AR058914A1 - Metodo para la producion de metionina mediante el cultivo de un microorganismo modificado para potenciar la produccion de cisteina - Google Patents
Metodo para la producion de metionina mediante el cultivo de un microorganismo modificado para potenciar la produccion de cisteinaInfo
- Publication number
- AR058914A1 AR058914A1 ARP070100036A ARP070100036A AR058914A1 AR 058914 A1 AR058914 A1 AR 058914A1 AR P070100036 A ARP070100036 A AR P070100036A AR P070100036 A ARP070100036 A AR P070100036A AR 058914 A1 AR058914 A1 AR 058914A1
- Authority
- AR
- Argentina
- Prior art keywords
- production
- metionin
- cysteine
- crop
- power
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un proceso para la produccion de metionina o sus derivados mediante el cultivo de un microorganismo en un medio de cultivo apropiado que comprende una fuente de carbono y una fuente de azufre. El microorganismo reivindicado se modifica de manera tal que la produccion de cisterna y/o unidades C1 se potencie y/o se incremente u optimice el potencial de transferencia de las unidades C1 de la homocisteína. También se reivindica el aislamiento de la metionina o sus derivados del medio de fermentacion. Reivindicacion 4: El método de acuerdo con la reivindicacion 2, en el cual se incrementa por lo menos la expresion de cysE. Reivindicacion 5: El método de acuerdo con la reivindicacion 2, en el cual se incrementa por lo menos la expresion de cysM
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2006/050033 WO2007077041A1 (en) | 2006-01-04 | 2006-01-04 | Process for the preparation of methionine and its precursors homoserine or succinylhomoserine employing a microorganism with enhanced sulfate permease expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058914A1 true AR058914A1 (es) | 2008-03-05 |
Family
ID=37508334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100036A AR058914A1 (es) | 2006-01-04 | 2007-01-04 | Metodo para la producion de metionina mediante el cultivo de un microorganismo modificado para potenciar la produccion de cisteina |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8389250B2 (es) |
| EP (2) | EP2314710B1 (es) |
| JP (1) | JP5172697B2 (es) |
| CN (1) | CN101351558B (es) |
| AR (1) | AR058914A1 (es) |
| BR (1) | BRPI0620880B1 (es) |
| DK (1) | DK2314710T3 (es) |
| ES (1) | ES2459617T3 (es) |
| MY (1) | MY148979A (es) |
| PL (1) | PL1969130T3 (es) |
| WO (1) | WO2007077041A1 (es) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4110641B2 (ja) | 1998-11-17 | 2008-07-02 | 味の素株式会社 | 発酵法によるｌ−メチオニンの製造法 |
| US8389250B2 (en) * | 2006-01-04 | 2013-03-05 | Metabolic Explorer | Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine |
| BRPI0712219A2 (pt) * | 2006-05-24 | 2012-03-13 | Evonik Degussa Gmbh | processo para a preparação de l-metionina |
| KR100905381B1 (ko) | 2006-07-28 | 2009-06-30 | 씨제이제일제당 (주) | Ｌ-메치오닌 전구체 생산 균주 및 상기 ｌ-메치오닌전구체로부터의 ｌ-메치오닌 및 유기산의 생산방법 |
| WO2009043372A1 (en) * | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| US8556245B2 (en) | 2008-03-19 | 2013-10-15 | Hirata Corporation | Work inspector and carrier |
| US9005952B2 (en) * | 2008-04-04 | 2015-04-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| US7851180B2 (en) * | 2008-04-04 | 2010-12-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| WO2010020290A1 (en) | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Producing methionine without n-acetyl methionine |
| WO2010020289A1 (en) | 2008-08-22 | 2010-02-25 | Metabolic Explorer | Production of n-acetylated sulphur-containing amino acids with microorganisms having enhanced n-acetyltransferase enzymatic activity |
| ES2549003T3 (es) | 2008-12-31 | 2015-10-22 | Metabolic Explorer | Método para la preparación de dioles |
| US8609396B2 (en) | 2009-08-28 | 2013-12-17 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| JP2012223092A (ja) * | 2009-08-28 | 2012-11-15 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| RU2009136544A (ru) * | 2009-10-05 | 2011-04-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Способ получения l-цистеина с использованием бактерии семейства enterobacteriaceae |
| FR2951195B1 (fr) | 2009-10-14 | 2014-01-31 | Roquette Freres | Composition riche en methionine destinee a l'alimentation animale |
| CN102639691B (zh) | 2009-11-30 | 2014-04-16 | 味之素株式会社 | 生产l-半胱氨酸的细菌以及生产l-半胱氨酸的方法 |
| WO2011073738A1 (en) * | 2009-12-14 | 2011-06-23 | Metabolic Explorer | Use of inducible promoters in the production of methionine |
| WO2011080301A2 (en) | 2009-12-30 | 2011-07-07 | Metabolic Explorer | Strains and method for the production of methionine |
| MX2012007718A (es) * | 2009-12-30 | 2012-07-25 | Metabolic Explorer Sa | Aumento de la produccion de metionina mediante la sobreexpresion de succinato deshidrogenasa. |
| WO2012001003A1 (en) | 2010-07-02 | 2012-01-05 | Metabolic Explorer | Method for the preparation of hydroxy acids |
| TWI500768B (zh) | 2010-07-05 | 2015-09-21 | Metabolic Explorer Sa | 由蔗糖製備１，３－丙二醇之方法 |
| WO2012036151A1 (ja) | 2010-09-14 | 2012-03-22 | 味の素株式会社 | 含硫アミノ酸生産菌及び含硫アミノ酸の製造法 |
| KR101208267B1 (ko) * | 2010-10-20 | 2012-12-04 | 씨제이제일제당 (주) | Ｏ-포스포세린 설피드릴라제 변이체 |
| AR083468A1 (es) * | 2010-10-25 | 2013-02-27 | Metabolic Explorer Sa | Aumento de la disponibilidad de nadph para la produccion de metionina |
| WO2012090021A1 (en) | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| ES2528495T3 (es) | 2010-12-30 | 2015-02-10 | Metabolic Explorer | Producción fermentativa de análogo hidroxi de metionina (MHA) |
| EP2479279A1 (de) | 2011-01-20 | 2012-07-25 | Evonik Degussa GmbH | Verfahren zur fermentativen Herstellung schwefelhaltiger Aminosäuren |
| JP2014087259A (ja) | 2011-02-22 | 2014-05-15 | Ajinomoto Co Inc | Ｌ−システイン生産菌及びｌ−システインの製造法 |
| US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
| JP6020443B2 (ja) | 2011-04-01 | 2016-11-02 | 味の素株式会社 | Ｌ−システインの製造法 |
| AR086790A1 (es) | 2011-06-29 | 2014-01-22 | Metabolic Explorer Sa | Un microorganismo para la produccion de metionina con importacion de glucosa mejorada |
| EP2540834A1 (en) | 2011-06-29 | 2013-01-02 | Metabolic Explorer | Method for the preparation of 1,3-propanediol |
| US9410164B2 (en) | 2011-10-11 | 2016-08-09 | Metabolic Explorer | Biosynthesis pathway for prenol in a recombinant microorganism |
| FR2983870B1 (fr) | 2011-12-08 | 2015-07-17 | Roquette Freres | Composition en methionine destinee a l'alimentation animale |
| EP2628792A1 (de) | 2012-02-17 | 2013-08-21 | Evonik Industries AG | Zelle mit verringerter ppGppase-Aktivität |
| EP2647718A3 (en) | 2012-04-06 | 2014-12-24 | Metabolic Explorer | Process for producing 5-aminopentanoate empolying a recombinant microorganism |
| EP2861726B1 (en) | 2012-06-18 | 2017-05-31 | Evonik Degussa GmbH | Recombinant microorganism for the fermentative production of methionine |
| ES2689754T3 (es) | 2012-08-20 | 2018-11-15 | Evonik Degussa Gmbh | Procedimiento para la preparación fermentativa de L-aminoácidos utilizando cepas mejoradas de la familia Enterobacteriaceae |
| WO2014049382A2 (en) | 2012-09-26 | 2014-04-03 | Metabolic Explorer | Ethylenediamine fermentative production by a recombinant microorganism |
| WO2014071182A1 (en) | 2012-11-01 | 2014-05-08 | Massachusetts Institute Of Technology | Directed evolution of synthetic gene cluster |
| KR101773755B1 (ko) | 2013-05-13 | 2017-09-01 | 아지노모토 가부시키가이샤 | Ｌ-아미노산의 제조법 |
| PL3039153T3 (pl) | 2013-08-30 | 2019-02-28 | Evonik Degussa Gmbh | Mikroorganizm do wytwarzania metioniny o ulepszonej aktywności syntazy metioniny i wypływie metioniny |
| JP6459962B2 (ja) | 2013-10-21 | 2019-01-30 | 味の素株式会社 | Ｌ−アミノ酸の製造法 |
| BR112016008830B1 (pt) | 2013-10-23 | 2023-02-23 | Ajinomoto Co., Inc | Método para produzir uma substância alvo |
| JP6393898B2 (ja) * | 2014-08-03 | 2018-09-26 | 国立大学法人 奈良先端科学技術大学院大学 | 酵母の培養方法 |
| JP2017525379A (ja) | 2014-09-01 | 2017-09-07 | メタボリック エクスプローラー | メチオニン排出を改善した発酵によるメチオニン産生の方法及び微生物 |
| EP3050970B1 (en) | 2015-01-28 | 2019-09-18 | Metabolic Explorer | Modified microorganism for optimized production of 1,4-butanediol |
| CN107771214B (zh) | 2015-04-07 | 2022-01-18 | 代谢探索者公司 | 用于具有增加的2,4-二羟基丁酸外排物的优化的2,4-二羟基丁酸产生的修饰的微生物 |
| EP3095868A1 (en) | 2015-05-19 | 2016-11-23 | Evonik Degussa GmbH | Methionine production |
| EP3298156A1 (en) | 2015-07-10 | 2018-03-28 | Evonik Degussa GmbH | Amino acid production |
| MX2018000615A (es) | 2015-07-13 | 2018-08-01 | Pivot Bio Inc | Metodos y composiciones para mejorar atributos de plantas. |
| PL3331998T3 (pl) * | 2015-08-07 | 2020-12-28 | Evonik Operations Gmbh | Wytwarzanie przez fermentację l-metioniny zależne od tiokarboksylanu białka |
| EP3347478B1 (en) | 2015-09-10 | 2022-09-21 | Metabolic Explorer | New lactaldehyde reductases for the production of 1,2-propanediol |
| FR3041659B1 (fr) | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
| FR3041658B1 (fr) | 2015-09-30 | 2017-10-20 | Arkema France | Procede de production de l-methionine |
| US11479516B2 (en) | 2015-10-05 | 2022-10-25 | Massachusetts Institute Of Technology | Nitrogen fixation using refactored NIF clusters |
| MX2018006434A (es) | 2015-11-27 | 2018-09-28 | Evonik Degussa Gmbh | Metodo para producir l-metionina. |
| US20180355390A1 (en) | 2016-01-08 | 2018-12-13 | Evonik Degussa Gmbh | Method to produce L-methionine by a fermentative production |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| CN110799474B (zh) | 2017-01-12 | 2022-07-26 | 皮沃特生物公司 | 用于改良植物性状的方法及组合物 |
| JP7066977B2 (ja) | 2017-04-03 | 2022-05-16 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| CN110869503A (zh) | 2017-07-11 | 2020-03-06 | 安迪苏法国联合股份有限公司 | 甲硫氨酸生产酵母 |
| US20210163374A1 (en) * | 2017-08-09 | 2021-06-03 | Pivot Bio, Inc. | Methods and compositions for improving engineered microbes |
| EP3470512A1 (en) | 2017-10-10 | 2019-04-17 | Metabolic Explorer | Mutant phosphoserine aminotransferase for the conversion of homoserine into 4-hydroxy-2-ketobutyrate |
| CA3079955A1 (en) | 2017-10-25 | 2019-05-02 | Pivot Bio, Inc. | Methods and compositions for improving engineered microbes that fix nitrogen |
| CA3103977A1 (en) | 2018-06-27 | 2020-01-02 | Pivot Bio, Inc. | Agricultural compositions comprising remodeled nitrogen fixing microbes |
| BR112021005543A2 (pt) * | 2018-09-28 | 2021-06-29 | Ajinomoto Co., Inc. | método para produzir l-metionina |
| WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| US20220162655A1 (en) * | 2019-03-26 | 2022-05-26 | Zymergen Inc. | Engineered biosynthetic pathways for production of l-homocysteine by fermentation |
| KR102472558B1 (ko) * | 2019-06-28 | 2022-12-01 | 씨제이제일제당 주식회사 | 황 함유 아미노산 또는 그 유도체 제조방법 |
| KR102472559B1 (ko) * | 2019-06-28 | 2022-12-01 | 씨제이제일제당 주식회사 | 황 함유 아미노산 또는 그 유도체의 제조방법 |
| CN113388630B (zh) * | 2020-03-11 | 2022-07-26 | 华东理工大学 | 合成l-半胱氨酸的重组大肠杆菌的构建方法及其应用 |
| CN112592924B (zh) * | 2020-12-28 | 2022-07-01 | 宁夏伊品生物科技股份有限公司 | 一种yh66_10325基因改造的产l-异亮氨酸重组菌株及其构建方法与应用 |
| CN114350586B (zh) * | 2022-01-24 | 2023-07-28 | 浙江工业大学 | 高产l-半胱氨酸的基因工程菌、构建方法及应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000157267A (ja) | 1998-11-24 | 2000-06-13 | Ajinomoto Co Inc | 変異型ｍｅｔＪ遺伝子及びＬ−メチオニンの製造法 |
| US6831165B1 (en) * | 1999-06-25 | 2004-12-14 | Basf Aktiengesellschaft | Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation |
| ATE417094T1 (de) * | 1999-12-24 | 2008-12-15 | Ajinomoto Kk | Verfahren zur herstellung von l-aminosäure |
| US7220571B2 (en) * | 2000-09-28 | 2007-05-22 | Archer-Daniels-Midland Company | Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation |
| ES2313555T3 (es) | 2001-07-11 | 2009-03-01 | Evonik Degussa Gmbh | Proceso para la preparacion de l-treonina que utiliza cepas de la familia enterobacteriaceas. |
| EP1686184B1 (en) | 2001-07-11 | 2008-08-27 | Evonik Degussa GmbH | Process for the preparation of L-threonine using strains of the enterobacteriaceae family |
| US7160711B2 (en) * | 2001-08-06 | 2007-01-09 | Degussa Ag | Coryneform bacteria which produce chemical compounds I |
| DE10239308A1 (de) * | 2002-08-27 | 2004-03-11 | Basf Ag | Verfahren zur fermentativen Herstellung von schwefelhaltigen Feinchemikalien |
| EP2471930A1 (de) | 2002-12-20 | 2012-07-04 | Metanomics GmbH & Co. KGaA | Verfahren zur Herstellung von Aminosäuren |
| DE10305774A1 (de) | 2003-02-06 | 2004-08-26 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von L-Methionin |
| JP2006517796A (ja) | 2003-02-18 | 2006-08-03 | メタボリック エクスプローラー | 代謝経路の生成または改変を可能とする進化した微生物の生産方法 |
| WO2004108894A2 (en) * | 2003-05-30 | 2004-12-16 | Microbia, Inc. | Methods and compositions for amino acid production |
| RU2275425C2 (ru) * | 2003-11-03 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Бактерия, принадлежащая к роду escherichia, - продуцент l-цистеина и способ получения l-цистеина |
| DE10359668A1 (de) | 2003-12-18 | 2005-07-14 | Basf Ag | Verfahren zur Herstellung von Methionin |
| DE102004009454A1 (de) | 2004-02-27 | 2005-09-15 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von rekombinanten Mikroorganismen |
| DE102004013503A1 (de) * | 2004-03-18 | 2005-10-06 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| WO2005111202A1 (en) * | 2004-05-12 | 2005-11-24 | Metabolic Explorer | Recombinant enzyme with altered feedback sensitivity |
| MX2007009489A (es) * | 2005-02-07 | 2007-09-19 | Metabolic Explorer Sa | Microorganismos que comprenden enzimas expresadas con baja actividad de eliminacion gamma. |
| JP2009501550A (ja) * | 2005-07-18 | 2009-01-22 | ビーエーエスエフ ソシエタス・ヨーロピア | メチオニン生産組換え微生物 |
| US8389250B2 (en) * | 2006-01-04 | 2013-03-05 | Metabolic Explorer | Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine |
-
2006
- 2006-01-04 US US12/159,846 patent/US8389250B2/en active Active
- 2006-01-04 WO PCT/EP2006/050033 patent/WO2007077041A1/en active Application Filing
- 2006-01-04 PL PL06707666T patent/PL1969130T3/pl unknown
- 2006-01-04 CN CN2006800503269A patent/CN101351558B/zh not_active Expired - Fee Related
- 2006-01-04 DK DK10187418.8T patent/DK2314710T3/en active
- 2006-01-04 ES ES06707666.1T patent/ES2459617T3/es active Active
- 2006-01-04 EP EP10187418.8A patent/EP2314710B1/en not_active Not-in-force
- 2006-01-04 JP JP2008548953A patent/JP5172697B2/ja not_active Expired - Fee Related
- 2006-01-04 BR BRPI0620880A patent/BRPI0620880B1/pt not_active IP Right Cessation
- 2006-01-04 EP EP06707666.1A patent/EP1969130B1/en not_active Not-in-force
-
2007
- 2007-01-04 AR ARP070100036A patent/AR058914A1/es not_active Application Discontinuation
- 2007-01-04 MY MYPI20070009A patent/MY148979A/en unknown
-
2013
- 2013-01-09 US US13/737,188 patent/US9187775B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9187775B2 (en) | 2015-11-17 |
| BRPI0620880B1 (pt) | 2018-10-09 |
| BRPI0620880A2 (pt) | 2012-09-18 |
| JP2009521939A (ja) | 2009-06-11 |
| EP1969130A1 (en) | 2008-09-17 |
| ES2459617T3 (es) | 2014-05-12 |
| MY148979A (en) | 2013-06-28 |
| EP2314710A2 (en) | 2011-04-27 |
| CN101351558B (zh) | 2013-08-14 |
| US20080311632A1 (en) | 2008-12-18 |
| WO2007077041A1 (en) | 2007-07-12 |
| DK2314710T3 (en) | 2016-06-13 |
| US8389250B2 (en) | 2013-03-05 |
| US20130183726A1 (en) | 2013-07-18 |
| JP5172697B2 (ja) | 2013-03-27 |
| EP2314710B1 (en) | 2016-03-30 |
| EP1969130B1 (en) | 2014-03-12 |
| PL1969130T3 (pl) | 2014-08-29 |
| EP2314710A3 (en) | 2012-02-22 |
| CN101351558A (zh) | 2009-01-21 |
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