AR070469A1 - Derivados de naftiridina y composiciones farmaceuticas como inhibidores de quinasa con actividad sobre c- kit y pdgfr - Google Patents

Derivados de naftiridina y composiciones farmaceuticas como inhibidores de quinasa con actividad sobre c- kit y pdgfr

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Publication number
AR070469A1
AR070469A1 ARP090100626A ARP090100626A AR070469A1 AR 070469 A1 AR070469 A1 AR 070469A1 AR P090100626 A ARP090100626 A AR P090100626A AR P090100626 A ARP090100626 A AR P090100626A AR 070469 A1 AR070469 A1 AR 070469A1
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Argentina
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alkyl
halo
cycloalkyl
substituted
heterocycloalkyl
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ARP090100626A
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Irm Llc
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Publication of AR070469A1 publication Critical patent/AR070469A1/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

La presente proporciona una clase de compuestos, composiciones farmacéuticas que comprenden dichos compuestos y métodos para utilizar dichos compuestos para tratar o prevenir enfermedades o trastornos asociados con la actividad quinasa anormal o desregulada, particularmente enfermedades o trastornos que involucran la activacion anormal de quinasas c-kit, PDGFRalfa y PDGFRbeta. Reivindicacion 1: Un compuesto de la formula (1) en el cual R1 está seleccionado entre halo, alquilo C1-6, cicloalquilo C3-12, heterocicloalquilo C3-8, arilo C6-10 y heteroarilo C3-10; donde dicho alquilo C1-6 de R1 está sustituido en forma opcional con 1 a 3 radicales seleccionados en forma independiente entre halo, hidroxi, ciano, nitro, =N(OH), alcoxi C1-4 y benzoxi; donde dicho cicloalquilo, heterocicloalquilo, arilo o heteroarilo de R1 está sustituido en forma opcional con 1 a 3 radicales seleccionados en forma independiente entre halo, hidroxi, ciano, nitro, alquilo C1-6, alquilo C1-6 halo-sustituido, alquilo C1-6 hidroxi-sustituido, alcoxi C1-6, alcoxi C1-6 halo-sustituido, -X1NR3aR3b, -X1C(O)R3a, -X1C(O)OR3a, -X1OR3a, cicloalquilo C3-12, heterocicloalquilo C3-8, arilo C6-10 y heteroarilo C3-10; donde X1 está seleccionado entre un enlace y alquileno C1-4; donde R3a y R3b están seleccionados en forma independiente entre hidrogeno y alquilo C1-6; R2 se selecciona de metilo y etilo; A es un anillo insaturado de 5 miembros que contiene 2 o 3 heteroátomos o grupos seleccionados entre =N-, -NR4-, -O- y -S(O)0-2-; donde R4 está seleccionado entre hidrogeno, alquilo C1-4 y cicloalquilo C3-8; donde dicho alquilo C1-4 o cicloalquilo C3-8 de R4 puede tener un metileno reemplazado con un heteroátomo seleccionado entre O, S(O)0-2 y NR30; donde R30 está seleccionado entre H y alquilo C1-4; donde A puede estar opcionalmente sustituido por alquilo C1-2; o las sales aceptables para uso farmacéutico de los mismos.
ARP090100626A 2008-02-22 2009-02-24 Derivados de naftiridina y composiciones farmaceuticas como inhibidores de quinasa con actividad sobre c- kit y pdgfr AR070469A1 (es)

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US3091208P 2008-02-22 2008-02-22

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AR070469A1 true AR070469A1 (es) 2010-04-07

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ID=40577860

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ARP090100626A AR070469A1 (es) 2008-02-22 2009-02-24 Derivados de naftiridina y composiciones farmaceuticas como inhibidores de quinasa con actividad sobre c- kit y pdgfr

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Country Link
US (1) US8278452B2 (es)
EP (1) EP2252612B1 (es)
JP (1) JP5230755B2 (es)
KR (1) KR101216323B1 (es)
CN (1) CN102083828B (es)
AR (1) AR070469A1 (es)
AT (1) ATE551342T1 (es)
AU (1) AU2009217356B2 (es)
BR (1) BRPI0908849A2 (es)
CA (1) CA2714700C (es)
CL (1) CL2009000400A1 (es)
EA (1) EA018551B1 (es)
ES (1) ES2383331T3 (es)
MX (1) MX2010009207A (es)
PE (1) PE20091492A1 (es)
TW (1) TW200940538A (es)
WO (1) WO2009105712A1 (es)

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