-07 Metabolic Explorer Microorganism and method for the improved production of leucine and/or isoleucine
WO2024028428A1 (en) 2022-08-04 2024-02-08 Metabolic Explorer Microorganism and method for the improved production of serine and/or cysteine

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JP4110641B2 (ja) 1998-11-17 2008-07-02 味の素株式会社 発酵法によるｌ−メチオニンの製造法
JP2000157267A (ja) * 1998-11-24 2000-06-13 Ajinomoto Co Inc 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法
EP1307475A1 (en) 2000-08-02 2003-05-07 Degussa AG Nucleotide sequences which code for the meth gene
DE10116518A1 (de) 2001-04-03 2002-10-17 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
WO2003004674A2 (en) 2001-07-06 2003-01-16 Degussa Ag Process for the preparation of l-amino acids using strains of the enterobacteriaceae family
RU2245919C2 (ru) 2002-09-06 2005-02-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Способ получения l-аминокислоты, штамм escherichia coli tdh7δ mlc::cat/pprt614-продуцент l-треонина
DE10303571A1 (de) * 2003-01-30 2004-08-12 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae
MXPA05008857A (es) 2003-02-18 2006-03-09 Metabolic Explorer Sa Procedimiento de preparacion de microorganismos evolucionados que permite la creacion o la modificacion de vias metabolicas.
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JP5172697B2 (ja) * 2006-01-04 2013-03-27 メタボリック エクスプローラー 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法
WO2007119576A1 (en) * 2006-03-23 2007-10-25 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family
WO2009043372A1 (en) 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
BRPI0819509A2 (pt) 2007-12-18 2014-10-14 Korea Advanced Inst Sci & Tech MICROORGANISMO E VETOR RECOMBINANTE, SACAROSE FOSFOTRANSFERASE, GENE (ptsG), BETA-FRUTOFURANOSIDASE E MÉTODO PARA PRODUZIR METABÓLITOCOS, POLÍMEROS BIODEGRADÁVEIS OU PROTEÍNAS RECOMBINANTES
WO2010020290A1 (en) 2008-08-22 2010-02-25 Metabolic Explorer Producing methionine without n-acetyl methionine
AR083468A1 (es) 2010-10-25 2013-02-27 Metabolic Explorer Sa Aumento de la disponibilidad de nadph para la produccion de metionina
WO2012090021A1 (en) * 2010-12-30 2012-07-05 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine

Also Published As

Publication number Publication date
ES2654589T3 (es) 2018-02-14
BR112013033675B1 (pt) 2021-06-29
KR102029819B1 (ko) 2019-10-08
EP2726626B1 (en) 2017-11-15
BR112013033675A2 (pt) 2018-06-19
JP2014522642A (ja) 2014-09-08
EP2726626A1 (en) 2014-05-07
PL2726626T3 (pl) 2018-05-30
MY166543A (en) 2018-07-16
MX2013015202A (es) 2014-02-17
WO2013001055A1 (en) 2013-01-03
US9506092B2 (en) 2016-11-29
CN103781913B (zh) 2016-02-24
US20140134680A1 (en) 2014-05-15
CN103781913A (zh) 2014-05-07
KR20140043804A (ko) 2014-04-10
MX347843B (es) 2017-05-16

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