AR083468A1 - Aumento de la disponibilidad de nadph para la produccion de metionina - Google Patents

Aumento de la disponibilidad de nadph para la produccion de metionina

Info

Publication number
AR083468A1
AR083468A1 ARP110103848A ARP110103848A AR083468A1 AR 083468 A1 AR083468 A1 AR 083468A1 AR P110103848 A ARP110103848 A AR P110103848A AR P110103848 A ARP110103848 A AR P110103848A AR 083468 A1 AR083468 A1 AR 083468A1
Authority
AR
Argentina
Prior art keywords
production
metionin
availability
microorganism
increasing nadph
Prior art date
Application number
ARP110103848A
Other languages
English (en)
Original Assignee
Metabolic Explorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolic Explorer Sa filed Critical Metabolic Explorer Sa
Publication of AR083468A1 publication Critical patent/AR083468A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
    • C12Y604/01001—Pyruvate carboxylase (6.4.1.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente se refiere a un microorganismo para la producción de metionina, donde dicho microorganismo es modificado de modo de mejorar la actividad de transhidrogenasa de PntAB. En un aspecto preferido la actividad de la transhidrogenasa UdhA es atenuada en dicho microorganismo, además se refiere a un método para la producción de metionina mediante la fermentación.Reivindicación 1: Un microorganismo para la producción de metionina, donde dicho microorganismo es modificado a fin de mejorar la actividad de la transhidrogenasa de PntAB.
ARP110103848A 2010-10-25 2011-10-18 Aumento de la disponibilidad de nadph para la produccion de metionina AR083468A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40624910P 2010-10-25 2010-10-25
EP10306164 2010-10-25

Publications (1)

Publication Number Publication Date
AR083468A1 true AR083468A1 (es) 2013-02-27

Family

ID=43640178

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110103848A AR083468A1 (es) 2010-10-25 2011-10-18 Aumento de la disponibilidad de nadph para la produccion de metionina

Country Status (10)

Country Link
US (1) US9034611B2 (es)
EP (1) EP2633037B1 (es)
JP (2) JP2013539987A (es)
KR (1) KR20140002653A (es)
CN (2) CN103282488A (es)
AR (1) AR083468A1 (es)
BR (1) BR112013009618A2 (es)
ES (1) ES2637280T3 (es)
PL (1) PL2633037T3 (es)
WO (1) WO2012055798A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR086790A1 (es) 2011-06-29 2014-01-22 Metabolic Explorer Sa Un microorganismo para la produccion de metionina con importacion de glucosa mejorada
CA2875139A1 (en) 2012-06-18 2013-12-27 Metabolic Explorer Recombinant microorganism for the fermentative production of methionine
US9670479B2 (en) 2013-03-15 2017-06-06 F Cubed, LLC Sample preparation device and methods of use
WO2015028674A1 (en) 2013-08-30 2015-03-05 Metabolic Explorer Microorganism for methionine production with improved methionine synthase activity and methionine efflux
CN103710396A (zh) * 2013-12-30 2014-04-09 南京工业大学 一种提高厌氧发酵目标产物转化率的方法
CA2959563A1 (en) * 2014-09-01 2016-03-10 Metabolic Explorer Method and microorganism for methionine production by fermentation with improved methionine efflux
EP3050970B1 (en) 2015-01-28 2019-09-18 Metabolic Explorer Modified microorganism for optimized production of 1,4-butanediol
US10858675B2 (en) 2015-04-07 2020-12-08 Metabolic Explorer Modified microorganism for the optimized production of 2,4-dihydroxybutyrate with enhanced 2,4-dihydroxybutyrate efflux
WO2016162712A1 (en) 2015-04-07 2016-10-13 Metabolic Explorer Modified microorganism for the optimized production of 2,4-dihydroxyburyrate
HUE057284T2 (hu) 2015-06-04 2022-04-28 Cj Cheiljedang Corp O-Acetil-homoszerint termelõ mikroorganizmus, és eljárás O-Acetil-homoszerin elõállítására annak alkalmazásával
US20180223319A1 (en) 2015-08-07 2018-08-09 Evonik Degussa Gmbh Protein thiocarboxylate-dependent l-methionine production by fermentation
US10731137B2 (en) 2015-09-10 2020-08-04 Metabolic Explorer Lactaldehyde reductases for the production of 1,2-propanediol
EP3365427B1 (en) 2015-10-23 2020-08-19 Metabolic Explorer Microorganism modified for the assimilation of levulinic acid
US11034985B2 (en) 2015-11-27 2021-06-15 Evonik Operations Gmbh Method for producing L-methionine
US20190276859A1 (en) 2016-07-08 2019-09-12 Evonik Degussa Gmbh Method for the fermentative production of methionine or its hydroxy analog form by microorganisms comprising genes coding sugar phosphotransferase system (pts)
EP3296404A1 (en) 2016-09-15 2018-03-21 Evonik Degussa GmbH Modified microorganism for production of methionine
CN106635945B (zh) * 2016-12-29 2020-05-26 廊坊梅花生物技术开发有限公司 重组菌株及其制备方法和生产l-苏氨酸的方法
EP3342873A1 (en) 2016-12-29 2018-07-04 Metabolic Explorer Conversion of methylglyoxal into hydroxyacetone using enzymes and applications thereof
CN106501201B (zh) * 2016-12-31 2018-06-19 湖南永和阳光生物科技股份有限公司 一种用于检测同型半胱氨酸的酶循环方法
WO2019011942A1 (en) 2017-07-11 2019-01-17 Adisseo France S.A.S. YEAST PRODUCING METHIONINE
CN108486023B (zh) * 2018-03-08 2020-12-22 江苏省中国科学院植物研究所 一种产生p-羟基肉桂酸的基因工程菌株及其构建方法与应用
JP2021521897A (ja) 2018-05-04 2021-08-30 味の素株式会社 パントエア属細菌を用いたｌ−メチオニンの製造方法
JP7444164B2 (ja) 2018-09-28 2024-03-06 味の素株式会社 細菌を用いたｌ－メチオニンの製造方法
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
WO2020171227A1 (en) 2019-02-22 2020-08-27 Ajinomoto Co., Inc. METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE
BR112021017870A2 (pt) 2019-04-05 2021-12-07 Ajinomoto Kk Método para produzir um l-aminoácido
JP2022550084A (ja) 2019-09-25 2022-11-30 味の素株式会社 細菌の発酵によるｌ－アミノ酸の製造方法
CN113122487B (zh) * 2020-01-10 2022-05-24 中国科学院微生物研究所 一种高产l-高丝氨酸的重组菌及其制备方法与应用
CN112779200B (zh) * 2021-01-12 2022-07-08 浙江工业大学 高产l-甲硫氨酸的基因工程菌及其构建与应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1307477A2 (en) 2000-08-02 2003-05-07 Degussa AG Nucleotide sequences which code for the metf gene
DE10217058A1 (de) 2002-04-17 2003-11-27 Basf Ag Verfahren zur Herstellung von schwefelhaltigen Feinchemikalien
WO2005007862A2 (en) 2003-07-08 2005-01-27 Novus Internation, Inc Methionine recovery processes
FR2862068B1 (fr) * 2003-11-06 2007-10-12 Metabolic Explorer Sa Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph
DE10359668A1 (de) 2003-12-18 2005-07-14 Basf Ag Verfahren zur Herstellung von Methionin
WO2005111202A1 (en) * 2004-05-12 2005-11-24 Metabolic Explorer Recombinant enzyme with altered feedback sensitivity
CN101374940A (zh) * 2005-02-07 2009-02-25 代谢探索者公司 包含表达低γ-消除活性的酶的微生物
CN101356272A (zh) * 2005-08-18 2009-01-28 巴斯夫欧洲公司 甲硫氨酸合成效率增高的微生物
JP2009504172A (ja) * 2005-08-18 2009-02-05 ビーエーエスエフ ソシエタス・ヨーロピア 向上したメチオニン合成効率を有する微生物
JP5172697B2 (ja) * 2006-01-04 2013-03-27 メタボリック エクスプローラー 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法
EP2019868A2 (en) * 2006-05-24 2009-02-04 Evonik Degussa GmbH Process for the preparation of l-methionine
WO2009043372A1 (en) * 2007-10-02 2009-04-09 Metabolic Explorer Increasing methionine yield
WO2010020290A1 (en) 2008-08-22 2010-02-25 Metabolic Explorer Producing methionine without n-acetyl methionine
US20100143997A1 (en) * 2008-10-31 2010-06-10 Thomas Buelter Engineered microorganisms capable of producing target compounds under anaerobic conditions
WO2011073738A1 (en) 2009-12-14 2011-06-23 Metabolic Explorer Use of inducible promoters in the production of methionine

Also Published As

Publication number Publication date
US9034611B2 (en) 2015-05-19
US20130183727A1 (en) 2013-07-18
WO2012055798A1 (en) 2012-05-03
ES2637280T3 (es) 2017-10-11
PL2633037T3 (pl) 2018-02-28
BR112013009618A2 (pt) 2016-08-02
KR20140002653A (ko) 2014-01-08
JP2017169576A (ja) 2017-09-28
CN103282488A (zh) 2013-09-04
EP2633037A1 (en) 2013-09-04
EP2633037B1 (en) 2017-06-28
JP2013539987A (ja) 2013-10-31
CN106906176A (zh) 2017-06-30

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