WO2011115439A3 - 5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법 - Google Patents

5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법 Download PDF

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Publication number
WO2011115439A3
WO2011115439A3 PCT/KR2011/001866 KR2011001866W WO2011115439A3 WO 2011115439 A3 WO2011115439 A3 WO 2011115439A3 KR 2011001866 W KR2011001866 W KR 2011001866W WO 2011115439 A3 WO2011115439 A3 WO 2011115439A3
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WO
WIPO (PCT)
Prior art keywords
monophosphate
xanthosine
guanine
microorganism
production
Prior art date
Application number
PCT/KR2011/001866
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English (en)
French (fr)
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WO2011115439A2 (ko
Inventor
조진만
이진남
김혜원
이지혜
윤난영
이광우
오윤석
박장희
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씨제이제일제당 (주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 씨제이제일제당 (주) filed Critical 씨제이제일제당 (주)
Priority to EP11756570.5A priority Critical patent/EP2548949B1/en
Priority to CN201180019964.5A priority patent/CN102985529B/zh
Priority to US13/635,801 priority patent/US8859236B2/en
Priority to DK11756570.5T priority patent/DK2548949T3/da
Priority to JP2013501181A priority patent/JP5816258B2/ja
Priority to ES11756570.5T priority patent/ES2644477T3/es
Publication of WO2011115439A2 publication Critical patent/WO2011115439A2/ko
Publication of WO2011115439A3 publication Critical patent/WO2011115439A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/99—Oxidoreductases acting on the CH-NH group of donors (1.5) with other acceptors (1.5.99)
    • C12Y105/99008—Proline dehydrogenase (1.5.99.8)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 5'-크산틸산 생산능 및 5'-구아닐산 생산능이 증가된 미생물에 관한 것으로서, 구체적으로 프롤린 디하이드로게나아제 활성이 내재적 활성보다 증가된 코리네박테리아 속 미생물, 상기 형질전환되어 제조된 미생물을 배양하여 그 배양액으로부터 5'-크산틸산 또는 5'-구아닐산을 생산하는 방법 및 5'-크산틸산 또는 5'-구아닐산을 생산하기 위한 상기 미생물의 용도에 관한 것이다.
PCT/KR2011/001866 2010-03-19 2011-03-17 5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법 WO2011115439A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP11756570.5A EP2548949B1 (en) 2010-03-19 2011-03-17 Microorganism with improved production of 5'-xanthosine monophosphate and 5'-guanine monophosphate, and production method of 5'-xanthosine monophosphate and 5'-guanine monophosphate using same
CN201180019964.5A CN102985529B (zh) 2010-03-19 2011-03-17 改进地生产5’-黄苷一磷酸和5’-鸟苷一磷酸的微生物和使用其的5’-黄苷一磷酸和5’-鸟苷一磷酸的生产方法
US13/635,801 US8859236B2 (en) 2010-03-19 2011-03-17 Microorganism with improved production of 5′-xanthosine monophosphate and 5′-guanine monophosphate, and production method of 5′-xanthosine monophosphate and 5′-guanine monophosphate using same
DK11756570.5T DK2548949T3 (da) 2010-03-19 2011-03-17 Mikroorganisme med forbedret produktion af 5'-xanthosinmonophosphat og 5'-guaninmonophosphat samt fremgangsmåde til fremstilling af 5'-xanthosinmonophosphat og 5'-guaninmonophosphat under anvendelse af samme
JP2013501181A JP5816258B2 (ja) 2010-03-19 2011-03-17 ５’−キサンチル酸及び５’−グアニル酸の生産能が向上した微生物、及びこれを用いた５’−キサンチル酸及び５’−グアニル酸の生産方法
ES11756570.5T ES2644477T3 (es) 2010-03-19 2011-03-17 Microorganismos con producción mejorada de 5'-xantosina monofostato y 5'-guanina monofostato, y un procedimiento de producción de 5'-xantosina monofostato y 5'-guanina monofostato usando los mismos

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0024929 2010-03-19
KR1020100024929A KR101210704B1 (ko) 2010-03-19 2010-03-19 ５'－크산틸산 및 ５'－구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'－크산틸산 또는 ５'－구아닐산의 생산방법

Publications (2)

Publication Number Publication Date
WO2011115439A2 WO2011115439A2 (ko) 2011-09-22
WO2011115439A3 true WO2011115439A3 (ko) 2012-01-12

Family

ID=44649731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/001866 WO2011115439A2 (ko) 2010-03-19 2011-03-17 5'-크산틸산 및 5'-구아닐산 생산능이 향상된 미생물 및 이를 이용한 5'-크산틸산 또는 5'-구아닐산의 생산방법

Country Status (8)

Country Link
US (1) US8859236B2 (ko)
EP (1) EP2548949B1 (ko)
JP (2) JP5816258B2 (ko)
KR (1) KR101210704B1 (ko)
CN (1) CN102985529B (ko)
DK (1) DK2548949T3 (ko)
ES (1) ES2644477T3 (ko)
WO (1) WO2011115439A2 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101072708B1 (ko) * 2008-12-17 2011-10-11 씨제이제일제당 (주) ５＇－크산틸산 생산능이 향상된 미생물 및 이를 이용한 ５＇－크산틸산의 생산방법
KR102013873B1 (ko) 2018-01-25 2019-08-23 씨제이제일제당 주식회사 퓨린 뉴클레오티드를 생산하는 코리네박테리움 속 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법
KR101929158B1 (ko) 2018-06-07 2018-12-13 씨제이제일제당 (주) 5'-크산틸산을 생산하는 미생물 및 이를 이용한 5'-크산틸산의 제조방법
KR102006976B1 (ko) * 2019-02-26 2019-08-06 씨제이제일제당 주식회사 신규 프로모터 및 이를 이용한 퓨린 뉴클레오티드 제조방법
KR102185850B1 (ko) * 2020-02-21 2020-12-02 씨제이제일제당 주식회사 퓨린 뉴클레오티드를 생산하는 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법
KR102281365B1 (ko) * 2021-01-26 2021-07-22 씨제이제일제당 (주) 신규한 프롤린 탈수소효소 변이체 및 이를 이용한 l-발린 생산 방법
KR102419166B1 (ko) 2021-09-23 2022-07-08 씨제이제일제당 주식회사 신규한 글루타민 가수분해 gmp 합성효소 변이체 및 이를 이용한 퓨린 뉴클레오티드의 생산방법

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KR930008130A (ko) * 1991-10-14 1993-05-21 김정순 5'-크산틸산(5'Xanthyl산)을 생산하는 미생물
KR20020057470A (ko) * 2001-01-05 2002-07-11 손 경 식 5'-크산틸산을 고수율로 생산하는 미생물 코리네박테리움암모니아게네스 엔브이4-82-9 및 그를 이용한 5'-크산틸산생산방법
US20020098552A1 (en) * 2000-11-22 2002-07-25 Ajinomoto Co., Inc. Method for producing xanthosine-5'-monophosphate by fermentation using mutant strains of Coryneform bacteria
KR20070056491A (ko) * 2005-11-30 2007-06-04 씨제이 주식회사 포스포리보실 피로포스페이트 아미도트랜스퍼라제 코딩유전자가 도입된 미생물 및 이를 사용한 ５’-크산틸산의생산방법
KR20090080654A (ko) * 2008-01-22 2009-07-27 씨제이제일제당 (주) 5'-크산틸산 생산능이 향상된 코리네박테리움 속 미생물및 이를 이용한 5'-크산틸산의 생산 방법

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KR100405990B1 (ko) 2000-10-04 2003-11-20 김성준 유기게르마늄 함유 동충하초의 제조방법
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930008130A (ko) * 1991-10-14 1993-05-21 김정순 5'-크산틸산(5'Xanthyl산)을 생산하는 미생물
US20020098552A1 (en) * 2000-11-22 2002-07-25 Ajinomoto Co., Inc. Method for producing xanthosine-5'-monophosphate by fermentation using mutant strains of Coryneform bacteria
KR20020057470A (ko) * 2001-01-05 2002-07-11 손 경 식 5'-크산틸산을 고수율로 생산하는 미생물 코리네박테리움암모니아게네스 엔브이4-82-9 및 그를 이용한 5'-크산틸산생산방법
KR20070056491A (ko) * 2005-11-30 2007-06-04 씨제이 주식회사 포스포리보실 피로포스페이트 아미도트랜스퍼라제 코딩유전자가 도입된 미생물 및 이를 사용한 ５’-크산틸산의생산방법
KR20090080654A (ko) * 2008-01-22 2009-07-27 씨제이제일제당 (주) 5'-크산틸산 생산능이 향상된 코리네박테리움 속 미생물및 이를 이용한 5'-크산틸산의 생산 방법

Also Published As

Publication number Publication date
JP5816258B2 (ja) 2015-11-18
US20130095529A1 (en) 2013-04-18
EP2548949B1 (en) 2017-07-26
JP2013521826A (ja) 2013-06-13
US8859236B2 (en) 2014-10-14
WO2011115439A2 (ko) 2011-09-22
CN102985529A (zh) 2013-03-20
ES2644477T3 (es) 2017-11-29
CN102985529B (zh) 2015-07-29
KR101210704B1 (ko) 2012-12-10
KR20110105662A (ko) 2011-09-27
EP2548949A4 (en) 2013-08-21
JP2015171380A (ja) 2015-10-01
EP2548949A2 (en) 2013-01-23
DK2548949T3 (da) 2017-11-06

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