CR11759A - Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas - Google Patents

Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas

Info

Publication number
CR11759A
CR11759A CR11759A CR11759A CR11759A CR 11759 A CR11759 A CR 11759A CR 11759 A CR11759 A CR 11759A CR 11759 A CR11759 A CR 11759A CR 11759 A CR11759 A CR 11759A
Authority
CR
Costa Rica
Prior art keywords
espiro
piperidines
treatment
neurodegenerative diseases
new class
Prior art date
Application number
CR11759A
Other languages
English (en)
Inventor
Michael Aaron Brodney
Chiristopher John Helal
Brian Thomas O'neill
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CR11759A publication Critical patent/CR11759A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se desvelan compuestos y sales farmaceuticamente aceptables de los compuestos, teniendo los compuestos la estructura de la formula I, como se define en la memoria descriptiva.
CR11759A 2008-05-05 2010-10-26 Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas CR11759A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5042308P 2008-05-05 2008-05-05

Publications (1)

Publication Number Publication Date
CR11759A true CR11759A (es) 2010-11-22

Family

ID=40902870

Family Applications (1)

Application Number Title Priority Date Filing Date
CR11759A CR11759A (es) 2008-05-05 2010-10-26 Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas

Country Status (22)

Country Link
US (1) US20110046160A1 (es)
EP (1) EP2300484B1 (es)
JP (1) JP2011519913A (es)
KR (1) KR20110000749A (es)
CN (1) CN102083841A (es)
AP (1) AP2010005456A0 (es)
AT (1) ATE537178T1 (es)
AU (1) AU2009245322B2 (es)
BR (1) BRPI0912433A2 (es)
CA (1) CA2721786A1 (es)
CO (1) CO6321280A2 (es)
CR (1) CR11759A (es)
DO (1) DOP2010000317A (es)
EA (1) EA201001566A1 (es)
EC (1) ECSP10010597A (es)
ES (1) ES2375913T3 (es)
IL (1) IL208793A0 (es)
MA (1) MA32290B1 (es)
MX (1) MX2010012066A (es)
NZ (1) NZ588589A (es)
SV (1) SV2010003725A (es)
WO (1) WO2009136350A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
JP2013523806A (ja) * 2010-04-09 2013-06-17 ファイザー・インク スルタム化合物
EP2694521B1 (en) 2011-04-07 2015-11-25 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
WO2012138734A1 (en) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2747769B1 (en) 2011-08-22 2017-08-02 Merck Sharp & Dohme Corp. 2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
WO2016100823A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2359707T3 (es) * 2004-01-08 2011-05-26 F. Hoffmann-La Roche Ag Derivados de diaza-espiropiperidina.
JP2006044497A (ja) * 2004-08-05 2006-02-16 Toyota Motor Corp 車輪情報処理装置
JP2008515989A (ja) * 2004-10-13 2008-05-15 メルク エンド カムパニー インコーポレーテッド アルツハイマー病を治療するためのβ−セクレターゼ阻害薬として有用なスピロピペリジン化合物
CN101238124A (zh) * 2005-07-18 2008-08-06 默克公司 用于治疗阿尔茨海默氏病的螺哌啶β-分泌酶抑制剂
US20100298342A1 (en) * 2006-09-07 2010-11-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's Disease
AU2007342368A1 (en) * 2007-01-04 2008-07-17 Merck & Co., Inc. Bicyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease

Also Published As

Publication number Publication date
KR20110000749A (ko) 2011-01-05
EP2300484A1 (en) 2011-03-30
WO2009136350A1 (en) 2009-11-12
AU2009245322A1 (en) 2009-11-12
AP2010005456A0 (en) 2010-12-31
EP2300484B1 (en) 2011-12-14
CN102083841A (zh) 2011-06-01
ES2375913T3 (es) 2012-03-07
IL208793A0 (en) 2010-12-30
NZ588589A (en) 2012-07-27
DOP2010000317A (es) 2010-11-15
MX2010012066A (es) 2010-12-06
AU2009245322B2 (en) 2011-07-14
ATE537178T1 (de) 2011-12-15
CA2721786A1 (en) 2009-11-12
ECSP10010597A (es) 2010-12-30
JP2011519913A (ja) 2011-07-14
SV2010003725A (es) 2011-07-05
CO6321280A2 (es) 2011-09-20
BRPI0912433A2 (pt) 2015-12-22
EA201001566A1 (ru) 2011-04-29
MA32290B1 (fr) 2011-05-02
US20110046160A1 (en) 2011-02-24

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)